基于“脾气散精”理论探讨助脾散精法对2型糖尿病患者肠道菌群及免疫功能的影响
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摘要
肠道菌群与免疫功能是当今生物医学领域研究的热点,研究发现,肠道菌群和免疫功能与胰岛素抵抗(IR)的发生发展均有相关性。而IR是2型糖尿病(T2DM)发病的主要机制。因而,调整肠道菌群、改善免疫功能可能是治疗T2DM新的切入点。在中医理论中,脾失健运、精不正化是T2DM的根本病机且与肠道菌群失调和免疫功能降低密切相关。故笔者基于"脾气散精"理论探讨助脾散精法对T2DM患者肠道菌群及免疫功能的影响。
Intestinal microflora and immune function are the hot spots in the field of biomedical research. It is found that intestinal flora and immune function are related to the development of insulin resistance(IR). IR is the main mechanism of type 2 diabetes mellitus(T2DM). Therefore, adjusting the intestinal flora and improving the immune function may be a new breakthrough point in the treatment of T2DM. In the theory of traditional Chinese medicine, dysfunction of spleen in transportation and the essence not positively formed, are the fundamental pathogenesis of T2DM, which is closely related to the imbalance of intestinal flora and the decrease of immune function. Therefore, based on the theory of ‘spleen qi dispersing essence', the authors discussed the effect of the method of promoting the spleen and dispersing essence on the intestinal flora and immune function of T2DM patients.
Intestinal microflora and immune function are the hot spots in the field of biomedical research. It is found that intestinal flora and immune function are related to the development of insulin resistance(IR). IR is the main mechanism of type 2 diabetes mellitus(T2DM). Therefore, adjusting the intestinal flora and improving the immune function may be a new breakthrough point in the treatment of T2DM. In the theory of traditional Chinese medicine, dysfunction of spleen in transportation and the essence not positively formed, are the fundamental pathogenesis of T2DM, which is closely related to the imbalance of intestinal flora and the decrease of immune function. Therefore, based on the theory of ‘spleen qi dispersing essence', the authors discussed the effect of the method of promoting the spleen and dispersing essence on the intestinal flora and immune function of T2DM patients.
引文
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[14]张博荀,岳仁宋.浅谈“调精理气法”在糖尿病治疗中的运用.江苏中医药,2016,48(3):45-46
[2]岳仁宋,陈源,王帅,等.试论助脾散精法治疗糖尿病.新中医,2011,43(2):155-156
[3]Cildir G,Akincilar S C,Tergaonkar V.Chronic adipose tissue infammation:All immune cells on the stage.Trends Mol Med,2013,19:487-500
[4]刘砺,张丽娜,满富丽,等.肥胖与免疫研究进展.北京医学,2017,39(6):631-633
[5]王彩宁,史丽萍,李秋云.2型糖尿病患者T淋巴细胞亚群变化及临床意义.山东医药,2010,50(37):111-112
[6]杨志华,柳树英,任耀全,等.运脾止泻剂对湿热泻小鼠肠道菌群的调节作用.时珍国医国药,2016,27(5):1077-1078
[7]刘名波.香砂六君子汤对脾虚泄泻免疫功能和肠道微生态的影响.苏州:苏州大学,2015
[8]Spanogiannopoulos Peter,Bess Elizabeth N,Carmody Rachel N,et al.The microbial pharmacists within us:A metagenomic view of xenobiotic metabolism.Nature Reviews Microbiology,2016,14(5):273-287
[9]Koh A,De Vadder F,Kovatcheva-Datchary P,et al.From dietary fiber to host physiology:Short-chain fatty acids as key bacterial metabolites.Cell,2013,165(6):1332-1345
[10]张国荣,刘海鸿,陶柯衡,等.肠道菌群与糖尿病的研究进展.中国微生态学杂志,2018,30(1):121-124
[11]Tai N,Wong F S,Wen L.The role of gut microbiota in the development of type 1,type 2 diabetes mellitus and obesity.Rev Endocr Metab Disord,2015,16(1):55-65
[12]王歌,白龙,王素娟,等.补虚健脾法对大肠癌术后脾虚证疗效及对免疫功能的临床研究.世界中西医结合杂志,2018,13(3):399-402
[13]周建龙,岳仁宋,邓朵朵,等.从挽精逐浊法论治代谢性疾病.中华中医药杂志,2017,32(2):593-595
[14]张博荀,岳仁宋.浅谈“调精理气法”在糖尿病治疗中的运用.江苏中医药,2016,48(3):45-46