非移植闭塞性细支气管炎动物模型研究进展
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摘要
闭塞性细支气管炎(bronchiolitis obliterans,BO)是一种小气道炎性损伤所致的慢性气流受限综合征,病理主要表现为细支气管管腔部分或完全闭塞。BO根据不同的病理表现类型可分为限制性细支气管炎和增殖性细支气管炎。良好的动物模型有助于阐明BO发病机制和探索新治疗方案;不同造模方法所建立的BO动物模型均拥有各自的优势和局限性。本文就BO非移植动物模型的相关研究进展进行综述。
Bronchiolitis obliterans(BO) is a clinical syndrome characterized by chronic obstruction of the bronchioles.Pathologically,BO is characterized by partial or complete occlusion of the bronchioles.Pathological types include constrictive bronchiolitis and proliferative bronchiolitis.Ideal animal models have contributed to characterizing the pathogenesis of BO and exploring new therapeutic schedules.Animal models of BO have been established by different methods.These models each have their own advantages and limitations.This article reviews the recent progress in research on animals models of nontransplant BO.
Bronchiolitis obliterans(BO) is a clinical syndrome characterized by chronic obstruction of the bronchioles.Pathologically,BO is characterized by partial or complete occlusion of the bronchioles.Pathological types include constrictive bronchiolitis and proliferative bronchiolitis.Ideal animal models have contributed to characterizing the pathogenesis of BO and exploring new therapeutic schedules.Animal models of BO have been established by different methods.These models each have their own advantages and limitations.This article reviews the recent progress in research on animals models of nontransplant BO.
引文
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[2]Shaw RJ,Djukanovic R,Tashkin DP,et al.The role of small airways in lung disease[J].Respir Med,2002,96(2):67-80.
[3]Chang AB,Masel JP,Masters B.Post-infectious bronchiolitis obliterans:clinical,radiological and pulmonary function sequelae[J].Pediatr Radiol,1998,28(1):23-29.
[4]Kim CK,Kim SW,Kim JS,et al.Bronchiolitis obliterans in the1990s in Korea and the United States[J].Chest,2001,120(4):1101-1106.
[5]Lobo AL,Guardiano M,Nunes T,et al.Pos-infectious bronchiolitis obliterans in children[J].Rev Port Pneumol,2007,13(4):495-509.
[6]Castleman WL.Bronchiolitis obliterans and pneumonia induced in young dogs by experimental adenovirus infection[J].Am JPathol,1985,119(3):495-504.
[7]Philippou S,Otto P,Reinhold P,et al.Respiratory syncytial virus-induced chronic bronchiolitis in experimentally infected calves[J].Virchows Arch,2000,436(6):617-621.
[8]Masot AJ,Gazquez A,Regodon S,et al.Lesions in lambs experimentally infected with bovine respiratory syncytial virus[J].Histol Histopathol,1995,10(1):71-77.
[9]Darniot M,Pitoiset C,Petrella T,et al.Age-associated aggravation of clinical disease after primary metapneumovirus infection of BALB/c mice[J].J Virol,2009,83(7):3323-3332.
[10]Palmer SM,Flake GP,Kelly FL,et al.Severe airway epithelial injury,aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats[J].PLoS One,2011,6(3):e17644.
[11]Boswell RT,Mccunney RJ.Bronchiolitis obliterans from exposure to incinerator fly ash[J].J Occup Environ Med,1995,37(7):850-855.
[12]Kreiss K,Gomaa A,Kullman G,et al.Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant[J].New Engl J Med,2002,347(5):330-338.
[13]Boag AH,Colby TV,Fraire AE,et al.The pathology of interstitial lung disease in nylon flock workers[J].Am J Surg Pathol,1999,23(12):1539-1545.
[14]Romero S,Hernandez L,Gil J,et al.Organizing pneumonia in textile printing workers:a clinical description[J].Eur Respir J,1998,11(2):265-271.
[15]Konichezky S,Schattner A,Ezri T,et al.Thionyl-chlorideinduced lung injury and bronchiolitis obliterans[J].Chest,1993,104(3):971-973.
[16]O'Koren EG,Hogan BLM,Gunn MD.Loss of basal cells precedes bronchiolitis obliterans-like pathological changes in a murine model of chlorine gas inhalation[J].Am J Resp Cell Molec Biol,2013,49(5):788-797.
[17]Moran TJ,Hellstrom HR.Bronchiolitis obliterans:an experimental study of the pathogenesis and the use of cortisone in modification of the lesions[J].AMA Arch Pathol,1958,66(6):691-707.
[18]Coalson JJ,Collins JF.Nitric acid-induced injury in the hamster lung[J].Br J Exp Pathol,1985,66(2):205-215.
[19]Costa CL,Spilborghs GM,Martins MA,et al.Nitric acidinduced bronchiolitis in rats mimics childhood bronchiolitis obliterans[J].Respiration,2005,72(6):642-649.
[20]Winternitz MC,Smith GH,Mcnamara FP.Effect of intrabronchial insufflation of acid[J].J Exp Med,1920,32(2):199-204.
