超顺磁性氧化铁纳米颗粒应用于干细胞定向归巢中的研究进展
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摘要
干细胞在组织器官的自我更新和修复过程中起重要作用。在外加磁场的作用下,用纳米磁铁颗粒标记干细胞,可增加干细胞的定向归巢和存留,从而放大干细胞的修复效应。本文就纳米磁铁颗粒靶向干细胞的原理,以及其在各种病理模型应用的研究进展作一综述。
Stem cells play an important role in self-renewal and repair of tissues and organs.Under the influence of the external magnetic field,labeling the stem cells with magnetic nanoparticles can increase the directional homing and retention of the stem cells,thereby amplifying the repair effect of the stem cells.In this paper,the principle of magnetic nanoparticles targeting stem cells and its progress in the application of various pathological models are reviewed.
Stem cells play an important role in self-renewal and repair of tissues and organs.Under the influence of the external magnetic field,labeling the stem cells with magnetic nanoparticles can increase the directional homing and retention of the stem cells,thereby amplifying the repair effect of the stem cells.In this paper,the principle of magnetic nanoparticles targeting stem cells and its progress in the application of various pathological models are reviewed.
引文
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[3]YANAI A,HFELI U O,METCALFE A L,et al.Focused magnetic stem cell targeting to the retina using superparamagnetic iron oxide nanoparticles[J].Cell Transplant,2012,21(6):1137-1148.
[4]SHINOZUKA K,DAILEY T,TAJIRI N,et al.Stem cell transplantation for neuroprotection in stroke[J].Brain Sci,2013,3(1):239-261.
[5]VERFAILLIE C M.Optimizing hematopoietic stem cell engraftment:a novel role for thrombopoietin[J].J Clin Invest,2002,110(3):303-304.
[6]SENSENIG R,SAPIR Y,MACDONALD C,et al.Magnetic nanoparticle-based approaches to locally target therapy and enhance tissue regeneration in vivo[J].Nanomedicine,2012,7(9):1425-1442.
[7]FRANGIONI J V,HAJJAR R J.In vivo tracking of stem cells for clinical trials in cardiovascular disease[J].Circulation.2004,110(21):3378-3383.
[8]ARBAB A L,JORDAN E K,WILSON L B,et al.In vivo trafficking and targeted delivery of magnetically labeled stem cells[J].Hum Gene Ther,2004,15(4):351-360.
[9]MARKIDES H,ROTHERHAM M,EI HAJ A J.Biocompatibility and toxicity of magnetic nanoparticles in regenerative medicine[J].Nanomater.2012,2012:1-11.
[10]AITZIBER L C,DANIEL O,SANDRA M O,et al.Engineering iron oxide nanoparticles for clinical settings[J].Nanobiomedicine,2014,1(2):1-20.
[11]SINGH N,JENKINS G J,ASADI R,et al.Potential toxicity of superparamagnetic iron oxide nanoparticles(SPION)[J].Nano Rev,2010,1(7):10.
[12]MAHMOUDI M,SANT S,WANG B,et al.Superparamagnetic iron oxide nanoparticles(SPIONs):development,surface modification and applications in chemotherapy[J].Adv Drug Deliv Rev,2011,63(1-2):24-46.
[13]BULTE J W.In vivo MRI cell tracking:clinical studies[J].AJR Am J Roentgenol,2009,193(2):314-325.
[14]XIE J,CHEN K,LEE H Y,et al.Ultrasmall c(RGDyK)-coated Fe3O4 nanoparticles and their specific targeting to integrin alpha(v)beta3-rich tumor cells[J].J Am Chemi Soc,2008,130(24):7542-7543.
[15]PEI N,HUANG Z,MA W,et al.In vitro study of deep capture of paramagnetic particle for targeting therapeutics[J].Magn Mater,2009,321(18):2911-2915.
[16]HUANG Z,PEI N,WANG Y,et al.Deep magnetic capture of magnetically loaded cells for spatially targeted therapeutics[J].Biomaterials,2010,31(8):2130-2140.
[17]HUANG Z,SHEN Y,PEI N,et al.The effect of nonuniform magnetic targeting of intracoronary-delivering mesenchymal stem cells on coronary embolisation[J].Biomaterials,2013,34(38):9905-9916.
[18]CHEN J,HUANG N,MA B,et al.Guidance of stem cells to a target destination in vivo by magnetic nanoparticles in a magnetic field[J].ACS Appl Mater Interfaces,2013,10,5(13):5976-5985.
[19]SUN S N,WEI C,ZHU Z Z,et al.Magnetic iron oxide nanoparticles:synthesis and surface coating techniques for biomedical applications[J].Chin Phys,2014,23(3):13-31.
[20]Umut E.Surface modification of nanoparticles used in biomedical applications[J].Mod Surf Eng Treat.2013,5(8):185-208.
[21]HUONG N T,GIANG L T K,BINH N T,et al.Surface modification of iron oxide nanoparticles and their conjuntion with water soluble polymers for biomedical application[J].Phys Conf Ser,2009,6(1):187-191.
[29]DANGAS G,KUEPPER F.Cardiology patient page.Restenosis:repeat narrowing of a coronary artery:prevention and treatment[J].Circulation,2002,105(22):2586-2587.
[30]GUTOVA M,FRANK J A,D’APUZZO M,et al.Magnetic resonance imaging tracking of ferumoxytol-labeled human neural stem cells:studies leading to clinical use[J].Stem Cells Transl Med,2013,2(10):766-775.
[31]LUMA L G,DAVOLA P A,LEE R J,et al.The new face of bispecific antibodies:targeting cancer and much more[J].Exp Hematol.2006,34(1):1-6.
[32]TANG J,SHEN D,ZHANG J,et al.Bispecific antibodies,nanoparticles and cells:bringing the right cells to get the job done[J].Expert Opin Biol Ther,2015,15(9):1251-1255.