乳果糖口服液治疗产后便秘61例
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摘要
目的观察乳果糖口服液治疗产后便秘的疗效与不良反应。方法选择产后发生单纯便秘、无其他病理因素的患者120例,采用随机数字表分为治疗组61例和对照组59例。治疗组给予乳果糖口服液15 m L,bid,po;对照组给予小麦纤维素颗粒3.5 g,bid,po,症状改善后药物均改为每天1次,疗程均为2周。观察患者治疗前、治疗中及治疗后1周疗效及复发情况。结果治疗组和对照组的周排便次数在治疗第1周时分别为(3.83±1.61),(3.09±1.53)次(P<0.05),治疗第2周时分别为(6.22±1.96),(5.15±1.71)次(P<0.01),治疗结束后1周时分别为(6.43±1.87),(5.29±1.64)次(P<0.01);对药物的接受程度分别为100.00%,76.27%(P<0.01)。治疗后60 d,治疗组和对照组总复发率分别为4.92%,10.17%(P>0.05)。两组均无明显不良反应。结论乳果糖口服液治疗产后便秘疗效确切,复发率低,无明显不良反应,患者易于接受,值得临床推广使用。
Objective To study the effect and adverse reaction of lactulose oral solution on the treatment of postpartum constipation. Methods A total of 120 patients with postpartum constipation were randomly divided into treatment group( n =61) and control group( n = 59). The treatment group received 15 m L lactulose oral solution,twice a day. The control group received wheat cellulose particles 3.5 g,twice a day. After the improvement of symptoms,the patient's medication frequency was changed to 1 time a day,the course of treatment was 2 weeks long. The curative effect( including before treatment,period during the treatment,and the first week after finish the whole treatment) and the recurrence of constipation after treatment were observed.Results The frequency of defecation per week in the treatment group was( 3.83± 1.61) times,that in the control group was( 3.09±1.53) times at the first week after treatment( P<0.05),those were( 6.22±1.96) and( 5.15±1.71) times respectively in the second week( P<0.01),and( 6.43±1.87),( 5.29± 1.64) times respectively at the first week after treatment( P< 0.05). The total recurrence rate in the two groups were 4. 92% and 10. 17% respectively( P > 0. 05) after follow-up to 60 d. The degree of drug acceptance in two groups was 100.00% and 76. 27% respectively( P < 0. 01). There was no obvious adverse reaction in both two groups. Conclusion The effect of lactulose oral solution on the treatment of postpartum constipation is definite and with low recurrence rate. Lactulose oral solution has a good taste,easily to be taken and to be accepted,it is worthy of clinical application.
Objective To study the effect and adverse reaction of lactulose oral solution on the treatment of postpartum constipation. Methods A total of 120 patients with postpartum constipation were randomly divided into treatment group( n =61) and control group( n = 59). The treatment group received 15 m L lactulose oral solution,twice a day. The control group received wheat cellulose particles 3.5 g,twice a day. After the improvement of symptoms,the patient's medication frequency was changed to 1 time a day,the course of treatment was 2 weeks long. The curative effect( including before treatment,period during the treatment,and the first week after finish the whole treatment) and the recurrence of constipation after treatment were observed.Results The frequency of defecation per week in the treatment group was( 3.83± 1.61) times,that in the control group was( 3.09±1.53) times at the first week after treatment( P<0.05),those were( 6.22±1.96) and( 5.15±1.71) times respectively in the second week( P<0.01),and( 6.43±1.87),( 5.29± 1.64) times respectively at the first week after treatment( P< 0.05). The total recurrence rate in the two groups were 4. 92% and 10. 17% respectively( P > 0. 05) after follow-up to 60 d. The degree of drug acceptance in two groups was 100.00% and 76. 27% respectively( P < 0. 01). There was no obvious adverse reaction in both two groups. Conclusion The effect of lactulose oral solution on the treatment of postpartum constipation is definite and with low recurrence rate. Lactulose oral solution has a good taste,easily to be taken and to be accepted,it is worthy of clinical application.
引文
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[6]妇产科通便药合理应用专家委员会.通便药在妇产科合理应用专家共识[J].中华医学杂志,2014,94(46):3619-3622.
