阴茎层次训练法治疗早泄的临床观察
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摘要
目的:观察阴茎层次训练法治疗早泄的疗效。方法:中南大学湘雅医院中西医结合男科门诊随机选取64例早泄患者,将其分为阴茎层次训练组和达泊西汀组,各有32例,治疗4周,记录治疗前后的阴道内射精潜伏时间(IELT),中国早泄患者性功能评价表(CIPE-5)评分。结果:10例患者中途退出研究。54例随访患者中,阴茎层次训练组29例,达泊西汀组25例。阴茎层次训练法显著增加了患者IELT[从(0.89±0.75)min增至(3.12±2.39)min]和CIPE-5评分[从(8.95±3.26)分增至(18.16±5.27)分],其差异均具有统计学意义(均P<0.05)。结论:阴茎层次训练法可以有效延长性生活时间,治疗早泄。
Objective: To evaluate the effect of the gradational training method of penis in the treatment of premature ejaculation( PE). Methods: 64 PE patients were randomly selected from Department of Andrology Integrated Traditional Chinese and Western Medicine of Xiangya Hospital of Central South University to receive the gradational training method of penis( experimental group,n = 32) or oral medication of dapoxetine hydrochloride( control group,n = 32),all for 4 weeks. The clinical effect was evaluated by means of recording and comparing the changes in the intravaginal ejaculation latency time( IELT) and Chinese Index of Premature Ejaculation( CIPE)scores between before and after training or medication. Results: 10 patients dropped out. Of the 54 patients followed up,there were 29 cases from experimental group and 25 cases from control group. Compared with the baseline,the IELT was significantly increased after 4 weeks of treatment,experimental group [( 0. 89 ± 0. 75) mins vs( 3. 12 ± 2. 39) mins],P < 0. 05 and the control group [( 0. 93 ± 0. 51) mins vs( 2. 81 ± 1. 69) mins],P < 0. 05,and so was the CIPE score in the experimental group [( 8. 95 ± 3. 26) vs( 18. 16 ± 5. 27) ],P < 0. 05 and control group [( 9. 31 ± 2. 13) vs( 17. 54 ± 6. 47) ],P < 0. 05. Conclusions: The gradational training method of penis has a definite and lasting effect in the treatment of PE.
Objective: To evaluate the effect of the gradational training method of penis in the treatment of premature ejaculation( PE). Methods: 64 PE patients were randomly selected from Department of Andrology Integrated Traditional Chinese and Western Medicine of Xiangya Hospital of Central South University to receive the gradational training method of penis( experimental group,n = 32) or oral medication of dapoxetine hydrochloride( control group,n = 32),all for 4 weeks. The clinical effect was evaluated by means of recording and comparing the changes in the intravaginal ejaculation latency time( IELT) and Chinese Index of Premature Ejaculation( CIPE)scores between before and after training or medication. Results: 10 patients dropped out. Of the 54 patients followed up,there were 29 cases from experimental group and 25 cases from control group. Compared with the baseline,the IELT was significantly increased after 4 weeks of treatment,experimental group [( 0. 89 ± 0. 75) mins vs( 3. 12 ± 2. 39) mins],P < 0. 05 and the control group [( 0. 93 ± 0. 51) mins vs( 2. 81 ± 1. 69) mins],P < 0. 05,and so was the CIPE score in the experimental group [( 8. 95 ± 3. 26) vs( 18. 16 ± 5. 27) ],P < 0. 05 and control group [( 9. 31 ± 2. 13) vs( 17. 54 ± 6. 47) ],P < 0. 05. Conclusions: The gradational training method of penis has a definite and lasting effect in the treatment of PE.
引文
[1]郭军,王福,耿强,等.国际性医学会(ISSM)《早泄诊治指南(2010年版)》解读.中国性科学,2011,20(7):5-8.
[2]Pryor JL,Althof SE,Steidle C,et al.Efficacy and tolerability of dapoxetine in treatment of premature ejaculation:An integrated analysis of two double-blind,randomised controlled trials.Lancet,2006,368(9539):929-937.
[3]Kaufman JM,Rosen RC,Mudumbi RV,et al.Treatment benefit of Dapoxetine for premature ejaculation:Results from a placebo-controlled phase III trial.BJU Int,2009,103(5):651-658.
[4]杨林,贺大林.2015版欧洲性功能障碍指南最新简介——早泄.现代泌尿外科杂志,2016,21(9):717-719.
[5]王宁华,苏元华,董锐,等.心理治疗联合盐酸舍曲林治疗早泄效果及对患者性生活满意度的影响.中国性科学,2017,26(2):10-12.
[6]王光,袁学明,梁如生,等.单纯性早泄综合治疗的临床研究.广州医学院学报,2015(4):104-105,113.
[7]夏佳东,戴玉田.早泄神经生物学发病机制的研究进展.中华男科学杂志,2014,20(12):1131-1135.
[8]蒋毅.早泄的研究进展.中国冶金工业医学杂志,2013,30(5):524-525.
