香砂六君子丸协同“四联疗法”治疗脾胃虚弱合Hp型慢性胃炎的疗效分析
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摘要
目的:探讨香砂六君子丸协同"四联疗法"治疗脾胃虚弱合Hp型慢性胃炎的临床疗效。方法:选取符合纳入标准的60例脾胃虚弱合Hp型慢性胃炎患者随机分为对照组和研究组,每组30例,对照组患者采用传统的"四联疗法"治疗,研究组患者在对照组的基础上口服香砂六君子丸治疗,比较两组患者的临床疗效、治疗前后中医证候评分、Hp清除率及复发率。结果:研究组患者的治疗总有效率及Hp清除率显著高于对照组,复发率显著低于对照组,两组比较具有显著差异性(P <0. 05),治疗前两组患者各中医证候评分之间比较无显著性差异(P> 0. 05),治疗后两组患者各中医证候评分均明显降低,且研究组显著优于对照组,差异具有统计学意义(P <0. 05)。结论:香砂六君子丸协同"四联疗法"可有效改善患者的中医证候,清除Hp,减少复发,提高治疗效果,在脾胃虚弱合Hp型慢性胃炎的治疗中具有重要应用价值。
Objective: To explore the clinical efficacy of Xiangsha Liujunzi Pill combined with "Quadruple Therapy"in treatment of Hp related chronic gastritis due to deficiency of Spleen and Stomach. Methods: 60 patients with Hp related chronic gastritis due to deficiency of Spleen and Stomach were randomly divided into the control group and the study group,with 30 cases in each group. The control group was treated with traditional "Quadruple Therapy"; on which basis,the study group was also treated with Xiangsha Liujunzi Pill.Clinical effect,TCM syndrome scores,Hp clearance rate,and recurrence rate were compared between the two groups before and after treatment. Results: The total effective rate and Hp clearance rate were obviously higher in the study group than those in the control group( P < 0. 05); the recurrence rate was significantly lower in the study group than that in the control group( P < 0. 05). There was no significant difference in TCM syndrome scores between the two groups before treatment( P > 0. 05); TCM syndrome scores were both decreased in the two groups after treatment( P < 0. 05); the decrease of the study group was more significant compared to that of the control group( P < 0. 05). Conclusion: Xiangsha Liujunzi Pill combined with"Quadruple Therapy"has significant value in treatment of Hp related chronic gastritis due to deficiency of Spleen and Stomach,it can effectively improve TCM syndrome scores,remove Hp and decrease recurrence rate to increase the curative efficacy.
Objective: To explore the clinical efficacy of Xiangsha Liujunzi Pill combined with "Quadruple Therapy"in treatment of Hp related chronic gastritis due to deficiency of Spleen and Stomach. Methods: 60 patients with Hp related chronic gastritis due to deficiency of Spleen and Stomach were randomly divided into the control group and the study group,with 30 cases in each group. The control group was treated with traditional "Quadruple Therapy"; on which basis,the study group was also treated with Xiangsha Liujunzi Pill.Clinical effect,TCM syndrome scores,Hp clearance rate,and recurrence rate were compared between the two groups before and after treatment. Results: The total effective rate and Hp clearance rate were obviously higher in the study group than those in the control group( P < 0. 05); the recurrence rate was significantly lower in the study group than that in the control group( P < 0. 05). There was no significant difference in TCM syndrome scores between the two groups before treatment( P > 0. 05); TCM syndrome scores were both decreased in the two groups after treatment( P < 0. 05); the decrease of the study group was more significant compared to that of the control group( P < 0. 05). Conclusion: Xiangsha Liujunzi Pill combined with"Quadruple Therapy"has significant value in treatment of Hp related chronic gastritis due to deficiency of Spleen and Stomach,it can effectively improve TCM syndrome scores,remove Hp and decrease recurrence rate to increase the curative efficacy.
引文
[1] PAVLe Matak,MYLENe Heinis,JACQUES R R. Mathieu et al. Myeloid HIF-1 Is Protective in Helicobacter pylori-Mediated Gastritis[J]. The Journal of Immunology:Official Journal of the American Association of Immunologists,2015,194(7):3259-3266.
[2]朱婷婷.六君子丸联合四联疗法提高脾胃虚弱型Hp感染者根除率的研究[D].北京:北京中医药大学,2013.
[3]孟繁璞.中西医结合治疗慢性胃炎伴幽门螺杆菌感染的疗效观察[D].北京:北京中医药大学,2013.
[4]韩建信.香砂六君子汤合四逆散治疗慢性萎缩性胃炎60例[J].陕西中医,2013,34(2):178-179.
[5]余晓春.辨证分型联合西药治疗慢性萎缩性胃炎随机平行对照研究[J].实用中医内科杂志,2017,31(2):34-36.