[21]尹嘉宁,黄飞,具杨花,等.硝酸吸入闭塞性细支气管炎小鼠模型的建立和评价[J].国际呼吸杂志,2016(10):726-729.
[22]Garippo AL,Parra ER,Teodoro WR,et al.Immune cell infiltration and broncovascular remodeling after nitric acid nasal instillation in a mouse bronchiolitis obliterans model[J].Lung,2006,184(4):229-238.
[23]Garippo A,Parra E,Teodoro W,et al.Nasal tolerance with collagen V protein reverts bronchovascular axis remodeling in experimental bronchiolitis obliterans[J].Clinics(Sao Paulo),2007,62(4):499-506.
[24]Mink SN,Coalson JJ,Whitley L,et al.Pulmonary function tests in the detection of small airway obstruction in a canine model of bronchiolitis obliterans[J].Am Rev Respir Dis,1984,130(6):1125-1133.
[25]Morgan DL,Jokinen MP,Price HC,et al.Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors:implications for bronchiolitis obliterans in humans[J].Toxicol Pathol,2012,40(3):448-465.
[26]Morgan DL,Jokinen MP,Johnson CL,et al.Chemical reactivity and respiratory toxicity of the alpha-diketone flavoring agents:2,3-butanedione,2,3-pentanedione,and 2,3-hexanedione[J].Toxicol Pathol,2016,44(5):763-783.
[27]李松,张素倩,邹琳,等.闭塞性细支气管炎小鼠模型的建立与评价[J].第三军医大学学报,2014(22):2283-2286.
[28]Flake GP,Morgan DL.Pathology of diacetyl and 2,3-pentanedione airway lesions in a rat model of obliterative bronchiolitis[J].Toxicology,2017,388:40-47.
[29]Lai RS,Chiang AA,Wu MT,et al.Outbreak of bronchiolitis obliterans associated with consumption of Sauropus androgynus in Taiwan[J].Lancet,1996,348(9020):83-85.
[30]Lai RS,Wang JS,Lee PC.Sauropus androgynus and papaverine do not induce bronchiolitis obliterans in Sprague-Dawley rats[J].Zhonghua Yi Xue Za Zhi(Taipei),2000,63(7):536-541.
[31]Svetlecic J,Molteni A,Chen Y,et al.Transplant-related bronchiolitis obliterans(BOS)demonstrates unique cytokine profiles compared to toxicant-induced BOS[J].Exp Mol Pathol,2005,79(3):198-205.
[32]Musah S,Schlueter CF,Humphrey DJ,et al.Acute lung injury and persistent small airway disease in a rabbit model of chlorine inhalation[J].Toxicol Appl Pharmacol,2017,315:1-11.
[33]Sommer W,Knofel AK,Madrahimov N,et al.Allogeneic CD4+CD25high T cells regulate obliterative bronchiolitis of heterotopic bronchus allografts in both porcinized and humanized mouse models[J].2015,99(3):482-491.
[34]Kawakami T,Ito K,Matsuda Y,et al.Cytotoxicity of natural kller cells activated through NKG2D contributes to the development of bronchiolitis obliterans in a murine heterotopic tracheal transplant model[J].Am J Transplant,2017,17(9):2338-2349.
[35]Ropponen JO,Keranen MA,Raissadati A,et al.Increased myeloid cell hypoxia-inducible factor-1 delays obliterative airway disease in the mouse[J].J Heart Lung Transplant,2016,35(5):671-678.
[2]Shaw RJ,Djukanovic R,Tashkin DP,et al.The role of small airways in lung disease[J].Respir Med,2002,96(2):67-80.
[3]Chang AB,Masel JP,Masters B.Post-infectious bronchiolitis obliterans:clinical,radiological and pulmonary function sequelae[J].Pediatr Radiol,1998,28(1):23-29.
[4]Kim CK,Kim SW,Kim JS,et al.Bronchiolitis obliterans in the1990s in Korea and the United States[J].Chest,2001,120(4):1101-1106.
[5]Lobo AL,Guardiano M,Nunes T,et al.Pos-infectious bronchiolitis obliterans in children[J].Rev Port Pneumol,2007,13(4):495-509.
[6]Castleman WL.Bronchiolitis obliterans and pneumonia induced in young dogs by experimental adenovirus infection[J].Am JPathol,1985,119(3):495-504.
[7]Philippou S,Otto P,Reinhold P,et al.Respiratory syncytial virus-induced chronic bronchiolitis in experimentally infected calves[J].Virchows Arch,2000,436(6):617-621.
[8]Masot AJ,Gazquez A,Regodon S,et al.Lesions in lambs experimentally infected with bovine respiratory syncytial virus[J].Histol Histopathol,1995,10(1):71-77.
[9]Darniot M,Pitoiset C,Petrella T,et al.Age-associated aggravation of clinical disease after primary metapneumovirus infection of BALB/c mice[J].J Virol,2009,83(7):3323-3332.
[10]Palmer SM,Flake GP,Kelly FL,et al.Severe airway epithelial injury,aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats[J].PLoS One,2011,6(3):e17644.
[11]Boswell RT,Mccunney RJ.Bronchiolitis obliterans from exposure to incinerator fly ash[J].J Occup Environ Med,1995,37(7):850-855.
