天麻对心血管及代谢性疾病的作用机制研究进展
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摘要
中药天麻传统用于神经系统疾病的治疗,然而该药对心血管及代谢性疾病亦具有一定的药理作用。为了拓展天麻的临床价值,从抗心肌缺血再灌注损伤、降血压、保护血管、抗血小板聚集、抗血栓等方面综述天麻及其复方、主要活性成分对心血管疾病的作用和机制,同时综述了天麻对糖尿病、高脂血症等代谢性疾病的作用及相关机制。
Gastrodiae Rhizoma is traditionally used in the treatment of nervous system diseases. However, it also shows pharmacological effects on the cardiovascular and metabolic diseases. In order to expand the clinical value of Gastrodiae Rhizoma, the effects and mechanisms of Gastrodiae Rhizoma and its compound recipes and main active components on the cardiovascular diseases are reviewed, from the aspects of anti-myocardial ischemia-reperfusion injury, anti-hypertension, vascular protection, anti-platelet aggregation, anti-thrombosis and so on. Meanwhile, the effects and related mechanisms of Gastrodiae Rhizoma on the metabolic diseases such as diabetes and hyperlipidemia are also reviewed.
Gastrodiae Rhizoma is traditionally used in the treatment of nervous system diseases. However, it also shows pharmacological effects on the cardiovascular and metabolic diseases. In order to expand the clinical value of Gastrodiae Rhizoma, the effects and mechanisms of Gastrodiae Rhizoma and its compound recipes and main active components on the cardiovascular diseases are reviewed, from the aspects of anti-myocardial ischemia-reperfusion injury, anti-hypertension, vascular protection, anti-platelet aggregation, anti-thrombosis and so on. Meanwhile, the effects and related mechanisms of Gastrodiae Rhizoma on the metabolic diseases such as diabetes and hyperlipidemia are also reviewed.
引文
[1] 国家药典委员会.中华人民共和国药典:一部[M].北京:中国医药科技出版社,2015:58- 59.
[2] 单鸣秋,张丽,于生,等.HPLC- MS法同时测定天麻饮片中8种活性成分[J].中草药,2015,46(14):2087- 2091.
[3] 谢淼,邵明莎,翟庆超,等.天麻中巴利森苷类成分研究进展[J].广东化工,2016,43(22):93- 95.
[4] 肖佳佳,黄红,雷有成,等.天麻HPLC指纹图谱建立及判别分析[J].中国中药杂志,2017,42(13):2524- 2531.
[5] 李云,王志伟,刘大会,等.天麻化学成分研究进展[J].山东科学,2016,29(4):24- 29.
[6] LIU Y,GAO J L,PENG M,et al.A Review on Central Nervous System Effects of Gastrodin[J].Front Pharmacol,2018,9:24.
[7] 熊金富,陈清华,彭磊,等.天麻通心脑方对垂体后叶素致大鼠急性心肌缺血的保护作用[J].云南中医中药杂志,2014,35(5):75- 77.
[8] 洪全,周敏,张凯.乌天麻抗大鼠心肌缺血再灌注损伤的保护作用[J].黑龙江医学,2009,33(8):589- 591.
[9] 杨伟,滕林,丁家望,等.天麻素对大鼠心脏缺血再灌注损伤的保护作用[J].临床心血管病杂志,2017,33(4):381- 385.
[10] 王飞,位凯,沈兵,等.天麻素预处理对大鼠心肌缺血再灌注损伤的保护作用[J].中国药学杂志,2012,47(23):1905- 1910.
[11] ZHU M F,DENG W,DI S H,et al.Gastrodin Protects Cardiomyocytes from Anoxia/Reoxygenation Injury by 14- 3- 3η [J].Oxid Med Cell Longev,2018,2018:3685391.doi:10.1155/2018/3685391.
[12] FU S S,CHEN L L,WU Y Z,et al.Gastrodin pretreatment alleviates myocardial ischemia/reperfusion injury through promoting autophagic flux[J].Biochem Biophys Res Commun,2018,503(4):2421- 2428.
