不同预处理策略促进间充质干细胞的归巢
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摘要
背景:归巢是干细胞发挥组织修复作用的初始及关键环节。目前研究表明骨髓间充质干细胞无法高效地归巢至靶组织是影响修复效果的主要障碍。预处理策略为促进干细胞归巢提供了新思路。目的:对促进间充质干细胞归巢的预处理策略进行综述。方法:以"stem cell,mesenchymal stem cells,preconditioning,homing,migration"为检索词按不同组合在PubM ed数据库中检索2000年1月至2015年9月关于预处理策略促进间充质干细胞归巢的文章,根据纳入标准,最终选择72篇文章进行综述。结果与结论:移植间充质干细胞前对靶组织或间充质干细胞进行预处理,可显著促进其归巢至受损组织从而增强组织修复效应。组织预处理策略正是通过影响局部微环境,达到上调趋化因子表达等效果,从而促进间充质干细胞归巢。间充质干细胞预处理策略,例如基因修饰、细胞因子诱导等,主要以间充质干细胞表面趋化因子受体为效应器,通过上调其表达来促进靶向归巢。预处理策略将为干细胞治疗应用于临床带来了极大希望。
BACKGROUND: Homing is the initial and key procedure of stem cells-based tissue restoration. Current studies have shown that the inability to recruit bone marrow mesenchymal stem cells to target tissue with high efficiency remains a significant barrier to tissue restoration. Preconditioning strategy provides a new insight to promote stem cell homing. OBJECTIVE: To review preconditioning strategies for promoting the homing of stem cells. METHODS: In Pub Med database, different combinations of terms from "stem cell, mesenchymal stem cells, preconditioning, homing, migration" served as search terms to retrieve articles referring preconditioning strategies for promoting mesenchymal stem cell homing published from January 2000 to September 2015. According to the inclusion criteria, 72 articles were selected for final review. RESULTS AND CONCLUSION: Pretreating target tissue or mesenchymal stem cells ahead of cell transplantation, known as tissue preconditioning or cell preconditioning, prominently promotes the homing of mesenchymal stem cells, therefore enhancing tissue restoration effect. Tissue preconditioning is designed to up-regulate expression of chemokines by varying the local microenvironment, thereby increasing homing ability of mesechymal stem cells. Mesenchymal stem cell preconditioning strategies, for example, gene modification and cytokine induction, are mainly to up-regulate expression of chemokine receptors on the surface of mesenchymal stem cells as effectors, and thus promote targeted cell homing. Overall, preconditioning strategy will bring great hope to apply stem cell therapy into the clinic.
BACKGROUND: Homing is the initial and key procedure of stem cells-based tissue restoration. Current studies have shown that the inability to recruit bone marrow mesenchymal stem cells to target tissue with high efficiency remains a significant barrier to tissue restoration. Preconditioning strategy provides a new insight to promote stem cell homing. OBJECTIVE: To review preconditioning strategies for promoting the homing of stem cells. METHODS: In Pub Med database, different combinations of terms from "stem cell, mesenchymal stem cells, preconditioning, homing, migration" served as search terms to retrieve articles referring preconditioning strategies for promoting mesenchymal stem cell homing published from January 2000 to September 2015. According to the inclusion criteria, 72 articles were selected for final review. RESULTS AND CONCLUSION: Pretreating target tissue or mesenchymal stem cells ahead of cell transplantation, known as tissue preconditioning or cell preconditioning, prominently promotes the homing of mesenchymal stem cells, therefore enhancing tissue restoration effect. Tissue preconditioning is designed to up-regulate expression of chemokines by varying the local microenvironment, thereby increasing homing ability of mesechymal stem cells. Mesenchymal stem cell preconditioning strategies, for example, gene modification and cytokine induction, are mainly to up-regulate expression of chemokine receptors on the surface of mesenchymal stem cells as effectors, and thus promote targeted cell homing. Overall, preconditioning strategy will bring great hope to apply stem cell therapy into the clinic.
引文
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[43]Huang Z,Ma T,Ren PG,et al.Effects of orthopedic polymer particles on chemotaxis of macrophages and mesenchymal stem cells.J Biomed Mater Res A.2010;94(4):1264-1269.
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[2]Horwitz EM,Le Blanc K,Dominici M,et al.Clarification of the nomenclature for MSC:The International Society for Cellular Therapy position statement.Cytotherapy.2005;7(5):393-395.
[3]Dominici M,Le Blanc K,Mueller I,et al.Minimal criteria for defining multipotent mesenchymal stromal cells.The International Society for Cellular Therapy position statement.Cytotherapy.2006;8(4):315-317.
