影响腱骨愈合的因素及促进腱骨愈合的策略
|
摘要
通过检索PubMed、中国知网、万方等数据库查阅有关促进腱骨愈合方法的文献,整理和分析,正常的腱骨止点由复杂的4层结构组成,腱骨愈合受多种因素影响,促进腱骨愈合的方法较多,如生长因子、细胞学方法、基因治疗等.但多数促进腱骨愈合的方法尚处于动物实验阶段,仍需大量的临床研究来验证其有效性.
Through searching PubMed, CNKI(China National Knowledge Infrastructure), Wanfang Data and other databases, we found that the normal tendon-bone insertion point consists of four layers structure complex. the tendon-bone healing is affected by many factors.; there are many methods to promote tendon-bone healing, such as growth factors, cell-based therapy, gene therapy, and so on. However, most of the methods to promote tendon-bone healing are still in the animal experimental stage, and a large number of clinical studies are still needed to verify its effectiveness.
Through searching PubMed, CNKI(China National Knowledge Infrastructure), Wanfang Data and other databases, we found that the normal tendon-bone insertion point consists of four layers structure complex. the tendon-bone healing is affected by many factors.; there are many methods to promote tendon-bone healing, such as growth factors, cell-based therapy, gene therapy, and so on. However, most of the methods to promote tendon-bone healing are still in the animal experimental stage, and a large number of clinical studies are still needed to verify its effectiveness.
引文
[1] SAMMER D M, CHUNG K C. Advances in the healing of flexor tendon injuries[J]. Wound Repair and Regeneration, 2014, 22(S1): 25-29.
[2] BAYKAN M A. Current concepts in ACL reconstruction[J]. Journal of Sports Science and Medicine, 2008, 7(3): 424-425.
[3] STEINER M E, MURRAY M M, RODEO S A. Strategies to improve anterior cruciate ligament healing and graft placement[J]. The American Journal of Sports Medicine, 2008, 36(1): 176-189.
[4] GALATZ L M, BALL C M, TEEFEY S A, et al. The outcome and repair integrity of completely arthroscopically repaired large and massive rotator cuff tears[J]. JBJS, 2004, 86(2): 219-224.
[5] ROSSETTI L, KUNTZ L A, KUNOLD E, et al. The microstructure and micromechanics of the tendon-bone insertion[J]. Nature Materials, 2017, 16(6): 664.
[6] GENIN G M, THOMOPOULOS S. The tendon-to-bone attachment: Unification through disarray[J]. Nature Materials, 2017, 16(6): 607.
[7] RODEO S A, ARNOCZKY S P, TORZILLI P A, et al. Tendon-healing in a bone tunnel. A biomechanical and histological study in the dog[J]. JBJS, 1993, 75(12): 1795-1803.
[8] HAYS P L, KAWAMURA S, DENG X H, et al. The role of macrophages in early healing of a tendon graft in a bone tunnel[J]. JBJS, 2008, 90(3): 565-579.
[9] MULLER B, BOWMAN K F, BEDI A. ACL graft healing and biologics[J]. Clinics in Sports Medicine, 2013, 32(1): 93-109.
[10] TIEN Y C, CHIH H W, CHENG Y M, et al. The influence of the gap size on the interfacial union between the bone and the tendon[J]. The Kaohsiung Journal of Medical Sciences, 1999, 15(10): 581-588.
[11] BERG E E, POLLARD M E, KANG Q. Interarticular bone tunnel healing[J]. Arthroscopy, 2001, 17(2): 189-195.
[12] YAMAKADO K, KITAOKA K, YAMADA H, et al. The influence of mechanical stress on graft healing in a bone tunnel[J]. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 2002, 18(1): 82-90.
[13] 赵宗峤. 生长因子对前交叉韧带重建后腱-骨愈合影响的研究现状[J]. 中国矫形外科杂志, 2011, 19(6): 471-474. ZHAO Z Q. Research status of growth factors on tendon bone healing after anterior cruciate ligament reconstruction[J]. Orthopedic Journal of China, 2011, 19(6): 471-474.
