心肺复苏药物治疗的新进展
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摘要
<正>心搏骤停(cardiac arrest,CA)是一种严重威胁人类生命的急症,无论是院外心搏骤停还是院内心搏骤停,自主循环恢复(return of spontaneous circulation,ROSC)率和存活率均较低~([1])。美国和欧洲的院内心搏骤停存活率为7%～26%~([2]),院外心搏骤停存活率为5%～20%~([3]),而北京院外心搏骤停和院内心搏骤停出院存活率仅为1.3%~([4])和
High-quality cardiopulmonary resuscitation(CPR)and proper drug therapy in CPR are both important parts to improve the success rate of CPR.With the development of evidence-based medicine,although the clinical research of drug therapy in CPR such as vasoactive drug therapy has made some progresses,it is still limited.
High-quality cardiopulmonary resuscitation(CPR)and proper drug therapy in CPR are both important parts to improve the success rate of CPR.With the development of evidence-based medicine,although the clinical research of drug therapy in CPR such as vasoactive drug therapy has made some progresses,it is still limited.
引文
[1]胡莹莹,徐军,朱华栋,等.急诊心搏骤停患者心肺复苏概况和预后调查:一项多中心前瞻性观察性研究[J].中华危重病急救医学,2018,30(3):234-239.
[2] Ehlenbach WJ,Barnato AE,Curtis JR,et al.Epidemiologic study of in-hospital cardiopulmonary resuscitation in the elderly[J].N Engl J Med,2009,361(1):22
[3] Berdowski J,Berg RA,Tijssen JG,et al.Global incidences of out-of-hospital cardiac arrest and survival rates:systematic review of 67prospective studies[J].Resuscitation,2010,81(11):1479-1487.
[4] Shao F,Li CS,Liang LR,et al.Outcome of out-of-hospital cardiac arrests in Beijing,China[J].Resuscitation,2014,85(11):1411-1417.
[5] Shao F,Li CS,Liang LR,et al.Incidence and outcome of adult in-hospital cardiac arrest in Beijing,China[J].Resuscitation,2016,102:51-56.
[6] Paradis NA,Martin GB,Rivers EP,et al.Coronary perfusion pressure and the return of spontaneous circulation in human cardiopulmonary resuscitation[J].JAMA,1990,263:1106-1113.
[7] Donnino MW,Salciccioli JD,Howell MD,et al.Time to administration of epinephrine and outcome after inhospital cardiac arrest with nonshockable rhythms:retrospective analysis of large in-hospital data registry[J].BMJ,2014,348:g3028.
[8] Homma Y,Shiga T,Funakoshi H,et al.Association of the time to first epinephrine administration and outcomes in out-of-hospital cardiac arrest:SOS-KANTO2012study[J].Am J Emerg Med,2018.
[9] Tanaka H,Takyu H,Sagisaka R,et al.Favorable neurological outcomes by early epinephrine administration within 19minutes after EMS call for out-of-hospital cardiac arrest patients[J].Am J Emerg Med,2016,34:2284-2290.
[10]Andersen LW,Kurth T,Chase M,et al.Early administration of epinephrine(adrenaline)in patients with cardiac arrest with initial shockable rhythm in hospital:propensity score matched analysis[J].BMJ,2016,353:i1577.
[11]Link MS,Berkow LC,Kudenchuk PJ,et al.Part7:adult advanced cardiovascular life support:2015American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care[J].Circulation,2015,132(18Suppl 2):S444-S464.
[12]Fisk CA,Olsufka M,Yin L,et al.Lower-dose epinephrine administration and out-of-hospital cardiac arrest outcomes[J].Resuscitation,2018,124:43-48.
[13]Lin S,Callaway CW,Shah PS,et al.Adrenaline for out-of-hospital cardiac arrest resuscitation:A systematic review and meta-analysis of randomized controlled trials[J].Resuscitation,2014,85:732-740.
[14] Warren SA,Huszti E,Bradley SM,et al.Adrenaline(epinephrine)dosing period and survival after in-hospital cardiac arrest:a retrospective review of prospectively collected data[J].Resuscitation,2014,85:350-358.
[15]Hoyme DB,Patel SS,Samson RA,et al.Epinephrine dosing interval and survival outcomes during pediatric in-hospital cardiac arrest[J].Resuscitation,2017,117:18-23.
[16]Ristagno G,Tang W,Huang L,et al.Epinephrine reduces cerebral perfusion during cardiopulmonary resuscitation[J].Crit Care Med,2009,37(4):1408-1415.
[17]Neumar RW,Otto CW,Link MS,et al.Part 8:adult advanced cardiovascular life support:2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care[J].Circulation,2010,122:S729-S767.
[18] Ong ME,Tiah L,Leong BS,et al.A randomized,double-blind,multicentre trial comparing vasopressin and adrenaline in patients with cardiac arrest presenting to or in the Emergency Department[J].Resuscitation,2012,83(8):953-960.
[19]Ducros L,Vicaut E,Soleil C,et al.Effect of the addition of vasopressin or vasopressin plus nitroglycerin to epinephrine on arterial blood pressure during cardiopulmonary resuscitation in humans[J].J Emerg Med,2011,41(5):453-459.
[20]Wenzel V,Krismer AC,Arntz HR,et al.A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation[J].N Engl J Med,2004,350(2):105-113.
[21]Kudenchuk P J,Brown S P,Daya M,et al.Amiodarone,Lidocaine,or Placebo in Out-of-Hospital Cardiac Arrest[J].N Engl J Med,2016,374(18):1711-1722.
[22]Huang Y,He Q,Yang M,et al.Anti-arrhythmia drugs for cardiac arrest:a systemic review and meta-analysis[J].Crit Care,2013,17:R173.
