骨折愈合时间的研究进展及其法医学意义
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摘要
目的探讨骨折愈合时间在不同评估方法中的研究现状及其在法医学中的应用价值。方法参阅国内外发表的相关文献,综述近年来国内外关于骨折愈合时间的研究进展,探讨其在法医学中的意义。结果骨折愈合时间的评估方法包括影像学片观察法、振动分析法、骨密度定量检测法、分子生物学检测法等,运用可量化的方法推断骨折具体形成时间成为近年来研究骨折愈合时间的热点。在法医学鉴定中,骨折愈合时间的研究有助于明确骨折与外伤的关联性,并为法医鉴定标准的完善提供技术支持。结论骨折愈合时间的研究具有重要的法医学应用价值,同时有待更深一步的探索。
Objective To study the current situation of fracture healing time and its application value in forensic medicine. Methods Related literatures were searched,and the research progress of fracture healing time in recent years was reviewed and the significance of forensic medicine was discussed. Results The evaluation methods of fracture healing time included the imaging observation method,the vibration analysis method,the bone mineral density quantitative detection method,the molecular biological detection method and so on. Using the quantitative methods to infer fracture processes had become a hot spot in recent years. In the forensic identification,the study of fracture healing time was helpful to clarify the relationship between fracture and trauma,and provide technical support for the improvement of forensic identification standards. Conclusion The study of fracture healing time has important value in forensic medicine,but it still needs to be further studied.
Objective To study the current situation of fracture healing time and its application value in forensic medicine. Methods Related literatures were searched,and the research progress of fracture healing time in recent years was reviewed and the significance of forensic medicine was discussed. Results The evaluation methods of fracture healing time included the imaging observation method,the vibration analysis method,the bone mineral density quantitative detection method,the molecular biological detection method and so on. Using the quantitative methods to infer fracture processes had become a hot spot in recent years. In the forensic identification,the study of fracture healing time was helpful to clarify the relationship between fracture and trauma,and provide technical support for the improvement of forensic identification standards. Conclusion The study of fracture healing time has important value in forensic medicine,but it still needs to be further studied.
引文
[1]秦向阳.X线数字图像法推断人前臂骨折形成时间探究[J].中国民康医学,2013,25(21):42-43.
[2]薛若冰,薛华新,王英元.Photoshop软件在研究骨折愈合影响因素中的应用[J].山西医科大学学报,2015,46(8):826-828.
[3]江洁清,张继宗,刘旭丹.X线数字图像法推断前臂骨折形成时间[J].中国法医学杂志,2010,25(3):165-168.
[4]Davis BJ,Roberts PJ,Moorcroft CI,et al.Reliability of radiographs in defining union of internally fixed fractures[J].Injury,2004,35(6):557-561.
[5]Krestan CR,Noske H,Vasilevska V,et al.MDCT versus digital radiography in the evaluation of bone healing in orthopedic patients[J].Am J Roentgenol,2006,186(6):1754-1760.
[6]Corrales LA,Morshed S,Bhandari M.Variability in the assessment of fracture-healing in orthopaedic trauma studies[J].Bone Joint Sur Am,2008,90(9):1862-1868.
[7]苏汝堃,刘兴漠,邓颖辉.定量超声骨质测量各参数变化对骨质疏松性骨折的评估[J].中国组织工程研究,2005,9(15):246-247.
[8]Protopappas VC,Vavva MG,Fotiadis DI,et al.Ultrasonic monitoring of bone fracture healing[J].IEEE Trans Ultrason Ferroelectri Freq Control,2008,55(6):1243-1255.
[9]Hacihaliloglu I,Abugharbieh R,Hodgson AJ,et al.Bone surface localization in ultrasound using image phase-based features[J].Ultrasound Med Biol,2009,35(9):1475-1487.
[10]陶广宇,鲍健,唐旭东.放射吸收法在骨密度测量中的应用[J].中国临床医学影像杂志,2007,18(10):747-749.
