血管内介入方法制备非人灵长类动物局部脑缺血模型的研究进展
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摘要
由于多项转化研究的失败,卒中治疗专业委员会建议,应该在非人灵长类动物局部脑缺血模型上进行临床前研究。采用血管内介入方法制备局部脑缺血模型与人类卒中发病过程一致,而且还可以进行血管内介入治疗,因此是模拟缺血性脑卒中发病与治疗过程的最佳动物模型。目前研究采用多种血管内介入方法制备模型,结果也不一致,本文将对血管内介入方法制备的非人灵长类动物进行总结,对各种模型的优缺点和潜在应用进行分析。此外,本文还根据不同类型的栓子,不同的闭塞部位,异常的血流动力学和可能的应用范围进行进一步的分析。选择合适的非人灵长类动物模型将有助于推动转化研究开展。
The Stroke Therapy Academic Industry Roundtable(STAIR) committee has suggested that nonhuman primates(NHPs) should be used for preclinical stroke studies owing to previous translational failures. Ischemia induced by endovascular method closely mimics thromboembolic or thrombotic cerebrovascular occlusion in patients. This method also shows potential for endovascular treatment. This review provides a detailed summary of NHP models using endovascular method,including advantages and disadvantages,and potential applications. Additionally,we also provide further analysis based on different kinds of emboli,infract size,and abnormal hemodynamics. Selection of the optimum model will pave the way for translational research.
The Stroke Therapy Academic Industry Roundtable(STAIR) committee has suggested that nonhuman primates(NHPs) should be used for preclinical stroke studies owing to previous translational failures. Ischemia induced by endovascular method closely mimics thromboembolic or thrombotic cerebrovascular occlusion in patients. This method also shows potential for endovascular treatment. This review provides a detailed summary of NHP models using endovascular method,including advantages and disadvantages,and potential applications. Additionally,we also provide further analysis based on different kinds of emboli,infract size,and abnormal hemodynamics. Selection of the optimum model will pave the way for translational research.
引文
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[17]Zhao B,Shang G,Chen J,et al.A more consistent intraluminal rhesus monkey model of ischemic stroke[J].Neural Regen Res,2014,9(23):2087-2094.
[18]del Zoppo GJ,Copeland BR,Harker LA,et al.Experimental acute thrombotic stroke in baboons[J].Stroke,1986,17(6):1254-1265.
[19]Sommer CJ.Ischemic stroke:experimental models and reality[J].Acta Neuropathol,2017,133(2):245-261.
[20]Fukuda S,del Zoppo GJ.Models of focal cerebral ischemia in the nonhuman primate[J].ILAR J,2003,44(2):96-104.
[21]Kito G,Nishimura A,Susumu T,et al.Experimental thromboembolic stroke in cynomolgus monkeys[J].J Neurosci Methods,2001,105(1):45-53.
[22]Gauberti M,Obiang P,Guedin P,et al.Thrombotic stroke in the anesthetized monkey(Macaca mulatta):characterization by MRI-a pilot study[J].Cerebrovasc Dis,2012,33(4):329-339.
[23]Qureshi AI,Suri MF,Ali Z,et al.Intraarterial reteplase and intravenous abciximab for treatment of acute ischemic stroke.A preliminary feasibility and safety study in a nonhuman primate model[J].Neuroradiology,2005,47(11):845-854.
[24]Susumu T,Yoshikawa T,Akiyoshi Y,et al.Effects of intraarterial urokinase on a non-human primate thromboembolic stroke model[J].J Pharmacol Sci,2006,100(4):278-284.
[25]Cook DJ,Tymianski M.Nonhuman primate models of stroke for translational neuroprotection research[J].Neurotherapeutics,2012,9(2):371-379.
[26]Hacke W,Schwab S,Horn M,et al.‘Malignant’middle cerebral artery territory infarction:clinical course and prognostic signs[J].Arch Neurol,1996,53(4):309-315.
[27]Jickling GC,Sharp FR.Improving the translation of animal ischemic stroke studies to humans[J].Metab Brain Dis,2015,30(2):461-467.
[28]Joseph R,Welch KM,Oster SB,et al.A plasmatic factor may cause platelet activation in acute ischemic stroke[J].Circ Res,1989,65(6):1679-1687.
[29]Fan J,Li Y,Fu X,et al.Nonhuman primate models of focal cerebral ischemia[J].Neural Regen Res,2017,12(2):321-328.
[30]田肇隆,马艳辉,李丽,等.恒河猴大脑中动脉M1段栓塞建模中麻醉方案的选择[J].中国比较医学杂志,2017,27(6):53-55.
[31]匡德宣,叶尤松,唐东红,等.浅谈兽医在非人灵长类动物实验福利中的作用[J].中国比较医学杂志,2007,17(1):55-57.
[32]朱华,李秦,徐艳峰,等.光化学法制作食蟹猴局部脑缺血模型[J].中国比较医学杂志,2008,18(9):32-34.
[2]Fisher M,Feuerstein G,Howells DW,et al.Update of the stroke therapy academic industry roundtable preclinical recommendations[J].Stroke,2009,40(12):2244-2250.
[3]田朝阳,杨守凯.非人灵长类动物在医学科学实验中的应用[J].中国比较医学杂志,2009,19(6):74-77.
[4]Wu D,Chandra A,Chen J,et al.Endovascular ischemic stroke models in nonhuman primates[J].Neurotherapeutics,2018,15(1):146-155.
[5]D’Arceuil HE,Duggan M,He J,et al.Middle cerebral artery occlusion in Macaca fascicularis:acute and chronic stroke evolution[J].J Med Primatol,2006,35(2):78-86.
