腹腔镜手术治疗结肠癌的疗效及对患者血清中MIF、VEGF、Ang-2和Tie-2的影响
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摘要
目的探讨腹腔镜手术治疗结肠癌的疗效及对患者血清中巨噬细胞游走抑制因子(macrophage migration inhibitory factor,MIF)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、血管生成素-2 (Angiogenin-2,Ang-2)及其受体Tie2的影响。方法将100例结肠癌患者随机分为观察组(给予腹腔镜手术,n=50)和对照组(传统开腹切除术,n=50)。观察2组患者疗效、术后并发症及手术治疗前后患者血清中MIF、VEGF、Ang-2和Tie-2浓度变化。结果观察组患者术后切口长度、术中出血量和肠道功能恢复时间较对照组明显减少,术后住院时间比对照组明显缩短,差异具有统计学意义(P <0. 05); 2组患者手术时间、总费用没有明显差异(P> 0. 05)。与对照组相比,观察组患者手术治疗后切口感染、肠梗阻、腹腔积液、皮下气肿和肺部感染等并发症人数明显减少,差异具有统计学意义(P <0. 05)。与治疗前相比,治疗后对照组和观察组患者血清内MIF、VEGF、Ang-2及Tie-2含量显著下降(P <0. 05),且观察组较对照组下降更为显著,差异具有统计学意义(P <0. 05)。结论腹腔镜手术治疗结肠癌具有较好的临床疗效,创伤小,并发症少,可有效降低患者体内MIF、VEGF、Ang-2和Tie-2浓度表达。
Objective To investigate the efficacy of laparoscopic surgery for colon cancer and to detect macrophage migration inhibitory factor( MIF),vascular endothelial growth factor( VEGF) and angiogenin in serum.-2( Angiogenin-2,Ang-2)and its receptor Tie2 effects. Methods One hundred colon cancer patients were randomized into an observation group( laparoscopic surgery,n = 50) and a control group( traditional open resection,n = 50). The serum concentrations of MIF,VEGF,Ang-2 and Tie-2 in the serum of the two groups were observed before and after surgery. Results The length of incision,intraoperative blood loss and intestinal function recovery time in the observation group were significantly lower than those in the control group.The postoperative hospital stay was significantly shorter than the control group,and the difference was statistically significant( P <0. 05). There was no significant difference in operation time and total cost( P > 0. 05). Compared with the control group,the number of complications such as wound infection,intestinal obstruction,ascites,subcutaneous emphysema and pulmonary infection was significantly reduced in the observation group,and the difference was statistically significant( P < 0. 05). Compared with before treatment,the serum levels of MIF,VEGF,Ang-2 and Tie-2 in the control group and the observation group were significantly decreased( P < 0. 05). The observation group was more significant than the control group,and the difference was statistically significant( P < 0. 05). Conclusion Laparoscopic surgery for colon cancer has a good clinical effect,with less trauma and less complications,which can effectively reduce the expression of MIF,VEGF,Ang-2 and Tie-2 in patients.
Objective To investigate the efficacy of laparoscopic surgery for colon cancer and to detect macrophage migration inhibitory factor( MIF),vascular endothelial growth factor( VEGF) and angiogenin in serum.-2( Angiogenin-2,Ang-2)and its receptor Tie2 effects. Methods One hundred colon cancer patients were randomized into an observation group( laparoscopic surgery,n = 50) and a control group( traditional open resection,n = 50). The serum concentrations of MIF,VEGF,Ang-2 and Tie-2 in the serum of the two groups were observed before and after surgery. Results The length of incision,intraoperative blood loss and intestinal function recovery time in the observation group were significantly lower than those in the control group.The postoperative hospital stay was significantly shorter than the control group,and the difference was statistically significant( P <0. 05). There was no significant difference in operation time and total cost( P > 0. 05). Compared with the control group,the number of complications such as wound infection,intestinal obstruction,ascites,subcutaneous emphysema and pulmonary infection was significantly reduced in the observation group,and the difference was statistically significant( P < 0. 05). Compared with before treatment,the serum levels of MIF,VEGF,Ang-2 and Tie-2 in the control group and the observation group were significantly decreased( P < 0. 05). The observation group was more significant than the control group,and the difference was statistically significant( P < 0. 05). Conclusion Laparoscopic surgery for colon cancer has a good clinical effect,with less trauma and less complications,which can effectively reduce the expression of MIF,VEGF,Ang-2 and Tie-2 in patients.
引文
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[4]李梅.腹腔镜与开腹手术对妇科疾病患者凝血功能及术后静脉血栓相关事件的影响[J].血栓与止血学,2017,23(6):950-952.