[6]伍伟雄,李茜,骆子牛.中西医结合治疗脾胃虚寒型幽门螺杆菌感染慢性胃炎70例[J].中国民族民间医药,2017,26(3):121-123.
[7]毕晓菊,何秀堂.中西医结合治疗脾胃湿热型幽门螺杆菌相关性慢性胃炎[J].湖北中医杂志,2015,37(1):43.
[8]赵明慧.中西医结合治疗老年慢性胃炎疗效观察[J].中国老年保健医学,2015,13(3):39-40.
[9]汪楠,王垂杰,李玉锋.中药联合“四联疗法”治疗Hp阳性慢性胃炎疗效观察[J].中国中西医结合杂志,2017,37(4):406-409.
[10]由丽娜,高璇,热依汗古丽·乌修尔,等.中西医结合治疗脾胃湿热型幽门螺杆菌相关性慢性胃炎的临床观察[J].中国全科医学,2012,15(16):1891-1892.
[11]郭明冬.中西医结合治疗老年脾胃虚弱型慢性胃炎患者的疗效[J].中国老年学杂志,2014,34(5):1409-1410.
[12]刘娟,唐红,秦萍,等.十味温脾汤治疗脾胃虚弱型慢性萎缩性胃炎疗效观察[J].陕西中医,2017,38(9):1185-1186.
[13]丁玉玲.中西医结合治疗脾胃湿热型幽门螺杆菌相关性慢性胃炎的疗效分析[J].甘肃科技,2017,33(16):133-134.
[14]王彦. Hp相关性慢性胃炎证素研究及中医药治疗的疗效评价研究[D].北京:北京中医药大学,2013.
[15]唐友明.香砂六君子丸治疗脾胃虚寒型慢性萎缩性胃炎75例临床观察[J].云南中医中药杂志,2010,31(12):48-49.
[16]田腊群,郭军,邵建明.李学武运用香砂六君子汤加味治疗脾虚型慢性萎缩性胃炎临床经验[J].陕西中医,2015,36(12):1641-1642.
[2]朱婷婷.六君子丸联合四联疗法提高脾胃虚弱型Hp感染者根除率的研究[D].北京:北京中医药大学,2013.
[3]孟繁璞.中西医结合治疗慢性胃炎伴幽门螺杆菌感染的疗效观察[D].北京:北京中医药大学,2013.
[4]韩建信.香砂六君子汤合四逆散治疗慢性萎缩性胃炎60例[J].陕西中医,2013,34(2):178-179.
[5]余晓春.辨证分型联合西药治疗慢性萎缩性胃炎随机平行对照研究[J].实用中医内科杂志,2017,31(2):34-36.
[6]伍伟雄,李茜,骆子牛.中西医结合治疗脾胃虚寒型幽门螺杆菌感染慢性胃炎70例[J].中国民族民间医药,2017,26(3):121-123.
[7]毕晓菊,何秀堂.中西医结合治疗脾胃湿热型幽门螺杆菌相关性慢性胃炎[J].湖北中医杂志,2015,37(1):43.
[8]赵明慧.中西医结合治疗老年慢性胃炎疗效观察[J].中国老年保健医学,2015,13(3):39-40.
[9]汪楠,王垂杰,李玉锋.中药联合“四联疗法”治疗Hp阳性慢性胃炎疗效观察[J].中国中西医结合杂志,2017,37(4):406-409.
[10]由丽娜,高璇,热依汗古丽·乌修尔,等.中西医结合治疗脾胃湿热型幽门螺杆菌相关性慢性胃炎的临床观察[J].中国全科医学,2012,15(16):1891-1892.
[11]郭明冬.中西医结合治疗老年脾胃虚弱型慢性胃炎患者的疗效[J].中国老年学杂志,2014,34(5):1409-1410.
[12]刘娟,唐红,秦萍,等.十味温脾汤治疗脾胃虚弱型慢性萎缩性胃炎疗效观察[J].陕西中医,2017,38(9):1185-1186.
[13]丁玉玲.中西医结合治疗脾胃湿热型幽门螺杆菌相关性慢性胃炎的疗效分析[J].甘肃科技,2017,33(16):133-134.
[14]王彦. Hp相关性慢性胃炎证素研究及中医药治疗的疗效评价研究[D].北京:北京中医药大学,2013.
[15]唐友明.香砂六君子丸治疗脾胃虚寒型慢性萎缩性胃炎75例临床观察[J].云南中医中药杂志,2010,31(12):48-49.
[16]田腊群,郭军,邵建明.李学武运用香砂六君子汤加味治疗脾虚型慢性萎缩性胃炎临床经验[J].陕西中医,2015,36(12):1641-1642.