基于代谢组学的胃癌检测研究进展
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摘要
代谢组学是一种快速有效识别新的癌症生物标志物的方法,已逐渐成为基因组学和蛋白质组学的补充技术。全文通过整理近五年基于代谢组学技术研究胃癌检测的相关研究,归纳胃癌相关特异代谢产物及物质代谢路径,认为今后可从葡萄糖或支链氨基酸代谢等作为切入点来探究胃癌检测的代谢组学相关物质指标。
Metabonomics was a fast and effective method to identify new cancer biomarkers,it has gradually become a complementary technology of genomics and proteomics. In this paper,researches in the past five years on gastric cancer detection based on metabolomics technology were reviewed,the specific metabolites and metabolic pathways of gastric cancer were summarized,in the future,glucose metabolism or branched chain amino acids maybe the breakthrough point to probe into gastric cancer detection indicators of metabolomics related material.
Metabonomics was a fast and effective method to identify new cancer biomarkers,it has gradually become a complementary technology of genomics and proteomics. In this paper,researches in the past five years on gastric cancer detection based on metabolomics technology were reviewed,the specific metabolites and metabolic pathways of gastric cancer were summarized,in the future,glucose metabolism or branched chain amino acids maybe the breakthrough point to probe into gastric cancer detection indicators of metabolomics related material.
引文
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[4]Wang H,Zhang H,Deng P,et al.Tissue metabolic profiling of human gastric cancer assessed by(1)H-NMR[J].BMC Cancer,2016,16:371.
[5]Corona G,Cannizzaro R,Miolo G,et al.Use of metabolomics as a complementary omic approach to implement risk criteria for first-degree relatives of gastric cancer patients[J].Int J Mol Sci,2018,19(3):E750.
[6]Lima AR,Araújo AM,Pinto J,et al.Gc-ms-based endometabolome analysis differentiates prostate cancer from normal prostate cells[J].Metabolites,2018,8(1):E23.
[7]Lou YB,Fan FX,Mu YC.The implication of diabetes metabolomics in the early diagnosis and pathogenesis of pancreatic cancer[J].J Biol Regul Homeost Agents,2018,32(1):75-82.
[8]Shu X,Xiang YB,Rothman N,et al.Prospective study of blood metabolites associated with colorectal cancer risk[J].Int J Cancer,2018,143(3):527-534.
[9]Bharti SK,Wildes F,Hung CF,et al.Metabolomic characterization of experimental ovarian cancer ascitic fluid[J].Metabolomics,2017,13:113.
[10]Yu L,Li K.Next-generation metabolomics in lung cancer diagnosis,treatment and precision medicine:mini review[J].Oncotarget,2017,8(70):115774-115786.
[11]Shi K,Wang Q,Su Y,et al.Identification and functional analyses of differentially expressed metabolites in early stage endometrial carcinoma[J].Cancer Sci,2018,109(4):1032-1043.
[12]Zhang H,Cui L,Liu W,et al.H NMR metabolic profiling of gastric cancer patients with lymph node metastasis[J].Metabolomics,2018,14(4):47.
[13]Gu J,Hu X,Shao W,et al.Metabolomic analysis reveals altered metabolic pathways in a rat model of gastric carcinogenesis[J].Oncotarget,2016,7(37):60053-60073.
[14]Chan AW,Mercier P,Schiller D,et al.(1)H-NMR urinary metabolomic profiling for diagnosis of gastric cancer[J].Br J Cancer,2016,114(1):59-62.
[15]Liang Q,Wang C.Metabolomic analysis using liquid chromatography/mass spectrometry for gastric cancer[J].Appl Biochem Biotechnol,2015,176(8):2170-2184.
[16]Chen JL,Fan J.CE-MS based on moving reaction boundary method for urinary metabolomic analysis of gastric cancer patients[J].Electrophoresis,2014,35(7):1032-1039.
[17]Companioni O,Sanz-Anquela JM,Pardo ML,et al.Gene expression study and pathway analysis of histological subtypes of intestinal metaplasia that progress to gastric cancer[J].PLoS One,2017,12(4):e0176043.
[18]Yuan LW,Yamashita H.Glucose metabolism in gastric cancer:The cutting-edge[J].World J Gastroenterol,2016,22(6):2046-2059.
[19]Wang D,Li W,Zou Q,et al.Serum metabolomic profiling of human gastric cancer and its relationship with the prognosis[J].Oncotarget,2017,8(66):110000-110015.
[20]Lario S,Ramírez-Lázaro MJ,Sanjuan-Herráez D,et al.Plasma sample based analysis of gastric cancer progression using targeted metabolomics[J].Sci Rep,2017,7(1):17774.
[21]Yang T,Luo P,Li Y,et al.A serum metabolomics study of gastric cancer based on pseudotargeted liquid chromatography-mass spectrometry approach[J].Se Pu,2014,32(2):126-132.
[22]Chen Y,Zhang J,Guo L,et al.A characteristic biosignature for discrimination of gastric cancer from healthy population by high throughput GC-MS analysis[J].Oncotarget,2016,7(52):87496-87510.
[23]Jung J,Jung Y,Bang EJ,et al.Noninvasive diagnosis and evaluation of curative surgery for gastric cancer by using NMR-based metabolomic profiling[J].Ann Surg Oncol,2014,21 Suppl 4:S736-S742.
[24]Ananieva EA.Branched-chain amino acid metabolism in cancer[J].Curr Opin Clin Nutr Metab Care,2018,21(1):64-70.