[14] ZHANG C, LIU Y J. Biomechanic and histologic analysis of fibroblastic effects of tendon-to-bone healing by transforming growth factor β1 (TGF-β1) in rotator cuff tears[J]. Acta Cirurgica Brasileira, 2017, 32(12): 1045-1055.
[15] WU G, XU P C, WU P, et al. Advances in the treatment of rotator cuff lesions by cytokines[J]. Frontiers in Bioscience (Landmark edition), 2017, 22: 516-529.
[16] YAMAZAKI S, YASUDA K, TOMITA F, et al. The effect of transforming growth factor-beta1 on intraosseous healing of flexor tendon autograft replacement of anterior cruciate ligament in dogs[J]. Arthroscopy: the Journal of Arthroscopic & Related Surgery, 2005, 21(9):1034-1041.
[17] MANNING C N, KIM H M, SAKIYAMA-ELBERT S, et al. Sustained delivery of transforming growth factor beta three enhances tendon-to-bone healing in a rat model[J]. Journal of Orthopaedic Research, 2011, 29(7): 1099-1105.
[18] YOSHIKAWA T, TOHYAMA H, KATSURA T, et al. Effects of local administration of vascular endothelial growth factor on mechanical characteristics of the semitendinosus tendon graft after anterior cruciate ligament reconstruction in sheep[J]. The American Journal of Sports Medicine, 2006, 34(12): 1918-1925.
[19] 张力, 靳安民, 李奇. rhBMP-2 增强前交叉韧带重建术后腱骨界面愈合能力的实验研究[J]. 南方医科大学学报, 2008, 28(10): 1869-1873. ZHANG L, ZHAN A M, LI Q. Recombinant human bone morphogenetic protein-2 promotes tendon-bone healing after anterior cruciate ligament reconstruction in rabbits[J]. Journal of First Military Medical University, 2008, 28(10): 1869-1873.
[20] HEE C K, DINES J S, DINES D M, et al. Augmentation of a rotator cuff suture repair using rhPDGF-BB and a type I bovine collagen matrix in an ovine model[J]. The American Journal of Sports Medicine, 2011, 39(8): 1630-1640.
[21] SáNCHEZ M, ANITUA E, AZOFRA J, et al. Ligamentization of tendon grafts treated with an endogenous preparation rich in growth factors: gross morphology and histology[J]. Arthroscopy, 2010, 26(4): 470-480.
[22] ZHANG Z, WANG Y, SUN J. The effect of platelet-rich plasma on arthroscopic double-row rotator cuff repair: a clinical study with 12-month follow-up[J]. Acta Orthopaedica et Traumatologica Turcica, 2016, 50(2): 191-197.
[23] 王亚斌, 于绍斌, 董启榕. 富血小板血浆凝胶在同种异体肌腱重建前交叉韧带后腱-骨愈合中的作用[J]. 中华创伤杂志, 2010(3): 280-284. WANG Y B, YU S B, DONG Q R. Role of platelet-rich plasma in tendon-bone healing after anterior cruciate ligament reconstruction with tendon allograft[J]. Chinese Juernal of Trauma, 2010(3): 280-284.
[24] 董佩龙, 唐晓波, 王健, 等. 富血小板血浆在膝关节前十字韧带重建术中的应用[J]. 中华骨科杂志, 2014, 34(6): 672-678. DONG P L, TANG X B, WANG J, et al. The effect of platelet-rich plasma in anterior cruciate ligament reconstruction[J]. Chinese Journal of Orthopaedics, 2014, 34(6): 672-678.
[25] CHEN B, LI B, QI Y J, et al. Enhancement of tendon-to-bone healing after anterior cruciate ligament reconstruction using bone marrow-derived mesenchymal stem cells genetically modified with bFGF/BMP2[J]. Scientific Reports, 2016, 6: 25940.
[26] WANG X, ZHAI R, YANG J, et al.Effect of hamstring tendon transfected with adenovirus- mediated transforming growth factor β1 gene on histomorphology of tendon-bone interface healing after anterior cruciate ligament reconstruction in rabbits[J]. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(12):1488.
