卵黄抗体在病毒性疾病防治中的应用
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摘要
病毒性传染病一直以来对动物与人的危害极大,而常见抗病毒药物对细胞有较大毒性,且病毒容易发生变异,因此给抗病毒药物的研制增加了难度。卵黄抗体因其获取方便、获得量大、生产工艺相对简单、可进行规模化生产、性质稳定,因此广泛应用于动物与人的病毒性疫病防治中。论文阐述了卵黄抗体的产生、结构、优势、作用机理等内容,并对卵黄抗体在动物与人病毒性疾病防治中的应用和已商品化的产品现状进行了综述,汇总研究之不足,若卵黄抗体能得到更深入的研究,克服不足,在今后的应用过程中将具有更加广阔的前景。
Animals and humans were always extremely harmed by viral infectious diseases.Common antiviral drugs were highly toxic to cells,and viruses were easy to mutation.So research on antiviral drugs has become more difficult.Egg yolk antibody is widely used in the prevention and treatment of viral diseases of animals and humans because of its convenient access,large amount of acquisition,relatively simple production process,large-scale production and stable nature.It was widely used in the prevention and treatment of human and animal diseases.In the article,the production,structure,advantages and mechanism of yolk antibody were elaborated,and the application of yolk antibody in the prevention and treatment of animal and human viral diseases and the status of marketization were reviewed.Study's shortcomings were pointed out.It was concluded that if the yolk antibody can be studied in more depth and overcome the shortcomings,it will have a broader prospect in the future application process.
Animals and humans were always extremely harmed by viral infectious diseases.Common antiviral drugs were highly toxic to cells,and viruses were easy to mutation.So research on antiviral drugs has become more difficult.Egg yolk antibody is widely used in the prevention and treatment of viral diseases of animals and humans because of its convenient access,large amount of acquisition,relatively simple production process,large-scale production and stable nature.It was widely used in the prevention and treatment of human and animal diseases.In the article,the production,structure,advantages and mechanism of yolk antibody were elaborated,and the application of yolk antibody in the prevention and treatment of animal and human viral diseases and the status of marketization were reviewed.Study's shortcomings were pointed out.It was concluded that if the yolk antibody can be studied in more depth and overcome the shortcomings,it will have a broader prospect in the future application process.
引文
[1]张璐,刘珍珍,宁长申,等.IgY在免疫检测及治疗中的应用进展[J].动物医学进展,2017,38(1):78-81.
[2]Xu Y,Li X,Jin L,et al.Application of chicken egg yolk immunoglobulins in the control of terrestrial and aquatic animal diseases:a review[J].Biotechnol Adv,2011,29(6):860-868.
[3]Kovacs-Nolan J,Mine Y.Egg yolk antibodies for passive immunity[J].Annu Rev Food Sci Technol,2012,34(3):163-182.
[4]高岭.猪传染性胃肠炎病毒与猪流行性腹泻病毒卵黄抗体的制备及纯化工艺研究[D].河北保定:河北农业大学,2014.
[5]Spillner E,Braren I,Greunke K,et al.Avian IgY antibodies and their recombinant equivalents in research,diagnostics and therapy[J].Biologicals,2012,40(5):313-322.
[6]高岭,刘聚祥,杨娜娜.鸡卵黄抗体及其在养猪业中的应用研究进展[J].动物医学进展,2013,34(5):110-114.
[7]Lívia S M,Gilberto D V,Geferson F,et al.Avian IgY antibodies:characteristics and applications in immunodiagnostic[J].Ciencia Rural,2014,44(1):153-160.
[8]Yeganial M,Korveral D R.Application of egg yolk antibodies as replacement for antibiotics in poultry[J].World Poult Sci J,2010,66(1):27-38.
[9]Liou J F,Shiau J W,Tai C,et al.Production of egg yolk immunoglobulin against Escherichia coli from White Leghorn and Lohmann chickens[J].J Anim Vet Adv,2011,10(18):2349-2356.
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[12]李建.新城疫和禽流感精制卵黄抗体的制备及其应用研究[D].山东泰安:山东农业大学,2013.
[13]薛晓阳.鸡新城疫卵黄抗体的提取工艺及应用研究[D].河北保定:河北农业大学,2012.
[14]杨晓伟,杨万秋,陆婧,等.禽腺病毒Ⅰ群血清4型的分子鉴定及其卵黄抗体的防控效果[J].畜牧与兽医,2018,50(1):113-117.
[15]杨燚,李守军,刘冠星,等.一种I群4型腺病毒长效卵黄抗体制备方法:天津,CN107880119A[P].2018-04-06.
[16]李宇琴.鸭肝炎病毒分离株的鉴定及其卵黄抗体的制备[D].江苏扬州:扬州大学兽医学院,2010.
[17]王蕾,刘玉庆,宋道祯,等.一例I型鸭病毒性肝炎及其高免卵黄抗体的制备[J].家禽科学,2015,37(6):13-16.