[6]Zhang X,Tong F,Li CX,et al.Temporal evolution of ischemic lesions in nonhuman primates:a diffusion and perfusion MRI study[J].PLo S One,2015,10:e0117290.
[7]Tong FC,Zhang X,Kempf DJ,et al.An enhanced model of middle cerebral artery occlusion in nonhuman primates using an endovascular trapping[J].AJNR Am J Neuroradiol,2015,36(12):2354-2359.
[8]Cook DJ,Teves L,Tymianski M.A translational paradigm for the preclinical evaluation of the stroke neuroprotectant TatNR2B9c in gyrencephalic nonhuman primates[J].Sci Transl Med,2012,4(154):154ra133.
[9]Sato Y,Chin Y,Kato T,et al.White matter activated glial cells produce BDNF in a stroke model of monkeys[J].Neurosci Res,2009,65:71-78.
[10]de Crespigny AJ,D’Arceuil HE,Maynard KI,et al.Acute studies of a new primate model of reversible middle cerebral artery occlusion[J].J Stroke Cerebrovasc Dis,2005,14(2):80-87.
[11]Yi KS,Choi CH,Lee SR,et al.Sustained diffusion reversal with inbore reperfusion in monkey stroke models:confirmed by prospective magnetic resonance imaging[J].J Cereb Blood Flow Metab,2017,37(12):2002-2012.
[12]Wu D,Chen J,Wang B,et al.Endovascular ischemic stroke models of adult rhesus monkeys:a comparison of two endovascular methods[J].Sci Rep,2016,6:31608.
[13]Gao H,Liu Y,Lu S,et al.A reversible middle cerebral artery occlusion model using intraluminal balloon technique in monkeys[J].J Stroke Cerebrovasc Dis,2006,15(5):202-208.
[14]Hamberg LM,Hunter GJ,Maynard KI,et al.Functional CT perfusion imaging in predicting the extent of cerebral infarction from a 3-hour middle cerebral arterial occlusion in a primate stroke model[J].AJNR Am J Neuroradiol,2002,23(6):1013-1021.
[15]Zhang Y,Fan F,Zeng G,et al.Temporal analysis of bloodbrain barrier disruption and cerebrospinal fluid matrix metalloproteinases in rhesus monkeys subjected to transient ischemic stroke[J].J Cereb Blood Flow Metab,2017,37(12):2963-2974.
[16]Guo J,Zheng HB,Duan JC,et al.Diffusion tensor MRI for the assessment of cerebral ischemia/reperfusion injury in the penumbra of non-human primate stroke model[J].Neurol Res,2011,33(1):108-112.
[17]Zhao B,Shang G,Chen J,et al.A more consistent intraluminal rhesus monkey model of ischemic stroke[J].Neural Regen Res,2014,9(23):2087-2094.
[18]del Zoppo GJ,Copeland BR,Harker LA,et al.Experimental acute thrombotic stroke in baboons[J].Stroke,1986,17(6):1254-1265.
[19]Sommer CJ.Ischemic stroke:experimental models and reality[J].Acta Neuropathol,2017,133(2):245-261.
[20]Fukuda S,del Zoppo GJ.Models of focal cerebral ischemia in the nonhuman primate[J].ILAR J,2003,44(2):96-104.
[21]Kito G,Nishimura A,Susumu T,et al.Experimental thromboembolic stroke in cynomolgus monkeys[J].J Neurosci Methods,2001,105(1):45-53.
[22]Gauberti M,Obiang P,Guedin P,et al.Thrombotic stroke in the anesthetized monkey(Macaca mulatta):characterization by MRI-a pilot study[J].Cerebrovasc Dis,2012,33(4):329-339.
[23]Qureshi AI,Suri MF,Ali Z,et al.Intraarterial reteplase and intravenous abciximab for treatment of acute ischemic stroke.A preliminary feasibility and safety study in a nonhuman primate model[J].Neuroradiology,2005,47(11):845-854.
[24]Susumu T,Yoshikawa T,Akiyoshi Y,et al.Effects of intraarterial urokinase on a non-human primate thromboembolic stroke model[J].J Pharmacol Sci,2006,100(4):278-284.
[25]Cook DJ,Tymianski M.Nonhuman primate models of stroke for translational neuroprotection research[J].Neurotherapeutics,2012,9(2):371-379.
[26]Hacke W,Schwab S,Horn M,et al.‘Malignant’middle cerebral artery territory infarction:clinical course and prognostic signs[J].Arch Neurol,1996,53(4):309-315.
[27]Jickling GC,Sharp FR.Improving the translation of animal ischemic stroke studies to humans[J].Metab Brain Dis,2015,30(2):461-467.
[28]Joseph R,Welch KM,Oster SB,et al.A plasmatic factor may cause platelet activation in acute ischemic stroke[J].Circ Res,1989,65(6):1679-1687.
[29]Fan J,Li Y,Fu X,et al.Nonhuman primate models of focal cerebral ischemia[J].Neural Regen Res,2017,12(2):321-328.
[30]田肇隆,马艳辉,李丽,等.恒河猴大脑中动脉M1段栓塞建模中麻醉方案的选择[J].中国比较医学杂志,2017,27(6):53-55.
[31]匡德宣,叶尤松,唐东红,等.浅谈兽医在非人灵长类动物实验福利中的作用[J].中国比较医学杂志,2007,17(1):55-57.
[32]朱华,李秦,徐艳峰,等.光化学法制作食蟹猴局部脑缺血模型[J].中国比较医学杂志,2008,18(9):32-34.