腹腔镜子宫肌瘤剔除术与GnRH-a联合治疗临床疗效分析
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摘要
目的探讨腹腔镜子宫肌瘤剔除术与GnRH-a联合治疗临床疗效。方法从本院选取2016年至2017年收治的100例子宫肌瘤患者进行研究,采用随机数字表法将所有患者分为两组,每组50例,对照组采用腹腔镜子宫肌瘤剔除术进行治疗,观察组采用腹腔镜子宫肌瘤剔除术联合GnRH-a进行治疗。对比分析两组患者子宫体积变化情况、肌瘤体积变化情况、各项手术指标变化情况、治疗效果以及不良反应发生情况。结果观察组患者采用腹腔镜子宫肌瘤剔除术联合GnRH-a治疗后,观察组子宫体积变化情况、各项手术指标变化情况优于对照组,观察组肌瘤体积变化情况和不良反应发生情况低于对照组,观察组治疗效果高于对照组,两组间差异有统计学意义(P<0.05)。结论应用腹腔镜子宫肌瘤剔除术与GnRH-a联合治疗后,可有效改善患者子宫变化情况、肌瘤体积和手术指标变化,降低患者不良反应发生率,提高临床疗效,值得应用。
Objective To investigate the clinical efficacy of combination of laparoscopic myomectomy and GnRH-a. Methods A total of 100 patients with uterine fibroids who were admitted between 2016 to 2017 were selected for study. All patients were divided into 2 groups with 50 patients in each group using a random number table method. The control group was treated with laparoscopic myomectomy. For treatment, the observation group was treated with laparoscopic myomectomy and GnRH-a. The changes in uterine volume, changes in fibroid volume, changes in various surgical indicators, treatment effects, and occurrence of adverse reactions were compared between the two groups. Results After observation group patients were treated with laparoscopic myomectomy and GnRH-a, the changes of uterine volume and the changes of various surgical indexes in the observation group were better than those in the control group. Changes in the volume of fibroids and occurrence of adverse reactions in the observation group were observed. Lower than the control group, the observation group treatment effect is higher than the control group, the difference between the two groups was significant(P<0.05). Conclusion After laparoscopic myomectomy combined with GnRH-a treatment, it can effectively improve the uterus changes, fibroid volume and surgical index changes, reduce the incidence of adverse reactions, improve clinical efficacy, it is worthy of application.
Objective To investigate the clinical efficacy of combination of laparoscopic myomectomy and GnRH-a. Methods A total of 100 patients with uterine fibroids who were admitted between 2016 to 2017 were selected for study. All patients were divided into 2 groups with 50 patients in each group using a random number table method. The control group was treated with laparoscopic myomectomy. For treatment, the observation group was treated with laparoscopic myomectomy and GnRH-a. The changes in uterine volume, changes in fibroid volume, changes in various surgical indicators, treatment effects, and occurrence of adverse reactions were compared between the two groups. Results After observation group patients were treated with laparoscopic myomectomy and GnRH-a, the changes of uterine volume and the changes of various surgical indexes in the observation group were better than those in the control group. Changes in the volume of fibroids and occurrence of adverse reactions in the observation group were observed. Lower than the control group, the observation group treatment effect is higher than the control group, the difference between the two groups was significant(P<0.05). Conclusion After laparoscopic myomectomy combined with GnRH-a treatment, it can effectively improve the uterus changes, fibroid volume and surgical index changes, reduce the incidence of adverse reactions, improve clinical efficacy, it is worthy of application.
引文
[1]孙凤艳,王玉敏,王楠,等.腹腔镜子宫肌瘤剔除术与GnRH-a联合治疗临床疗效观察[J].中国实用医刊,2017,44(8):68-71.
[2]叶明珠,邓新粮,朱小刚,等.高强度聚焦超声消融技术联合GnRH-a及LNG-IUS治疗子宫腺肌病痛经的临床研究[J].中华妇产科杂志,2016,51(9):643-649.
[3]边立华,王楠,范文生,等.促性腺激素释放激素激动剂预防腹腔镜子宫肌瘤剔除术后复发的疗效观察[J].解放军医学院学报,2017,38(3):199-201.
[4]殷美静,张纯溪,张萍.大孕周子宫肌瘤患者行腹腔镜下子宫肌瘤剔除术前后GnRH-a的应用价值[J].山东医药,2016,56(45):62-64.
[5]张翠兰.腹腔镜分别联合GnRH-a与孕三烯酮治疗子宫内膜异位症的疗效对比[J].中国实用医药,2016,11(21):177-178.
