RSV-寄主-介体三者间相互作用研究进展
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摘要
为了解国内外关于水稻条纹病毒(Rice stripe virus, RSV)-寄主-介体三者间互作关系的研究现状,采用文献检索的方法,对研究结果进行总结和比较分析。结果表明:1)RSV自身编码蛋白间存在着较为复杂的直接互作,从而保证了病毒生命过程的有序衔接。2)RSV与寄主水稻及介体灰飞虱间的间接互作,大多与病毒造成的在植物上症状,病毒经介体卵传播等特点相吻合。3)RSV编码蛋白与介体因子间的直接互作,参与了病毒在介体中的复制,传播及抵御介体免疫等生命过程。4) RSV-寄主-介体三者间互作关系的研究已成为领域内的研究热点,国内每年高水平研究论文不断涌现。针对RSV-介体互作研究中病毒与介体遗传体系均不成熟的现状,提出以下的解决方案:加快RSV全长侵染性cDNA克隆的构建或者RSV微小复制子的构建;另外可以对现有的CRISPR/Cas9技术进行优化,尽快实现对灰飞虱进行高通量的基因敲除。
To investigate the current research status of tripartite interactions of Rice stripe virus(RSV)-host-vector from home and abroad, recent researches are summarized and compared by literature search. The results show that: 1) The complex and direct interactions between the RSV encoded proteins ensured the orderly connections of the viral life cycle. 2) The indirect interactions of RSV-host-vector are mostly consistent with the characteristics of virus infection symptoms on the plant and virus transmission through the planthopper's eggs. 3) The direct interactions between viral proteins and vector factors participate in the life cycle of virus replication, transmission, and resistance to the planthopper's immunity. 4) The studies of RSV-host-vector interactions have already become a hot topic in plant virology and high-level researches are emerging now in China. In view of the immature genetic system of RSV and planthopper in studies of RSV-vector interactions, solutions such as accelerating the construction of the full-length cDNA infectious clone or the mini-replicon of RSV and optimizing of the existing CRISPR/Cas9 technology to achieve high-through gene knockout of planthopper are proposed.
To investigate the current research status of tripartite interactions of Rice stripe virus(RSV)-host-vector from home and abroad, recent researches are summarized and compared by literature search. The results show that: 1) The complex and direct interactions between the RSV encoded proteins ensured the orderly connections of the viral life cycle. 2) The indirect interactions of RSV-host-vector are mostly consistent with the characteristics of virus infection symptoms on the plant and virus transmission through the planthopper's eggs. 3) The direct interactions between viral proteins and vector factors participate in the life cycle of virus replication, transmission, and resistance to the planthopper's immunity. 4) The studies of RSV-host-vector interactions have already become a hot topic in plant virology and high-level researches are emerging now in China. In view of the immature genetic system of RSV and planthopper in studies of RSV-vector interactions, solutions such as accelerating the construction of the full-length cDNA infectious clone or the mini-replicon of RSV and optimizing of the existing CRISPR/Cas9 technology to achieve high-through gene knockout of planthopper are proposed.
引文
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