[11]尹东,杨惠林,唐天驷,等.双能X线骨密度仪测定骨痂骨密度变化的实验研究[J].中国医学影像学杂志,2004,12(6):430-432.
[12]商敏.DXA诊断椎体压缩性骨折的应用进展[J].中国骨质疏松杂志,2012,18(5):490-494.
[13]杨小明,熊海,周翔平,等.双能X线骨密度仪与定量CT测量骨密度准确性的研究[J].四川大学学报(医学版),2005,36(1):132-133.
[14]刘珺,王维,童琼娟,等.双能X线骨密度仪(DXA)与定量CT(QCT)测量骨密度的比较研究[J].临床放射学杂志,2007,26(5):504-507.
[15]张纲,李焰,谭颖徽.细胞生长因子在骨折愈合中的作用研究进展[J].重庆医学,2008,37(2):196-7.
[16]Arvidson K,Abdallah BM,Applegate LA,et al.Bone regeneration and stem cells[J].J Cell Mol Med,2011,15(4):718-746.
[17]Sarahrudi K,Thomas A,Mousavi M,et al.Elevated transforming growth factor-beta 1(TGF-β1)levels in human fracture healing[J].Injury,2011,42(8):833-837.
[18]Asaumi K,Nakanishi T,Asahara H,et al.Expression of neurotrophins and their receptors(TRK)during fracture healing[J].Bone,2000,26(6):625-633.
[19]Weiss S,Zimmermann G,Pufe T,et al.The systemic angiogenic response during bone healing[J].Arch Orthop Trauma Surg,2009,129(7):989-997.
[20]苏发丽,李利华,赵丽萍,等.生长因子在骨折愈合过程中作用的研究进展[J].现代生物医学进展,2013,13(26):5173-5175.
[21]张德雨,朱旭阳,方伟敏,等.螺旋CT三维重建在肋骨骨折法医临床鉴定中的应用[J].法医学杂志,2007,23(6):431-433.
[22]董业强,武兴杰,韩菊,等.根据长骨线性骨折愈合X线表现与骨折时间推算[J].中国法医学杂志,2010,25(4):262-264.
[23]王旭.人身损害受伤人员“三期”评定的基本原则[J].中国法医学杂志,2011,26(2):169-172.
[24]李琳,吴军.人身损害赔偿"三期"的法医学鉴定[J].中国司法鉴定,2004,(4):42-43.
[25]刘瑞珏,程亦斌,范利华.法医临床学『三期』鉴定中的若干问题思考[J].中国司法鉴定,2007,(4):39-41.
[26]韩实媚,李军堂,郝大鹏.颌面部骨折愈合时间窗的影像学评价[J].医学与法学,2016,8(1):109-110.
[27]寇红伟,董鲁平,李峰,等.DHS和PFNA固定治疗老年股骨粗隆间骨折疗效比较[J].中国现代药物应用,2015,9(21):83-84.
[28]周忠,汪阳,黄杰,等.不同疗法对创伤骨科患者骨折愈合及疼痛发生情况的影响[J].湖南师范大学学报(医学版),2015,12(3):125-127.
[2]薛若冰,薛华新,王英元.Photoshop软件在研究骨折愈合影响因素中的应用[J].山西医科大学学报,2015,46(8):826-828.
[3]江洁清,张继宗,刘旭丹.X线数字图像法推断前臂骨折形成时间[J].中国法医学杂志,2010,25(3):165-168.
[4]Davis BJ,Roberts PJ,Moorcroft CI,et al.Reliability of radiographs in defining union of internally fixed fractures[J].Injury,2004,35(6):557-561.
[5]Krestan CR,Noske H,Vasilevska V,et al.MDCT versus digital radiography in the evaluation of bone healing in orthopedic patients[J].Am J Roentgenol,2006,186(6):1754-1760.
[6]Corrales LA,Morshed S,Bhandari M.Variability in the assessment of fracture-healing in orthopaedic trauma studies[J].Bone Joint Sur Am,2008,90(9):1862-1868.
