帕金森病传统疗法及间充质干细胞移植疗法的现状
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摘要
帕金森病是一种中老年人常见的神经系统疾病,我国越来越多的帕金森病患者给社会带来很大负担。传统治疗方法只能缓解症状,并不能延缓病情进展,更不能逆转病情。间充质干细胞移植疗法已开展到临床试验阶段并且见到了了可喜成果,本文就帕金森病传统疗法及间充质干细胞移植疗法的现状进行综述。
Parkinson's disease is a common neurological disease in middle and old aged people. More and more Parkinson disease patients in China are bringing great burden to the society. Traditional therapy can only relieve symptoms, and can not delay the progress of the disease, nor can it cure the disease. Mesenchymal stem cells transplantation has been carried out in the clinical trial stage and has seen good results. This article reviews the current status of traditional Parkinson's disease therapy and mesenchymal stem cell transplantation.
Parkinson's disease is a common neurological disease in middle and old aged people. More and more Parkinson disease patients in China are bringing great burden to the society. Traditional therapy can only relieve symptoms, and can not delay the progress of the disease, nor can it cure the disease. Mesenchymal stem cells transplantation has been carried out in the clinical trial stage and has seen good results. This article reviews the current status of traditional Parkinson's disease therapy and mesenchymal stem cell transplantation.
引文
[1]de Lau L M,Breteler M M.Epidemiology of Parkinson's disease[J].Lancet Neurology,2006,5(6):525-535.
[2]Alves G,Forsaa EB,Pedersen KF,et al.Epidemiology of Parkinson’s disease[J].Parkinsonism&Related Disorders,1973,66(2):202.
[3]刘疏影,陈彪.帕金森病流行现状[J].中国现代神经疾病杂志,2016,16(2):98-101.
[4]Utsumi H,Okuma Y,Kano O,et al.Evaluation of the efficacy of pramipexole for treating levodopa-induced dyskinesia in patients with Parkinson's disease[J].Internal Medicine,2013,52(3):325-332.
[5]Rascol O,Fitzer-Attas C J,Hauser R,et al.A double-blind,delayed-start trial of rasagiline in Parkinson's disease(the ADAGIO study):prespecified and post-hoc analyses of the need for additional therapies,changes in UPDRS scores,and non-motor outcomes[J].Lancet Neurology,2011,10(5):415-423.
[6]Stocchi F,Rabey J M.Effect of rasagiline as adjunct therapy to levodopa on severity of OFF in Parkinson’s disease[J].European Journal of Neurology,2011,18(12):1373-1378.
[7]马如钧,张伟,刘永,等.微电极导向立体定向技术行脑内核团毁损和脑深部电刺激治疗帕金森病的效果观察[J].中国医药导刊,2012,14(8):1333-1334,1336.
[8]Xie T,Kang U J,Warnke P.Effect of stimulation frequency on immediate freezing of gait in newly activated STN DBS in Parkinson's disease[J].Journal of Neurology Neurosurgery&Psychiatry,2012,83(10):1015-7.
[9]赵澎,程焱,陶华英,等.重复经颅磁刺激对帕金森病运动功能及运动诱发电位的影响[J].中国临床神经科学,2007,15(4):397-401.
[10]Pohl M,Rockstroh G,Rückriem S,et al.Immediate effects of speeddependent treadmill training on gait parameters in early Parkinson's disease[J].Archives of Physical Medicine&Rehabilitation,2003,84(12):1760-1766.
[11]Ustinova K,Chernikova L,Bilimenko A,et al.Effect of robotic locomotor training in an individual with Parkinson's disease:a case report[J].Disability&Rehabilitation Assistive Technology,2011,6(1):77-85.
[12]Lo A C.Lokomat Training to Improve Gait in Multiple Sclerosis and Freezing of Gait in Parkinson's Disease[J].Topics in Spinal Cord Injury Rehabilitation,2011,17(1):66-69.
[13]Friedenstein A J,Piatetzkyshapiro I I,Petrakova K V.Osteogenesis i n t r a n s p l a n t s o f b o n e m a r r o w c e l l s[J].J E m b r y o l E x p Morphol,1966,16(3):381-390.
[14]Zhao Y,Xin J,Sun C,et al.Safrole oxide induced neuronal differentiation of rat bone-marrow mesenchymal stem cells by elevating Hsp70[J].Gene,2012,509(1):85-92.
