高尿酸血症与肾脏疾病关系的研究进展
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摘要
高尿酸血症是多个系统疾病发生发展的危险因素,近年来越来越多的研究发现高尿酸血症在肾脏疾病的发生发展中发挥着重要作用。高尿酸血症与免疫球蛋白A肾病、慢性肾脏疾病、急性肾损伤关系密切。现对高尿酸血症与急慢性肾脏疾病、免疫球蛋白A肾病、肾小管间质损伤等肾脏疾病关系的研究进展进行综述。
Hyperuricemia is a risk factor of multiple system diseases and plays an important role in the occurrence and development of kidney disease. Researches have found close relation of hyperuricemia with immunoglobulin( Ig) A nephropathy,chronic renal disease and acute kidney injury. This paper reviewed the relation between hyperuricemia and kidney injuries including acute and chronic renal disease,Ig A nephropathy and tubulointerstitial injury.
Hyperuricemia is a risk factor of multiple system diseases and plays an important role in the occurrence and development of kidney disease. Researches have found close relation of hyperuricemia with immunoglobulin( Ig) A nephropathy,chronic renal disease and acute kidney injury. This paper reviewed the relation between hyperuricemia and kidney injuries including acute and chronic renal disease,Ig A nephropathy and tubulointerstitial injury.
引文
[1] Liu R,Han C,Wu D,et al. Prevalence of hyperuricemia and gout in Mainland China from 2000 to 2014:A systematic review and meta-analysis[J]. Biomed Res Int,2015,2015:762820. DOI:10. 1155/2015/762820.
[2] Zurlo A,Veronese N,Giantin V,et al. High serum uric acid levels increase the risk of metabolic syndrome in elderly women:The PRO. V. A study[J]. Nutr Metab Cardiovasc Dis,2016,26(1):27-35. DOI:10. 1016/j. numecd. 2015. 10. 007.
[3] Rock KL,Kataoka H,Lai JJ. Uric acid as a danger signal in gout and its comorbidities[J]. Nat Rev Rheumatol,2013,9(1):13-23. DOI:10. 1038/nrrheum. 2012. 143.
[4]段宇,刘超.《高尿酸血症和痛风治疗中国专家共识》解读[J].国际内分泌代谢杂志,2013,33(6):376-378. DOI:10. 3760/cma. j. issn. 1673-4157. 2013. 06. 005.Duan Y,Liu C. Comments on Chinese guideline of hyperuricemia and gout[J]. International Journal of Endocrinology and Metabolism,2013,33(6):376-378. DOI:10. 3760/cma. j. issn. 1673-4157. 2013. 06. 005.
[5] Nagura M,Tamura Y,Kumagai T,et al. Uric acid metabolism of kidney and intestine in a rat model of chronic kidney disease[J].Nucleosides Nucleotides Nucleic Acids,2016,35(10-12):550-558.
[6] Jalal DI,Chonchol M,Chen W,et al. Uric acid as a target of therapy in CKD[J]. Am J Kidney Dis,2013,61(1):134-146.DOI:10. 1053/j. ajkd. 2012. 07. 021.
[7] Isaka Y,Takabatake Y,Takahashi A,et al. Hyperuricemiainduced inflammasome and kidney diseases[J]. Nephrol Dial Transplant,2016,31(6):890-896. DOI:10. 1093/ndt/gfv024.
[8] Xu X,Hu J,Song N,et al. Hyperuricemia increases the risk of acute kidney injury:a systematic review and meta-analysis[J].BMC Nephrol,2017,18(1):27. DOI:10. 1186/s12882-016-0433-1.
[9] Zuo T,Jiang L,Mao S,et al. Hyperuricemia and contrast-induced acute kidney injury:A systematic review and meta-analysis[J].Int J Cardiol,2016,224:286-294. DOI:10. 1016/j. ijcard. 2016.09. 033.
[10] Erol T,Tekin A,Katrcba爧MT,et al. Efficacy of allopurinol pretreatment for prevention of contrast-induced nephropathy:a randomized controlled trial[J]. Int J Cardiol,2013,167(4):1396-1399. DOI:10. 1016/j. ijcard. 2012. 04. 068.
