考虑过程安全的半间歇搅拌釜加料速率优化
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摘要
反应釜的半间歇操作广泛应用于精细化工和医药等行业中的强放热反应,在保证安全性的基础上缩短加料时间,降低操作周期是提高过程效率的主要途径。本工作建立了以边界图为约束条件的半间歇搅拌釜安全操作工艺条件的优化方法,比较了单段和分段恒速加料在优化条件下的反应效果。在反应开始阶段采用较大加料速率,可快速提高物料温度,启动反应。与单段恒速加料相比,采用分段恒速加料在确保安全的同时可有效地缩短反应时间,提高反应效率。
The semi-batch reactor has been applied extensively for strong exothermic reaction in fine chemical and pharmaceutical industries. On the basis of ensuring safety, shortening feeding time and reducing operation cycle are the main ways to promote the process more efficient. In this paper, an optimization method for the safe operation conditions of semi-batch reactor with boundary diagram constraint was established, and the reaction results of single constant feeding rate and segregated constant feeding rates were evaluated. At the beginning, a large feeding rate should be used to increase the reactant temperature rapidly and ignite the reaction. Compared with the single constant feeding rate, the segregated constant feeding rates could significantly shorten the reaction time and improve the reaction efficiency while ensuring safety.
The semi-batch reactor has been applied extensively for strong exothermic reaction in fine chemical and pharmaceutical industries. On the basis of ensuring safety, shortening feeding time and reducing operation cycle are the main ways to promote the process more efficient. In this paper, an optimization method for the safe operation conditions of semi-batch reactor with boundary diagram constraint was established, and the reaction results of single constant feeding rate and segregated constant feeding rates were evaluated. At the beginning, a large feeding rate should be used to increase the reactant temperature rapidly and ignite the reaction. Compared with the single constant feeding rate, the segregated constant feeding rates could significantly shorten the reaction time and improve the reaction efficiency while ensuring safety.
引文
[1]陈志平,章序文,林兴华.搅拌与混合设备设计选用手册[M].北京:化学工业出版社,2004.
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[12]Ni L,Mebarki A,Jiang J,et al.Semi-batch reactors:thermal runaway risk[J].Journal of Loss Prevention in the Process Industries,2016,43:559-566.
[13]Ni L,Jiang J,Mannan M S,et al.Thermal runaway risk of semi-batch processes:esterification reaction with autocatalytic behavior[J].Industrial&Engineering Chemistry Research,2017,56(6):1534-1542.
[14]Westerterp K R,Lewak M,Molga E J.Boundary diagrams safety criterion for liquid phase homogeneous semibatch reactors[J].Industrial&Engineering Chemistry Research,2014,53(14):5778-5791.
[15]隋志军,杨榛,魏永明.化工数值计算与MATLAB[M].上海:华东理工大学出版社,2015.
[2]时钧,汪家鼎,余过琮.化学工程手册.第二版[M].北京:化学工业出版社,1996.
[3]Hugo P,Steinbach J.Practically oriented representation of thermal safe limits for an indirectly cooled semi-batch reactor[J].Chem Ing Tech,1985,57(9):780-782.
[4]Hugo P,Steinbach J.A comparison of the limits of safe operation of a SBR and a CSTR[J].Chemical Engineering Science,1986,41(4):1081-1087.
[5]Steensma M,Westerterp K R.Thermally safe operation of a semibatch reactor for liquid-liquid reactions:slow reactions[J].Industrial and Engineering Chemistry Research,1990,29(7):1259-1270.
[6]Steensma M,Westerterp K R.Thermally safe operation of a semibatch reactor for liquid-liquid reactions:fast reactions[J].Chemical Engineering&Technology,1991,14(6):367-375.
[7]Steensma M,Westerterp K R.Thermally safe operation of a cooled semi-batch reactor slow liquid-liquid reactions[J].Chemical Engineering Science,1988,43(8):2125-2132.
[8]Maestri F,Rota R.Safe and productive operation of homogeneous semibatch reactors.I:development of a general procedure[J].Industrial&Engineering Chemistry Research,2006,45(24):8002-8013.
[9]Maestri F,Rota R.Safe and productive operation of homogeneous semibatch reactors involving autocatalytic reactions with arbitrary reaction order[J].Industrial&Engineering Chemistry Research,2007,46(16):5333-5339.
[10]Maestri F,Rota R.Thermally safe operation of liquid-liquid semibatch reactors.Part I:single kinetically controlled reactions with arbitrary reaction order[J].Chemical Engineering Science,2005,60(12):3309-3322.
[11]Maestri F,Rota R.Thermally safe operation of liquid-liquid semibatch reactors.Part II:single diffusion controlled reactions with arbitrary reaction order[J].Chemical Engineering Science,2005,60(20):5590-5602.
[12]Ni L,Mebarki A,Jiang J,et al.Semi-batch reactors:thermal runaway risk[J].Journal of Loss Prevention in the Process Industries,2016,43:559-566.
[13]Ni L,Jiang J,Mannan M S,et al.Thermal runaway risk of semi-batch processes:esterification reaction with autocatalytic behavior[J].Industrial&Engineering Chemistry Research,2017,56(6):1534-1542.
[14]Westerterp K R,Lewak M,Molga E J.Boundary diagrams safety criterion for liquid phase homogeneous semibatch reactors[J].Industrial&Engineering Chemistry Research,2014,53(14):5778-5791.
[15]隋志军,杨榛,魏永明.化工数值计算与MATLAB[M].上海:华东理工大学出版社,2015.