黄芩清热除痹胶囊配合外敷治疗急性痛风性关节炎的临床观察
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摘要
目的:基于Toll样受体4观察黄芩清热除痹胶囊内服配合外敷治疗急性痛风性关节炎的临床疗效,为中医药治疗痛风性关节炎提供有效方案。方法:将60例急性痛风性关节炎患者随机分为黄芩清热除痹胶囊口服联合芙蓉膏外敷治疗组和美洛昔康口服对照组各30例。观察治疗前后外周血TLR4阳性率、中医症候积分、VAS疼痛评分及炎症、安全性指标的变化。结果:治疗组总有效率90%,优于对照组的80%。与治疗前相比较,两组急性痛风性关节炎患者TLR4表达水平、血尿酸、ESR、CRP、中医症候积分、VAS疼痛评分均显著降低。与对照组相比较,治疗组能够显著降低中医症候积分、TLR4、ESR、CRP。结论:黄芩清热除痹胶囊内服配合芙蓉膏外敷治疗急性痛风性关节炎疗效显著,其机制可能与抑制了TLR4介导的炎症有关。
Objective:Toll like receptor 4based on clinical observation of Baicalin in Qingre Tongbi capsule combined with external treatment of acute gouty arthritis,to provide effective solutions for the treatment of gouty arthritis by traditional Chinese medicine.Methods:60cases of acute gouty arthritis were randomly divided into Huangqin Qingre Chubi capsules of Furong ointment in the treatment group and meloxicam Kang oral 30 cases in the control group.Before and after treatment were observed in peripheral blood TLR4 positive rate,TCM syndrome score,VAS pain score and inflammation,safety index changes.Results:The total efficiency of treatment group was 90%,better than 80%in the control group.Compared with before treatment,two groups of acute gouty arthritis the expression level of TLR4 patients,serum uric acid,ESR,CRP,TCM syndrome score,VAS pain scores were significantly lower.Compared with the control group,the treatment group can significantly reduce the symptom score,TLR4,ESR,CRP.Conclusion:Huangqin Qingre Chubi capsule taken orally with Furong ointment in the treatment of acute gouty arthritis significantly,the mechanism may be related to inhibit TLR4 mediated inflammation.
Objective:Toll like receptor 4based on clinical observation of Baicalin in Qingre Tongbi capsule combined with external treatment of acute gouty arthritis,to provide effective solutions for the treatment of gouty arthritis by traditional Chinese medicine.Methods:60cases of acute gouty arthritis were randomly divided into Huangqin Qingre Chubi capsules of Furong ointment in the treatment group and meloxicam Kang oral 30 cases in the control group.Before and after treatment were observed in peripheral blood TLR4 positive rate,TCM syndrome score,VAS pain score and inflammation,safety index changes.Results:The total efficiency of treatment group was 90%,better than 80%in the control group.Compared with before treatment,two groups of acute gouty arthritis the expression level of TLR4 patients,serum uric acid,ESR,CRP,TCM syndrome score,VAS pain scores were significantly lower.Compared with the control group,the treatment group can significantly reduce the symptom score,TLR4,ESR,CRP.Conclusion:Huangqin Qingre Chubi capsule taken orally with Furong ointment in the treatment of acute gouty arthritis significantly,the mechanism may be related to inhibit TLR4 mediated inflammation.
引文
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[5]葛平,张贺,孙肖深,等.黄芩清热除痹胶囊对佐剂性关节炎大鼠血清IL-1β和IL-6的影响[J].中药新药与临床,2014,25(1):8-10.
[6]江莹,张静,孟楣,等.黄芩清热除痹胶囊对佐剂性关节炎大鼠的抗炎作用[J].华西药学杂志,2015,30(2):178-180.
[7]贾伟琳.止痛如神汤治疗急性痛风性关节炎42例[J].陕西中医,2010,31(4):358-359.
[8]庄丽华,胡家才,吴昊,等.威草胶囊配合西药治疗急性痛风疗效观察[J].陕西中医,2015(4):462-465.
[9]李巧凤,梅艳,吕春花,等.痛风性关节炎25例的高频超声表现[J].中国临床保健杂志,2015,18(3):318.
[10]Khanna P,Khanna D.Health-related quality of life and outcome measures in gout.In:Terkeltaub R,editor.Gout and other crystal arthropathies[J].Elsevier,Philadelphia,2011:217-225.
[2]石鹏,林为民,赵武,等.杨宗善治疗痛风经验总结[J].陕西中医,2013,34(1):75-78.
[3]汪元,刘健.中医药治疗痛风的研究进展[J].中国临床保健杂志,2014,17(4):444-446.
[4]崔晓军.浅谈痛风病临床诊治[J].陕西中医.2012,33(2):180-183.
[5]葛平,张贺,孙肖深,等.黄芩清热除痹胶囊对佐剂性关节炎大鼠血清IL-1β和IL-6的影响[J].中药新药与临床,2014,25(1):8-10.
[6]江莹,张静,孟楣,等.黄芩清热除痹胶囊对佐剂性关节炎大鼠的抗炎作用[J].华西药学杂志,2015,30(2):178-180.
[7]贾伟琳.止痛如神汤治疗急性痛风性关节炎42例[J].陕西中医,2010,31(4):358-359.
[8]庄丽华,胡家才,吴昊,等.威草胶囊配合西药治疗急性痛风疗效观察[J].陕西中医,2015(4):462-465.
[9]李巧凤,梅艳,吕春花,等.痛风性关节炎25例的高频超声表现[J].中国临床保健杂志,2015,18(3):318.
[10]Khanna P,Khanna D.Health-related quality of life and outcome measures in gout.In:Terkeltaub R,editor.Gout and other crystal arthropathies[J].Elsevier,Philadelphia,2011:217-225.