超声介导氨溴索经肺俞穴给药对支气管肺炎患儿的免疫调节
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摘要
目的:探讨超声介导氨溴索经肺俞穴给药对支气管肺炎患儿免疫的影响。方法:选取2015年6月~2017年6月在我院接受治疗的120例支气管肺炎患者,并随机分为静脉组、雾化组、超声导入组3组,每组各40例,静脉组给予静脉输入氨溴索;雾化组给予氨溴索高压泵雾化吸入;超声导入组患儿使用超声介导药物靶向技术经肺俞穴局部导入氨溴索化痰;检测3组患儿血清免疫球蛋白和T细胞亚群。结果:3组患儿经治疗后,CD3、CD4、CD4/CD8、IgG均升高,但CD4/CD8、IgG 3组差异无统计学意义(P> 0. 05),而超声导入组CD3、CD4升高较其余两组更显著,且差异有统计学意义(P <0. 05)。结论:超声介导氨溴索经肺俞穴给药治疗支气管肺炎可以在一定程度上增强患儿免疫能力,促进肺炎患儿康复。
Objective: To investigate the effect for immunity of chuildren with bronchopneumonia treated by ambroxol delivered by ultrasound through Feishu point. Methods: All 120 children diagnosed as bronchopneumonia were enrolled in our hospital from June 2015 to June 2017 and were randomly divided into venous group,nebulization group and ultrasound guided group,with 40 cases in each group. Three groups have different approaches to ambroxol. All patients were detected about serum immune globulin and T cell subset before and after tretment. Results: After treatment,the average of CD3、CD4、CD4/CD8、IgG in three groups' children were higher than those before treatment. But the difference of three group on CD4/CD8、IgG were not statistically significant( P > 0. 05). While the average of CD3 and CD4 in the ultrasound guided group were significantly higher than that of the venous and nebulization group,the difference was statistically significant( P < 0. 05). Conclusion: Ambroxol delived by ultrasound through Feishu point can enhance the immunity of children with bronchopneumonia in a way,promote rehabilitation of patient.
Objective: To investigate the effect for immunity of chuildren with bronchopneumonia treated by ambroxol delivered by ultrasound through Feishu point. Methods: All 120 children diagnosed as bronchopneumonia were enrolled in our hospital from June 2015 to June 2017 and were randomly divided into venous group,nebulization group and ultrasound guided group,with 40 cases in each group. Three groups have different approaches to ambroxol. All patients were detected about serum immune globulin and T cell subset before and after tretment. Results: After treatment,the average of CD3、CD4、CD4/CD8、IgG in three groups' children were higher than those before treatment. But the difference of three group on CD4/CD8、IgG were not statistically significant( P > 0. 05). While the average of CD3 and CD4 in the ultrasound guided group were significantly higher than that of the venous and nebulization group,the difference was statistically significant( P < 0. 05). Conclusion: Ambroxol delived by ultrasound through Feishu point can enhance the immunity of children with bronchopneumonia in a way,promote rehabilitation of patient.
引文
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[9]余晓芬,陈新伟,陈进.经肺俞穴导入阿奇霉素治疗小儿肺炎支原体感染疗效观察[J].临床医学工程,2015,22(5):614-615.
[10]张雷家,张金萍,刘香荣.支气管肺炎患儿红细胞免疫功能、T细胞亚群与自由基的临床研究[J].中华微生物学和免疫学杂志,2003,11(5):348-349.
[11]梁娟英,农少云.支气管肺炎患儿细胞及体液免疫功能检测分析[J].海南医学,2010,21(16):105-106.
[12]武金萍.微波照射肺俞穴与抗感染同步治疗小儿肺炎对临床症状及免疫因子水平的影响[J].医学理论与实践,2018,31(1):53-54.
[2] Yang F. Oxygen-driving and atomized mucosolvan inhalation combined with holistic nursing in the treatment of children severe bronchial pneumonia[J]. Pakistan Journal of Pharmaceutical Sciences,2015,28(4):1477-1480.
[3]胡亚美,江载芳.诸福棠实用儿科学[M].第7版.北京:人民卫生出版社,2002:1174-1216.
[4]王卫平.儿科学[M].第8版.北京:人民卫生出版社,2013:278-284.
[5]王慧,赵焱,姜春红,等.超声透皮给药的临床进展[J].中国医药指南,2013(12):72-73.
[6]吴兆利,张庆荣.肺俞穴的古今研究[J].辽宁中医杂志,2007,34(4):504-505.
[7]吴惠敏.肺俞穴中药离子导入治疗小儿肺炎的疗效评价[J].中国医药导刊,2017,19(6). 608-609.
[8]陈会新,孔繁菊,刘淑艳,等.微波照射肺俞穴与抗感染同步治疗小儿肺炎的疗效观察[J].中国中医急症,2015,24(7):1301-1302.
[9]余晓芬,陈新伟,陈进.经肺俞穴导入阿奇霉素治疗小儿肺炎支原体感染疗效观察[J].临床医学工程,2015,22(5):614-615.
[10]张雷家,张金萍,刘香荣.支气管肺炎患儿红细胞免疫功能、T细胞亚群与自由基的临床研究[J].中华微生物学和免疫学杂志,2003,11(5):348-349.
[11]梁娟英,农少云.支气管肺炎患儿细胞及体液免疫功能检测分析[J].海南医学,2010,21(16):105-106.
[12]武金萍.微波照射肺俞穴与抗感染同步治疗小儿肺炎对临床症状及免疫因子水平的影响[J].医学理论与实践,2018,31(1):53-54.