[27] KYUNG H S, KIM S Y, OH C W, et al. Tendon-to-bone tunnel healing in a rabbit model: the effect of periosteum augmentation at the tendon-to-bone interface[J]. Knee Surgery, Sports Traumatology, Arthroscopy, 2003, 11(1): 9-15.
[28] 陈百成, 栾广, 张展翅, 等. 自体骨膜包裹肌腱对腱骨愈合的影响[J]. 中华骨科杂志, 2006, 26(2): 118-122. CHEN B C, LUAN G, ZHANG Z C, et al. The study of autologous periosteum wrapping tendon graft improves tendon healing inside a bone tunnel[J]. Chinese Journal of Orthopaedics, 2006, 26(2): 118-122.
[29] 赵杨, 戴海峰, 刘莎莎,等. 自体骨膜促进兔肩袖腱骨愈合的疗效[J]. 中国比较医学杂志, 2018, 28(2): 74-79. ZHAO Y, DAI H F, LIU S S, et al. Therapeutic effect of autologous periosteum on the healing of tendon-bone interface in rabbit rotator cuff tear[J]. Chinese Journal of Comparative Medicine, 2018, 28(2): 74-79.
[30] 赖凡, 唐康来. 细胞学方法促进腱骨愈合研究进展[J]. 中国运动医学杂志, 2015, 34(9): 905-909. LAI F, TANG K L. Research progress in promoting tendon bone healing by cytological methods[J]. Chinese Journal of Sports Medicine, 2015, 34(9): 905-909.
[31] CHAMBERLAIN G, FOX J, ASHTON B, et al. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing[J]. Stem Cells, 2007, 25(11): 2739-2749.
[32] NOURISSAT G, DIOP A, MAUREL N, et al. Mesenchymal stem cell therapy regenerates the native bone-tendon junction after surgical repair in a degenerative rat model[J]. PloS One, 2010, 5(8): e12248.
[33] HERNIGOU P, LACHANIETTE C H F, DELAMBRE J, et al. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study[J]. International Orthopaedics, 2014, 38(9): 1811-1818.
[34] VOSS A, MCCARTHY M B, SINGH H, et al. The influence of trocar fenestration and volume on connective tissue progenitor cells (stem cells) in arthroscopic bone marrow aspiration from the proximal humerus[J]. Arthroscopy, 2017, 33(6): 1167-1174. e1.
[35] VOSS A, MCCARTHY M B, ALLEN D, et al. Fibrin scaffold as a carrier for mesenchymal stem cells and growth factors in shoulder rotator cuff repair[J]. Arthroscopy Techniques, 2016, 5(3): e447-e451.
[36] OH J H, CHUNG S W, KIM S H, et al. 2013 Neer Award: effect of the adipose-derived stem cell for the improvement of fatty degeneration and rotator cuff healing in rabbit model[J]. Journal of Shoulder and Elbow Surgery, 2014, 23(4): 445-455.
[37] CHENG B, GE H, ZHOU J, et al. TSG-6 mediates the effect of tendon derived stem cells for rotator cuff healing[J]. Eur Rev Med Pharmacol Sci, 2014, 18(2): 247-251.
[38] BI Y, EHIRCHIOU D, KILTS T M, et al. Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche[J]. Nature Medicine, 2007, 13(10): 1219.
[39] NAGURA I, KOKUBU T, MIFUNE Y, et al. Characterization of progenitor cells derived from torn human rotator cuff tendons by gene expression patterns of chondrogenesis, osteogenesis, and adipogenesis[J]. Journal of Orthopaedic Surgery and Research, 2016, 11(1): 40.
[40] UTSUNOMIYA H, UCHIDA S, SEKIYA I, et al. Isolation and characterization of human mesenchymal stem cells derived from shoulder tissues involved in rotator cuff tears[J]. The American Journal of Sports Medicine, 2013, 41(3): 657-668.