[11] Jha V,Garcia-Garcia G,Iseki K,et al. Chronic kidney disease:global dimension and perspectives[J]. Lancet,2013,382(9888):260-272. DOI:10. 1016/S0140-6736(13)60687-X.
[12] Chou YC,Kuan JC,Yang T,et al. Elevated uric acid level as a significant predictor of chronic kidney disease:a cohort study with repeated measurements[J]. J Nephrol,2015,28(4):457-462.DOI:10. 1007/s40620-014-0158-9.
[13] Chang YH,Lei CC,Lin KC,et al. Serum uric acid level as an indicator for CKD regression and progression in patients with type 2diabetes mellitus-a 4. 6-year cohort study[J]. Diabetes Metab Res Rev,2016,32(6):557-564. DOI:10. 1002/dmrr. 2768.
[14] Feng S,Jiang L,Shi Y,et al. Uric acid levels and all-cause mortality in peritoneal dialysis patients[J]. Kidney Blood Press Res,2013,37(2-3):181-189. DOI:10. 1159/000350143.
[15] Tsai CW,Lin SY,Kuo CC,et al. Serum uric acid and progression of kidney disease:A longitudinal analysis and mini-review[J].PLo S One,2017,12(1):e0170393. DOI:10. 1371/journal.pone. 0170393.
[16] Uchida S,Chang WX,Ota T,et al. Targeting uric acid and the inhibition of progression to end-stage renal disease—A propensity score analysis[J]. PLo S One,2015,10(12):e0145506. DOI:10. 1371/journal. pone. 0145506.
[17] Chang WX,Xu N,Kumagai T,et al. Uric acid in the follow-up determines 30%decline in estimated GFR over 2 years:a propensity score analysis[J]. Kidney Blood Press Res,2017,42(6):1053-1067. DOI:10. 1159/000485593.
[18] Levy G,Shi JM,Cheetham TC,et al. Urate-lowering therapy in moderate to severe chronic kidney disease[J]. Perm J,2018,22.DOI:10. 7812/TPP/17-142.
[19] Bose B,Badve SV,Hiremath SS,et al. Effects of uric acid-lowering therapy on renal outcomes:a systematic review and meta-analysis[J].Nephrol Dial Transplant,2014,29(2):406-413. DOI:10. 1093/ndt/gft378.
[20] Liu X,Zhai T,Ma R,et al. Effects of uric acid-lowering therapy on the progression of chronic kidney disease:a systematic review and meta-analysis[J]. Ren Fail,2018,40(1):289-297. DOI:10. 1080/0886022X. 2018. 1456463.
[21] Nacak H,van Diepen M,de Goeij MC,et al. Uric acid:association with rate of renal function decline and time until start of dialysis in incident pre-dialysis patients[J]. BMC Nephrol,2014,15:91.DOI:10. 1186/1471-2369-15-91.
[22] Nacak H,van Diepen M,Qureshi AR,et al. Uric acid is not associated with decline in renal function or time to renal replacement therapy initiation in a referred cohort of patients with StageⅢ,ⅣandⅤchronic kidney disease[J]. Nephrol Dial Transplant,2015,30(12):2039-2045. DOI:10. 1093/ndt/gfv225.
[23] Kohagura K,Kochi M,Miyagi T,et al. An association between uric acid levels and renal arteriolopathy in chronic kidney disease:a biopsy-based study[J]. Hypertens Res,2013,36(1):43-49.DOI:10. 1038/hr. 2012. 135.
[24] Cheng GY,Liu DW,Zhang N,et al. Clinical and prognostic implications of serum uric acid levels on Ig A nephropathy:a cohort study of 348 cases with a mean 5-year follow-up[J]. Clin Nephrol,2013,80(1):40-46. DOI:10. 5414/CN107813.
[25] Caliskan Y,Ozluk Y,Celik D,et al. The Clinical Significance of Uric acid and complement activation in the progression of Ig A nephropathy[J]. Kidney Blood Press Res,2016,41(2):148-157. DOI:10. 1159/000443415.
[26] Bakan A,Oral A,Elcioglu OC,et al. Hyperuricemia is associated with progression of Ig A nephropathy[J]. Int Urol Nephrol,2015,47(4):673-678. DOI:10. 1007/s11255-015-0939-7.