[4]Chamberlain G,Fox J,Ashton B,et al.Concise review:mesenchymal stem cells:their phenotype,differentiation capacity,immunological features,and potential for homing.Stem Cells.2007;25(11):2739-2749.
[5]Deak E,Seifried E,Henschler R.Homing pathways of mesenchymal stromal cells(MSCs)and their role in clinical applications.Int Rev Immunol.2010;29(5):514-529.
[6]Fong EL,Chan CK,Goodman SB.Stem cell homing in musculoskeletal injury.Biomaterials.2011;32(2):395-409.
[7]Zhu XY,Lerman A,Lerman LO.Concise review:mesenchymal stem cell treatment for ischemic kidney disease.Stem Cells.2013;31(9):1731-1736.
[8]Cashman TJ,Gouon-Evans V,Costa KD.Mesenchymal stem cells for cardiac therapy:practical challenges and potential mechanisms.Stem Cell Rev.2013;9(3):254-265.
[9]Chou SH,Lin SZ,Kuo WW,et al.Mesenchymal stem cell insights:prospects in cardiovascular therapy.Cell Transplant.2014;23(4-5):513-529.
[10]Karp JM,Leng Teo GS.Mesenchymal stem cell homing:the devil is in the details.Cell Stem Cell.2009;4(3):206-216.
[11]Rombouts WJ,Ploemacher RE.Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture.Leukemia.2003;17(1):160-170.
[12]Phinney DG,Prockop DJ.Concise review:mesenchymal stem/multipotent stromal cells:the state of transdifferentiation and modes of tissue repair-current views.Stem Cells.2007;25(11):2896-2902.
[13]Chen J,Li Y,Wang L,et al.Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats.Stroke.2001;32(4):1005-1011.
[14]Wu J,Sun Z,Sun HS,et al.Intravenously administered bone marrow cells migrate to damaged brain tissue and improve neural function in ischemic rats.Cell Transplant.2008;16(10):993-1005.
[15]Freyman T,Polin G,Osman H,et al.A quantitative,randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction.Eur Heart J.2006;27(9):1114-1122.
[16]Omori Y,Honmou O,Harada K,et al.Optimization of a therapeutic protocol for intravenous injection of human mesenchymal stem cells after cerebral ischemia in adult rats.Brain Res.2008;1236:30-38.
[17]Bai ZM,Deng XD,Li JD,et al.Arterially transplanted mesenchymal stem cells in a mouse reversible unilateral ureteral obstruction model:in vivo bioluminescence imaging and effects on renal fibrosis.Chin Med J(Engl).2013;126(10):1890-1894.
[18]Yu SP,Wei Z,Wei L.Preconditioning strategy in stem cell transplantation therapy.Transl Stroke Res.2013;4(1):76-88.
[19]Liu ZJ,Zhuge Y,Velazquez OC.Trafficking and differentiation of mesenchymal stem cells.J Cell Biochem.2009;106(6):984-991.
[20]Chen FM,Wu LA,Zhang M,et al.Homing of endogenous stem/progenitor cells for in situ tissue regeneration:Promises,strategies,and translational perspectives.Biomaterials.2011;32(12):3189-3209.
[21]Vanden Berg-Foels WS.In situ tissue regeneration:chemoattractants for endogenous stem cell recruitment.Tissue Eng Part B Rev.2014;20(1):28-39.
[22]Wynn RF,Hart CA,Corradi-Perini C,et al.A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow.Blood.2004;104(9):2643-2645.
[23]Sharma M,Afrin F,Satija N,et al.Stromal-derived factor-1/CXCR4 signaling:indispensable role in homing and engraftment of hematopoietic stem cells in bone marrow.Stem Cells Dev.2011;20(6):933-946.
[24]Zhu H,Mitsuhashi N,Klein A,et al.The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix.Stem Cells.2006;24(4):928-935.
[25]Sackstein R,Merzaban JS,Cain DW,et al.Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone.Nat Med.2008;14(2):181-187.
[26]Zhang A,Wang Y,Ye Z,et al.Mechanism of TNF-α-induced migration and hepatocyte growth factor production in human mesenchymal stem cells.J Cell Biochem.2010;111(2):469-475.
[27]Ryu CH,Park SA,Kim SM,et al.Migration of human umbilical cord blood mesenchymal stem cells mediated by stromal cell-derived factor-1/CXCR4 axis via Akt,ERK,and p38 signal transduction pathways.Biochem Biophys Res Commun.2010;398(1):105-110.
[28]Marquez-Curtis LA,Janowska-Wieczorek A.Enhancing the migration ability of mesenchymal stromal cells by targeting the SDF-1/CXCR4 axis.Biomed Res Int.2013;2013:561098.