[41] ZHAO S, PENG L, XIE G, et al. Effect of the interposition of calcium phosphate materials on tendon-bone healing during repair of chronic rotator cuff tear[J]. The American Journal of Sports Medicine, 2014, 42(8): 1920-1929.
[42] 沈灏, 曹红彬, 蒋垚. 采用骨诱导性钙磷生物材料促进肌腱在骨隧道内愈合的组织学研究[J]. 中华创伤骨科杂志, 2006, 8(11): 1053-1056. SHEN H, CAO H B, JIANG Y. Histological research of calcium phosphate biomaterials promoting tendon healing in bone tunnels[J]. Chinese Journal of Orthopaedic Trauma, 2006, 8(11): 1053-1056.
[43] CHENG P, HAN P, ZHAO C, et al. High-purity magnesium interference screws promote fibrocartilaginous entheses regeneration in the anterior cruciate ligament reconstruction rabbit model via accumulation of BMP-2 and VEGF[J]. Biomaterials, 2016, 81: 14-26.
[44] SPALAZZI J P, DAGHER E, DOTY S B, et al. In vivo evaluation of a multiphased scaffold designed for orthopaedic interface tissue engineering and soft tissue-to-bone integration[J]. Journal of Biomedical Materials Research Part A, 2008, 86(1): 1-12.
[45] WU X, REN J, LI J. Fibrin glue as the cell-delivery vehicle for mesenchymal stromal cells in regenerative medicine[J]. Cytotherapy, 2012, 14(5): 555-562.
[46] YOKOYA S, MOCHIZUKI Y, NAGATA Y, et al. Tendon-bone insertion repair and regeneration using polyglycolic acid sheet in the rabbit rotator cuff injury model[J]. The American Journal of Sports Medicine, 2008, 36(7): 1298-1309.
[47] LOVRIC V, LEDGER M, GOLDBERG J, et al. The effects of low-intensity pulsed ultrasound on tendon-bone healing in a transosseous-equivalent sheep rotator cuff model[J]. Knee Surgery, Sports Traumatology, Arthroscopy, 2013, 21(2): 466-475.
[48] WANG C J, KO J Y, CHOU W Y, et al. Shockwave therapy improves anterior cruciate ligament reconstruction[J]. Journal of Surgical Research, 2014, 188(1): 110-118.
[49] 杨伟毅, 潘建科, 谢辉,等. 补肾中药促进兔前交叉韧带重建术后腱-骨愈合的组织学观察[J]. 世界中西医结合杂志, 2016, 11(5):636-639. YANG W Y, PAN J K, XIE H, et al. Histological study of herbal medicine for kidney tonification on tendon-bone healing after anterior cruciate ligament reconstruction in rabbits[J]. World Journal of Integrated Traditional and Western Medicine, 2016, 11(5):636-639.
[50] 罗程, 欧阳丽斯, 雷万龙,等. 红花黄色素对兔前交叉韧带重建术后骨腱愈合影响的生物力学研究[J]. 解剖学研究, 2016(3):191-193. LUO C, OUYANG L S, LEI W L, et al. Biomechanical study of safflower yellow on tendon healing after anterior cruciate ligament reconstruction in rabbits[J]. Anatomy Research, 2016(3):191-193.
[51] SALAZAR T E, RICHARDSON M R, BELI E, et al. Electroacupuncture promotes central nervous system-dependent release of mesenchymal stem cells[J]. Stem Cells, 2017, 35(5): 1303-1315.
[52] RHA D, PARK G Y, KIM Y K, et al. Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial[J]. Clinical Rehabilitation, 2013, 27(2): 113-122.
[53] 蔡凯. 温针灸肩三针治疗肩袖修补术患者的临床观察[J]. 光明中医, 2017(23):3443-3444. CAI K. Clinical observation on treatment of rotator cuff repair with warm needle moxibustion and shoulder three needles[J]. Guangming Journal of Chinese Medicine, 2017(23):3443-3444.