[15]Nian X,Hecheng Y,Ling L,et al.b FGF promotes the differentiation and effectiveness of human bone marrow mesenchymal stem cells in a rotenone model for Parkinson's disease[J].Environmental Toxicology&Pharmacology,2013,36(2):411-22.
[16]Jackson J,Chapon C,Jones W,et al.In vivo,multimodal imaging of stem cell transplantation in a rodent model of Parkinson's disease[J].J Neurosci Methods,2009,183(2):141-148.
[17]Chao Y X,He B P,Tay S S.Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson's disease[J].Journal of Neuroimmunolo gy,2009,216(1):39-50.
[18]王旭,张志彬,贾芙蓉,等.自体骨髓间充质干细胞移植治疗帕金森病的疗效[J].中国老年学杂志,2014,34(1):22-23.
[19]Wang W T,Gu P,Qiu F C,et al.Intravenous Transplantation of Allograft h UC-MSC was More Effective Than Subarachnoid Transplantation of BMMSCs in Patients with Parkinson's Syndrome and Secondary Parkinson's Syndrome[J].Journal of Biomaterials&Tissue Engineering,2016,6(2):158-164.
[20]Wexler S A,Donaldson C,Denning-Kendall P,et al.Adult bone marrow is a rich source of human mesenchymal'stem'cells but umbilical cord and mobilized adult blood are not[J].Br J Haematol,2003,121(2):368-374.
[21]Mitchell K E,Weiss M L,Mitchell B M,et al.Matrix cells from Wharton's jelly form neurons and glia[J].Stem Cells,2003,21(1):50-60.
[22]马廉,崔冰琳,冯学永,等.人脐带间充质干细胞的生物学特性及向神经样细胞分化的研究[J].中华儿科杂志,2006,44(7):513-517.
[23]王卫民,丁妍.BHA诱导人脐带间充质干细胞分化为神经细胞[J].东南大学学报(医学版),2013,32(2):201-205.
[24]刘学元,李德华,单伟,等.维甲酸联合音猬因子诱导人脐带间充质干细胞分化为运动神经元[J].解剖学杂志,2012,35(2):149-153.
[25]Weiss M L,Medicetty S,Bledsoe A R,et al.Human Umbilical Cord Matrix Stem Cells:Preliminary Characterization and Effect of Transplantation in a Rodent Model of Parkinson's Disease[J].Stem Cells,2006,24(3):781-792.
[26]王革生,张庆俊,韩忠朝.人脐带间充质干细胞移植对大鼠脊髓损伤神经功能恢复的评价[J].中华神经外科杂志,2006,22(1):18-21.
[27]赵璨,李慧,赵贤婧,等.人脐带间充质干细胞源性多巴胺能样神经元对帕金森病模型大鼠的疗效[J].江苏医药,2015(14):1616-1620.
[28]卢爱丽.脐带间充质干细胞治疗帕金森病的疗效[J].中国老年学杂志,2013,33(21):5245-5247.
[29]邱云,汪铮,路红社.脐带间充质干细胞移植治疗帕金森病8例[J].中国组织工程研究,2011,15(36):6833-6836.
[30]季兴,李波,李婛,等.脐带间充质干细胞移植治疗帕金森病效果分析[J].中国实用神经疾病杂志,2014,17(2):8-10.
[31]顾平,张忠霞,仇福成,等.人脐带间充质干细胞移植在缺血缺氧性脑病治疗中的作用[J].中国综合临床,2015(3):206-211.
[32]Cova L,Armentero M T,Zennaro E,et al.Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson's disease[J].Brain Research,2010,1311(1311):12-27.
[33]顾蔚,顾健.脐带间充质干细胞的归巢机制[J].中国组织工程研究,2013,17(6):1135-1140.
[34]Levy Y S,Bahatstroomza M,Levy Y S,et al.Regenerative effect of neuralinduced human mesenchymal stromal cells in rat models of Parkinson's disease[J].Cytotherapy,2008,10(4):340-352.
[35]Zhao Y,Yang C,Wang H,et al.Therapeutic effects of bone marrowderived mesenchymal stem cells on pulmonary impact injury complicated with endotoxemia in rats[J].International Immunopharmacolo gy,2013,15(2):246-53.
[36]Lee O K,Kuo T K,Chen W M,et al.Isolation of multipotent mesenchymal stem cells from umbilical cord blood[J].Blood,2004,103(5):1669-1675.
[37]蔡琼霞,熊华锋,胡葵葵,等.脐血源性和脐带源性的间充质干细胞生物学特性的比较[J].北京医学,2008,30(7):438-440.
