摘要
为优选银怡片水提浸膏喷雾干燥工艺,以总黄酮含量、葛根素含量、含水量和出粉率为综合考察指标,选取恒流泵转速、进风温度、浸膏比重、雾化器频率4个因素进行响应面试验设计,采用熵权法确定各指标权重,优选银怡片水提浸膏喷雾干燥工艺。结果表明,最佳喷雾干燥工艺条件为:恒流泵转速41 r/min,进风温度171℃,浸膏比重1.09 (60℃),雾化器频率230 Hz。该条件下的喷雾干燥综合评分为56.68分,与响应面模型预测值相近(相对偏差0.26%)。优选的喷雾干燥工艺稳定可行,此次试验为银怡片的产业化提供了参考。
To optimize the spray drying process of water extract paste of Yinyi tablet, with content of total flavonoids,puerarin, moisture and powder rate as comprehensive evaluating indexes, entropy weighting method was applied to determine the weight of each index, and design-response surface method was used to optimize constant current pump speed, inlet air temperature, extract density and atomizer frequency. The result showed that optimum spray drying process was the constant current pump speed 41 r/min, the inlet air temperature 171 ℃, extract density 1.09(60 ℃), and atomizer frequency 230 Hz.Under these conditions, the average comprehensive score was 56.68, which was close to the model prediction(the relative deviation was 0.26%). The optimized spray drying process of water extract paste of Yinyi tablet is stable and feasible, which can provide a reference for production of Yinyi tablet.
引文
[1]国家药典委员会.中华人民共和国药典(一部)[S].北京:中国医药科技出版社, 2015:333.
[2]王本富,王华洋,耿东升.以芦丁为对照品对莲威阿那奇处方醇提工艺研究[J].时珍国医国药, 2012, 23(10):2511-2512.
[3]韩书成,李丹,熊建华,等.基于熵权——模糊综合评价模型的城市土地集约利用评价——以广东省惠州市为例[J].国土资源科技管理, 2016, 33(3):86-92.
[4]吴英俊,苏宜强,成乐祥.基于熵权法和专家打分法的企业节能减排效果评估方法[J].电器与能效管理技术,2015(16):63-68.
[5]卢义龙,王明力,李慧慧,等.喷雾干燥技术在食品工业中的应用现状[J].安徽农业科学, 2015(11):276-278.
[6]邱志芳,陈勇,王龙虎,等.中药浸膏干燥技术研究进展[J].世界科学技术(中医药现代化), 2008, 10(2):122-126.
[7]蔡薇,韩静,李智.喷雾干燥技术在中药领域中的应用及进展[J].沈阳药科大学学报, 2006, 23(9):613-616.
[8]陈建珍,赖志娟.熵理论及其应用[J].南昌师范学院学报,2005, 26(6):9-12.
[9]王清源,潘旭海.熵权法在重大危险源应急救援评估中的应用[J].南京工业大学学报(自然科学版), 2011, 33(3):87-92.
[10]万星火,李艳,檀亦丽,等.基于信息熵的赋权法研究及其应用[J].统计与决策, 2008(18):153-154.