[54] PACKER J D, BEDI A, FOX A J, et al. Effect of immediate and delayed high-strain loading on tendon-to-bone healing after anterior cruciate ligament reconstruction[J]. The Journal of Bone and Joint Surgery. American Volume, 2014, 96(9): 770.
[55] RODEO S A, VOIGT C, MA R, et al. Use of a new model allowing controlled uniaxial loading to evaluate tendon healing in a bone tunnel[J]. Journal of Orthopaedic Research, 2016, 34(5): 852-859.
[56] SGROI T A, CILENTI M. Rotator cuff repair: post-operative rehabilitation concepts[J]. Current Reviews in Musculoskeletal Medicine, 2018, 11(1): 86-91.
[57] LIN J, ZHOU W, HAN S, et al. Cell-material interactions in tendon tissue engineering[J]. Acta Biomaterialia, 2018, 4(1): 1-11.
[2] BAYKAN M A. Current concepts in ACL reconstruction[J]. Journal of Sports Science and Medicine, 2008, 7(3): 424-425.
[3] STEINER M E, MURRAY M M, RODEO S A. Strategies to improve anterior cruciate ligament healing and graft placement[J]. The American Journal of Sports Medicine, 2008, 36(1): 176-189.
[4] GALATZ L M, BALL C M, TEEFEY S A, et al. The outcome and repair integrity of completely arthroscopically repaired large and massive rotator cuff tears[J]. JBJS, 2004, 86(2): 219-224.
[5] ROSSETTI L, KUNTZ L A, KUNOLD E, et al. The microstructure and micromechanics of the tendon-bone insertion[J]. Nature Materials, 2017, 16(6): 664.
[6] GENIN G M, THOMOPOULOS S. The tendon-to-bone attachment: Unification through disarray[J]. Nature Materials, 2017, 16(6): 607.
[7] RODEO S A, ARNOCZKY S P, TORZILLI P A, et al. Tendon-healing in a bone tunnel. A biomechanical and histological study in the dog[J]. JBJS, 1993, 75(12): 1795-1803.
[8] HAYS P L, KAWAMURA S, DENG X H, et al. The role of macrophages in early healing of a tendon graft in a bone tunnel[J]. JBJS, 2008, 90(3): 565-579.
[9] MULLER B, BOWMAN K F, BEDI A. ACL graft healing and biologics[J]. Clinics in Sports Medicine, 2013, 32(1): 93-109.
[10] TIEN Y C, CHIH H W, CHENG Y M, et al. The influence of the gap size on the interfacial union between the bone and the tendon[J]. The Kaohsiung Journal of Medical Sciences, 1999, 15(10): 581-588.
[11] BERG E E, POLLARD M E, KANG Q. Interarticular bone tunnel healing[J]. Arthroscopy, 2001, 17(2): 189-195.
[12] YAMAKADO K, KITAOKA K, YAMADA H, et al. The influence of mechanical stress on graft healing in a bone tunnel[J]. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 2002, 18(1): 82-90.
[13] 赵宗峤. 生长因子对前交叉韧带重建后腱-骨愈合影响的研究现状[J]. 中国矫形外科杂志, 2011, 19(6): 471-474. ZHAO Z Q. Research status of growth factors on tendon bone healing after anterior cruciate ligament reconstruction[J]. Orthopedic Journal of China, 2011, 19(6): 471-474.
[14] ZHANG C, LIU Y J. Biomechanic and histologic analysis of fibroblastic effects of tendon-to-bone healing by transforming growth factor β1 (TGF-β1) in rotator cuff tears[J]. Acta Cirurgica Brasileira, 2017, 32(12): 1045-1055.
[15] WU G, XU P C, WU P, et al. Advances in the treatment of rotator cuff lesions by cytokines[J]. Frontiers in Bioscience (Landmark edition), 2017, 22: 516-529.
[16] YAMAZAKI S, YASUDA K, TOMITA F, et al. The effect of transforming growth factor-beta1 on intraosseous healing of flexor tendon autograft replacement of anterior cruciate ligament in dogs[J]. Arthroscopy: the Journal of Arthroscopic & Related Surgery, 2005, 21(9):1034-1041.
