RTVue XR和Keratograph测量下泪河高度的重复性和再现性比较
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摘要
目的:比较RTVue XR和Keratograph眼表综合分析仪测量下泪河高度(LTMH)的差异,评估两种设备在初始眼以及FS-LASIK术后眼中测量LTMH的重复性和再现性。方法:选择2019-01在广州爱尔眼科医院就诊的初始眼以及FS-LASIK术后眼各52只。分别使用RTVue XR和Keratograph眼表综合分析仪进行LTMH测量。比较两种设备测量值的差异。采用组内标准偏差(Sw),重复测量重复度(2.77Sw),变异系数(CoV)和组内相关系数(ICC)评价两种设备测量的重复性和再现性。结果:初始眼组中,RTVue XR和Keratograph测量的LTMH分别为261.12±80.29、235.05±78.40μm;平均CoV为5.55%、14.90%;平均ICC为0.98、0.87。FS-LASIK眼组中,RTVue XR和Keratograph测量的LTMH分别为234.55±68.38、208.22±73.85μm;平均CoV为5.29%、16.16%;平均ICC为0.97、0.87。结论:在初始眼及FS-LASIK术后眼中,RTVue XR测量的LTMH值较Keratograph测量值偏大约25μm,测量的信度更高。RTVue XR可以用于临床上初始眼以及FS-LASIK术后眼的LTMH的评估。
AIM: To observe the agreement of the lower tear meniscus height(LTMH) measurements using RTVue XR and Keratograph ocular surface analyzer, and to compare intraobserver repeatability and interobserver reproducibility between the two devices in the virginal and FS-LASIK eyes.METHODS: Totally 52 virginal eyes and 52 FS-LASIK eyes were included during January 2019 in Guangzhou Aier Eye Hospital.LTMH measurements were performed using RTVue XR and Keratograph Ocular Surface Analyzer.A paired t-test was used to compare the difference between LTMH values using the two devices.The with-subject standard deviation(Sw), test-retest repeatability(2.77Sw), coefficient of variation(CoV) and intraclass correlation coefficient(ICC) were calculated to evaluate the repeatability and reproducibility.RESULTS: In the virginal eyes group, the average LTMH obtained with RTVue XR and Keratograph were 261.12±80.29μm and 235.05±78.40μm, respectively.CoV and ICC were 5.55% and 0.98 for RTVue XR, 14.90% and 0.87 for Keratograph, respectively.In the FS-LASIK group, the average LTMH were 234.55±68.38μm and 208.22±73.85μm, respectively.CoV and ICC were 5.29% and 0.97 for RTVue XR, 16.16% and 0.87 for Keratograph, respectively.CONCLUSION: In the virginal and FS-LASIK eyes, the LTMH value obtained with RTVue XR is 25μm greater than Keratograph.RTVue XR has a better reliability than Keratograph and can be used to measure the LTMH.
AIM: To observe the agreement of the lower tear meniscus height(LTMH) measurements using RTVue XR and Keratograph ocular surface analyzer, and to compare intraobserver repeatability and interobserver reproducibility between the two devices in the virginal and FS-LASIK eyes.METHODS: Totally 52 virginal eyes and 52 FS-LASIK eyes were included during January 2019 in Guangzhou Aier Eye Hospital.LTMH measurements were performed using RTVue XR and Keratograph Ocular Surface Analyzer.A paired t-test was used to compare the difference between LTMH values using the two devices.The with-subject standard deviation(Sw), test-retest repeatability(2.77Sw), coefficient of variation(CoV) and intraclass correlation coefficient(ICC) were calculated to evaluate the repeatability and reproducibility.RESULTS: In the virginal eyes group, the average LTMH obtained with RTVue XR and Keratograph were 261.12±80.29μm and 235.05±78.40μm, respectively.CoV and ICC were 5.55% and 0.98 for RTVue XR, 14.90% and 0.87 for Keratograph, respectively.In the FS-LASIK group, the average LTMH were 234.55±68.38μm and 208.22±73.85μm, respectively.CoV and ICC were 5.29% and 0.97 for RTVue XR, 16.16% and 0.87 for Keratograph, respectively.CONCLUSION: In the virginal and FS-LASIK eyes, the LTMH value obtained with RTVue XR is 25μm greater than Keratograph.RTVue XR has a better reliability than Keratograph and can be used to measure the LTMH.