[9]陈潇雨,屈颖伟,王锁刚.达泊西汀治疗早泄的疗效和安全性分析.中华男科学杂志,2016,22(5):411-414.
[10]陈盛镱,徐潘,谢作钢.生物反馈训练治疗早泄60例.浙江中西医结合杂志,2014,24(10):898-900.
[11]王晓峰.早泄诊断和治疗.中华男科学杂志,2011,17(1):3-7.
[12]Bustato W,Galindo CC.Topical anaesthetic use for treating premature ejaculation:A double-blind,randomised,placebo-controlled study.BJU Int,2004,93(7):1018-1021.
[13]张春影,张海峰,郭军,等.改良式阴茎背神经切断术治疗原发性早泄128例.中华男科学杂志,2005,11(10):789,791.
[14]孙中义,周波,靳风烁.早泄的外科治疗——慎思笃行.现代泌尿外科杂志,2014,19(9):570-573.
[15]Melnik T,Glina S,Rodrigues OM Jr.Psychological intervention for premature ejaculation.Nat Rev Urol,2009,6(9):501-508.
[16]陈国宏,宋竖旗,张亚强.行为-心理疗法治疗早泄的临床试验研究.中华男科学杂志,2009,15(10):929-931.
[17]夏佳东,韩友峰,龚曹科,等.阴茎背神经体感诱发电位对早泄的诊断价值.中国男科学杂志,2012,26(12):17-21.
[18]丁庆标.选择性阴茎背神经分支离断术治疗早泄78例报告.中国实用神经疾病杂志,2017,20(7):129-130.
[19]Althof SE,Mc Mahon CG,Waldinger MD,et al.An update of the international society of sexual medicine’s guidelines for the diagnosis and treatment of premature ejaculation(PE).Sex Med,2014,2(2):60-90.
[20]周庭友,李彦锋.盐酸达泊西汀治疗早泄的临床研究进展.中华男科学杂志,2015,21(10):931-936.
[2]Pryor JL,Althof SE,Steidle C,et al.Efficacy and tolerability of dapoxetine in treatment of premature ejaculation:An integrated analysis of two double-blind,randomised controlled trials.Lancet,2006,368(9539):929-937.
[3]Kaufman JM,Rosen RC,Mudumbi RV,et al.Treatment benefit of Dapoxetine for premature ejaculation:Results from a placebo-controlled phase III trial.BJU Int,2009,103(5):651-658.
[4]杨林,贺大林.2015版欧洲性功能障碍指南最新简介——早泄.现代泌尿外科杂志,2016,21(9):717-719.
[5]王宁华,苏元华,董锐,等.心理治疗联合盐酸舍曲林治疗早泄效果及对患者性生活满意度的影响.中国性科学,2017,26(2):10-12.
[6]王光,袁学明,梁如生,等.单纯性早泄综合治疗的临床研究.广州医学院学报,2015(4):104-105,113.
[7]夏佳东,戴玉田.早泄神经生物学发病机制的研究进展.中华男科学杂志,2014,20(12):1131-1135.
[8]蒋毅.早泄的研究进展.中国冶金工业医学杂志,2013,30(5):524-525.
[9]陈潇雨,屈颖伟,王锁刚.达泊西汀治疗早泄的疗效和安全性分析.中华男科学杂志,2016,22(5):411-414.
[10]陈盛镱,徐潘,谢作钢.生物反馈训练治疗早泄60例.浙江中西医结合杂志,2014,24(10):898-900.
[11]王晓峰.早泄诊断和治疗.中华男科学杂志,2011,17(1):3-7.
[12]Bustato W,Galindo CC.Topical anaesthetic use for treating premature ejaculation:A double-blind,randomised,placebo-controlled study.BJU Int,2004,93(7):1018-1021.
[13]张春影,张海峰,郭军,等.改良式阴茎背神经切断术治疗原发性早泄128例.中华男科学杂志,2005,11(10):789,791.
[14]孙中义,周波,靳风烁.早泄的外科治疗——慎思笃行.现代泌尿外科杂志,2014,19(9):570-573.
[15]Melnik T,Glina S,Rodrigues OM Jr.Psychological intervention for premature ejaculation.Nat Rev Urol,2009,6(9):501-508.
[16]陈国宏,宋竖旗,张亚强.行为-心理疗法治疗早泄的临床试验研究.中华男科学杂志,2009,15(10):929-931.
[17]夏佳东,韩友峰,龚曹科,等.阴茎背神经体感诱发电位对早泄的诊断价值.中国男科学杂志,2012,26(12):17-21.
[18]丁庆标.选择性阴茎背神经分支离断术治疗早泄78例报告.中国实用神经疾病杂志,2017,20(7):129-130.
[19]Althof SE,Mc Mahon CG,Waldinger MD,et al.An update of the international society of sexual medicine’s guidelines for the diagnosis and treatment of premature ejaculation(PE).Sex Med,2014,2(2):60-90.
[20]周庭友,李彦锋.盐酸达泊西汀治疗早泄的临床研究进展.中华男科学杂志,2015,21(10):931-936.