[17] MANNING C N, KIM H M, SAKIYAMA-ELBERT S, et al. Sustained delivery of transforming growth factor beta three enhances tendon-to-bone healing in a rat model[J]. Journal of Orthopaedic Research, 2011, 29(7): 1099-1105.
[18] YOSHIKAWA T, TOHYAMA H, KATSURA T, et al. Effects of local administration of vascular endothelial growth factor on mechanical characteristics of the semitendinosus tendon graft after anterior cruciate ligament reconstruction in sheep[J]. The American Journal of Sports Medicine, 2006, 34(12): 1918-1925.
[19] 张力, 靳安民, 李奇. rhBMP-2 增强前交叉韧带重建术后腱骨界面愈合能力的实验研究[J]. 南方医科大学学报, 2008, 28(10): 1869-1873. ZHANG L, ZHAN A M, LI Q. Recombinant human bone morphogenetic protein-2 promotes tendon-bone healing after anterior cruciate ligament reconstruction in rabbits[J]. Journal of First Military Medical University, 2008, 28(10): 1869-1873.
[20] HEE C K, DINES J S, DINES D M, et al. Augmentation of a rotator cuff suture repair using rhPDGF-BB and a type I bovine collagen matrix in an ovine model[J]. The American Journal of Sports Medicine, 2011, 39(8): 1630-1640.
[21] SáNCHEZ M, ANITUA E, AZOFRA J, et al. Ligamentization of tendon grafts treated with an endogenous preparation rich in growth factors: gross morphology and histology[J]. Arthroscopy, 2010, 26(4): 470-480.
[22] ZHANG Z, WANG Y, SUN J. The effect of platelet-rich plasma on arthroscopic double-row rotator cuff repair: a clinical study with 12-month follow-up[J]. Acta Orthopaedica et Traumatologica Turcica, 2016, 50(2): 191-197.
[23] 王亚斌, 于绍斌, 董启榕. 富血小板血浆凝胶在同种异体肌腱重建前交叉韧带后腱-骨愈合中的作用[J]. 中华创伤杂志, 2010(3): 280-284. WANG Y B, YU S B, DONG Q R. Role of platelet-rich plasma in tendon-bone healing after anterior cruciate ligament reconstruction with tendon allograft[J]. Chinese Juernal of Trauma, 2010(3): 280-284.
[24] 董佩龙, 唐晓波, 王健, 等. 富血小板血浆在膝关节前十字韧带重建术中的应用[J]. 中华骨科杂志, 2014, 34(6): 672-678. DONG P L, TANG X B, WANG J, et al. The effect of platelet-rich plasma in anterior cruciate ligament reconstruction[J]. Chinese Journal of Orthopaedics, 2014, 34(6): 672-678.
[25] CHEN B, LI B, QI Y J, et al. Enhancement of tendon-to-bone healing after anterior cruciate ligament reconstruction using bone marrow-derived mesenchymal stem cells genetically modified with bFGF/BMP2[J]. Scientific Reports, 2016, 6: 25940.
[26] WANG X, ZHAI R, YANG J, et al.Effect of hamstring tendon transfected with adenovirus- mediated transforming growth factor β1 gene on histomorphology of tendon-bone interface healing after anterior cruciate ligament reconstruction in rabbits[J]. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(12):1488.
[27] KYUNG H S, KIM S Y, OH C W, et al. Tendon-to-bone tunnel healing in a rabbit model: the effect of periosteum augmentation at the tendon-to-bone interface[J]. Knee Surgery, Sports Traumatology, Arthroscopy, 2003, 11(1): 9-15.
[28] 陈百成, 栾广, 张展翅, 等. 自体骨膜包裹肌腱对腱骨愈合的影响[J]. 中华骨科杂志, 2006, 26(2): 118-122. CHEN B C, LUAN G, ZHANG Z C, et al. The study of autologous periosteum wrapping tendon graft improves tendon healing inside a bone tunnel[J]. Chinese Journal of Orthopaedics, 2006, 26(2): 118-122.
