摘要
目的:评价5-羟色胺(5-hydroxytryptamine, 5-HT)和去甲肾上腺素(norepinephrine, NE)再摄取抑制剂治疗非典型性牙痛的效果及副作用。方法:回顾分析22例非典型性牙痛病人接受5-HT和NE再摄取抑制剂(度洛西汀或文拉法辛)治疗后1周、2周、1月、2月末疼痛数字评分(numeric ratingscales, NRS)、汉密尔顿抑郁评分(hamilton depression scale, HAMD)、汉密尔顿焦虑评分(hamilton anxi-ety scale, HAMA)及副作用发生情况。结果:22例非典型性牙痛病人中12例接受度洛西汀、10例接受文拉法辛治疗。治疗1周末NRS、HAMD及HAMA评分即明显低于治疗前(P <0.01),治疗后2周、1月、2月末进一步降低(P <0.01),治疗过程中无严重的副作用发生。结论:5-HT和NE再摄取抑制剂对非典型性牙痛病人的疼痛和抑郁焦虑的状态有明显改善的作用。
Objective: To evaluate the effectiveness and side effect of serotonin and norepinephrine reuptake inhibitors(SNRIs) in the treatment of patients with atypical odontalgia(AO). Methods: Retrospectively analyze the numeric rating scales(NRS) of pain, Hamilton depression scale(HAMD), Hamilton anxiety scale(HAMA)and the side effects related to the treatment of 22 patients treated with SNRIs(Duloxetine or Venlafaxine).Results: The scores of NRS of pain, HAMD and HAMA at 1 week after the treatment were signi?cantly lower than the baseline values(P < 0.01). At 2 weeks, 1 month and 2 months after the treatment, the scores of NRS of pain, HAMD and HAMA decreased further as compared with the baseline values(P < 0.01). No signi?cant side effects were observed. Conclusion: SNRIs are effective and safe in the treatment of AO patients in improving the state of both local pain and the psychological symptoms of depression and anxiety.
引文
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