[27]李申恒,史伟,夏运风,等.尿酸升高Ig A肾病临床病理特征变化的比较分析[J].南方医科大学学报,2010,30(1):133-136.Li SH,Shi W,Xia YF,et al. A comparative study of the clinicopathological features in patients with Ig A nephropathy with elevated uric acid level[J]. Journal of Southern Medical University,2010,30(1):133-136.
[28] Zhou J,Chen Y,Liu Y,et al. Plasma uric acid level indicates tubular interstitial lesions at early stage of Ig A nephropathy[J].BMC Nephrol,2014,15:11. DOI:10. 1186/1471-2369-15-11.
[29]崔明姬,张宝红,肖庆飞,等.高尿酸血症与Ig A肾病临床病理的相关性分析[J].中华内科杂志,2011,50(8):659-663. DOI:10. 3760/cma. j. issn. 0578-1426. 2011. 08. 013.Cui MJ,Zhang BH,Xiao QF,et al. The relationship between hyperuricaemia and clinic pathology of Ig A nephropathy[J].Chinese Journal of Internal Medicine,2011,50(8):659-663.DOI:10. 3760/cma. j. issn. 0578-1426. 2011. 08. 013.
[30] Nagasawa Y,Yamamoto R,Shoji T,et al. Serum uric acid level predicts progression of Ig A nephropathy in females but not in males[J].PLo S One,2016,11(8):e0160828. DOI:10. 1371/journal.pone. 0160828.
[31] Zhuang Y,Yu Y,Huang Y,et al. Study on hyperuricemia in HBV-associated glomerulonephritis[J]. Am J Clin Pathol,2014,141(1):72-77. DOI:10. 1309/AJCP2H0FOVIRWMSU.
[32] Verzola D,Ratto E,Villaggio B,et al. Uric acid promotes apoptosis in human proximal tubule cells by oxidative stress and the activation of NADPH oxidase NOX 4[J]. PLo S One,2014,9(12):e115210.DOI:10. 1371/journal. pone. 0115210.
[33] Liu H,Xiong J,He T,et al. High uric acid-induced epithelialmesenchymal transition of renal tubular epithelial cells viathe TLR4/NF-kB signaling pathway[J]. Am J Nephrol,2017,46(4):333-342. DOI:10. 1159/000481668.
[34] Johnson RJ,Nakagawa T,Jalal D,et al. Uric acid and chronic kidney disease:which is chasing which?[J]. Nephrol Dial Transplant,2013,28(9):2221-2228. DOI:10. 1093/ndt/gft029.
[35] Feig DI. Serum uric acid and the risk of hypertension and chronic kidney disease[J]. Curr Opin Rheumatol,2014,26(2):176-185. DOI:10. 1097/BOR. 0000000000000033.
[2] Zurlo A,Veronese N,Giantin V,et al. High serum uric acid levels increase the risk of metabolic syndrome in elderly women:The PRO. V. A study[J]. Nutr Metab Cardiovasc Dis,2016,26(1):27-35. DOI:10. 1016/j. numecd. 2015. 10. 007.
[3] Rock KL,Kataoka H,Lai JJ. Uric acid as a danger signal in gout and its comorbidities[J]. Nat Rev Rheumatol,2013,9(1):13-23. DOI:10. 1038/nrrheum. 2012. 143.
[4]段宇,刘超.《高尿酸血症和痛风治疗中国专家共识》解读[J].国际内分泌代谢杂志,2013,33(6):376-378. DOI:10. 3760/cma. j. issn. 1673-4157. 2013. 06. 005.Duan Y,Liu C. Comments on Chinese guideline of hyperuricemia and gout[J]. International Journal of Endocrinology and Metabolism,2013,33(6):376-378. DOI:10. 3760/cma. j. issn. 1673-4157. 2013. 06. 005.
[5] Nagura M,Tamura Y,Kumagai T,et al. Uric acid metabolism of kidney and intestine in a rat model of chronic kidney disease[J].Nucleosides Nucleotides Nucleic Acids,2016,35(10-12):550-558.
