中药指纹图谱中常用的数理统计方法
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摘要
本文从药材质量优劣鉴别、产地判定等方面介绍了中药指纹图谱中常用的数理统计方法,旨在更好地评价中药质量。
This paper introduces the commonly used mathematical statistics methods in the identification of raw materials and the determination of origin, and aims to better evaluate the quality of traditional Chinese medicine.
This paper introduces the commonly used mathematical statistics methods in the identification of raw materials and the determination of origin, and aims to better evaluate the quality of traditional Chinese medicine.
引文
[1]黄立兰,程文胜,陈耀娣,等.人参指纹图谱的研究进展[J].中草药,2013,44(2):241-246.
[2]张玉婷.人参提取物化学成分及质量研究[D].上海:中国食品药品检定研究院,2013.
[3]陈冬冬,周萍,白刚刚,等.基于HPLC中药指纹图谱技术延胡索药材及其制剂的质量控制探讨[J].中国中药杂志,2015,40(12):2470-2473.
[4]刘娜,李军,李宝国.多元统计分析在中药质量控制中的应用和思考[J].中国中药杂志,2014,39(21):4268-4271.
[5]邓海燕.聚类分析与判别分析的区别[J].武汉学刊,2006(1):29-31.
[6]Yang J,Chen LH,Zhang Q,et al.Quality assessment of Cortex cinnamomi by HPLC chemical fingerprint,principle component analysis and cluster analysis[J].J Sep Sci,200730(9):1276-1283.
[7]谢春英,贺巍,林敬明,等.中药黄芩及其混伪品的模糊聚类分析[J].广东微量元素科学,2000,7(12):52-55.
[8]李小亭,李瑞盈,相海恩,等.基于HPLC指纹图谱及聚类分析对不同产地枸杞质量评价研究[J].现代食品科技,2012,28(9):1251-1253;1261.
[9]罗静,何中燕,裴瑾,等.橘核的HPLC指纹图谱研究及聚类分析[J].中国药房,2015,26(3):419-421.
[10]张志锋,刘圆,张浩.傅里叶变换红外光谱法并结合主成分分析法鉴别灯盏花和多舌飞蓬的研究[J].光谱学与光谱分析,2009,29(12):3263-3266.
[11]李少旦,李延志.主成分分析法用于中草药中微量元素含量的研究[J].化学分析计量,2008,17(5):25-26.
[12]陈宇航,郭巧生,王澄亚,等.夏枯草形态学性状的遗传变异、相关及主成分分析[J].中国中药杂志,2009,34(15):1886-1889.
[13]洪燕,韩艳全,夏伦祝,等.不同产地苍耳子UPLC指纹图谱研究[J].中国中药杂志,2013,38(11):1766-1771.
[14]郑晓珂,魏悦,冯卫生.不同采收期连翘的HPLC指纹图谱研究[J].中国实验方剂学杂志,2007,13(3):1-4.
[15]茅银燕,岳显可.基于主成分分析的不同产地千年健GC指纹图谱研究[J].实用药物与临床,2017,20(8):933-936.
[16]王静,夏结来,叶冬青.判别分析方法在医学应用中的进展[J].数理统计与管理,2008,27(2):369-376.
[17]Tianniam S,Bamba T,Fukusaki E.Pyrolysis GC-MS-based metabolite fingerprinting for quality evaluation of commercial Angelica acutiloba roots[J].J Biosci Bioeng,2010,109(1):89-93.
[18]Wang D,He F,Lv Z,et al.Phytochemical composition,antioxidant activity and HPLC fingerprinting profiles of three pyrola species from different regions[J/OL].PLoS One,20149(5):e96329.doi:10.1371/journal.pone.0096329.
[19]Cheng XM,Zhao T,Yang T,et al.HPLC fingerprints combined with principal component analysis,hierarchical cluster analysis and linear discriminant analysis for the classification and differentiation of Peganum sp.indigenous to China[J].Phytochem Anal,2010,21(3):279-289.
[20]李雨.基于植物性中药基原性状药性判别模型的比较[D]济南:山东大学,2011.
[21]王露露,孙倩怡,杨慧海,等.模式识别及其在中药质量评价中的应用[J].中草药,2016,47(23):4282-4288.
[22]肖佳佳,黄红,雷有成,等.天麻HPLC指纹图谱建立及判别分析[J].中国中药杂志,2017,42(13):2524-2531.
[23]苏建春,柯华香,赵俊霞,等.基于UPLC指纹图谱和判别分析鉴别黄芩产地研究[J].亚太传统医药,2015,11(4):24-27.
[24]张洪坤,黄玉瑶,路丽,等.基于HPLC-ELSD指纹图谱的亳州和河北知母的聚类和判别研究[J].时珍国医国药,2017,28(11):2670-2673.
[25]段杰,张智立.基于因子分析的创意产业竞争力评价及策略研究[J].现代产业经济,2014(z1):65-73.
