补肾益髓法对帕金森病肾虚髓减证患者非运动症状的影响
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摘要
目的观察补肾益髓法治疗帕金森病肾虚髓减证患者非运动症状的疗效。方法将60例帕金森病肾虚髓减证患者随机分为治疗组和对照组各30例,两组均以抗帕金森病西药治疗为基础,治疗组加用补肾益髓法方药治疗3个月,于治疗前及治疗1、3个月进行帕金森病睡眠量表(PDSS)、疲劳量表、嗜睡量表、便秘量表评分,于治疗前和治疗3个月采用蒙特利尔认知评估量表(MoCA)进行评分,并判定临床疗效。结果治疗3个月,治疗组临床疗效总有效率为90. 00%,对照组为66. 67%,治疗组总有效率高于对照组(P <0. 05)。治疗组治疗3个月PDSS、疲劳量表、嗜睡量表、便秘量表评分均较本组治疗前降低,且低于同时间对照组(P <0. 05);两组治疗前后MoCA评分差异无统计学意义(P> 0. 05)。结论补肾益髓法可改善帕金森病肾虚髓减证患者疲劳、日间嗜睡、睡眠障碍、便秘等非运动症状。
Objective To explore the effects of tonifying kidney and benefiting marrow method on non-motor symptoms of Parkinson' s disease with kidney deficiency and marrow reduction. Methods A total of 60 patients with Parkinson's disease with kidney deficiency and marrow reduction were randomly divided into a treatment group and a control group. Both groups were treated based on the western medicine of anti-Parkinson' s disease,and the treatment group was added with the recipe of tonifying kidney and benefiting marrow method for 3 months. The Parkinson disease sleep scale( PDSS),fatigue scale,Epworth somnolence scale,and constipation scale were scored before treatment,1 and 3 months after treatment. The Montreal cognitive assessment scale( MoCA) was used to explore the clinical effects. Results After 3 months' treatment,the total effective rate was 90. 00% in the treatment group,and 66. 67% in the control group,the treatment group significantly higher than the control group( P < 0. 05). After 3 months' treatment,scores of the PDSS,fatigue scale,Epworth somnolence scale,and constipation scale of the treatment group were lower than before treatment,and lower than the control group at the same time( P < 0. 05). There was no difference in the MoCA score of the 2 groups before and after treatment( P > 0. 05). Conclusion Tonifying kidney and benefiting marrow method is effective in improving the non-motor symptoms of Parkinson' s disease with kidney deficiency and marrow reduction,such as fatigue,daytime sleepiness,sleep disorders and constipation.
Objective To explore the effects of tonifying kidney and benefiting marrow method on non-motor symptoms of Parkinson' s disease with kidney deficiency and marrow reduction. Methods A total of 60 patients with Parkinson's disease with kidney deficiency and marrow reduction were randomly divided into a treatment group and a control group. Both groups were treated based on the western medicine of anti-Parkinson' s disease,and the treatment group was added with the recipe of tonifying kidney and benefiting marrow method for 3 months. The Parkinson disease sleep scale( PDSS),fatigue scale,Epworth somnolence scale,and constipation scale were scored before treatment,1 and 3 months after treatment. The Montreal cognitive assessment scale( MoCA) was used to explore the clinical effects. Results After 3 months' treatment,the total effective rate was 90. 00% in the treatment group,and 66. 67% in the control group,the treatment group significantly higher than the control group( P < 0. 05). After 3 months' treatment,scores of the PDSS,fatigue scale,Epworth somnolence scale,and constipation scale of the treatment group were lower than before treatment,and lower than the control group at the same time( P < 0. 05). There was no difference in the MoCA score of the 2 groups before and after treatment( P > 0. 05). Conclusion Tonifying kidney and benefiting marrow method is effective in improving the non-motor symptoms of Parkinson' s disease with kidney deficiency and marrow reduction,such as fatigue,daytime sleepiness,sleep disorders and constipation.
引文
[1]FORSAA EB,LARSEN JP,WENTZEL-LARSEN T,et al.What predicts mortality in Parkinson disease:a prospective population-based long-term study[J]. Neurology,2010,75(14):1270-1276.
[2]陈路,陈志刚,侯月.滋肾益髓方治疗帕金森病运动及非运动症状的疗效观察[J].北京中医药大学学报,2014,10(3):57-59.
