纳米技术在药物领域中的应用
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摘要
纳米技术作为一门综合性科学,发展十分迅速,正逐渐渗入人们的日常生活中,为人们日常生活带来便利。将纳米技术充分的应用于药物研究领域,不仅能降低药物的毒副作用,改善药物的释放体系,提高药物的生物利用度等,而且能够降低药品的生产成本,提高生产效率,让药物更好的发挥临床疗效。本文将对目前国内外纳米技术在药物研究中的应用进行阐述,并对目前常用的纳米制剂、纳米药物载体以及影响纳米药物性质的主要因素进行简单介绍。
Nanotechnology,as a comprehensive science,develops very quickly,and is gradually infiltrating into people's daily life,which brings convenience to people's daily life.The full application of nanotechnology in the field of drug research can not only reduce the toxicity and side effects of drugs,improve the drug release system,improve the bioavailability of drugs,but also reduce the production cost of drugs,increase production efficiency and make the drug better use of clinical efficacy.In this paper,the application of nanotechnology in drug research at home and abroad is expounded,and a brief introduction is given to the commonly used nano-agents,nano-drug carriers and the main factors affecting the properties of nano-drugs.
Nanotechnology,as a comprehensive science,develops very quickly,and is gradually infiltrating into people's daily life,which brings convenience to people's daily life.The full application of nanotechnology in the field of drug research can not only reduce the toxicity and side effects of drugs,improve the drug release system,improve the bioavailability of drugs,but also reduce the production cost of drugs,increase production efficiency and make the drug better use of clinical efficacy.In this paper,the application of nanotechnology in drug research at home and abroad is expounded,and a brief introduction is given to the commonly used nano-agents,nano-drug carriers and the main factors affecting the properties of nano-drugs.
引文
[1]刘晓辰,张蓉,杨云霜.纳米技术在中医中的应用[J].内蒙古医科大学学报,2014;36(5):458-464
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[6]陈洁,李博,吴定伟,等.多烯紫杉醇纳米乳的研制和质量评价[J].中国药学杂志,2010;4(7):534-538
[7]Müller H,Jacobs C,Kayser O.Nanosuspensions as particulate drug formulations in therapy.Rationale for development and what we can expect for the future[J].Advanced Drug Delivery Reviews,2011;47(1):3-9
[8]杨鹏飞陈卫东.纳米控释抗癌药物研究进展[J].中国药学杂志,2013;8(15):353-356
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[10]李晶汪森明胡丽娟,等.盐酸洛拉曲克壳聚糖纳米粒的制备及其特性研究[J].实用医学杂志,2011;27(9):1532-1535
[11]Guo Y,Wang L,Peng V,et al.Transferrin-conjugated doxorubicin-loaded lipid-coated nanoparticles for the targeting and therapy of lung ance[J].ncol Lett,2015;9(3):1065-1072
[12]Schofield JP,Caskey CT.Non-viral approaches to gene therapy[J].Br Merd Bul,1995;51(1):56-58
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[14]赵荣涛李杨贺亚南,等.基于氧化石墨烯的纳米材料在抗菌中的应用研究[J].公共卫生与预防医学,2015;26(1):68-71
[15]Hu W,Peng C,Luo W,et al.Graphene-based antibacterial paper[J].ACS Nano,2010;4(7):4317-4323
[16]吴宗山胡海洋任艺,等.纳米银的抗菌机理研究进展[J].化工进展,2015;34(5):1349-1356
[17]高凯民.纳米技术在新药开发和中药研究中的应用[J].实用医药杂志,2014;6:21(6):246-248
[18]Liu GX,Zhang JY,Pei-xing WU,et al.Application of nanotechnology in the research on traditional chinese medicine[J].Progress in Veterinary Medicine,2016;6(1):7-10
[19]Paliwal SR,Paliwal R,Agrawal GP,et al.Liposomal nanomedicine for breast cancer therapy[J].Nanomedicine,2017;6(6):1085-1089
[20]毛世瑞田野王琳琳.药物纳米载体——聚合物胶束的研究进展[J].沈阳药科大学学报,2010;27(12):979-986
[21]潘超,刘会丽,许俊鹏,等.抗肿瘤药H6聚合物胶束的制备及体外抗肿瘤作用研究[J].中国药房,2017;28(4):533-536
[22]孙聚魁,邓英杰,曹金娜.纳米脂质体研究进展[J].沈阳药科大学学报,2012;27(12):993-997
[23]Ko YJ,Canil CM,Mukherjee SD,et al.Nanoparticle albumin-bound paclitaxel for second-line treatment of metastatic urothelial carcinoma:A single group,Multicentre,Phase 2 study[J].Lancet Oncol,2013;14(8):769-772
[24]Ahmad J,Singhal M,Amin S,et al.Bile salt stabilized vesicles(bilosomes):A novel nano-pharmaceutical design for oral delivery of proteins and peptides[J].Current Pharmaceutical Design,2017;18(2):101-104
