头孢呋辛酯和克林霉素磷酸酯阴道乳膏治疗单纯需氧菌性阴道炎效果评价
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摘要
目的探讨头孢呋辛酯和克林霉素磷酸酯阴道乳膏对单纯需氧菌性阴道炎的治疗效果。方法收集2015年3月至2017年9月于清华大学附属北京清华长庚医院妇产科门诊就诊、经阴道微生态检测诊断为单纯需氧菌性阴道炎的患者共计274例,按其治疗方法分为两组:甲组159例,头孢呋辛酯250mg口服,2次/d,连续7d;乙组115例,克林霉素磷酸酯阴道乳膏5g/0.1g阴道给药,1次/d,连续7d。对两组的治疗效果进行回顾性分析。结果 274例患者治疗7d后总有效率84.3%(231/274)。甲组有效率为83.6%(133/159),乙组有效率为85.2%(98/115),两组比较差异无统计学意义(P>0.05)。结论口服头孢呋辛酯及克林霉素磷酸酯阴道乳膏治疗单纯需氧菌性阴道炎均能取得较好的效果。
Objective To compare the therapeutic effect on simple aerobic vaginitis between the oral cefuroxime axetil and clindamycin phosphate vaginal cream.Methods This was a retrospective study of 274 patients under aerobic vaginitis who were diagnosed by Vaginal microbial evaluation system from gynecology clinic in Beijing Tsinghua Changgung Hospital between March 2015 to September 2017.Patients were divided into two groups by the treatment methods,Group A:cefuroxime axetil,250 mg,by oral,bid,seven days,159 patients;Group B:clindamycin phosphate vaginal cream,5 g/0.1 g,by vaginal,Qd,seven days,115 patients. Results 7 days after treatment,the total effective rate was 84.3%(231/274),was 83.6%(133/159)in group A and 85.2%(98/115)in group B,the therapeutic effect showed no significant difference between the two groups(P>0.05).Conclusion cefuroxime axetil and clindamycin phosphate vaginal cream can both obtained good therapeutic effect.
Objective To compare the therapeutic effect on simple aerobic vaginitis between the oral cefuroxime axetil and clindamycin phosphate vaginal cream.Methods This was a retrospective study of 274 patients under aerobic vaginitis who were diagnosed by Vaginal microbial evaluation system from gynecology clinic in Beijing Tsinghua Changgung Hospital between March 2015 to September 2017.Patients were divided into two groups by the treatment methods,Group A:cefuroxime axetil,250 mg,by oral,bid,seven days,159 patients;Group B:clindamycin phosphate vaginal cream,5 g/0.1 g,by vaginal,Qd,seven days,115 patients. Results 7 days after treatment,the total effective rate was 84.3%(231/274),was 83.6%(133/159)in group A and 85.2%(98/115)in group B,the therapeutic effect showed no significant difference between the two groups(P>0.05).Conclusion cefuroxime axetil and clindamycin phosphate vaginal cream can both obtained good therapeutic effect.
引文
[1]Donders GG,Vereecken A,Bosmans E,et al.Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis:aerobic vaginitis[J].BJOG,2002,109(1):34-43.
[2]Donders GGG,Bellen G,Grinceviciene S,et al.Aerobic vaginitis:no longer a stranger[J].Res Microbiol,2017,168(9-10):845-858.
[3]王辰,薛凤霞.阴道微生态评价对需氧菌性阴道炎的诊断作用[J].中国妇产科临床杂志,2017,33(8):779-782.
[4]Fan A,Yue Y,Geng N,et al.Aerobic vaginitis and mixed infections:comparison of clinical and laboratory findings[J].Arch Gynecol Obstet,2013,287(2):329-335.
[5]Tempera G,Abbadessa G,Bonfiglio G,et al.Topical kanamycin:an effective therapeutic option in aerobic vaginitis[J].J Chemother,2006,18(4):409-414.
[6]Tempera G,Furneri PM.Management of aerobic vaginitis[J].Gynecol Obstet Invest,2010,70(4):244-249.
[7]Donders G,Bellen G,Rezeberga D.Aerobic vaginitis in pregnancy[J].BJOG,2011,118(11):63-70.
[8]Han C,Wu W,Fan A,et al.Diagnostic and therapeutic advancements for aerobic vaginitis[J].Arch Gynecol Obstet,2015,291(2):251-257.
[9]耿女,王辰,岳莹利,等.莫西沙星治疗需氧菌性阴道炎疗效分析[J].中国实用妇科与产科杂志,2017,33(11):1199-1202.
[10]陈丽华,关红琼.母体抗生素应用对新生儿肠道菌群建立的影响[J].现代消化及介入诊疗,2016,21(3):431-433.
[11]陈锦.克林霉素磷酸酯栓与乳酸菌阴道胶囊治疗妊娠期需氧菌性阴道炎的临床效果分析[J].中外女性健康研究,2016,9:196-196,194.
[2]Donders GGG,Bellen G,Grinceviciene S,et al.Aerobic vaginitis:no longer a stranger[J].Res Microbiol,2017,168(9-10):845-858.
[3]王辰,薛凤霞.阴道微生态评价对需氧菌性阴道炎的诊断作用[J].中国妇产科临床杂志,2017,33(8):779-782.
[4]Fan A,Yue Y,Geng N,et al.Aerobic vaginitis and mixed infections:comparison of clinical and laboratory findings[J].Arch Gynecol Obstet,2013,287(2):329-335.
[5]Tempera G,Abbadessa G,Bonfiglio G,et al.Topical kanamycin:an effective therapeutic option in aerobic vaginitis[J].J Chemother,2006,18(4):409-414.
[6]Tempera G,Furneri PM.Management of aerobic vaginitis[J].Gynecol Obstet Invest,2010,70(4):244-249.
[7]Donders G,Bellen G,Rezeberga D.Aerobic vaginitis in pregnancy[J].BJOG,2011,118(11):63-70.
[8]Han C,Wu W,Fan A,et al.Diagnostic and therapeutic advancements for aerobic vaginitis[J].Arch Gynecol Obstet,2015,291(2):251-257.
[9]耿女,王辰,岳莹利,等.莫西沙星治疗需氧菌性阴道炎疗效分析[J].中国实用妇科与产科杂志,2017,33(11):1199-1202.
[10]陈丽华,关红琼.母体抗生素应用对新生儿肠道菌群建立的影响[J].现代消化及介入诊疗,2016,21(3):431-433.
[11]陈锦.克林霉素磷酸酯栓与乳酸菌阴道胶囊治疗妊娠期需氧菌性阴道炎的临床效果分析[J].中外女性健康研究,2016,9:196-196,194.