[13] LI X,ZHU Q H,LIU Y Y,et al.Gastrodin protects myocardial cells against hypoxia/reoxygenation injury in neonatal rats by inhibiting cell autophagy through the activation of mTOR signals in PI3K- Akt pathway[J].J Pharm Pharmacol,2018,70(2):259- 267.
[14] LI Y,WANG X,LOU C.Gastrodin Pretreatment Impact on Sarcoplasmic Reticulum Calcium Transport ATPase (SERCA) and Calcium Phosphate (PLB) Expression in Rats with Myocardial Ischemia Reperfusion[J].Med Sci Monit,2016,22:3309- 3315.
[15] 钱善军,张敏.天麻钩藤饮对自发性高血压大鼠血清儿茶酚胺的影响研究[J].实用中医药杂志,2012,28(10):814- 815.
[16] 栗源,可燕,蒋嘉烨,等.天麻钩藤饮对自发性高血压大鼠血管功能及肾脏蛋白表达的影响[J].中国中西医结合杂志,2015,35(4):481- 487.
[17] 王现珍,蒋嘉烨,罗珊珊,等.半夏白术天麻汤对自发性高血压大鼠血管内皮功能的影响[J].中国中西医结合杂志,2011,31(6):811- 815.
[18] 张宇霞,杨雨民,周芸慧,等.半夏白术天麻汤对痰湿壅盛型高血压大鼠血清ET- 1及NO含量的影响[J].内蒙古中医药,2018,37(6):99- 101.
[19] DAI R,WANG T,SI X Q,et al.Vasodilatory effects and underlying mechanisms of the ethyl acetate extracts from Gastrodia elata[J].Can J Physiol Pharmacol,2017,95(5):564- 571.
[20] CHEN S,HAO X W,YU L,et al.Gastrodin causes vasodilation by activating KATP channels in vascular smooth muscles via PKA- dependent signaling pathway[J].J Recept Signal Transduct Res,2017,37(6):543- 549.
[21] XIE Y L,ZHOU M,MA H H,et al.Vasorelaxation effect of gastrodin on isolated thoracic aorta rings of rats[J].Chin J Integr Med,2015,21(12):944- 948.
[22] LIU W,WANG L Y,YU J H,et al.Gastrodin Reduces Blood Pressure by Intervening with RAAS and PPARγ in SHRs[J].Evid Based Complement Alternat Med,2015,2015:828427.doi:10.1155/2015/828427.
[23] ZHU L H,GUAN H J,CUI C P,et al.Gastrodin inhibits cell proliferation in vascular smooth muscle cells and attenuates neointima formation in vivo[J].Int J Mol Med,2012,30(5):1034- 1040.
[24] CHEN X,XIAO F,WANG Y,et al.Structure-activity relationship study of WSS25 derivatives with anti-angiogenesis effects[J].Glycoconj J,2012,29(5- 6):389- 398.
[25] HWANG S M,LEE Y J,KANG D G,et al.Anti- inflammatory effect of Gastrodia elata rhizome in human umbilical vein endothelial cells[J].Am J Chin Med,2009,37(2):395- 406.
[26] 姜丽,王玉蓉,曹唯仪,等.基于改善微循环药效的天麻素与葛根素配伍合理性研究[J].世界科学技术-中医药现代化,2013,15(2):244- 248.
[27] 申婷,肖纯,向彬,等.天麻成分对羟基苯甲醛抗血小板聚集的作用机制研究[J].中国药业,2017,26(18):4- 7.
[28] 郭营营,蒋石,林青,等.天麻中对羟基苯甲醇抗血小板聚集的作用及机制研究[J].时珍国医国药,2014,25(1):4- 6.
[29] 张勇,武燕彬,孔维佳.天麻素在KK- Ay小鼠中抗糖尿病作用的实验研究[J].中国药理学通报,2018,34(7):917- 924.