[26]Xia WU,Kang Z,Zhao F,et al.Construction of Inorganic Elemental Fingerprint and Multivariate Statistical analysis of marine traditional Chinese medicine meretricis concha from Rushan Bay[J].J Ocean Univ China,2014,13(4):712-716.
[27]张峰.唐古特大黄不同居群药用部位化学成分差异与环境因子的相关性分析[D].西安:陕西师范大学,2012.
[28]马丽,康廷国,孟宪生,等.基于无机元素特征的不同产地鳖甲药材质量分析[J].广东微量元素科学,2011,18(7):24-31.
[29]李彬,郭力城.鳖甲临床应用研究概况[J].云南中医中药杂志,2009,30(1):66-67.
[30]于鹤丹.多元统计分析方法在中药质量评价中的应用[J].数理医药学杂志,2006,19(1):85-87.
[31]Song XY,Jin L,Shi YP,et al.Multivariate statistical analysis based on a chromatographic fingerprint for the evaluation of important environmental factors that affect the quality of Angelica sinensis[J].Anal Methods,2014,6(20):8268-8276.
[32]金鹏程,赵艳丽,张霁,等.紫外光谱结合多元统计分析鉴别药用灵芝产地[C]//中国生态学学会中药资源生态专业委员会第五次全国学术研讨会暨世界中医药联合会药用植物资源利用与保护专业委员会第二届学术年会论文集.北京:中国生态学学会,2014:257-262.
[33]Chang WT,Thissen U,Ehlert KA,et al.Effects of growth conditions and processing on Rehmannia glutinosa using fingerprint strategy[J].Planta Med,2006,72(5):458-467.
[34]Zhang D,Duan X,Deng S,et al.Fingerprint analysis,multicomponent quantitation,and antioxidant activity for the quality evaluation of Salvia miltiorrhiza var.alba by highperformance liquid chromatography and chemometrics[J].JSep Sci,2015,38(19):3337-3344.
[35]包永睿,王帅,唐爽,等.基于指纹图谱结合多元统计分析的天麻总苷差异指标的研究[J].中药材,2016(5):1082-1085.
[36]王丽.沙棘的氢核磁共振图谱-多元统计分析研究[D].成都:四川大学,2007.
[37]Zhang X,Ning Z,Ji D,et al.Approach based on highperformance liquid chromatography fingerprint coupled with multivariate statistical analysis for the quality evaluation of Gastrodia rhizoma[J].J Sep Sci,2015,38(22):3825-3831.
[38]Wang HL,Yao WF,Zhu DN,et al.Chemical fingerprinting by HPLC-DAD-ELSD and principal component analysis of Polygala japonica from different locations in China[J]Chinese J Nat Med,2010,8(5):343-348.
[2]张玉婷.人参提取物化学成分及质量研究[D].上海:中国食品药品检定研究院,2013.
[3]陈冬冬,周萍,白刚刚,等.基于HPLC中药指纹图谱技术延胡索药材及其制剂的质量控制探讨[J].中国中药杂志,2015,40(12):2470-2473.
[4]刘娜,李军,李宝国.多元统计分析在中药质量控制中的应用和思考[J].中国中药杂志,2014,39(21):4268-4271.
[5]邓海燕.聚类分析与判别分析的区别[J].武汉学刊,2006(1):29-31.
[6]Yang J,Chen LH,Zhang Q,et al.Quality assessment of Cortex cinnamomi by HPLC chemical fingerprint,principle component analysis and cluster analysis[J].J Sep Sci,200730(9):1276-1283.
[7]谢春英,贺巍,林敬明,等.中药黄芩及其混伪品的模糊聚类分析[J].广东微量元素科学,2000,7(12):52-55.
[8]李小亭,李瑞盈,相海恩,等.基于HPLC指纹图谱及聚类分析对不同产地枸杞质量评价研究[J].现代食品科技,2012,28(9):1251-1253;1261.
[9]罗静,何中燕,裴瑾,等.橘核的HPLC指纹图谱研究及聚类分析[J].中国药房,2015,26(3):419-421.
[10]张志锋,刘圆,张浩.傅里叶变换红外光谱法并结合主成分分析法鉴别灯盏花和多舌飞蓬的研究[J].光谱学与光谱分析,2009,29(12):3263-3266.
[11]李少旦,李延志.主成分分析法用于中草药中微量元素含量的研究[J].化学分析计量,2008,17(5):25-26.
[12]陈宇航,郭巧生,王澄亚,等.夏枯草形态学性状的遗传变异、相关及主成分分析[J].中国中药杂志,2009,34(15):1886-1889.
[13]洪燕,韩艳全,夏伦祝,等.不同产地苍耳子UPLC指纹图谱研究[J].中国中药杂志,2013,38(11):1766-1771.