[12]Kreiss K,Gomaa A,Kullman G,et al.Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant[J].New Engl J Med,2002,347(5):330-338.
[13]Boag AH,Colby TV,Fraire AE,et al.The pathology of interstitial lung disease in nylon flock workers[J].Am J Surg Pathol,1999,23(12):1539-1545.
[14]Romero S,Hernandez L,Gil J,et al.Organizing pneumonia in textile printing workers:a clinical description[J].Eur Respir J,1998,11(2):265-271.
[15]Konichezky S,Schattner A,Ezri T,et al.Thionyl-chlorideinduced lung injury and bronchiolitis obliterans[J].Chest,1993,104(3):971-973.
[16]O'Koren EG,Hogan BLM,Gunn MD.Loss of basal cells precedes bronchiolitis obliterans-like pathological changes in a murine model of chlorine gas inhalation[J].Am J Resp Cell Molec Biol,2013,49(5):788-797.
[17]Moran TJ,Hellstrom HR.Bronchiolitis obliterans:an experimental study of the pathogenesis and the use of cortisone in modification of the lesions[J].AMA Arch Pathol,1958,66(6):691-707.
[18]Coalson JJ,Collins JF.Nitric acid-induced injury in the hamster lung[J].Br J Exp Pathol,1985,66(2):205-215.
[19]Costa CL,Spilborghs GM,Martins MA,et al.Nitric acidinduced bronchiolitis in rats mimics childhood bronchiolitis obliterans[J].Respiration,2005,72(6):642-649.
[20]Winternitz MC,Smith GH,Mcnamara FP.Effect of intrabronchial insufflation of acid[J].J Exp Med,1920,32(2):199-204.
[21]尹嘉宁,黄飞,具杨花,等.硝酸吸入闭塞性细支气管炎小鼠模型的建立和评价[J].国际呼吸杂志,2016(10):726-729.
[22]Garippo AL,Parra ER,Teodoro WR,et al.Immune cell infiltration and broncovascular remodeling after nitric acid nasal instillation in a mouse bronchiolitis obliterans model[J].Lung,2006,184(4):229-238.
[23]Garippo A,Parra E,Teodoro W,et al.Nasal tolerance with collagen V protein reverts bronchovascular axis remodeling in experimental bronchiolitis obliterans[J].Clinics(Sao Paulo),2007,62(4):499-506.
[24]Mink SN,Coalson JJ,Whitley L,et al.Pulmonary function tests in the detection of small airway obstruction in a canine model of bronchiolitis obliterans[J].Am Rev Respir Dis,1984,130(6):1125-1133.
[25]Morgan DL,Jokinen MP,Price HC,et al.Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors:implications for bronchiolitis obliterans in humans[J].Toxicol Pathol,2012,40(3):448-465.
[26]Morgan DL,Jokinen MP,Johnson CL,et al.Chemical reactivity and respiratory toxicity of the alpha-diketone flavoring agents:2,3-butanedione,2,3-pentanedione,and 2,3-hexanedione[J].Toxicol Pathol,2016,44(5):763-783.
[27]李松,张素倩,邹琳,等.闭塞性细支气管炎小鼠模型的建立与评价[J].第三军医大学学报,2014(22):2283-2286.
[28]Flake GP,Morgan DL.Pathology of diacetyl and 2,3-pentanedione airway lesions in a rat model of obliterative bronchiolitis[J].Toxicology,2017,388:40-47.
[29]Lai RS,Chiang AA,Wu MT,et al.Outbreak of bronchiolitis obliterans associated with consumption of Sauropus androgynus in Taiwan[J].Lancet,1996,348(9020):83-85.
[30]Lai RS,Wang JS,Lee PC.Sauropus androgynus and papaverine do not induce bronchiolitis obliterans in Sprague-Dawley rats[J].Zhonghua Yi Xue Za Zhi(Taipei),2000,63(7):536-541.
[31]Svetlecic J,Molteni A,Chen Y,et al.Transplant-related bronchiolitis obliterans(BOS)demonstrates unique cytokine profiles compared to toxicant-induced BOS[J].Exp Mol Pathol,2005,79(3):198-205.
[32]Musah S,Schlueter CF,Humphrey DJ,et al.Acute lung injury and persistent small airway disease in a rabbit model of chlorine inhalation[J].Toxicol Appl Pharmacol,2017,315:1-11.
[33]Sommer W,Knofel AK,Madrahimov N,et al.Allogeneic CD4+CD25high T cells regulate obliterative bronchiolitis of heterotopic bronchus allografts in both porcinized and humanized mouse models[J].2015,99(3):482-491.
[34]Kawakami T,Ito K,Matsuda Y,et al.Cytotoxicity of natural kller cells activated through NKG2D contributes to the development of bronchiolitis obliterans in a murine heterotopic tracheal transplant model[J].Am J Transplant,2017,17(9):2338-2349.
[35]Ropponen JO,Keranen MA,Raissadati A,et al.Increased myeloid cell hypoxia-inducible factor-1 delays obliterative airway disease in the mouse[J].J Heart Lung Transplant,2016,35(5):671-678.