[30] YANG H J,KIM M J,KWON D Y,et al.Anti- Diabetic Activities of Gastrodia elata Blume Water Extracts Are Mediated Mainly by Potentiating Glucose- Stimulated Insulin Secretion and Increasing β- Cell Mass in Non- Obese Type 2 Diabetic Animals[J].Nutrients,2016,8(3):161.
[31] 杜晓红,毛瑞阳,刘毅,等.天麻素对高糖诱导的神经小胶质细胞IL- 1β,IL- 6表达的影响[J].中国中药杂志,2009,34(12):1535- 1539.
[32] ZHANG T H,HUANG C M,GAO X,et al.Gastrodin inhibits high glucose- induced human retinal endothelial cell apoptosis by regulating the SIRT1/TLR4/NF- κBp65 signaling pathway[J].Mol Med Rep,2018,17(6):7774- 7780.
[33] 韩磊,乔爱敏,刘青.天麻素的抗糖尿病作用实验[J].华侨大学学报(自然科学版),2013,34(6):682- 686.
[34] 贾宝贤,左增艳.天麻粉对高脂小鼠降血脂和谷丙转氨酶的实验观察[J].中国当代医药,2013,20(25):130- 131.
[35] KIM K J,LEE O H,HAN C K,et al.Acidic polysaccharide extracts from Gastrodia Rhizomes suppress the atherosclerosis risk index through inhibition of the serum cholesterol composition in Sprague Dawley rats fed a high- fat diet[J].Int J Mol Sci,2012,13(2):1620- 1631.
[36] QU L L,YU B,LI Z,et al.Gastrodin Ameliorates Oxidative Stress and Proinflammatory Response in Nonalcoholic Fatty Liver Disease through the AMPK/Nrf2 Pathway[J].Phytother Res,2016,30(3):402- 411.
[37] PARK S,KIM D S,KANG S.Gastrodia elata Blume water extracts improve insulin resistance by decreasing body fat in diet- induced obese rats:vanillin and 4- hydroxybenzaldehyde are the bioactive candidates[J].Eur J Nutr,2011,50(2):107- 118.
[38] KHO M C,LEE Y J,CHA J D,et al.Gastrodia elata Ameliorates High-Fructose Diet-Induced Lipid Metabolism and Endothelial Dysfunction[J].Evid Based Complement Alternat Med,2014,2014:101624.doi:10.1155/2014/101624.
[39] CHEN L M,LIU X,WANG H,et al.Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen- Activated Protein Kinase-Associated Inflammatory Responses in Mice[J].Neurosci Bull,2017,33(3):264- 272.
[40] WANG X L,XING G H,HONG B,et al.Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson’s disease:involvement of ERK1/2-Nrf2 signaling pathway[J].Life Sci,2014,114(2):77- 85.
[41] BI Y F,JIANG Y,HE J,et al.Status of cardiovascular health in Chinese adults[J].J Am Coll Cardiol,2015,65(10):1013- 1025.
[42] LU J L,WANG L M,LI M,et al.Metabolic Syndrome Among Adults in China:The 2010 China Noncommunicable Disease Surveillance[J].J Clin Endocrinol Metab,2017,102(2):507- 515.
[2] 单鸣秋,张丽,于生,等.HPLC- MS法同时测定天麻饮片中8种活性成分[J].中草药,2015,46(14):2087- 2091.
[3] 谢淼,邵明莎,翟庆超,等.天麻中巴利森苷类成分研究进展[J].广东化工,2016,43(22):93- 95.
[4] 肖佳佳,黄红,雷有成,等.天麻HPLC指纹图谱建立及判别分析[J].中国中药杂志,2017,42(13):2524- 2531.
[5] 李云,王志伟,刘大会,等.天麻化学成分研究进展[J].山东科学,2016,29(4):24- 29.
[6] LIU Y,GAO J L,PENG M,et al.A Review on Central Nervous System Effects of Gastrodin[J].Front Pharmacol,2018,9:24.
[7] 熊金富,陈清华,彭磊,等.天麻通心脑方对垂体后叶素致大鼠急性心肌缺血的保护作用[J].云南中医中药杂志,2014,35(5):75- 77.
