基于浊毒论治疗代谢综合征相关性胆结石的临床研究
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摘要
目的探讨代谢综合征相关因素与胆结石的关系以及运用浊毒论治疗胆结石的有效性。方法以60例胆结石住院患者为研究对象从其合并代谢性疾病分布来研究代谢综合征与胆结石的相关性,并通过二分类logsitic回归分析以明确影响胆结石疗效的代谢因素。结果从胆结石合并代谢性疾病分布来说,考虑胆结石的形成与代谢综合征有关;通过二分类logsitic回归分析证明胆结石治疗效果与高密度脂蛋白呈正相关;以浊毒论治疗胆结石总有效率63. 3%。结论高密度脂蛋白是影响胆结石治疗效果的关键因素,且从浊毒论治胆结石有显著的临床疗效。
Objective To investigate the relationship between metabolic syndrome related factors and gall-stones and the effectiveness of turbidity toxin theory in the treatment of gallstones. Methods 60 patients with gallstones were enrolled as the study objects to analyze the correlation between metabolic syndrome and gallstones from the distribution of metabolic diseases. The binary logistic regression analysis was used to determine the metabolic factors influencing the curative effect of gallstones. Results From the distribution of gallstones with metabolic diseases,the formation of gallstones was considered to be related to metabolic syndrome. The binary logistic regression analysis showed that The therapeutic effect of gallstones was positively correlated with HDL-C. The total effective rate of turbidity toxin theory in the treatment of gallstones was 63. 3%. Conclusion HDL-C is the key factor affecting the therapeutic effect of gallstones,and turbidity toxin has significant clinical efficacy in the treatment of gallstones,which is worthy of further study and promotion.
Objective To investigate the relationship between metabolic syndrome related factors and gall-stones and the effectiveness of turbidity toxin theory in the treatment of gallstones. Methods 60 patients with gallstones were enrolled as the study objects to analyze the correlation between metabolic syndrome and gallstones from the distribution of metabolic diseases. The binary logistic regression analysis was used to determine the metabolic factors influencing the curative effect of gallstones. Results From the distribution of gallstones with metabolic diseases,the formation of gallstones was considered to be related to metabolic syndrome. The binary logistic regression analysis showed that The therapeutic effect of gallstones was positively correlated with HDL-C. The total effective rate of turbidity toxin theory in the treatment of gallstones was 63. 3%. Conclusion HDL-C is the key factor affecting the therapeutic effect of gallstones,and turbidity toxin has significant clinical efficacy in the treatment of gallstones,which is worthy of further study and promotion.
引文
[1]叶军锋,吴新民,张柏茁,等.《2016年欧洲肝病学会临床实践指南:胆石病的预防、诊断和治疗》推荐意见[J].临床肝胆病杂志,2016,32(8):1446-1449.
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[3]冯青青,樊拖迎,李春安,等.男性肝炎后肝硬化患者胆石形成与血清雌二醇关系探讨[J].疑难病杂志,2010,9(10):763-764.
[4]叶军锋,吴新民,亓文磊,等.《2016年日本胃肠病学会胆石症循证临床实践指南》推荐意见[J].临床肝胆病杂志,2017,33(2):244-246.
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[11]张振海,吴硕东,金俊哲,等.胆结石患者血液及胆囊组织内胃动素、胃泌素及血管活性肠肽含量的变化及意义[J].中国老年学杂志,2008,28(5):490-492.
[12]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志,2018,38(4):292-344.
[13]梁海清,王世和,李延青,等.胆结石与代谢综合征的关系分析[J].山东医药,2007,47(16):44-45.
[14]梁翠梅,孙颂歌,胡慧.代谢综合征中医体质分布规律及相关因素研究[J].世界中西医结合杂志,2016,11(10):1372-1375,1464.
[15]王昌儒.温肾健脾法对代谢综合征大鼠LKB1/AMPK信号通路的影响及机制[J].世界中西医结合杂志,2016,11(3):338-340,376.
[16]冯青青,樊拖迎,李春安,等.乙型肝炎后肝硬化患者胆结石形成的机制探讨[J].东南国防医药,2011,13(3):217-218.
[17]李文,熊春霖,魏轶,等.横栏居民2型糖尿病与胆囊炎、胆结石、脂代谢的相关因素研究[J].南方医科大学学报,2010,30(6):1435-1436.
[2]李军祥,陈誩,梁健.胆石症中西医结合诊疗共识意见(2017年)[J].中国中西医结合消化杂志,2018,26(2):132-138.
[3]冯青青,樊拖迎,李春安,等.男性肝炎后肝硬化患者胆石形成与血清雌二醇关系探讨[J].疑难病杂志,2010,9(10):763-764.
[4]叶军锋,吴新民,亓文磊,等.《2016年日本胃肠病学会胆石症循证临床实践指南》推荐意见[J].临床肝胆病杂志,2017,33(2):244-246.
[5]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:281-285.
[6]李佃贵.中医浊毒论[M].北京:人民卫生出版社,2016:246-257.
[7]何青红.胆结石患者血清瘦素水平与糖尿病形成的相关性分析[J].现代中西医结合杂志,2012,21(28):3124-3125.
[8]骆助林,汪涛,田伏洲,等.保胆取石术后复发与代谢综合征的相关性观察[J].中华全科医学,2012,10(7):1010-1011.
[9]王海生.胆囊结石与血脂水平关系的分析[J].中国社区医师,2016,32(19):125-126.
[10]李志周,祁峰,薛小玲,等.胆囊结石患者的胃粘膜病变200例临床分析[J].延安大学学报(医学科学版),2009,7(3):21,24.
[11]张振海,吴硕东,金俊哲,等.胆结石患者血液及胆囊组织内胃动素、胃泌素及血管活性肠肽含量的变化及意义[J].中国老年学杂志,2008,28(5):490-492.
[12]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志,2018,38(4):292-344.
[13]梁海清,王世和,李延青,等.胆结石与代谢综合征的关系分析[J].山东医药,2007,47(16):44-45.
[14]梁翠梅,孙颂歌,胡慧.代谢综合征中医体质分布规律及相关因素研究[J].世界中西医结合杂志,2016,11(10):1372-1375,1464.
[15]王昌儒.温肾健脾法对代谢综合征大鼠LKB1/AMPK信号通路的影响及机制[J].世界中西医结合杂志,2016,11(3):338-340,376.
[16]冯青青,樊拖迎,李春安,等.乙型肝炎后肝硬化患者胆结石形成的机制探讨[J].东南国防医药,2011,13(3):217-218.
[17]李文,熊春霖,魏轶,等.横栏居民2型糖尿病与胆囊炎、胆结石、脂代谢的相关因素研究[J].南方医科大学学报,2010,30(6):1435-1436.