[18]张占龙,李敏,宋永鸿,等.鸭甲肝病毒基因A型和C型双价卵黄抗体的研制与保护效果研究[J].黑龙江畜牧兽医,2015,39(17):222-224.
[19]蔡丝丝,王小庆,魏平华.鸭坦布苏病毒冻干卵黄抗体的研制[J].养禽与禽病防治,2017,35(11):2-5.
[20]李冰,张显浩,裴仉福,等.抗猪流行性腹泻病毒卵黄抗体的制备及应用[J].中国畜牧兽医,2014,41(10):68-72.
[21]潘孝成,赵瑞宏,沈学怀,等.猪流行性腹泻病毒卵黄抗体的制备与应用[J].养猪,2016,30(3):119-120.
[22]高睿,程一肃,邓留坤,等.猪蓝耳病卵黄抗体的制备与初步应用试验[J].畜牧与饲料科学,2012,33(7):108-110.
[23]Snodgrass D R,Terzolo H R,Sherwood D,et al.A etiology of diarrhoea in young calves[J].Vet Res,2013,119(2):31-34.
[24]Vega C,Bok M,Chacana P,et al.Egg yolk IgY:protection against rotavirus induced diarrhea and modulatory effect on the systemic and mucosal antibody responses in newborn calves[J].Vet Immunol Immunopathol,2011,142(3-4):156-169.
[25]郑龙龙,朱玲云,宋春莲,等.云南省犬细小病毒VP2基因检测分析[J].动物医学进展,2015,36(1):66-70.
[26]周洛.犬细小病毒高免卵黄抗体的制备与保护效果研究[J].中兽医学杂志,2015,42(7):5-6.
[27]朱向红,齐红燕,汪毅.抗犬细小病毒卵黄抗体制备与临床应用初探[J].畜禽业,2010,17(12):32-34.
[28]Guo E,Korkut G G,Jaree P,et al.A Pacifastacus leniusculus serine protease interacts with WSSV[J].Fish Shellfish Immunol,2017,68(4):211-219.
[29]Lu Y,Liu J,Jin L,et al.Passive protection of shrimp against white spot syndrome virus(WSSV)using specific antibody from egg yolk of chickens immunized with inactivated virus or a WSSV-DNA vaccine[J].Fish Shellfish Immunol,2008,25(5):604-610.
[30]刘君君.对虾白斑综合症病毒特异性卵黄免疫球蛋白的制备及性能研究[D].辽宁大连:大连理工大学,2007.
[31]陈爱平,江育林,钱冬,等.水生动物疫病病种介绍之:罗氏沼虾肌肉白浊病[J].中国水产,2011,38(4):65-66.
[32]林蠡,伊丽竹.利用卵黄抗体预防罗氏沼虾肌肉白浊病[J].科学养鱼,2015,29(5):57-58.
[33]Hlaing M T,Theingi W M,Mo W,et al.Immunoglobulin Y-fortified infant milk formula as adjunct to treatment of diarrhea among rotavirus-infected hospitalized children in Myanmar:a randomized,double-blind,placebo-controlled trial[J].J Appl Pharm Sci,2015,23(3):16-18.
[34]Dai Y,Zhang X,Tan M,et al.A dual chicken lgY against rotavirus and norovirus[J].Antiviral Res,2013,97(1):293-300.
[35]Sudjarwo S A,Indriyani W,Nsaroundin N,et al.Acute oral toicity of immunoglobulin Y(lgY)anti HIV in mice[J].J Appl Pharm Sci,2015,5(2):123-126.
[2]Xu Y,Li X,Jin L,et al.Application of chicken egg yolk immunoglobulins in the control of terrestrial and aquatic animal diseases:a review[J].Biotechnol Adv,2011,29(6):860-868.
[3]Kovacs-Nolan J,Mine Y.Egg yolk antibodies for passive immunity[J].Annu Rev Food Sci Technol,2012,34(3):163-182.
[4]高岭.猪传染性胃肠炎病毒与猪流行性腹泻病毒卵黄抗体的制备及纯化工艺研究[D].河北保定:河北农业大学,2014.
[5]Spillner E,Braren I,Greunke K,et al.Avian IgY antibodies and their recombinant equivalents in research,diagnostics and therapy[J].Biologicals,2012,40(5):313-322.
[6]高岭,刘聚祥,杨娜娜.鸡卵黄抗体及其在养猪业中的应用研究进展[J].动物医学进展,2013,34(5):110-114.
[7]Lívia S M,Gilberto D V,Geferson F,et al.Avian IgY antibodies:characteristics and applications in immunodiagnostic[J].Ciencia Rural,2014,44(1):153-160.
[8]Yeganial M,Korveral D R.Application of egg yolk antibodies as replacement for antibiotics in poultry[J].World Poult Sci J,2010,66(1):27-38.
[9]Liou J F,Shiau J W,Tai C,et al.Production of egg yolk immunoglobulin against Escherichia coli from White Leghorn and Lohmann chickens[J].J Anim Vet Adv,2011,10(18):2349-2356.