[8] 洪全,周敏,张凯.乌天麻抗大鼠心肌缺血再灌注损伤的保护作用[J].黑龙江医学,2009,33(8):589- 591.
[9] 杨伟,滕林,丁家望,等.天麻素对大鼠心脏缺血再灌注损伤的保护作用[J].临床心血管病杂志,2017,33(4):381- 385.
[10] 王飞,位凯,沈兵,等.天麻素预处理对大鼠心肌缺血再灌注损伤的保护作用[J].中国药学杂志,2012,47(23):1905- 1910.
[11] ZHU M F,DENG W,DI S H,et al.Gastrodin Protects Cardiomyocytes from Anoxia/Reoxygenation Injury by 14- 3- 3η [J].Oxid Med Cell Longev,2018,2018:3685391.doi:10.1155/2018/3685391.
[12] FU S S,CHEN L L,WU Y Z,et al.Gastrodin pretreatment alleviates myocardial ischemia/reperfusion injury through promoting autophagic flux[J].Biochem Biophys Res Commun,2018,503(4):2421- 2428.
[13] LI X,ZHU Q H,LIU Y Y,et al.Gastrodin protects myocardial cells against hypoxia/reoxygenation injury in neonatal rats by inhibiting cell autophagy through the activation of mTOR signals in PI3K- Akt pathway[J].J Pharm Pharmacol,2018,70(2):259- 267.
[14] LI Y,WANG X,LOU C.Gastrodin Pretreatment Impact on Sarcoplasmic Reticulum Calcium Transport ATPase (SERCA) and Calcium Phosphate (PLB) Expression in Rats with Myocardial Ischemia Reperfusion[J].Med Sci Monit,2016,22:3309- 3315.
[15] 钱善军,张敏.天麻钩藤饮对自发性高血压大鼠血清儿茶酚胺的影响研究[J].实用中医药杂志,2012,28(10):814- 815.
[16] 栗源,可燕,蒋嘉烨,等.天麻钩藤饮对自发性高血压大鼠血管功能及肾脏蛋白表达的影响[J].中国中西医结合杂志,2015,35(4):481- 487.
[17] 王现珍,蒋嘉烨,罗珊珊,等.半夏白术天麻汤对自发性高血压大鼠血管内皮功能的影响[J].中国中西医结合杂志,2011,31(6):811- 815.
[18] 张宇霞,杨雨民,周芸慧,等.半夏白术天麻汤对痰湿壅盛型高血压大鼠血清ET- 1及NO含量的影响[J].内蒙古中医药,2018,37(6):99- 101.
[19] DAI R,WANG T,SI X Q,et al.Vasodilatory effects and underlying mechanisms of the ethyl acetate extracts from Gastrodia elata[J].Can J Physiol Pharmacol,2017,95(5):564- 571.
[20] CHEN S,HAO X W,YU L,et al.Gastrodin causes vasodilation by activating KATP channels in vascular smooth muscles via PKA- dependent signaling pathway[J].J Recept Signal Transduct Res,2017,37(6):543- 549.
[21] XIE Y L,ZHOU M,MA H H,et al.Vasorelaxation effect of gastrodin on isolated thoracic aorta rings of rats[J].Chin J Integr Med,2015,21(12):944- 948.
[22] LIU W,WANG L Y,YU J H,et al.Gastrodin Reduces Blood Pressure by Intervening with RAAS and PPARγ in SHRs[J].Evid Based Complement Alternat Med,2015,2015:828427.doi:10.1155/2015/828427.
[23] ZHU L H,GUAN H J,CUI C P,et al.Gastrodin inhibits cell proliferation in vascular smooth muscle cells and attenuates neointima formation in vivo[J].Int J Mol Med,2012,30(5):1034- 1040.
[24] CHEN X,XIAO F,WANG Y,et al.Structure-activity relationship study of WSS25 derivatives with anti-angiogenesis effects[J].Glycoconj J,2012,29(5- 6):389- 398.
[25] HWANG S M,LEE Y J,KANG D G,et al.Anti- inflammatory effect of Gastrodia elata rhizome in human umbilical vein endothelial cells[J].Am J Chin Med,2009,37(2):395- 406.