[5]吕震.急性胆囊炎患者腹腔镜胆囊切除术转开腹手术的危险因素分析[J].现代诊断与治疗,2017,28(2):346-347.
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[9]王春英,徐璨,薛梅平.早期活动对腹腔镜肾部分切除患者术后康复的影响[J].现代医学,2017,45(9):1355-1357.
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[12]杨青春.腹腔镜手术联合米非司酮对子宫内膜异位症患者血清MIF、VEGF和VEGFR的影响[J].河北医药,2015,37(19):2900-2903.
[13]黄荣,汪泓,陈保华,等.巨噬细胞移动抑制因子促进有氧糖酵解与直肠癌细胞耐药性的关系[J].中国普通外科杂志,2017,26(10):1265-1271.
[14]徐海波,熊异平,余恒勇.膀胱癌组织中MMP-2、MMP-9、Survivin、Livin和VEGF表达的临床意义分析[J].标记免疫分析与临床,2017,24(1):51-54.
[15]李敬,刘定海,邹宁,等.HIF-2α、VEGF、COX-2、MM-P-9表达及其与肾细胞癌血管生成的关系分析[J].标记免疫分析与临床,2017,24(11):1243-1246.
[16]克尤木·阿不来提,周应恩,布瓦扎尔·沙吾提.鸦胆子油乳剂辅助经导管肝动脉化疗栓塞术治疗肝癌患者临床疗效及对血浆内毒素、血管内皮生长因子水平影响[J].临床军医杂志,2017,45(8):851-853+856.
[17]吕彦,王冰,陈会生.阿托伐他汀对大鼠血清VEG-F、Ang-1以及Ang-2影响[J].临床军医杂志,2017,45(2):116-118,123.
[2]王益,万远太,刘蓓,等.趋化因子受体CcR5在结肠癌中的表达及临床意义[J].实用癌症杂志,2017,32(2):214-217.
[3]黄志敏,尹鹤松.腹腔镜修补术与胃大部分切除治疗急性胃穿孔的效果比较[J].现代医学,2017,45(6):849-851.
[4]李梅.腹腔镜与开腹手术对妇科疾病患者凝血功能及术后静脉血栓相关事件的影响[J].血栓与止血学,2017,23(6):950-952.
[5]吕震.急性胆囊炎患者腹腔镜胆囊切除术转开腹手术的危险因素分析[J].现代诊断与治疗,2017,28(2):346-347.
[6]张澍田.中国早期结直肠癌及癌前病变筛查与诊治共识[M].北京:人民卫生出版社,2015:26-31.
[7]李世拥.实用结直肠癌外科学[M].北京:人民卫生出版社,2012:451-455.
[8]张金倩,陈洪.ACLY在结肠癌组织中的表达及其临床意义[J].东南大学学报(医学版),2017,36(6):962-965.
[9]王春英,徐璨,薛梅平.早期活动对腹腔镜肾部分切除患者术后康复的影响[J].现代医学,2017,45(9):1355-1357.
[10]方健.腹腔镜结肠癌手术患者快速康复外科护理的应用及效果分析[J].实用临床医药杂志,2017,21(6):125-128.
[11]张利军,王旺河,宋娇娇.开腹手术与腹腔镜对结肠癌患者术中出血量、术后进食时间及远期疗效对比的研究[J].齐齐哈尔医学院学报,2017,38(6):659-660.
[12]杨青春.腹腔镜手术联合米非司酮对子宫内膜异位症患者血清MIF、VEGF和VEGFR的影响[J].河北医药,2015,37(19):2900-2903.
[13]黄荣,汪泓,陈保华,等.巨噬细胞移动抑制因子促进有氧糖酵解与直肠癌细胞耐药性的关系[J].中国普通外科杂志,2017,26(10):1265-1271.
[14]徐海波,熊异平,余恒勇.膀胱癌组织中MMP-2、MMP-9、Survivin、Livin和VEGF表达的临床意义分析[J].标记免疫分析与临床,2017,24(1):51-54.
[15]李敬,刘定海,邹宁,等.HIF-2α、VEGF、COX-2、MM-P-9表达及其与肾细胞癌血管生成的关系分析[J].标记免疫分析与临床,2017,24(11):1243-1246.
[16]克尤木·阿不来提,周应恩,布瓦扎尔·沙吾提.鸦胆子油乳剂辅助经导管肝动脉化疗栓塞术治疗肝癌患者临床疗效及对血浆内毒素、血管内皮生长因子水平影响[J].临床军医杂志,2017,45(8):851-853+856.
[17]吕彦,王冰,陈会生.阿托伐他汀对大鼠血清VEG-F、Ang-1以及Ang-2影响[J].临床军医杂志,2017,45(2):116-118,123.