[6]郭玉琳.腹腔镜下子宫肌瘤剔除术与传统开腹子宫肌瘤剔除术治疗子宫肌瘤疗效对比研究[J].陕西医学杂志,2016,45(7):824-826.
[7]谢秀玲.腹腔镜子宫肌瘤剔除术与传统开腹手术治疗子宫肌瘤的临床疗效比较[J].齐齐哈尔医学院学报,2016,37(19):2432-2433.
[8]褚达明,欧阳玲.子宫肌瘤剔除术联合GnRH-a治疗弥漫性子宫平滑肌瘤病六例[J].实用肿瘤杂志,2017,32(2):147-151.
[9]张翼海.GnRHa与米非司酮在腹腔镜子宫肌瘤剔除术预处理中效果对比[J].中国冶金工业医学杂志,2016,33(1):33.
[10]蒋玮琳.GnRHa用于子宫肌瘤腹腔镜手术前治疗效果的前瞻性分析[J].深圳中西医结合杂志,2016,26(11):138-139.
[11]刘丽敏.腹腔镜病灶切除联合GnRH-a治疗子宫腺肌病疗效观察[J].泰山医学院学报,2017,38(7):804-806.
[12]蒋海霞,罗祥力,林川.用腹腔镜手术联合GnRH-α治疗子宫内膜异位症的疗效分析[J].当代医药论丛,2017,15(6):5-6.
[13]刘双平.舒芬太尼联合丙泊酚静脉麻醉在腹腔镜子宫肌瘤剔除术中的应用分析[J].当代医学,2015,21(15):59-60.
[14]刘岚,齐红,康高杨,等.联合腹腔镜下子宫肌瘤剔除术及醋酸亮丙瑞林治疗巨大子宫肌瘤临床效果[J].当代医学,2017,23(16):149-150.
[2]叶明珠,邓新粮,朱小刚,等.高强度聚焦超声消融技术联合GnRH-a及LNG-IUS治疗子宫腺肌病痛经的临床研究[J].中华妇产科杂志,2016,51(9):643-649.
[3]边立华,王楠,范文生,等.促性腺激素释放激素激动剂预防腹腔镜子宫肌瘤剔除术后复发的疗效观察[J].解放军医学院学报,2017,38(3):199-201.
[4]殷美静,张纯溪,张萍.大孕周子宫肌瘤患者行腹腔镜下子宫肌瘤剔除术前后GnRH-a的应用价值[J].山东医药,2016,56(45):62-64.
[5]张翠兰.腹腔镜分别联合GnRH-a与孕三烯酮治疗子宫内膜异位症的疗效对比[J].中国实用医药,2016,11(21):177-178.
[6]郭玉琳.腹腔镜下子宫肌瘤剔除术与传统开腹子宫肌瘤剔除术治疗子宫肌瘤疗效对比研究[J].陕西医学杂志,2016,45(7):824-826.
[7]谢秀玲.腹腔镜子宫肌瘤剔除术与传统开腹手术治疗子宫肌瘤的临床疗效比较[J].齐齐哈尔医学院学报,2016,37(19):2432-2433.
[8]褚达明,欧阳玲.子宫肌瘤剔除术联合GnRH-a治疗弥漫性子宫平滑肌瘤病六例[J].实用肿瘤杂志,2017,32(2):147-151.
[9]张翼海.GnRHa与米非司酮在腹腔镜子宫肌瘤剔除术预处理中效果对比[J].中国冶金工业医学杂志,2016,33(1):33.
[10]蒋玮琳.GnRHa用于子宫肌瘤腹腔镜手术前治疗效果的前瞻性分析[J].深圳中西医结合杂志,2016,26(11):138-139.
[11]刘丽敏.腹腔镜病灶切除联合GnRH-a治疗子宫腺肌病疗效观察[J].泰山医学院学报,2017,38(7):804-806.
[12]蒋海霞,罗祥力,林川.用腹腔镜手术联合GnRH-α治疗子宫内膜异位症的疗效分析[J].当代医药论丛,2017,15(6):5-6.
[13]刘双平.舒芬太尼联合丙泊酚静脉麻醉在腹腔镜子宫肌瘤剔除术中的应用分析[J].当代医学,2015,21(15):59-60.
[14]刘岚,齐红,康高杨,等.联合腹腔镜下子宫肌瘤剔除术及醋酸亮丙瑞林治疗巨大子宫肌瘤临床效果[J].当代医学,2017,23(16):149-150.