[6] Jalal DI,Chonchol M,Chen W,et al. Uric acid as a target of therapy in CKD[J]. Am J Kidney Dis,2013,61(1):134-146.DOI:10. 1053/j. ajkd. 2012. 07. 021.
[7] Isaka Y,Takabatake Y,Takahashi A,et al. Hyperuricemiainduced inflammasome and kidney diseases[J]. Nephrol Dial Transplant,2016,31(6):890-896. DOI:10. 1093/ndt/gfv024.
[8] Xu X,Hu J,Song N,et al. Hyperuricemia increases the risk of acute kidney injury:a systematic review and meta-analysis[J].BMC Nephrol,2017,18(1):27. DOI:10. 1186/s12882-016-0433-1.
[9] Zuo T,Jiang L,Mao S,et al. Hyperuricemia and contrast-induced acute kidney injury:A systematic review and meta-analysis[J].Int J Cardiol,2016,224:286-294. DOI:10. 1016/j. ijcard. 2016.09. 033.
[10] Erol T,Tekin A,Katrcba爧MT,et al. Efficacy of allopurinol pretreatment for prevention of contrast-induced nephropathy:a randomized controlled trial[J]. Int J Cardiol,2013,167(4):1396-1399. DOI:10. 1016/j. ijcard. 2012. 04. 068.
[11] Jha V,Garcia-Garcia G,Iseki K,et al. Chronic kidney disease:global dimension and perspectives[J]. Lancet,2013,382(9888):260-272. DOI:10. 1016/S0140-6736(13)60687-X.
[12] Chou YC,Kuan JC,Yang T,et al. Elevated uric acid level as a significant predictor of chronic kidney disease:a cohort study with repeated measurements[J]. J Nephrol,2015,28(4):457-462.DOI:10. 1007/s40620-014-0158-9.
[13] Chang YH,Lei CC,Lin KC,et al. Serum uric acid level as an indicator for CKD regression and progression in patients with type 2diabetes mellitus-a 4. 6-year cohort study[J]. Diabetes Metab Res Rev,2016,32(6):557-564. DOI:10. 1002/dmrr. 2768.
[14] Feng S,Jiang L,Shi Y,et al. Uric acid levels and all-cause mortality in peritoneal dialysis patients[J]. Kidney Blood Press Res,2013,37(2-3):181-189. DOI:10. 1159/000350143.
[15] Tsai CW,Lin SY,Kuo CC,et al. Serum uric acid and progression of kidney disease:A longitudinal analysis and mini-review[J].PLo S One,2017,12(1):e0170393. DOI:10. 1371/journal.pone. 0170393.
[16] Uchida S,Chang WX,Ota T,et al. Targeting uric acid and the inhibition of progression to end-stage renal disease—A propensity score analysis[J]. PLo S One,2015,10(12):e0145506. DOI:10. 1371/journal. pone. 0145506.
[17] Chang WX,Xu N,Kumagai T,et al. Uric acid in the follow-up determines 30%decline in estimated GFR over 2 years:a propensity score analysis[J]. Kidney Blood Press Res,2017,42(6):1053-1067. DOI:10. 1159/000485593.
[18] Levy G,Shi JM,Cheetham TC,et al. Urate-lowering therapy in moderate to severe chronic kidney disease[J]. Perm J,2018,22.DOI:10. 7812/TPP/17-142.
[19] Bose B,Badve SV,Hiremath SS,et al. Effects of uric acid-lowering therapy on renal outcomes:a systematic review and meta-analysis[J].Nephrol Dial Transplant,2014,29(2):406-413. DOI:10. 1093/ndt/gft378.
[20] Liu X,Zhai T,Ma R,et al. Effects of uric acid-lowering therapy on the progression of chronic kidney disease:a systematic review and meta-analysis[J]. Ren Fail,2018,40(1):289-297. DOI:10. 1080/0886022X. 2018. 1456463.
[21] Nacak H,van Diepen M,de Goeij MC,et al. Uric acid:association with rate of renal function decline and time until start of dialysis in incident pre-dialysis patients[J]. BMC Nephrol,2014,15:91.DOI:10. 1186/1471-2369-15-91.