引文
1 Nguyen P,Huang D,Li Y,et al.Correlation between optical coherence tomography-derived assessments of lower tear meniscus parameters and clinical features of dry eye disease.Cornea 2012;31(6):680-685
2 Toda I.Dry Eye After LASIK.Invest Ophthalmol Vis Sci 2018;59(14):DES109-DES115
3中华医学会眼科学分会角膜病学组.干眼临床诊疗专家共识(2013年).中华眼科杂志 2013;49(1):73-75
4 Craig JP,Nichols KK,Akpek EK,et al.TFOS DEWS II Definition and Classification Report.Ocul Surf 2017;15(3):276-283
5 Imamura H,Tabuchi H,Nakakura S,et al.Usability and reproducibility of tear meniscus values generated via swept-source optical coherence tomography and the slit lamp with a graticule method.Int Ophthalmol 2018;38(2):679-686
6 Sweeney DF,Millar TJ,Raju SR.Tear film stability:a review.Exp Eye Res 2013;117:28-38
7 Czajkowski G,Kaluzny BJ,Laudencka A,et al.Tear meniscus measurement by spectral optical coherence tomography.Optom Vis Sci 2012;89(3):336-342
8 Huang D,Swanson EA,Lin CP,et al.Optical coherence tomography.Science 1991;254(5035):1178-1181
9 Fujimoto J,Swanson E.The Development,Commercialization,and Impact of Optical Coherence Tomography.Invest Ophthalmol Vis Sci 2016;57(9):OCT1-OCT13
10 Lee WD,Devarajan K,Chua J,et al.Optical coherence tomography angiography for the anterior segment.Eye Vis (Lond)2019;6(1):4
11 Baek J,Doh SH,Chung SK.Comparison of Tear Meniscus Height Measurements Obtained With the Keratograph and Fourier Domain Optical Coherence Tomography in Dry Eye.Cornea 2015;34(10):1209-1213
12 Koh S,Ikeda C,Watanabe S,et al.Effect of non-invasive tear stability assessment on tear meniscus height.Acta Ophthalmol 2015;93(2):e135-e139
13 Wei A,Le Q,Hong J,et al.Assessment of Lower Tear Meniscus.Optom Vis Sci 2016;93(11):1420-1425
14 Arriola-Villalobos P,Fernández-Vigo JI,Díaz-Valle D,et al.Assessment of lower tear meniscus measurements obtained with Keratograph and agreement with Fourier-domain optical-coherence tomography.Br J Ophthalmol 2015;99(8):1120-1125
15 Tian L,Qu JH,Zhang XY,et al.Repeatability and Reproducibility of Noninvasive Keratograph 5M Measurements in Patients with Dry Eye Disease.J Ophthalmol 2016;2016(2):8013621-8013626
16万珊珊,杨燕宁,袁静,等.眼表综合分析仪评价干眼患者相关指标的临床分析.中华眼视光学与视觉科学杂志2015;17(3):171-175
17张媛,贾冰冰,张岩,等.飞秒激光制瓣LASIK术后泪膜变化及相关性分析.中国实用眼科杂志2014;32(11):1313-1316
18 Keech A,Flanagan J,Simpson T,et al.Tear meniscus height determination using the OCT2 and the RTVue-100.Optom Vis Sci 2009;86(10):1154-1159
19 Carracedo G,Pastrana C,Serramito M,et al.Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation.Acta Ophthalmol 2018;35(Pt4):654
20 Hong J,Sun X,Wei A,et al.Assessment of tear film stability in dry eye with a newly developed keratograph.Cornea 2013;32(5):716-721