[14]郑晓珂,魏悦,冯卫生.不同采收期连翘的HPLC指纹图谱研究[J].中国实验方剂学杂志,2007,13(3):1-4.
[15]茅银燕,岳显可.基于主成分分析的不同产地千年健GC指纹图谱研究[J].实用药物与临床,2017,20(8):933-936.
[16]王静,夏结来,叶冬青.判别分析方法在医学应用中的进展[J].数理统计与管理,2008,27(2):369-376.
[17]Tianniam S,Bamba T,Fukusaki E.Pyrolysis GC-MS-based metabolite fingerprinting for quality evaluation of commercial Angelica acutiloba roots[J].J Biosci Bioeng,2010,109(1):89-93.
[18]Wang D,He F,Lv Z,et al.Phytochemical composition,antioxidant activity and HPLC fingerprinting profiles of three pyrola species from different regions[J/OL].PLoS One,20149(5):e96329.doi:10.1371/journal.pone.0096329.
[19]Cheng XM,Zhao T,Yang T,et al.HPLC fingerprints combined with principal component analysis,hierarchical cluster analysis and linear discriminant analysis for the classification and differentiation of Peganum sp.indigenous to China[J].Phytochem Anal,2010,21(3):279-289.
[20]李雨.基于植物性中药基原性状药性判别模型的比较[D]济南:山东大学,2011.
[21]王露露,孙倩怡,杨慧海,等.模式识别及其在中药质量评价中的应用[J].中草药,2016,47(23):4282-4288.
[22]肖佳佳,黄红,雷有成,等.天麻HPLC指纹图谱建立及判别分析[J].中国中药杂志,2017,42(13):2524-2531.
[23]苏建春,柯华香,赵俊霞,等.基于UPLC指纹图谱和判别分析鉴别黄芩产地研究[J].亚太传统医药,2015,11(4):24-27.
[24]张洪坤,黄玉瑶,路丽,等.基于HPLC-ELSD指纹图谱的亳州和河北知母的聚类和判别研究[J].时珍国医国药,2017,28(11):2670-2673.
[25]段杰,张智立.基于因子分析的创意产业竞争力评价及策略研究[J].现代产业经济,2014(z1):65-73.
[26]Xia WU,Kang Z,Zhao F,et al.Construction of Inorganic Elemental Fingerprint and Multivariate Statistical analysis of marine traditional Chinese medicine meretricis concha from Rushan Bay[J].J Ocean Univ China,2014,13(4):712-716.
[27]张峰.唐古特大黄不同居群药用部位化学成分差异与环境因子的相关性分析[D].西安:陕西师范大学,2012.
[28]马丽,康廷国,孟宪生,等.基于无机元素特征的不同产地鳖甲药材质量分析[J].广东微量元素科学,2011,18(7):24-31.
[29]李彬,郭力城.鳖甲临床应用研究概况[J].云南中医中药杂志,2009,30(1):66-67.
[30]于鹤丹.多元统计分析方法在中药质量评价中的应用[J].数理医药学杂志,2006,19(1):85-87.
[31]Song XY,Jin L,Shi YP,et al.Multivariate statistical analysis based on a chromatographic fingerprint for the evaluation of important environmental factors that affect the quality of Angelica sinensis[J].Anal Methods,2014,6(20):8268-8276.
[32]金鹏程,赵艳丽,张霁,等.紫外光谱结合多元统计分析鉴别药用灵芝产地[C]//中国生态学学会中药资源生态专业委员会第五次全国学术研讨会暨世界中医药联合会药用植物资源利用与保护专业委员会第二届学术年会论文集.北京:中国生态学学会,2014:257-262.
[33]Chang WT,Thissen U,Ehlert KA,et al.Effects of growth conditions and processing on Rehmannia glutinosa using fingerprint strategy[J].Planta Med,2006,72(5):458-467.
[34]Zhang D,Duan X,Deng S,et al.Fingerprint analysis,multicomponent quantitation,and antioxidant activity for the quality evaluation of Salvia miltiorrhiza var.alba by highperformance liquid chromatography and chemometrics[J].JSep Sci,2015,38(19):3337-3344.
[35]包永睿,王帅,唐爽,等.基于指纹图谱结合多元统计分析的天麻总苷差异指标的研究[J].中药材,2016(5):1082-1085.
[36]王丽.沙棘的氢核磁共振图谱-多元统计分析研究[D].成都:四川大学,2007.
[37]Zhang X,Ning Z,Ji D,et al.Approach based on highperformance liquid chromatography fingerprint coupled with multivariate statistical analysis for the quality evaluation of Gastrodia rhizoma[J].J Sep Sci,2015,38(22):3825-3831.
[38]Wang HL,Yao WF,Zhu DN,et al.Chemical fingerprinting by HPLC-DAD-ELSD and principal component analysis of Polygala japonica from different locations in China[J]Chinese J Nat Med,2010,8(5):343-348.