旋毛虫感染相关抗体及细胞因子的研究进展
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摘要
旋毛虫感染免疫很复杂,包括体液免疫和细胞免疫,而且多种细胞因子间相互影响、互相作用,在免疫攻击和病理反应中发挥各自的作用。旋毛虫感染除对人体造成危害外,也有可能防治某些疾病。其具体的作用机制,还有待深入研究。
Trichinella spiralis infection immunity is very complicated,including humoral immunity,cellular immunity and a variety of cytokine mutual influence between each other,that play a role in immune attack and pathological reaction.It is possible that Trichinella spiralis infection prevent and control some the diseases in addition to the harm.An intensive study will be made on the specific mechanisms in future.
Trichinella spiralis infection immunity is very complicated,including humoral immunity,cellular immunity and a variety of cytokine mutual influence between each other,that play a role in immune attack and pathological reaction.It is possible that Trichinella spiralis infection prevent and control some the diseases in addition to the harm.An intensive study will be made on the specific mechanisms in future.
引文
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[13]韩化敏,崔晶,王中全.白细胞介素在旋毛虫感染中的作用[J].热带病与寄生虫学,2004,2(3):180-184.
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[15]刘集鸿,罗秋云,许岸高.小鼠感染旋毛虫后血清中IL-2、IL-8含量变化的实验研究[J].中华医院感染学杂志,2004,14(4):381.
[16]Picherot M,Oswald IP,Cote M,et al.Swine infection with Trichinella spiralis:Comparative analysis of the mucosal in-testinal and systemic immune responses[J].Vet Parasitol,2007,143(3):122-130.
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[19]Khan WI,Richard M,Akiho H,et al.Modulation of intesti-nal muscle contraction by interleukin-9(IL-9)or IL-9neu-tralization:correlation with worm expulsion in murine nema-tode infections[J].Infect Immun,2003,71(5):2430-2438.
[20]Helmby H,Grencis RK.Contrasting roles for IL-10in protec-tive immunity to different life cycle stages of intestinal nema-tode parasites[J].Eur J Immunol,2003,33(9):2382-2390.
[21]Helmby H,Grencis RK.IFN-gamma-independent effects of IL-12during intestinal nematode infection[J].J Immunol,2003,171(7):3691-3696.
[22]Saunders KA,Raune T,Cooke A,et al.Inhibition of autoim-mune type1diabetes by gastrointestinal helminth infection[J].Infect Immun,2007,75(1):397-407.
[23]吴涛,张西臣,李建华,等.不同旋毛虫粗抗原对BALB/c小鼠体内Sp2/0肿瘤抑制作用观察[J].中国病原生物学杂志,2007,2(4):269-272.
[2]Khumjui C,Choomkasien P,Dekumyoy P,et al.Outbreak of Trichinellosis caused by Trichinella papuae,Thailand,2006[J].Emerg Infect Dis,2008,14(12):1913-1915.
[3]Venus M,Puntaric D,Grgic M,et al.The effect of pest con-trol on the incidence of trichinosis in Virovitica-Podravina County,Croatia[J].Vet Parasitol,2008,156(3-4):226-233.
[4]M ller L N,Koch A,Petersen E,et al.Trichinella infection in a hunting community in East Greenland[J].Epidemiol In-fect,2010,138(9):1252-1256.
[5]Lo YC,Hung CC,Lai CS,et al.Human Trichinosis after Con-sumption of Soft-Shelled Turtles,Taiwan[J].Emerg Infect Dis,2009,15(12):2056-2058.
[6]毛立群,牛秀珑,杨静,等.旋毛虫肌幼虫抗原免疫小鼠抗感染能力及其机制的研究[J].中国病原生物学杂志,2010,5(12):915-917.
[7]马军莉,段效明,陈会海,等.肥大细胞介导的ADCC效应在旋毛虫病免疫中的作用研究[J].中国病原生物学杂志,2011,6(4):280-282,285.
[8]Dixon H,Little MC,Else KJ.Characterisation of the protec-tive immune response following subcutaneous vaccination of susceptible mice against Trichuris muris[J].Int J Parasitol,2010,40(6):683-693.
[9]李立宏,陈立峰,石永威,等.感染旋毛虫兔血嗜酸性粒细胞计数的动态变化[J].中国热带医学,2011,11(9):1074-1075.
[10]贺亚奇,刘攀,吴秀萍,等.非特异性效应细胞抗旋毛虫感染作用机制研究进展[J].动物医学进展,2012,33(3):72-75.
[11]闫玉文,李鹏,邢杰,等.IgG和IgE介导的免疫反应在旋毛虫病免疫机理中的作用[J].武警医学院学报,2007,16(4):348-351.
[12]邢杰,董铮,马萍,等.IgE在小鼠旋毛虫感染急性期免疫反应中的作用[J].热带医学杂志,2010,10(12):1372-1375,1379.
[13]韩化敏,崔晶,王中全.白细胞介素在旋毛虫感染中的作用[J].热带病与寄生虫学,2004,2(3):180-184.
[14]张光玉,王云甫,黄朝芬,等.IL-2对小鼠旋毛虫感染的影响[J].Journal of Tropical Medicine,2006,6(5):542.
[15]刘集鸿,罗秋云,许岸高.小鼠感染旋毛虫后血清中IL-2、IL-8含量变化的实验研究[J].中华医院感染学杂志,2004,14(4):381.
[16]Picherot M,Oswald IP,Cote M,et al.Swine infection with Trichinella spiralis:Comparative analysis of the mucosal in-testinal and systemic immune responses[J].Vet Parasitol,2007,143(3):122-130.
[17]Akiho H,Blennerhassett P,Deng Y,et al.Role of IL-4,IL-13,and STAT6in inflammation-induced hypercontrac-tility of murine smooth muscle cells[J].Am J Physiol Gastro-intest Liver Physiol,2002,282(2):226-232.
[18]Marillier RG,Brombacher TM,Dewals B,et al.IL-4Rα-responsive smooth muscle cells increase intestinal hy-percontractility and contribute to resistance during acute schistosomiasis[J].Am J Physiol Gastrointest Liver Physiol,2010,298(6):G943-95l.
[19]Khan WI,Richard M,Akiho H,et al.Modulation of intesti-nal muscle contraction by interleukin-9(IL-9)or IL-9neu-tralization:correlation with worm expulsion in murine nema-tode infections[J].Infect Immun,2003,71(5):2430-2438.
[20]Helmby H,Grencis RK.Contrasting roles for IL-10in protec-tive immunity to different life cycle stages of intestinal nema-tode parasites[J].Eur J Immunol,2003,33(9):2382-2390.
[21]Helmby H,Grencis RK.IFN-gamma-independent effects of IL-12during intestinal nematode infection[J].J Immunol,2003,171(7):3691-3696.
[22]Saunders KA,Raune T,Cooke A,et al.Inhibition of autoim-mune type1diabetes by gastrointestinal helminth infection[J].Infect Immun,2007,75(1):397-407.
[23]吴涛,张西臣,李建华,等.不同旋毛虫粗抗原对BALB/c小鼠体内Sp2/0肿瘤抑制作用观察[J].中国病原生物学杂志,2007,2(4):269-272.