基于增材制造技术修复缺损颅骨的研究和应用
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摘要
该文运用增材制造技术快速制备三维重建的缺损颅骨植入体,通过对骨植入体材料对比分析,选择多孔羟基磷灰石材料应用于颅骨植入手术中。运用Mimics 10.0软件对临床计算机断层扫描(CT)影像数据重建三维植人体模型,采用增材制造技术制备多孔羟基磷灰石颅骨植入体,与颅骨贴合度好,表面光滑平顺,而多孔羟基磷灰石能够引导和诱导骨的形成,大大提高其生物相容性。增材制造技术快速制备的特点促使个性化颅骨修补植入物成为可能,个性化医用三维模型用于植入手术降低手术风险,术后效果好,具有推广应用的前景。
The work selected porous hydroxyapatite(HAp) for skull surgery via comparing and analyzing the disadvantages and advantages of various implant materials.Then,the HAp was fabricated into three dimensional implants for defective skull via additive manufacturing.We applied Mimics 10.0 software to reconstruct three dimensional implant model based on clinical GT imaging data.Results show that the HAp implant produced via additive manufacturing can fit skull well and the surface is smooth.In addition,the three dimensional porous HAp could lead and guide the formation of bone and improve the biocompatibility of implant.Additive manufacturing has the rapid preparation feature,which makes it possible to produce personalized implant of skull.Application of personalized three dimensional model to implant surgery can reduce the risk of surgery and has a good post- surgical effects,which indicates that the additive manufacturing technology has promising application.
The work selected porous hydroxyapatite(HAp) for skull surgery via comparing and analyzing the disadvantages and advantages of various implant materials.Then,the HAp was fabricated into three dimensional implants for defective skull via additive manufacturing.We applied Mimics 10.0 software to reconstruct three dimensional implant model based on clinical GT imaging data.Results show that the HAp implant produced via additive manufacturing can fit skull well and the surface is smooth.In addition,the three dimensional porous HAp could lead and guide the formation of bone and improve the biocompatibility of implant.Additive manufacturing has the rapid preparation feature,which makes it possible to produce personalized implant of skull.Application of personalized three dimensional model to implant surgery can reduce the risk of surgery and has a good post- surgical effects,which indicates that the additive manufacturing technology has promising application.
引文
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[11]韩艳君,姜庆辉,李木森.多孔羟基磷灰石的研究现状与发展[J].材料科学与工程学报,2004,22(6):929-932.
[12]张琳,田杰谟.多孔HA人工骨的研究[J].透析人工器官,2002,13(2):5-9.
[13]Hulbert SF,Morrison SJ,Klawitter JJ.Tissue reaction to three ceramics of porous and non-porous structures[J].J Biomed Mater Res,1972,6:3471-3474.
[14]Vaz L,Lopes AB,Almeida M.Porosity control of hydroxyapatite implants[J].J Mater Sci:Mater in Medicine,1999,10:239-242.
[15]Zeltinger J,Sherwood JK,Graham DA,et al.Effects of pore size and void fraction on cellular adhesion,proliferation,and matrix deposition[J].Tissue Eng,2001,7(5):557-572.
[2]罗新名,焦秋云,刘正义,等.颅骨缺损状态下区域血流速度变化[J].微循环学杂志,2002,12(3):12-13.
[3]Isago T,Nozaki M,Kikuchi Y,et al.Sinking skin flap syndrome:a case of improved cerebral blood flow after cranioplasty[J].Ann Plast Surg,2004,53(3):288-292.
[4]徐恭达,赵东升,姚天才.颅骨修补术后脑血流变化研究分析[J].中国医师进修杂志,2013,23:35-36.
[5]韦立煌.外伤性颅骨缺损后早期颅骨修补术30例临床观察[J].微创医学,2009,4(3):247-249.
[6]Dujovny M,Fernandez P,Alperin,et al.Post-cranioplasty cerebrospinal fluid hydrodynamic change:magnetic resonance imaging quantitative analysis[J].Neurol Res,1997,19(13):311-316.
[7]高玉华,张远明.颅骨修补术后脑血流与记忆功能变化的研究[J].临床神经外科杂志,2014,2:143-144.
[8]沈卫良,姚杏荣,于林忠,等.计算机辅助三维成型颅骨修补术与传统颅骨修补术的对比研究[J].全科医学临床教育,2013,11(1):42-44.
[9]王玮竹,朱晏军,阎玉华.颅骨修复材料的研究进展[J].化学新型材料,2004,9(32):21-23.
[10]Liu QB,Leu MC,Schmitt SM.Rapid prototyping in dentistry:technology and application[J].Int J AdvManuf Technol,2006,29(3):317-335.
[11]韩艳君,姜庆辉,李木森.多孔羟基磷灰石的研究现状与发展[J].材料科学与工程学报,2004,22(6):929-932.
[12]张琳,田杰谟.多孔HA人工骨的研究[J].透析人工器官,2002,13(2):5-9.
[13]Hulbert SF,Morrison SJ,Klawitter JJ.Tissue reaction to three ceramics of porous and non-porous structures[J].J Biomed Mater Res,1972,6:3471-3474.
[14]Vaz L,Lopes AB,Almeida M.Porosity control of hydroxyapatite implants[J].J Mater Sci:Mater in Medicine,1999,10:239-242.
[15]Zeltinger J,Sherwood JK,Graham DA,et al.Effects of pore size and void fraction on cellular adhesion,proliferation,and matrix deposition[J].Tissue Eng,2001,7(5):557-572.