宫腔镜子宫内膜切除术联合孕激素对子宫内膜非典型增生的疗效分析
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摘要
目的探究子宫内膜非典型增生(AEH)患者接受宫腔镜子宫内膜切除术(TCRE)与孕激素联合治疗的效果。方法 120例子宫内膜非典型增生患者,以区组随机化法分为实验组和对照组,每组60例。实验组在宫腔镜子宫内膜切除术术后接受醋酸甲羟孕酮治疗,对照组接受醋酸甲羟孕酮治疗。对两组患者治疗效果以及治疗1年后受孕率、癌变率以及复发率进行观察比较,并对比两组治疗前后经期。结果实验组患者的总有效率为96.67%,高于对照组的73.33%,差异具有统计学意义(P<0.05)。治疗1年后,实验组患者的受孕率明显高于对照组,复发率低于对照组,差异具有统计学意义(P<0.05);两组癌变率比较,差异无统计学意义(P>0.05)。两组患者治疗后的经期均短于治疗前,且实验组明显短于对照组,差异具有统计学意义(P<0.05)。结论子宫内膜非典型增生患者接受宫腔镜子宫内膜切除术与孕激素联合治疗,可取得较高的价值。
Objective To investigate the effect of transcervical resection of endometrium(TCRE) combined with progesterone on atypical endometrium hyperplasia(AEH). Methods A total of 120 patients with atypical endometrium hyperplasia were divided into experimental group and control group by block randomization method, 60 cases in each group. The experimental group received medroxyprogesterone acetate after transcervical resection of endometrium(TCRE), the control group received medroxyprogesterone acetate. The treatment effect, the pregnancy rate, canceration rate and relapse rate after one year of treatment, the menstrual period before and after treatment between the two groups were compared. Results The total effective rate of the experimental group was 96.67%, which was significantly higher than 73.33% of the control group, the difference was statistically significant(P<0.05). One year after treatment, the pregnancy rate of the experimental group was significantly higher than that of the control group, and the recurrence rate of the experimental group was significantly lower than that of the control group, the differences were statistically significant(P<0.05). There was no significant difference in the canceration rate between the two groups(P>0.05). The menstrual period of the two groups after treatment were significantly shorter than those before treatment, and that of the experimental group was significantly shorter than that of the control group, the differences were statistically significant(P<0.05). Conclusion Patients with atypical endometrial hyperplasia who received transcervical resection of endometrium combined with progesterone for treatment can achieve higher value.
Objective To investigate the effect of transcervical resection of endometrium(TCRE) combined with progesterone on atypical endometrium hyperplasia(AEH). Methods A total of 120 patients with atypical endometrium hyperplasia were divided into experimental group and control group by block randomization method, 60 cases in each group. The experimental group received medroxyprogesterone acetate after transcervical resection of endometrium(TCRE), the control group received medroxyprogesterone acetate. The treatment effect, the pregnancy rate, canceration rate and relapse rate after one year of treatment, the menstrual period before and after treatment between the two groups were compared. Results The total effective rate of the experimental group was 96.67%, which was significantly higher than 73.33% of the control group, the difference was statistically significant(P<0.05). One year after treatment, the pregnancy rate of the experimental group was significantly higher than that of the control group, and the recurrence rate of the experimental group was significantly lower than that of the control group, the differences were statistically significant(P<0.05). There was no significant difference in the canceration rate between the two groups(P>0.05). The menstrual period of the two groups after treatment were significantly shorter than those before treatment, and that of the experimental group was significantly shorter than that of the control group, the differences were statistically significant(P<0.05). Conclusion Patients with atypical endometrial hyperplasia who received transcervical resection of endometrium combined with progesterone for treatment can achieve higher value.
引文
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[2]苏椿淋,李昕,陆慧娟,等.达英-35联合二甲双胍治疗多囊卵巢综合征合并子宫内膜不典型增生及早期子宫内膜样腺癌.中华生殖与避孕杂志, 2017, 37(12):975-979.
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[6]党丽萍.炔雌醇环丙孕酮治疗子宫内膜息肉样增生的临床探究.中国保健营养, 2017, 27(27):285-286.
[7]黄永芳,严玮.宫腔镜、孕激素联合治疗子宫内膜非典型增生的疗效分析.中国医刊, 2013, 48(1):69-71.
[8]李春梅,罗颖,毛邱娴,等.宫腔镜电切术联合孕激素对早期子宫内膜癌保留生育功能治疗8例分析.实用妇产科杂志, 2013,29(3):224-226.
[9]苑文贺,史惠蓉.子宫内膜复杂性不典型增生及早期子宫内膜癌患者保留生育功能的预后分析.中国计划生育和妇产科,2018, 10(1):23-27.
[10]张晖,吴云燕.曼月乐联合宫腔镜手术治疗子宫内膜息肉80例.浙江中西医结合杂志, 2014, 24(6):551-552.
[2]苏椿淋,李昕,陆慧娟,等.达英-35联合二甲双胍治疗多囊卵巢综合征合并子宫内膜不典型增生及早期子宫内膜样腺癌.中华生殖与避孕杂志, 2017, 37(12):975-979.
[3]李翠芬,刘燕燕,杨宇峰,等.宫腔镜、孕激素联合治疗子宫内膜非典型增生的效果观察.中国实用医药, 2018, 13(12):124-126.
[4]杨莉.宫腔镜电切术联合孕激素对早期子宫内膜癌保留生育功能的疗效观察.现代诊断与治疗, 2017, 28(21):4039-4041.
[5]徐亚瑄.宫腔镜治疗子宫内膜息肉对体外受精-胚胎移植结局影响的回顾性分析.山东大学, 2017.
[6]党丽萍.炔雌醇环丙孕酮治疗子宫内膜息肉样增生的临床探究.中国保健营养, 2017, 27(27):285-286.
[7]黄永芳,严玮.宫腔镜、孕激素联合治疗子宫内膜非典型增生的疗效分析.中国医刊, 2013, 48(1):69-71.
[8]李春梅,罗颖,毛邱娴,等.宫腔镜电切术联合孕激素对早期子宫内膜癌保留生育功能治疗8例分析.实用妇产科杂志, 2013,29(3):224-226.
[9]苑文贺,史惠蓉.子宫内膜复杂性不典型增生及早期子宫内膜癌患者保留生育功能的预后分析.中国计划生育和妇产科,2018, 10(1):23-27.
[10]张晖,吴云燕.曼月乐联合宫腔镜手术治疗子宫内膜息肉80例.浙江中西医结合杂志, 2014, 24(6):551-552.