[23]何庆,黄煜.心肺复苏药物新进展及循证医学证据[J].心血管病学进展,2017,38(4):414-418.
[24]Ji XF,Yang L,Zhang MY,et al.Shen-fu injection attenuates post-resuscitation myocardial dysfunction in aporcine model of cardiac arrest[J].Shock,2011,35(5):530-536.
[25]Yin Q,Wu CJ,Yang J,et al.Effects of Shen fu Injection on cerebral metabolism in a porcine model of cardiac arrest[J].Chin J Integr Med,2017,23(1):33-39.
[2] Ehlenbach WJ,Barnato AE,Curtis JR,et al.Epidemiologic study of in-hospital cardiopulmonary resuscitation in the elderly[J].N Engl J Med,2009,361(1):22
[3] Berdowski J,Berg RA,Tijssen JG,et al.Global incidences of out-of-hospital cardiac arrest and survival rates:systematic review of 67prospective studies[J].Resuscitation,2010,81(11):1479-1487.
[4] Shao F,Li CS,Liang LR,et al.Outcome of out-of-hospital cardiac arrests in Beijing,China[J].Resuscitation,2014,85(11):1411-1417.
[5] Shao F,Li CS,Liang LR,et al.Incidence and outcome of adult in-hospital cardiac arrest in Beijing,China[J].Resuscitation,2016,102:51-56.
[6] Paradis NA,Martin GB,Rivers EP,et al.Coronary perfusion pressure and the return of spontaneous circulation in human cardiopulmonary resuscitation[J].JAMA,1990,263:1106-1113.
[7] Donnino MW,Salciccioli JD,Howell MD,et al.Time to administration of epinephrine and outcome after inhospital cardiac arrest with nonshockable rhythms:retrospective analysis of large in-hospital data registry[J].BMJ,2014,348:g3028.
[8] Homma Y,Shiga T,Funakoshi H,et al.Association of the time to first epinephrine administration and outcomes in out-of-hospital cardiac arrest:SOS-KANTO2012study[J].Am J Emerg Med,2018.
[9] Tanaka H,Takyu H,Sagisaka R,et al.Favorable neurological outcomes by early epinephrine administration within 19minutes after EMS call for out-of-hospital cardiac arrest patients[J].Am J Emerg Med,2016,34:2284-2290.
[10]Andersen LW,Kurth T,Chase M,et al.Early administration of epinephrine(adrenaline)in patients with cardiac arrest with initial shockable rhythm in hospital:propensity score matched analysis[J].BMJ,2016,353:i1577.
[11]Link MS,Berkow LC,Kudenchuk PJ,et al.Part7:adult advanced cardiovascular life support:2015American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care[J].Circulation,2015,132(18Suppl 2):S444-S464.
[12]Fisk CA,Olsufka M,Yin L,et al.Lower-dose epinephrine administration and out-of-hospital cardiac arrest outcomes[J].Resuscitation,2018,124:43-48.
[13]Lin S,Callaway CW,Shah PS,et al.Adrenaline for out-of-hospital cardiac arrest resuscitation:A systematic review and meta-analysis of randomized controlled trials[J].Resuscitation,2014,85:732-740.
[14] Warren SA,Huszti E,Bradley SM,et al.Adrenaline(epinephrine)dosing period and survival after in-hospital cardiac arrest:a retrospective review of prospectively collected data[J].Resuscitation,2014,85:350-358.
[15]Hoyme DB,Patel SS,Samson RA,et al.Epinephrine dosing interval and survival outcomes during pediatric in-hospital cardiac arrest[J].Resuscitation,2017,117:18-23.
[16]Ristagno G,Tang W,Huang L,et al.Epinephrine reduces cerebral perfusion during cardiopulmonary resuscitation[J].Crit Care Med,2009,37(4):1408-1415.
[17]Neumar RW,Otto CW,Link MS,et al.Part 8:adult advanced cardiovascular life support:2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care[J].Circulation,2010,122:S729-S767.
[18] Ong ME,Tiah L,Leong BS,et al.A randomized,double-blind,multicentre trial comparing vasopressin and adrenaline in patients with cardiac arrest presenting to or in the Emergency Department[J].Resuscitation,2012,83(8):953-960.
[19]Ducros L,Vicaut E,Soleil C,et al.Effect of the addition of vasopressin or vasopressin plus nitroglycerin to epinephrine on arterial blood pressure during cardiopulmonary resuscitation in humans[J].J Emerg Med,2011,41(5):453-459.
[20]Wenzel V,Krismer AC,Arntz HR,et al.A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation[J].N Engl J Med,2004,350(2):105-113.
[21]Kudenchuk P J,Brown S P,Daya M,et al.Amiodarone,Lidocaine,or Placebo in Out-of-Hospital Cardiac Arrest[J].N Engl J Med,2016,374(18):1711-1722.
[22]Huang Y,He Q,Yang M,et al.Anti-arrhythmia drugs for cardiac arrest:a systemic review and meta-analysis[J].Crit Care,2013,17:R173.
[23]何庆,黄煜.心肺复苏药物新进展及循证医学证据[J].心血管病学进展,2017,38(4):414-418.
[24]Ji XF,Yang L,Zhang MY,et al.Shen-fu injection attenuates post-resuscitation myocardial dysfunction in aporcine model of cardiac arrest[J].Shock,2011,35(5):530-536.
[25]Yin Q,Wu CJ,Yang J,et al.Effects of Shen fu Injection on cerebral metabolism in a porcine model of cardiac arrest[J].Chin J Integr Med,2017,23(1):33-39.