[3]中华医学会神经病学分会帕金森病及运动障碍学组.中国帕金森病的诊断标准(2016版)[J].中华神经科杂志,2016,49(4):268-271.
[4]佚名.中医老年颤证诊断和疗效评定标准(试行)[J].山东中医学院学报,1992,16(6):55.
[5]沈吉康,叶民,刘卫国,等.帕金森病非运动症状的临床研究[J].临床神经病学杂志,2010,23(4):251-253.
[6]赵辉,张伟,杨新新,等.应用量表研究86例帕金森病患者睡眠障碍及与其生活质量的关系[J].徐州医科大学学报,2017,37(11):751-753.
[7]姚力萌,潘玉君.帕金森病白天过度嗜睡的病因与治疗[J].卒中与神经疾病,2018,25(5):482-485.
[8]汤海艳,王军,魏其林,等. Mo CA和MMSE评估老年帕金森病患者认知障碍的分析[J].中风与神经疾病杂志,2013,30(8):719-723.
[9]王雁,李馨,李海燕,等.帕金森病非运动症状的量表介绍及评价[J].临床神经病学杂志,2015,28(4):314-316.
[10]BRAAK H,DE VOS RA,BOHL J,et al. Gastric alphasynuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology[J]. Neurosci Lett,2006,396(1):67-72.
[11]LANG AE. A critical appraisal of the premotor symptoms of Parkinson's disease:potential usefulness in early diagnosis and design of neuroprotective trials[J]. Mov Disord,2011,26(5):775-783.
[12]CHAUDHURI KR,HEALY DG,SCHAPIRA AH. Nonmotor symptoms of Parkinson's disease:diagnosis and management[J]. Lancet Neurol,2006,5(3):235-245.
[13]邹忆怀.王永炎教授治疗振颤病(帕金森氏病)经验探讨[J].北京中医药大学学报,1996,19(4):15-16.
[14]王筠,鞠大宏,陈彦静.从中医“髓”、“肾”、“络”理论探析脑病的发生机制[J].中医杂志,2012,53(3):205-206,237.
[2]陈路,陈志刚,侯月.滋肾益髓方治疗帕金森病运动及非运动症状的疗效观察[J].北京中医药大学学报,2014,10(3):57-59.
[3]中华医学会神经病学分会帕金森病及运动障碍学组.中国帕金森病的诊断标准(2016版)[J].中华神经科杂志,2016,49(4):268-271.
[4]佚名.中医老年颤证诊断和疗效评定标准(试行)[J].山东中医学院学报,1992,16(6):55.
[5]沈吉康,叶民,刘卫国,等.帕金森病非运动症状的临床研究[J].临床神经病学杂志,2010,23(4):251-253.
[6]赵辉,张伟,杨新新,等.应用量表研究86例帕金森病患者睡眠障碍及与其生活质量的关系[J].徐州医科大学学报,2017,37(11):751-753.
[7]姚力萌,潘玉君.帕金森病白天过度嗜睡的病因与治疗[J].卒中与神经疾病,2018,25(5):482-485.
[8]汤海艳,王军,魏其林,等. Mo CA和MMSE评估老年帕金森病患者认知障碍的分析[J].中风与神经疾病杂志,2013,30(8):719-723.
[9]王雁,李馨,李海燕,等.帕金森病非运动症状的量表介绍及评价[J].临床神经病学杂志,2015,28(4):314-316.
[10]BRAAK H,DE VOS RA,BOHL J,et al. Gastric alphasynuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology[J]. Neurosci Lett,2006,396(1):67-72.
[11]LANG AE. A critical appraisal of the premotor symptoms of Parkinson's disease:potential usefulness in early diagnosis and design of neuroprotective trials[J]. Mov Disord,2011,26(5):775-783.
[12]CHAUDHURI KR,HEALY DG,SCHAPIRA AH. Nonmotor symptoms of Parkinson's disease:diagnosis and management[J]. Lancet Neurol,2006,5(3):235-245.
[13]邹忆怀.王永炎教授治疗振颤病(帕金森氏病)经验探讨[J].北京中医药大学学报,1996,19(4):15-16.
[14]王筠,鞠大宏,陈彦静.从中医“髓”、“肾”、“络”理论探析脑病的发生机制[J].中医杂志,2012,53(3):205-206,237.