重组牛碱性成纤维细胞生长因子凝胶联合短波理疗仪治疗面部敏感性皮肤的疗效观察
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摘要
目的观察重组牛碱性成纤维细胞生长因子凝胶联合短波理疗仪对于修复面部敏感性皮肤的疗效及安全性。方法通过随机、自身半边脸对照实验,对35例面部敏感性皮肤患者进行治疗观察。一侧面部给予重组牛碱性成纤维细胞生长因子凝胶联合短波理疗仪治疗;对照侧给予卡波姆凝胶联合短波理疗仪治疗;每3天治疗一次,共5次;并于治疗结束后间隔2周对患者进行随访。对患者治疗前、后及随访时进行皮肤状况评分比较,并分别于治疗前及治疗后应用VISIA及CK测试仪检测皮肤各项生理指标。结果实验侧、对照侧皮肤状况评分均较治疗前明显改善(P<0.05),且实验侧改善情况优于对照侧(P<0.05),随访时实验侧皮肤状况评分明显优于对照侧(P<0.05)。VISIA及CK皮肤测试结果显示,5次治疗后,实验侧与对照侧面部皮肤的纹理、红色区、角质层含水量、皮脂含量及经皮水分丢失量均较治疗前得到明显改善(P<0.05);并且,试验侧优于对照侧(P<0.05)。治疗过程中,未观察到严重皮肤不良反应。结论重组牛碱性成纤维细胞生长因子凝胶联合短波理疗仪可较快修复受损的皮肤屏障功能,在治疗面部敏感性皮肤中临床疗效高,复发率低,无严重不良反应。
Objective To investigate the therapeutic effect and safety of recombinant bovine basic fibroblast growth factor( rb-b FGF) gel combined with short wave therapeutic apparatus in the treatment of sensitive facial skin. Methods A total of 35 women with sensitive facial skin were enrolled in this randomized split-face controlled study. They were treated with topical rb-b FGF gel combined with short wave therapeutic apparatus on one side of the face,and carbomer gel combined with short wave therapeutic apparatus on the other side of the face. The treatment was performed every three days for 5 times,and they were followed up two weeks after the final treatment. Changes in sensitive skin were evaluated using a skin conditions rating scale before and after treatment and at follow-up,and various physiological indicators of the skin were assessed through VISIA analysis system and CK analysis system before and after treat-ment. Results The skin condition scores on the experimental side and the control side were significantly improved compared with those before treatment( P < 0. 05),and the improvement on the experimental side was more remarkable than that on the control side( P < 0. 05). The skin condition scores on the experimental side were significantly higher than those on the control side at follow-up( P < 0. 05). The skin test results of VISIA and CK showed that after 5 treatments,the texture,red area,water content of stratum corneum,sebum content and transepidermal water loss of the experimental side and the control side were significantly improved compared with before treatment( P < 0. 05). And those indicators on experiment side was superior to those in the control side( P < 0. 05). No serious skin adverse reactions were observed during the treatment. Conclusion Rb-b FGF combined with short wave therapeutic apparatus can repair damaged skin barrier function quickly,and has high clinical efficacy,low recurrence rate and no serious adverse reactions in the treatment of sensitive facial skin.
Objective To investigate the therapeutic effect and safety of recombinant bovine basic fibroblast growth factor( rb-b FGF) gel combined with short wave therapeutic apparatus in the treatment of sensitive facial skin. Methods A total of 35 women with sensitive facial skin were enrolled in this randomized split-face controlled study. They were treated with topical rb-b FGF gel combined with short wave therapeutic apparatus on one side of the face,and carbomer gel combined with short wave therapeutic apparatus on the other side of the face. The treatment was performed every three days for 5 times,and they were followed up two weeks after the final treatment. Changes in sensitive skin were evaluated using a skin conditions rating scale before and after treatment and at follow-up,and various physiological indicators of the skin were assessed through VISIA analysis system and CK analysis system before and after treat-ment. Results The skin condition scores on the experimental side and the control side were significantly improved compared with those before treatment( P < 0. 05),and the improvement on the experimental side was more remarkable than that on the control side( P < 0. 05). The skin condition scores on the experimental side were significantly higher than those on the control side at follow-up( P < 0. 05). The skin test results of VISIA and CK showed that after 5 treatments,the texture,red area,water content of stratum corneum,sebum content and transepidermal water loss of the experimental side and the control side were significantly improved compared with before treatment( P < 0. 05). And those indicators on experiment side was superior to those in the control side( P < 0. 05). No serious skin adverse reactions were observed during the treatment. Conclusion Rb-b FGF combined with short wave therapeutic apparatus can repair damaged skin barrier function quickly,and has high clinical efficacy,low recurrence rate and no serious adverse reactions in the treatment of sensitive facial skin.
引文
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[7]卢凤艳,刘岳花,尹逊国,等.射频治疗仪联合舒敏保湿特护霜及复方甘草酸苷治疗面部激素依赖性皮炎的疗效观察[J].皮肤病与性病,2017,39(5):319-322.
[8]Rifkin DB,Moscatell D.Recent development in the cell biology of basic fibroblast growth factor[J].Cell Biol,1989,109(1):1-6.
[9]Akita S,Akino K,Hirano A.Basic fibroblast growth factor in scarless wound healing[J].Adv Wound Care(New Rochelle),2013,2(2):44-49.
[10]Matsumine H.Treatment of skin avulsion injuries with basic fibroblast growth factor[J].Plast Reconstr Surg Glob Open,2015,3(4):e371.
[11]Nakamizo S,Egawa G,Doi H,et al.Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion[J].Skin Pharmacol Physiol,2013,26(1):22-29.
[2]Ohta M,Hikima R,Ogawa T.Physiological characteristics of sensitive skin classified by stinging test[J].Journal of Japanese Cosmetic Science Scoiety,2000,23(6):163-167.
[3]Misery L,Stander S,Szepietowski JC,et al.Definition of sensitive skin:an expeposition paper from the special interest group on sensitive skin of the international forum for the study of itch[J].Acta Derm Venereol,2017,96(1):4-6.
[4]BuhéV,ViéK,GuéréC,et al.Pathophysiological study of sensitive skin[J].Acta Derm Venereol,2016,96(3):314-318.
[5]Cho HJ,Chung BY,Lee HB,et al.Quantitative study of stratum corneum ceramides contents in patients with sensitive skin[J].J Dermatol,2012,39(3):295-300.
[6]Pinto P,Rosado C,Parreirao C,et al.Is there any barrier impairment in sensitive skin?A quantitative analysis of sensitive skin by mathematical modeling of transepidermal water loss desorption curves[J].Skin Res Technol,2011,17(2):181-185.
[7]卢凤艳,刘岳花,尹逊国,等.射频治疗仪联合舒敏保湿特护霜及复方甘草酸苷治疗面部激素依赖性皮炎的疗效观察[J].皮肤病与性病,2017,39(5):319-322.
[8]Rifkin DB,Moscatell D.Recent development in the cell biology of basic fibroblast growth factor[J].Cell Biol,1989,109(1):1-6.
[9]Akita S,Akino K,Hirano A.Basic fibroblast growth factor in scarless wound healing[J].Adv Wound Care(New Rochelle),2013,2(2):44-49.
[10]Matsumine H.Treatment of skin avulsion injuries with basic fibroblast growth factor[J].Plast Reconstr Surg Glob Open,2015,3(4):e371.
[11]Nakamizo S,Egawa G,Doi H,et al.Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion[J].Skin Pharmacol Physiol,2013,26(1):22-29.