[38]Lee E S,Yu S H,Jang Y J,et al.Transplantation of Bone MarrowDerived Mesenchymal Stem Cells into the Developing Mouse Eye[J].Acta Histochemica Et Cytochemica,2011,44(5):213-221.
[39]吴立克,王晓娟,褚赛纯,等.脐血间充质干细胞移植治疗帕金森病30例[J].中国组织工程研究与临床康复,2009,13(40):7951-7954.
[40]黄仕雄,刘军,文国强,等.Nurr1基因修饰人脐血间充质干细胞源性多巴胺能神经元移植治疗帕金森病[J].中山大学学报(医学科学版),2009,30(5):522-526.
[2]Alves G,Forsaa EB,Pedersen KF,et al.Epidemiology of Parkinson’s disease[J].Parkinsonism&Related Disorders,1973,66(2):202.
[3]刘疏影,陈彪.帕金森病流行现状[J].中国现代神经疾病杂志,2016,16(2):98-101.
[4]Utsumi H,Okuma Y,Kano O,et al.Evaluation of the efficacy of pramipexole for treating levodopa-induced dyskinesia in patients with Parkinson's disease[J].Internal Medicine,2013,52(3):325-332.
[5]Rascol O,Fitzer-Attas C J,Hauser R,et al.A double-blind,delayed-start trial of rasagiline in Parkinson's disease(the ADAGIO study):prespecified and post-hoc analyses of the need for additional therapies,changes in UPDRS scores,and non-motor outcomes[J].Lancet Neurology,2011,10(5):415-423.
[6]Stocchi F,Rabey J M.Effect of rasagiline as adjunct therapy to levodopa on severity of OFF in Parkinson’s disease[J].European Journal of Neurology,2011,18(12):1373-1378.
[7]马如钧,张伟,刘永,等.微电极导向立体定向技术行脑内核团毁损和脑深部电刺激治疗帕金森病的效果观察[J].中国医药导刊,2012,14(8):1333-1334,1336.
[8]Xie T,Kang U J,Warnke P.Effect of stimulation frequency on immediate freezing of gait in newly activated STN DBS in Parkinson's disease[J].Journal of Neurology Neurosurgery&Psychiatry,2012,83(10):1015-7.
[9]赵澎,程焱,陶华英,等.重复经颅磁刺激对帕金森病运动功能及运动诱发电位的影响[J].中国临床神经科学,2007,15(4):397-401.
[10]Pohl M,Rockstroh G,Rückriem S,et al.Immediate effects of speeddependent treadmill training on gait parameters in early Parkinson's disease[J].Archives of Physical Medicine&Rehabilitation,2003,84(12):1760-1766.
[11]Ustinova K,Chernikova L,Bilimenko A,et al.Effect of robotic locomotor training in an individual with Parkinson's disease:a case report[J].Disability&Rehabilitation Assistive Technology,2011,6(1):77-85.
[12]Lo A C.Lokomat Training to Improve Gait in Multiple Sclerosis and Freezing of Gait in Parkinson's Disease[J].Topics in Spinal Cord Injury Rehabilitation,2011,17(1):66-69.
[13]Friedenstein A J,Piatetzkyshapiro I I,Petrakova K V.Osteogenesis i n t r a n s p l a n t s o f b o n e m a r r o w c e l l s[J].J E m b r y o l E x p Morphol,1966,16(3):381-390.
[14]Zhao Y,Xin J,Sun C,et al.Safrole oxide induced neuronal differentiation of rat bone-marrow mesenchymal stem cells by elevating Hsp70[J].Gene,2012,509(1):85-92.
[15]Nian X,Hecheng Y,Ling L,et al.b FGF promotes the differentiation and effectiveness of human bone marrow mesenchymal stem cells in a rotenone model for Parkinson's disease[J].Environmental Toxicology&Pharmacology,2013,36(2):411-22.
[16]Jackson J,Chapon C,Jones W,et al.In vivo,multimodal imaging of stem cell transplantation in a rodent model of Parkinson's disease[J].J Neurosci Methods,2009,183(2):141-148.
[17]Chao Y X,He B P,Tay S S.Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson's disease[J].Journal of Neuroimmunolo gy,2009,216(1):39-50.
[18]王旭,张志彬,贾芙蓉,等.自体骨髓间充质干细胞移植治疗帕金森病的疗效[J].中国老年学杂志,2014,34(1):22-23.