[29] 赵杨, 戴海峰, 刘莎莎,等. 自体骨膜促进兔肩袖腱骨愈合的疗效[J]. 中国比较医学杂志, 2018, 28(2): 74-79. ZHAO Y, DAI H F, LIU S S, et al. Therapeutic effect of autologous periosteum on the healing of tendon-bone interface in rabbit rotator cuff tear[J]. Chinese Journal of Comparative Medicine, 2018, 28(2): 74-79.
[30] 赖凡, 唐康来. 细胞学方法促进腱骨愈合研究进展[J]. 中国运动医学杂志, 2015, 34(9): 905-909. LAI F, TANG K L. Research progress in promoting tendon bone healing by cytological methods[J]. Chinese Journal of Sports Medicine, 2015, 34(9): 905-909.
[31] CHAMBERLAIN G, FOX J, ASHTON B, et al. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing[J]. Stem Cells, 2007, 25(11): 2739-2749.
[32] NOURISSAT G, DIOP A, MAUREL N, et al. Mesenchymal stem cell therapy regenerates the native bone-tendon junction after surgical repair in a degenerative rat model[J]. PloS One, 2010, 5(8): e12248.
[33] HERNIGOU P, LACHANIETTE C H F, DELAMBRE J, et al. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study[J]. International Orthopaedics, 2014, 38(9): 1811-1818.
[34] VOSS A, MCCARTHY M B, SINGH H, et al. The influence of trocar fenestration and volume on connective tissue progenitor cells (stem cells) in arthroscopic bone marrow aspiration from the proximal humerus[J]. Arthroscopy, 2017, 33(6): 1167-1174. e1.
[35] VOSS A, MCCARTHY M B, ALLEN D, et al. Fibrin scaffold as a carrier for mesenchymal stem cells and growth factors in shoulder rotator cuff repair[J]. Arthroscopy Techniques, 2016, 5(3): e447-e451.
[36] OH J H, CHUNG S W, KIM S H, et al. 2013 Neer Award: effect of the adipose-derived stem cell for the improvement of fatty degeneration and rotator cuff healing in rabbit model[J]. Journal of Shoulder and Elbow Surgery, 2014, 23(4): 445-455.
[37] CHENG B, GE H, ZHOU J, et al. TSG-6 mediates the effect of tendon derived stem cells for rotator cuff healing[J]. Eur Rev Med Pharmacol Sci, 2014, 18(2): 247-251.
[38] BI Y, EHIRCHIOU D, KILTS T M, et al. Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche[J]. Nature Medicine, 2007, 13(10): 1219.
[39] NAGURA I, KOKUBU T, MIFUNE Y, et al. Characterization of progenitor cells derived from torn human rotator cuff tendons by gene expression patterns of chondrogenesis, osteogenesis, and adipogenesis[J]. Journal of Orthopaedic Surgery and Research, 2016, 11(1): 40.
[40] UTSUNOMIYA H, UCHIDA S, SEKIYA I, et al. Isolation and characterization of human mesenchymal stem cells derived from shoulder tissues involved in rotator cuff tears[J]. The American Journal of Sports Medicine, 2013, 41(3): 657-668.
[41] ZHAO S, PENG L, XIE G, et al. Effect of the interposition of calcium phosphate materials on tendon-bone healing during repair of chronic rotator cuff tear[J]. The American Journal of Sports Medicine, 2014, 42(8): 1920-1929.
[42] 沈灏, 曹红彬, 蒋垚. 采用骨诱导性钙磷生物材料促进肌腱在骨隧道内愈合的组织学研究[J]. 中华创伤骨科杂志, 2006, 8(11): 1053-1056. SHEN H, CAO H B, JIANG Y. Histological research of calcium phosphate biomaterials promoting tendon healing in bone tunnels[J]. Chinese Journal of Orthopaedic Trauma, 2006, 8(11): 1053-1056.