[29]Gao H,Priebe W,Glod J,et al.Activation of signal transducers and activators of transcription 3 and focal adhesion kinase by stromal cell-derived factor 1 is required for migration of human mesenchymal stem cells in response to tumor cell-conditioned medium.Stem Cells.2009;27(4):857-865.
[30]Lee MJ,Jeon ES,Lee JS,et al.Lysophosphatidic acid in malignant ascites stimulates migration of human mesenchymal stem cells.J Cell Biochem.2008;104(2):499-510.
[31]Shang YC,Wang SH,Xiong F,et al.Wnt3a signaling promotes proliferation,myogenic differentiation,and migration of rat bone marrow mesenchymal stem cells.Acta Pharmacol Sin.2007;28(11):1761-1774.
[32]Ponte AL,Marais E,Gallay N,et al.The in vitro migration capacity of human bone marrow mesenchymal stem cells:comparison of chemokine and growth factor chemotactic activities.Stem Cells.2007;25(7):1737-1745.
[33]Ji JF,He BP,Dheen ST,et al.Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury.Stem Cells.2004;22(3):415-427.
[34]Sasaki M,Abe R,Fujita Y,et al.Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type.J Immunol.2008;180(4):2581-2587.
[35]Zhou SB,Wang J,Chiang CA,et al.Mechanical stretch upregulates SDF-1αin skin tissue and induces migration of circulating bone marrow-derived stem cells into the expanded skin.Stem Cells.2013;31(12):2703-2713.
[36]Burks SR,Nguyen BA,Tebebi PA,et al.Pulsed focused ultrasound pretreatment improves mesenchymal stromal cell efficacy in preventing and rescuing established acute kidney injury in mice.Stem Cells.2015;33(4):1241-1253.
[37]Wu S,Li L,Wang G,et al.Ultrasound-targeted stromal cell-derived factor-1-loaded microbubble destruction promotes mesenchymal stem cell homing to kidneys in diabetic nephropathy rats.Int J Nanomedicine.2014;9:5639-5651.
[38]Zhang Y,Ye C,Wang G,et al.Kidney-targeted transplantation of mesenchymal stem cells by ultrasound-targeted microbubble destruction promotes kidney repair in diabetic nephropathy rats.Biomed Res Int.2013;2013:526367.
[39]Oron U,Tuby H,Maltz L,et al.Autologous bone-marrow stem cells stimulation reverses post-ischemicreperfusion kidney injury in rats.Am J Nephrol.2014;40(5):425-433.
[40]Tuby H,Maltz L,Oron U.Induction of autologous mesenchymal stem cells in the bone marrow by low-level laser therapy has profound beneficial effects on the infarcted rat heart.Lasers Surg Med.2011;43(5):401-409.
[41]Aicher A,Heeschen C,Sasaki K,et al.Low-energy shock wave for enhancing recruitment of endothelial progenitor cells:a new modality to increase efficacy of cell therapy in chronic hind limb ischemia.Circulation.2006;114(25):2823-2830.
[42]Qiu X,Lin G,Xin Z,et al.Effects of low-energy shockwave therapy on the erectile function and tissue of a diabetic rat model.J Sex Med.2013;10(3):738-746.
[43]Huang Z,Ma T,Ren PG,et al.Effects of orthopedic polymer particles on chemotaxis of macrophages and mesenchymal stem cells.J Biomed Mater Res A.2010;94(4):1264-1269.
[44]Gibon E,Yao Z,Rao AJ,et al.Effect of a CCR1receptor antagonist on systemic trafficking of MSCs and polyethylene particle-associated bone loss.Biomaterials.2012;33(14):3632-3638.
[45]Cao Z,Zhang G,Wang F,et al.Protective effects of mesenchymal stem cells with CXCR4 up-regulation in a rat renal transplantation model.PLoS One.2013;8(12):e82949.
[46]Chen W,Li M,Cheng H,et al.Overexpression of the mesenchymal stem cell Cxcr4 gene in irradiated mice increases the homing capacity of these cells.Cell Biochem Biophys.2013;67(3):1181-1191.
[47]Kim SM,Kim DS,Jeong CH,et al.CXC chemokine receptor 1 enhances the ability of human umbilical cord blood-derived mesenchymal stem cells to migrate toward gliomas.Biochem Biophys Res Commun.2011;407(4):741-746.
[48]Huang J,Zhang Z,Guo J,et al.Genetic modification of mesenchymal stem cells overexpressing CCR1increases cell viability,migration,engraftment,and capillary density in the injured myocardium.Circ Res.2010;106(11):1753-1762.
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