[25]Muller RH,Weyhers H,Zur muhlen A,et al.Solid-a novel carriersystem forcosmetics and pharmaceutics.1st ommunication;properties,Roduction and scaling up[J].Pharm Ind,1997;59(5):423-428
[26]高玮,翁小斌,胡海洋,等.不同粒径多西他赛固体脂质纳米粒制剂及其细胞毒活性[J].沈阳药科大学学报,2010;27(12):940-945
[27]李伟.无载体高载药量的纳米药物的制备、表面功能化及其在癌症治疗方面的应用研究[J].苏州大学学报,2013;15(1):82-84
[28]徐雪.典型纳米粒子C60的生物毒性和生物相容性研究[J].西北农林科技大学学报,2014;14(3):258-260
[29]Hansschreier.药物靶向技术[M].北京:中国药科出版社,2004:138-140
[30]张英,杨巧荷,王晓琴.紫杉醇纳米制剂研究进展[J].内蒙古医科大学学报,2014;36(6):560-564
[2]Masood F,Chen P,Yasin T,et al.Encapsulation of ellipticine in poly-(3-hydroxybutyrate-co-3-hydroxyvalerate)based nanoparticlesand its in vitro application[J].Mater Sci Eng C Mater Biol Appl,2013;33(3):1054-1060
[3]高良秀,杨杰.纳米技术在生物制药领域的创新绩效研究[J].医药卫生:全文版,2017;(2):287
[4]王婉婷,李鑫,王贵弘,等.纳米乳制备方法的研究进展[J].黑龙江科技信息,2016;(22):141-143
[5]Borhade V,Pathak S,Sharma S,et al.Clotrimazole nanoemulsion for malaria chemotherapy.Part I:preformulation studies,Formulation design and physicochemical evaluation[J].International Journal of Pharmaceutics,2012;431(1/2):138-148
[6]陈洁,李博,吴定伟,等.多烯紫杉醇纳米乳的研制和质量评价[J].中国药学杂志,2010;4(7):534-538
[7]Müller H,Jacobs C,Kayser O.Nanosuspensions as particulate drug formulations in therapy.Rationale for development and what we can expect for the future[J].Advanced Drug Delivery Reviews,2011;47(1):3-9
[8]杨鹏飞陈卫东.纳米控释抗癌药物研究进展[J].中国药学杂志,2013;8(15):353-356
[9]陈大兵杨天智吕万良,等.紫杉醇长循环固态脂质纳米粒的制备和体内外研究[J].药学学报,2002;37:54-58
[10]李晶汪森明胡丽娟,等.盐酸洛拉曲克壳聚糖纳米粒的制备及其特性研究[J].实用医学杂志,2011;27(9):1532-1535
[11]Guo Y,Wang L,Peng V,et al.Transferrin-conjugated doxorubicin-loaded lipid-coated nanoparticles for the targeting and therapy of lung ance[J].ncol Lett,2015;9(3):1065-1072
[12]Schofield JP,Caskey CT.Non-viral approaches to gene therapy[J].Br Merd Bul,1995;51(1):56-58
[13]Dalezis P,Trafalis DT,Geromichalos GD,et al.Adriamycin in combination with dexamethasone and octreotide lacks activity on the treatment of a 4 T1metastatic breast cancer model[J].Anti-cancer drugs,2017;2:185-186
[14]赵荣涛李杨贺亚南,等.基于氧化石墨烯的纳米材料在抗菌中的应用研究[J].公共卫生与预防医学,2015;26(1):68-71
[15]Hu W,Peng C,Luo W,et al.Graphene-based antibacterial paper[J].ACS Nano,2010;4(7):4317-4323
[16]吴宗山胡海洋任艺,等.纳米银的抗菌机理研究进展[J].化工进展,2015;34(5):1349-1356
[17]高凯民.纳米技术在新药开发和中药研究中的应用[J].实用医药杂志,2014;6:21(6):246-248
[18]Liu GX,Zhang JY,Pei-xing WU,et al.Application of nanotechnology in the research on traditional chinese medicine[J].Progress in Veterinary Medicine,2016;6(1):7-10
[19]Paliwal SR,Paliwal R,Agrawal GP,et al.Liposomal nanomedicine for breast cancer therapy[J].Nanomedicine,2017;6(6):1085-1089
[20]毛世瑞田野王琳琳.药物纳米载体——聚合物胶束的研究进展[J].沈阳药科大学学报,2010;27(12):979-986
[21]潘超,刘会丽,许俊鹏,等.抗肿瘤药H6聚合物胶束的制备及体外抗肿瘤作用研究[J].中国药房,2017;28(4):533-536
[22]孙聚魁,邓英杰,曹金娜.纳米脂质体研究进展[J].沈阳药科大学学报,2012;27(12):993-997
[23]Ko YJ,Canil CM,Mukherjee SD,et al.Nanoparticle albumin-bound paclitaxel for second-line treatment of metastatic urothelial carcinoma:A single group,Multicentre,Phase 2 study[J].Lancet Oncol,2013;14(8):769-772
[24]Ahmad J,Singhal M,Amin S,et al.Bile salt stabilized vesicles(bilosomes):A novel nano-pharmaceutical design for oral delivery of proteins and peptides[J].Current Pharmaceutical Design,2017;18(2):101-104
[25]Muller RH,Weyhers H,Zur muhlen A,et al.Solid-a novel carriersystem forcosmetics and pharmaceutics.1st ommunication;properties,Roduction and scaling up[J].Pharm Ind,1997;59(5):423-428
[26]高玮,翁小斌,胡海洋,等.不同粒径多西他赛固体脂质纳米粒制剂及其细胞毒活性[J].沈阳药科大学学报,2010;27(12):940-945
[27]李伟.无载体高载药量的纳米药物的制备、表面功能化及其在癌症治疗方面的应用研究[J].苏州大学学报,2013;15(1):82-84
[28]徐雪.典型纳米粒子C60的生物毒性和生物相容性研究[J].西北农林科技大学学报,2014;14(3):258-260
[29]Hansschreier.药物靶向技术[M].北京:中国药科出版社,2004:138-140
[30]张英,杨巧荷,王晓琴.紫杉醇纳米制剂研究进展[J].内蒙古医科大学学报,2014;36(6):560-564