[19]Wang W T,Gu P,Qiu F C,et al.Intravenous Transplantation of Allograft h UC-MSC was More Effective Than Subarachnoid Transplantation of BMMSCs in Patients with Parkinson's Syndrome and Secondary Parkinson's Syndrome[J].Journal of Biomaterials&Tissue Engineering,2016,6(2):158-164.
[20]Wexler S A,Donaldson C,Denning-Kendall P,et al.Adult bone marrow is a rich source of human mesenchymal'stem'cells but umbilical cord and mobilized adult blood are not[J].Br J Haematol,2003,121(2):368-374.
[21]Mitchell K E,Weiss M L,Mitchell B M,et al.Matrix cells from Wharton's jelly form neurons and glia[J].Stem Cells,2003,21(1):50-60.
[22]马廉,崔冰琳,冯学永,等.人脐带间充质干细胞的生物学特性及向神经样细胞分化的研究[J].中华儿科杂志,2006,44(7):513-517.
[23]王卫民,丁妍.BHA诱导人脐带间充质干细胞分化为神经细胞[J].东南大学学报(医学版),2013,32(2):201-205.
[24]刘学元,李德华,单伟,等.维甲酸联合音猬因子诱导人脐带间充质干细胞分化为运动神经元[J].解剖学杂志,2012,35(2):149-153.
[25]Weiss M L,Medicetty S,Bledsoe A R,et al.Human Umbilical Cord Matrix Stem Cells:Preliminary Characterization and Effect of Transplantation in a Rodent Model of Parkinson's Disease[J].Stem Cells,2006,24(3):781-792.
[26]王革生,张庆俊,韩忠朝.人脐带间充质干细胞移植对大鼠脊髓损伤神经功能恢复的评价[J].中华神经外科杂志,2006,22(1):18-21.
[27]赵璨,李慧,赵贤婧,等.人脐带间充质干细胞源性多巴胺能样神经元对帕金森病模型大鼠的疗效[J].江苏医药,2015(14):1616-1620.
[28]卢爱丽.脐带间充质干细胞治疗帕金森病的疗效[J].中国老年学杂志,2013,33(21):5245-5247.
[29]邱云,汪铮,路红社.脐带间充质干细胞移植治疗帕金森病8例[J].中国组织工程研究,2011,15(36):6833-6836.
[30]季兴,李波,李婛,等.脐带间充质干细胞移植治疗帕金森病效果分析[J].中国实用神经疾病杂志,2014,17(2):8-10.
[31]顾平,张忠霞,仇福成,等.人脐带间充质干细胞移植在缺血缺氧性脑病治疗中的作用[J].中国综合临床,2015(3):206-211.
[32]Cova L,Armentero M T,Zennaro E,et al.Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson's disease[J].Brain Research,2010,1311(1311):12-27.
[33]顾蔚,顾健.脐带间充质干细胞的归巢机制[J].中国组织工程研究,2013,17(6):1135-1140.
[34]Levy Y S,Bahatstroomza M,Levy Y S,et al.Regenerative effect of neuralinduced human mesenchymal stromal cells in rat models of Parkinson's disease[J].Cytotherapy,2008,10(4):340-352.
[35]Zhao Y,Yang C,Wang H,et al.Therapeutic effects of bone marrowderived mesenchymal stem cells on pulmonary impact injury complicated with endotoxemia in rats[J].International Immunopharmacolo gy,2013,15(2):246-53.
[36]Lee O K,Kuo T K,Chen W M,et al.Isolation of multipotent mesenchymal stem cells from umbilical cord blood[J].Blood,2004,103(5):1669-1675.
[37]蔡琼霞,熊华锋,胡葵葵,等.脐血源性和脐带源性的间充质干细胞生物学特性的比较[J].北京医学,2008,30(7):438-440.
[38]Lee E S,Yu S H,Jang Y J,et al.Transplantation of Bone MarrowDerived Mesenchymal Stem Cells into the Developing Mouse Eye[J].Acta Histochemica Et Cytochemica,2011,44(5):213-221.
[39]吴立克,王晓娟,褚赛纯,等.脐血间充质干细胞移植治疗帕金森病30例[J].中国组织工程研究与临床康复,2009,13(40):7951-7954.
[40]黄仕雄,刘军,文国强,等.Nurr1基因修饰人脐血间充质干细胞源性多巴胺能神经元移植治疗帕金森病[J].中山大学学报(医学科学版),2009,30(5):522-526.