[43] CHENG P, HAN P, ZHAO C, et al. High-purity magnesium interference screws promote fibrocartilaginous entheses regeneration in the anterior cruciate ligament reconstruction rabbit model via accumulation of BMP-2 and VEGF[J]. Biomaterials, 2016, 81: 14-26.
[44] SPALAZZI J P, DAGHER E, DOTY S B, et al. In vivo evaluation of a multiphased scaffold designed for orthopaedic interface tissue engineering and soft tissue-to-bone integration[J]. Journal of Biomedical Materials Research Part A, 2008, 86(1): 1-12.
[45] WU X, REN J, LI J. Fibrin glue as the cell-delivery vehicle for mesenchymal stromal cells in regenerative medicine[J]. Cytotherapy, 2012, 14(5): 555-562.
[46] YOKOYA S, MOCHIZUKI Y, NAGATA Y, et al. Tendon-bone insertion repair and regeneration using polyglycolic acid sheet in the rabbit rotator cuff injury model[J]. The American Journal of Sports Medicine, 2008, 36(7): 1298-1309.
[47] LOVRIC V, LEDGER M, GOLDBERG J, et al. The effects of low-intensity pulsed ultrasound on tendon-bone healing in a transosseous-equivalent sheep rotator cuff model[J]. Knee Surgery, Sports Traumatology, Arthroscopy, 2013, 21(2): 466-475.
[48] WANG C J, KO J Y, CHOU W Y, et al. Shockwave therapy improves anterior cruciate ligament reconstruction[J]. Journal of Surgical Research, 2014, 188(1): 110-118.
[49] 杨伟毅, 潘建科, 谢辉,等. 补肾中药促进兔前交叉韧带重建术后腱-骨愈合的组织学观察[J]. 世界中西医结合杂志, 2016, 11(5):636-639. YANG W Y, PAN J K, XIE H, et al. Histological study of herbal medicine for kidney tonification on tendon-bone healing after anterior cruciate ligament reconstruction in rabbits[J]. World Journal of Integrated Traditional and Western Medicine, 2016, 11(5):636-639.
[50] 罗程, 欧阳丽斯, 雷万龙,等. 红花黄色素对兔前交叉韧带重建术后骨腱愈合影响的生物力学研究[J]. 解剖学研究, 2016(3):191-193. LUO C, OUYANG L S, LEI W L, et al. Biomechanical study of safflower yellow on tendon healing after anterior cruciate ligament reconstruction in rabbits[J]. Anatomy Research, 2016(3):191-193.
[51] SALAZAR T E, RICHARDSON M R, BELI E, et al. Electroacupuncture promotes central nervous system-dependent release of mesenchymal stem cells[J]. Stem Cells, 2017, 35(5): 1303-1315.
[52] RHA D, PARK G Y, KIM Y K, et al. Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial[J]. Clinical Rehabilitation, 2013, 27(2): 113-122.
[53] 蔡凯. 温针灸肩三针治疗肩袖修补术患者的临床观察[J]. 光明中医, 2017(23):3443-3444. CAI K. Clinical observation on treatment of rotator cuff repair with warm needle moxibustion and shoulder three needles[J]. Guangming Journal of Chinese Medicine, 2017(23):3443-3444.
[54] PACKER J D, BEDI A, FOX A J, et al. Effect of immediate and delayed high-strain loading on tendon-to-bone healing after anterior cruciate ligament reconstruction[J]. The Journal of Bone and Joint Surgery. American Volume, 2014, 96(9): 770.
[55] RODEO S A, VOIGT C, MA R, et al. Use of a new model allowing controlled uniaxial loading to evaluate tendon healing in a bone tunnel[J]. Journal of Orthopaedic Research, 2016, 34(5): 852-859.
[56] SGROI T A, CILENTI M. Rotator cuff repair: post-operative rehabilitation concepts[J]. Current Reviews in Musculoskeletal Medicine, 2018, 11(1): 86-91.
[57] LIN J, ZHOU W, HAN S, et al. Cell-material interactions in tendon tissue engineering[J]. Acta Biomaterialia, 2018, 4(1): 1-11.