[26] 姜丽,王玉蓉,曹唯仪,等.基于改善微循环药效的天麻素与葛根素配伍合理性研究[J].世界科学技术-中医药现代化,2013,15(2):244- 248.
[27] 申婷,肖纯,向彬,等.天麻成分对羟基苯甲醛抗血小板聚集的作用机制研究[J].中国药业,2017,26(18):4- 7.
[28] 郭营营,蒋石,林青,等.天麻中对羟基苯甲醇抗血小板聚集的作用及机制研究[J].时珍国医国药,2014,25(1):4- 6.
[29] 张勇,武燕彬,孔维佳.天麻素在KK- Ay小鼠中抗糖尿病作用的实验研究[J].中国药理学通报,2018,34(7):917- 924.
[30] YANG H J,KIM M J,KWON D Y,et al.Anti- Diabetic Activities of Gastrodia elata Blume Water Extracts Are Mediated Mainly by Potentiating Glucose- Stimulated Insulin Secretion and Increasing β- Cell Mass in Non- Obese Type 2 Diabetic Animals[J].Nutrients,2016,8(3):161.
[31] 杜晓红,毛瑞阳,刘毅,等.天麻素对高糖诱导的神经小胶质细胞IL- 1β,IL- 6表达的影响[J].中国中药杂志,2009,34(12):1535- 1539.
[32] ZHANG T H,HUANG C M,GAO X,et al.Gastrodin inhibits high glucose- induced human retinal endothelial cell apoptosis by regulating the SIRT1/TLR4/NF- κBp65 signaling pathway[J].Mol Med Rep,2018,17(6):7774- 7780.
[33] 韩磊,乔爱敏,刘青.天麻素的抗糖尿病作用实验[J].华侨大学学报(自然科学版),2013,34(6):682- 686.
[34] 贾宝贤,左增艳.天麻粉对高脂小鼠降血脂和谷丙转氨酶的实验观察[J].中国当代医药,2013,20(25):130- 131.
[35] KIM K J,LEE O H,HAN C K,et al.Acidic polysaccharide extracts from Gastrodia Rhizomes suppress the atherosclerosis risk index through inhibition of the serum cholesterol composition in Sprague Dawley rats fed a high- fat diet[J].Int J Mol Sci,2012,13(2):1620- 1631.
[36] QU L L,YU B,LI Z,et al.Gastrodin Ameliorates Oxidative Stress and Proinflammatory Response in Nonalcoholic Fatty Liver Disease through the AMPK/Nrf2 Pathway[J].Phytother Res,2016,30(3):402- 411.
[37] PARK S,KIM D S,KANG S.Gastrodia elata Blume water extracts improve insulin resistance by decreasing body fat in diet- induced obese rats:vanillin and 4- hydroxybenzaldehyde are the bioactive candidates[J].Eur J Nutr,2011,50(2):107- 118.
[38] KHO M C,LEE Y J,CHA J D,et al.Gastrodia elata Ameliorates High-Fructose Diet-Induced Lipid Metabolism and Endothelial Dysfunction[J].Evid Based Complement Alternat Med,2014,2014:101624.doi:10.1155/2014/101624.
[39] CHEN L M,LIU X,WANG H,et al.Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen- Activated Protein Kinase-Associated Inflammatory Responses in Mice[J].Neurosci Bull,2017,33(3):264- 272.
[40] WANG X L,XING G H,HONG B,et al.Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson’s disease:involvement of ERK1/2-Nrf2 signaling pathway[J].Life Sci,2014,114(2):77- 85.
[41] BI Y F,JIANG Y,HE J,et al.Status of cardiovascular health in Chinese adults[J].J Am Coll Cardiol,2015,65(10):1013- 1025.
[42] LU J L,WANG L M,LI M,et al.Metabolic Syndrome Among Adults in China:The 2010 China Noncommunicable Disease Surveillance[J].J Clin Endocrinol Metab,2017,102(2):507- 515.