大理州健康人群乙型肝炎表面抗体水平分析
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摘要
目的了解2016～2018年大理州人群乙型肝炎(乙肝)表面抗体水平(HBs Ab),为乙肝防控提供科学依据。方法采集11454份居民血清样本(12个行政区),通过酶联免疫吸附试验(ELISA)法分析HBs A水平情况。结果 (1)6231份血清样本检验为阳性(男性2767人,女性3464人),阳性率为31.31%～92.50%,其中:城市达到54.07%,农村达到54.41%(2)HBs Ab水平在8至17月齡人群中最高(92.50%),在25至34周岁人群中最低(31.31%)。(3)HBs Ab水平与年龄呈负相关(rs=-0.397,P <0.001),与免疫史呈正相关,差异均有统计学意义(P <0.001)。结论本地区居民HBs Ab水平较低,应积极推广成人乙肝疫苗接种,以防控乙型肝炎病毒的传播。
Objective: To observe the levels of HBsAb among healthy human living in Dali from 2016 to 2018 in order to provide the scientific evidences for preventing and controlling hepatitis B. Methods: In total, 11454 serums were collected from 12 regions, and the levels of HBs A was analyzed by enzyme-linked immunosorbent assay(ELISA). Results:(1) Finally, 6231 healthy were positive(male 2767, female 3464). The seropositivity was 31.31%～92.50%(urban healthy 54.7%, rural healthy 54.415).(2) The levels of HBsAb achieve the highest rate(92.50%) among 8-17 months of age, and the lowest rate(31.31%) among 25-34 year-olds.(3) There was a negative correlation between HBsAb and age, but found a positive correlation between HBsAb and immunization history. Conclusions: HBs Ab levels is low in local residents. Therefore, HBV vaccine inoculating will be actively popularized to prevent and control hepatitis B.
Objective: To observe the levels of HBsAb among healthy human living in Dali from 2016 to 2018 in order to provide the scientific evidences for preventing and controlling hepatitis B. Methods: In total, 11454 serums were collected from 12 regions, and the levels of HBs A was analyzed by enzyme-linked immunosorbent assay(ELISA). Results:(1) Finally, 6231 healthy were positive(male 2767, female 3464). The seropositivity was 31.31%～92.50%(urban healthy 54.7%, rural healthy 54.415).(2) The levels of HBsAb achieve the highest rate(92.50%) among 8-17 months of age, and the lowest rate(31.31%) among 25-34 year-olds.(3) There was a negative correlation between HBsAb and age, but found a positive correlation between HBsAb and immunization history. Conclusions: HBs Ab levels is low in local residents. Therefore, HBV vaccine inoculating will be actively popularized to prevent and control hepatitis B.
引文
[1]田兴国,褚彪,朱仁珍,等. 2013年六盘水市健康人群乙型肝炎表面抗体水平监测[J].预防医学论坛,2014,20(8):596-597.
[2]周舟,刘彦君.云南大理州2002-2009年GAVI项目乙肝疫苗免疫效果[J].中国热带医学,2011,11(12):1475-1476.
[3]何左,易寿生,李鸿钧,等.大理州8月龄至5岁儿童乙肝疫苗接种率及免疫效果[J].海峡预防医学杂志,2017,23(6):45-47.
[4]卫生部疾病预防控制局,中国疾病预防控制中心.全国人群乙肝病毒性肝炎血清流行病学调查报告[M].北京:人民卫生出版社,2011:8.
[5]王陇德.预防接种实践与管理[M].北京:人民卫生出版社,2006:149.
[6]陈剑锋,马斌,费怡,等. 2016年上海市浦东新区高东社区儿童青少年乙肝病毒感染及乙肝疫苗接种状况调查[J].实用预防医学,2018,25(4):433-437.
[7]贾文涛,杨兆民,陈彦炜,等.商洛市2006-2014年乙型病毒性肝炎流行病学特征分析[J].医学动物防制,2016,32(5):482-484.
[8]欧必东,潘宏,郭豫,等.2013年贵州省黔东南州健康人群乙型肝炎表面抗体监测结果[J].职业与健康,2014,30(18):2651-2653.
[9]翟如芳,邢秀生,王海娇,等.重组乙型肝炎疫苗(酵母)免疫后12年的抗体持久性研究[J].河北医学,2015,21(6):1049-1050.
[10]王存祯,刑秀生,王晓芳,等.重组乙型肝炎疫苗(酿酒酵母)免疫后15年的持久性效果研究[J].中国疫苗和免疫,2013,19(2):147-149.
[11]田飞,李兰,唐刚学,等. 2014年铜仁市健康人群乙型病毒性肝炎抗体水平监测结果的分析[J].中国当代医学,2015,22(25):154-156.
[12]喻文雅,李怡秋,闫玉英,等. 2013年石家庄市健康人群乙型肝炎免疫情况调查及影响因素分析[J].现代预防医学,2016,43(9):1688-1690.
[2]周舟,刘彦君.云南大理州2002-2009年GAVI项目乙肝疫苗免疫效果[J].中国热带医学,2011,11(12):1475-1476.
[3]何左,易寿生,李鸿钧,等.大理州8月龄至5岁儿童乙肝疫苗接种率及免疫效果[J].海峡预防医学杂志,2017,23(6):45-47.
[4]卫生部疾病预防控制局,中国疾病预防控制中心.全国人群乙肝病毒性肝炎血清流行病学调查报告[M].北京:人民卫生出版社,2011:8.
[5]王陇德.预防接种实践与管理[M].北京:人民卫生出版社,2006:149.
[6]陈剑锋,马斌,费怡,等. 2016年上海市浦东新区高东社区儿童青少年乙肝病毒感染及乙肝疫苗接种状况调查[J].实用预防医学,2018,25(4):433-437.
[7]贾文涛,杨兆民,陈彦炜,等.商洛市2006-2014年乙型病毒性肝炎流行病学特征分析[J].医学动物防制,2016,32(5):482-484.
[8]欧必东,潘宏,郭豫,等.2013年贵州省黔东南州健康人群乙型肝炎表面抗体监测结果[J].职业与健康,2014,30(18):2651-2653.
[9]翟如芳,邢秀生,王海娇,等.重组乙型肝炎疫苗(酵母)免疫后12年的抗体持久性研究[J].河北医学,2015,21(6):1049-1050.
[10]王存祯,刑秀生,王晓芳,等.重组乙型肝炎疫苗(酿酒酵母)免疫后15年的持久性效果研究[J].中国疫苗和免疫,2013,19(2):147-149.
[11]田飞,李兰,唐刚学,等. 2014年铜仁市健康人群乙型病毒性肝炎抗体水平监测结果的分析[J].中国当代医学,2015,22(25):154-156.
[12]喻文雅,李怡秋,闫玉英,等. 2013年石家庄市健康人群乙型肝炎免疫情况调查及影响因素分析[J].现代预防医学,2016,43(9):1688-1690.