[7]中华医学会消化病学分会胃肠动力学组,中华医学会外科学分会结直肠肛门外科学组.中国慢性便秘诊治指南(2013,武汉)[J].胃肠病学,2013,18(4):605-612.
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[9]李晓丽,李晓霞.穴位按摩合腹部按揉对产后排便的影响[J].现代中西医结合杂志,2007,16(35):5352-5353.
[10]CHEY W Y,JIN H O,LEE M H,et al.Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea[J].Am J Gastroenterol,2001,96(5):1499-1506.
[11]EVANS J M,FLEMING K C,TALLEY N J,et al.Relation of colonic transit to functional bowel disease in older people:a population-based study[J].J Am Gefiatr Soc,1998,46(1):83-87.
[12]潘国宗.走出便秘诊断和治疗的误区[J].中华全科医师杂志,2005,4(10):583-584.
[13]张龙,李姝汶,郭红宇,等.乳果糖防治产后便秘的疗效及安全性临床观察[J].兰州大学学报(医学版),2013,39(3):43-45.
[14]张宗城.乳果糖口服液防治阿片药物便秘的临床观察[J].按摩与康复医学,2012,3(10):43.
[15]汪健桥,胡桂风.乳果糖与小麦纤维素治疗妊娠期便秘的疗效观察[J].齐齐哈尔医学院学报,2015,36(24):3663-3665.
[16]王金亭.膳食纤维及其生理保健作用的研究进展[J].现化生物医学进展,2007,7(9):1414-1416.
[2]彭清慧,黄赛琼,雷法贤.运脾润通汤联合耳穴贴压治疗产后便秘60例临床观察[J].河北中医,2014,36(4):536-537.
[3]American College of Gastroenterology Chronic Constipation Task Force.An evidence-based approach to the management of chronic constipation in North America[J].Am J Gastroenterol,2005,100(Suppl 1):S1-S4.
[4]MABADEVAD U,KANE S.American Gastroenterological Association institute technical review on the use of gastrointestinal medications in pregnancy[J].Gastroenterology,2006,131(2):283-311.
[5]孟珊,潘英连,邓青春,等.乳果糖治疗产后便秘的疗效及安全[J].中华医学杂志,2015,95(28):2288-2290.
[6]妇产科通便药合理应用专家委员会.通便药在妇产科合理应用专家共识[J].中华医学杂志,2014,94(46):3619-3622.
[7]中华医学会消化病学分会胃肠动力学组,中华医学会外科学分会结直肠肛门外科学组.中国慢性便秘诊治指南(2013,武汉)[J].胃肠病学,2013,18(4):605-612.
[8]徐晓路.乳果糖合用金双歧胶囊治疗老年功能性便秘临床观察[J].北方药学,2013,10(3):32-33.
[9]李晓丽,李晓霞.穴位按摩合腹部按揉对产后排便的影响[J].现代中西医结合杂志,2007,16(35):5352-5353.
[10]CHEY W Y,JIN H O,LEE M H,et al.Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea[J].Am J Gastroenterol,2001,96(5):1499-1506.
[11]EVANS J M,FLEMING K C,TALLEY N J,et al.Relation of colonic transit to functional bowel disease in older people:a population-based study[J].J Am Gefiatr Soc,1998,46(1):83-87.
[12]潘国宗.走出便秘诊断和治疗的误区[J].中华全科医师杂志,2005,4(10):583-584.
[13]张龙,李姝汶,郭红宇,等.乳果糖防治产后便秘的疗效及安全性临床观察[J].兰州大学学报(医学版),2013,39(3):43-45.
[14]张宗城.乳果糖口服液防治阿片药物便秘的临床观察[J].按摩与康复医学,2012,3(10):43.
[15]汪健桥,胡桂风.乳果糖与小麦纤维素治疗妊娠期便秘的疗效观察[J].齐齐哈尔医学院学报,2015,36(24):3663-3665.
[16]王金亭.膳食纤维及其生理保健作用的研究进展[J].现化生物医学进展,2007,7(9):1414-1416.