[22] Nacak H,van Diepen M,Qureshi AR,et al. Uric acid is not associated with decline in renal function or time to renal replacement therapy initiation in a referred cohort of patients with StageⅢ,ⅣandⅤchronic kidney disease[J]. Nephrol Dial Transplant,2015,30(12):2039-2045. DOI:10. 1093/ndt/gfv225.
[23] Kohagura K,Kochi M,Miyagi T,et al. An association between uric acid levels and renal arteriolopathy in chronic kidney disease:a biopsy-based study[J]. Hypertens Res,2013,36(1):43-49.DOI:10. 1038/hr. 2012. 135.
[24] Cheng GY,Liu DW,Zhang N,et al. Clinical and prognostic implications of serum uric acid levels on Ig A nephropathy:a cohort study of 348 cases with a mean 5-year follow-up[J]. Clin Nephrol,2013,80(1):40-46. DOI:10. 5414/CN107813.
[25] Caliskan Y,Ozluk Y,Celik D,et al. The Clinical Significance of Uric acid and complement activation in the progression of Ig A nephropathy[J]. Kidney Blood Press Res,2016,41(2):148-157. DOI:10. 1159/000443415.
[26] Bakan A,Oral A,Elcioglu OC,et al. Hyperuricemia is associated with progression of Ig A nephropathy[J]. Int Urol Nephrol,2015,47(4):673-678. DOI:10. 1007/s11255-015-0939-7.
[27]李申恒,史伟,夏运风,等.尿酸升高Ig A肾病临床病理特征变化的比较分析[J].南方医科大学学报,2010,30(1):133-136.Li SH,Shi W,Xia YF,et al. A comparative study of the clinicopathological features in patients with Ig A nephropathy with elevated uric acid level[J]. Journal of Southern Medical University,2010,30(1):133-136.
[28] Zhou J,Chen Y,Liu Y,et al. Plasma uric acid level indicates tubular interstitial lesions at early stage of Ig A nephropathy[J].BMC Nephrol,2014,15:11. DOI:10. 1186/1471-2369-15-11.
[29]崔明姬,张宝红,肖庆飞,等.高尿酸血症与Ig A肾病临床病理的相关性分析[J].中华内科杂志,2011,50(8):659-663. DOI:10. 3760/cma. j. issn. 0578-1426. 2011. 08. 013.Cui MJ,Zhang BH,Xiao QF,et al. The relationship between hyperuricaemia and clinic pathology of Ig A nephropathy[J].Chinese Journal of Internal Medicine,2011,50(8):659-663.DOI:10. 3760/cma. j. issn. 0578-1426. 2011. 08. 013.
[30] Nagasawa Y,Yamamoto R,Shoji T,et al. Serum uric acid level predicts progression of Ig A nephropathy in females but not in males[J].PLo S One,2016,11(8):e0160828. DOI:10. 1371/journal.pone. 0160828.
[31] Zhuang Y,Yu Y,Huang Y,et al. Study on hyperuricemia in HBV-associated glomerulonephritis[J]. Am J Clin Pathol,2014,141(1):72-77. DOI:10. 1309/AJCP2H0FOVIRWMSU.
[32] Verzola D,Ratto E,Villaggio B,et al. Uric acid promotes apoptosis in human proximal tubule cells by oxidative stress and the activation of NADPH oxidase NOX 4[J]. PLo S One,2014,9(12):e115210.DOI:10. 1371/journal. pone. 0115210.
[33] Liu H,Xiong J,He T,et al. High uric acid-induced epithelialmesenchymal transition of renal tubular epithelial cells viathe TLR4/NF-kB signaling pathway[J]. Am J Nephrol,2017,46(4):333-342. DOI:10. 1159/000481668.
[34] Johnson RJ,Nakagawa T,Jalal D,et al. Uric acid and chronic kidney disease:which is chasing which?[J]. Nephrol Dial Transplant,2013,28(9):2221-2228. DOI:10. 1093/ndt/gft029.
[35] Feig DI. Serum uric acid and the risk of hypertension and chronic kidney disease[J]. Curr Opin Rheumatol,2014,26(2):176-185. DOI:10. 1097/BOR. 0000000000000033.