[7]苏汝堃,刘兴漠,邓颖辉.定量超声骨质测量各参数变化对骨质疏松性骨折的评估[J].中国组织工程研究,2005,9(15):246-247.
[8]Protopappas VC,Vavva MG,Fotiadis DI,et al.Ultrasonic monitoring of bone fracture healing[J].IEEE Trans Ultrason Ferroelectri Freq Control,2008,55(6):1243-1255.
[9]Hacihaliloglu I,Abugharbieh R,Hodgson AJ,et al.Bone surface localization in ultrasound using image phase-based features[J].Ultrasound Med Biol,2009,35(9):1475-1487.
[10]陶广宇,鲍健,唐旭东.放射吸收法在骨密度测量中的应用[J].中国临床医学影像杂志,2007,18(10):747-749.
[11]尹东,杨惠林,唐天驷,等.双能X线骨密度仪测定骨痂骨密度变化的实验研究[J].中国医学影像学杂志,2004,12(6):430-432.
[12]商敏.DXA诊断椎体压缩性骨折的应用进展[J].中国骨质疏松杂志,2012,18(5):490-494.
[13]杨小明,熊海,周翔平,等.双能X线骨密度仪与定量CT测量骨密度准确性的研究[J].四川大学学报(医学版),2005,36(1):132-133.
[14]刘珺,王维,童琼娟,等.双能X线骨密度仪(DXA)与定量CT(QCT)测量骨密度的比较研究[J].临床放射学杂志,2007,26(5):504-507.
[15]张纲,李焰,谭颖徽.细胞生长因子在骨折愈合中的作用研究进展[J].重庆医学,2008,37(2):196-7.
[16]Arvidson K,Abdallah BM,Applegate LA,et al.Bone regeneration and stem cells[J].J Cell Mol Med,2011,15(4):718-746.
[17]Sarahrudi K,Thomas A,Mousavi M,et al.Elevated transforming growth factor-beta 1(TGF-β1)levels in human fracture healing[J].Injury,2011,42(8):833-837.
[18]Asaumi K,Nakanishi T,Asahara H,et al.Expression of neurotrophins and their receptors(TRK)during fracture healing[J].Bone,2000,26(6):625-633.
[19]Weiss S,Zimmermann G,Pufe T,et al.The systemic angiogenic response during bone healing[J].Arch Orthop Trauma Surg,2009,129(7):989-997.
[20]苏发丽,李利华,赵丽萍,等.生长因子在骨折愈合过程中作用的研究进展[J].现代生物医学进展,2013,13(26):5173-5175.
[21]张德雨,朱旭阳,方伟敏,等.螺旋CT三维重建在肋骨骨折法医临床鉴定中的应用[J].法医学杂志,2007,23(6):431-433.
[22]董业强,武兴杰,韩菊,等.根据长骨线性骨折愈合X线表现与骨折时间推算[J].中国法医学杂志,2010,25(4):262-264.
[23]王旭.人身损害受伤人员“三期”评定的基本原则[J].中国法医学杂志,2011,26(2):169-172.
[24]李琳,吴军.人身损害赔偿"三期"的法医学鉴定[J].中国司法鉴定,2004,(4):42-43.
[25]刘瑞珏,程亦斌,范利华.法医临床学『三期』鉴定中的若干问题思考[J].中国司法鉴定,2007,(4):39-41.
[26]韩实媚,李军堂,郝大鹏.颌面部骨折愈合时间窗的影像学评价[J].医学与法学,2016,8(1):109-110.
[27]寇红伟,董鲁平,李峰,等.DHS和PFNA固定治疗老年股骨粗隆间骨折疗效比较[J].中国现代药物应用,2015,9(21):83-84.
[28]周忠,汪阳,黄杰,等.不同疗法对创伤骨科患者骨折愈合及疼痛发生情况的影响[J].湖南师范大学学报(医学版),2015,12(3):125-127.