[10]Schade R,Gutierrez Calzado E,Sarmiento R,et al.Chicken egg yolk antibodies(IgY-technology):a review of progress in production and use in research and human and veterinary medicine[J].Altern Lab Anim,2010,33(2):129-154.
[11]Gadde U,Rathinam T,Hyun S,et al.Passive immunization with hyperimmune egg-yolk lgY as prophylaxis and therapy for poultry diseases-A review[J].Anim Health Res Rev,2015,16(2):163-176.
[12]李建.新城疫和禽流感精制卵黄抗体的制备及其应用研究[D].山东泰安:山东农业大学,2013.
[13]薛晓阳.鸡新城疫卵黄抗体的提取工艺及应用研究[D].河北保定:河北农业大学,2012.
[14]杨晓伟,杨万秋,陆婧,等.禽腺病毒Ⅰ群血清4型的分子鉴定及其卵黄抗体的防控效果[J].畜牧与兽医,2018,50(1):113-117.
[15]杨燚,李守军,刘冠星,等.一种I群4型腺病毒长效卵黄抗体制备方法:天津,CN107880119A[P].2018-04-06.
[16]李宇琴.鸭肝炎病毒分离株的鉴定及其卵黄抗体的制备[D].江苏扬州:扬州大学兽医学院,2010.
[17]王蕾,刘玉庆,宋道祯,等.一例I型鸭病毒性肝炎及其高免卵黄抗体的制备[J].家禽科学,2015,37(6):13-16.
[18]张占龙,李敏,宋永鸿,等.鸭甲肝病毒基因A型和C型双价卵黄抗体的研制与保护效果研究[J].黑龙江畜牧兽医,2015,39(17):222-224.
[19]蔡丝丝,王小庆,魏平华.鸭坦布苏病毒冻干卵黄抗体的研制[J].养禽与禽病防治,2017,35(11):2-5.
[20]李冰,张显浩,裴仉福,等.抗猪流行性腹泻病毒卵黄抗体的制备及应用[J].中国畜牧兽医,2014,41(10):68-72.
[21]潘孝成,赵瑞宏,沈学怀,等.猪流行性腹泻病毒卵黄抗体的制备与应用[J].养猪,2016,30(3):119-120.
[22]高睿,程一肃,邓留坤,等.猪蓝耳病卵黄抗体的制备与初步应用试验[J].畜牧与饲料科学,2012,33(7):108-110.
[23]Snodgrass D R,Terzolo H R,Sherwood D,et al.A etiology of diarrhoea in young calves[J].Vet Res,2013,119(2):31-34.
[24]Vega C,Bok M,Chacana P,et al.Egg yolk IgY:protection against rotavirus induced diarrhea and modulatory effect on the systemic and mucosal antibody responses in newborn calves[J].Vet Immunol Immunopathol,2011,142(3-4):156-169.
[25]郑龙龙,朱玲云,宋春莲,等.云南省犬细小病毒VP2基因检测分析[J].动物医学进展,2015,36(1):66-70.
[26]周洛.犬细小病毒高免卵黄抗体的制备与保护效果研究[J].中兽医学杂志,2015,42(7):5-6.
[27]朱向红,齐红燕,汪毅.抗犬细小病毒卵黄抗体制备与临床应用初探[J].畜禽业,2010,17(12):32-34.
[28]Guo E,Korkut G G,Jaree P,et al.A Pacifastacus leniusculus serine protease interacts with WSSV[J].Fish Shellfish Immunol,2017,68(4):211-219.
[29]Lu Y,Liu J,Jin L,et al.Passive protection of shrimp against white spot syndrome virus(WSSV)using specific antibody from egg yolk of chickens immunized with inactivated virus or a WSSV-DNA vaccine[J].Fish Shellfish Immunol,2008,25(5):604-610.
[30]刘君君.对虾白斑综合症病毒特异性卵黄免疫球蛋白的制备及性能研究[D].辽宁大连:大连理工大学,2007.
[31]陈爱平,江育林,钱冬,等.水生动物疫病病种介绍之:罗氏沼虾肌肉白浊病[J].中国水产,2011,38(4):65-66.
[32]林蠡,伊丽竹.利用卵黄抗体预防罗氏沼虾肌肉白浊病[J].科学养鱼,2015,29(5):57-58.
[33]Hlaing M T,Theingi W M,Mo W,et al.Immunoglobulin Y-fortified infant milk formula as adjunct to treatment of diarrhea among rotavirus-infected hospitalized children in Myanmar:a randomized,double-blind,placebo-controlled trial[J].J Appl Pharm Sci,2015,23(3):16-18.
[34]Dai Y,Zhang X,Tan M,et al.A dual chicken lgY against rotavirus and norovirus[J].Antiviral Res,2013,97(1):293-300.
[35]Sudjarwo S A,Indriyani W,Nsaroundin N,et al.Acute oral toicity of immunoglobulin Y(lgY)anti HIV in mice[J].J Appl Pharm Sci,2015,5(2):123-126.