21 Jung JW,Kim JY,Chin HS,et al.Assessment of meibomian glands and tear film in post-refractive surgery patients.Clin Exp Ophthalmol 2017;45(9):857-866
2 Toda I.Dry Eye After LASIK.Invest Ophthalmol Vis Sci 2018;59(14):DES109-DES115
3中华医学会眼科学分会角膜病学组.干眼临床诊疗专家共识(2013年).中华眼科杂志 2013;49(1):73-75
4 Craig JP,Nichols KK,Akpek EK,et al.TFOS DEWS II Definition and Classification Report.Ocul Surf 2017;15(3):276-283
5 Imamura H,Tabuchi H,Nakakura S,et al.Usability and reproducibility of tear meniscus values generated via swept-source optical coherence tomography and the slit lamp with a graticule method.Int Ophthalmol 2018;38(2):679-686
6 Sweeney DF,Millar TJ,Raju SR.Tear film stability:a review.Exp Eye Res 2013;117:28-38
7 Czajkowski G,Kaluzny BJ,Laudencka A,et al.Tear meniscus measurement by spectral optical coherence tomography.Optom Vis Sci 2012;89(3):336-342
8 Huang D,Swanson EA,Lin CP,et al.Optical coherence tomography.Science 1991;254(5035):1178-1181
9 Fujimoto J,Swanson E.The Development,Commercialization,and Impact of Optical Coherence Tomography.Invest Ophthalmol Vis Sci 2016;57(9):OCT1-OCT13
10 Lee WD,Devarajan K,Chua J,et al.Optical coherence tomography angiography for the anterior segment.Eye Vis (Lond)2019;6(1):4
11 Baek J,Doh SH,Chung SK.Comparison of Tear Meniscus Height Measurements Obtained With the Keratograph and Fourier Domain Optical Coherence Tomography in Dry Eye.Cornea 2015;34(10):1209-1213
12 Koh S,Ikeda C,Watanabe S,et al.Effect of non-invasive tear stability assessment on tear meniscus height.Acta Ophthalmol 2015;93(2):e135-e139
13 Wei A,Le Q,Hong J,et al.Assessment of Lower Tear Meniscus.Optom Vis Sci 2016;93(11):1420-1425
14 Arriola-Villalobos P,Fernández-Vigo JI,Díaz-Valle D,et al.Assessment of lower tear meniscus measurements obtained with Keratograph and agreement with Fourier-domain optical-coherence tomography.Br J Ophthalmol 2015;99(8):1120-1125
15 Tian L,Qu JH,Zhang XY,et al.Repeatability and Reproducibility of Noninvasive Keratograph 5M Measurements in Patients with Dry Eye Disease.J Ophthalmol 2016;2016(2):8013621-8013626
16万珊珊,杨燕宁,袁静,等.眼表综合分析仪评价干眼患者相关指标的临床分析.中华眼视光学与视觉科学杂志2015;17(3):171-175
17张媛,贾冰冰,张岩,等.飞秒激光制瓣LASIK术后泪膜变化及相关性分析.中国实用眼科杂志2014;32(11):1313-1316
18 Keech A,Flanagan J,Simpson T,et al.Tear meniscus height determination using the OCT2 and the RTVue-100.Optom Vis Sci 2009;86(10):1154-1159
19 Carracedo G,Pastrana C,Serramito M,et al.Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation.Acta Ophthalmol 2018;35(Pt4):654
20 Hong J,Sun X,Wei A,et al.Assessment of tear film stability in dry eye with a newly developed keratograph.Cornea 2013;32(5):716-721
21 Jung JW,Kim JY,Chin HS,et al.Assessment of meibomian glands and tear film in post-refractive surgery patients.Clin Exp Ophthalmol 2017;45(9):857-866