374例新生儿脐血总IgE水平及影响因素分析
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摘要
目的本研究探讨新生儿脐血IgE水平的可能影响因素,为食物过敏早期干预提供依据。方法前瞻性连续选取孕期妇女及其所生婴儿374例,采用标准问卷调查获取资料,用荧光酶联免疫方法检测脐血总IgE水平。结果母亲孕期饮奶与脐血IgE水平的上升有关,且孕期饮奶量与脐血IgE水平正相关。结论妊娠期母亲饮奶是导致新生儿脐血IgE水平升高的危险因素。
Objective To study some factors which may be suspected of leading to high cord blood IgE levels. Methods Totally 374 mothers and their babies were involved in this study. A standard questionnaire was finished at the babies 3 days.Cord blood was collected when the baby was born for total IgE levels detecting. The factors influencing the cord blood IgE levels were analyzed. Results Mother′s milk consumption during pregnancy is associated with elevated cord blood IgE levels. Conclusion Mother′s milk consumption during pregnancy is a risk factor for elevated cord blood IgE levels.
Objective To study some factors which may be suspected of leading to high cord blood IgE levels. Methods Totally 374 mothers and their babies were involved in this study. A standard questionnaire was finished at the babies 3 days.Cord blood was collected when the baby was born for total IgE levels detecting. The factors influencing the cord blood IgE levels were analyzed. Results Mother′s milk consumption during pregnancy is associated with elevated cord blood IgE levels. Conclusion Mother′s milk consumption during pregnancy is a risk factor for elevated cord blood IgE levels.
引文
[1]PALOMARES O,AKDIS M,MARTíNFONTECHA M,et al.Mechanisms ofimmune regulation in allergic diseases:The role of regulatory T and B cells[J].Immunol Rev,2017,278(1):219.
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[3]蔡传旭,刘晓清,胡海圣,等.过敏性疾病患者外周血可溶性PD-L1的表达及意义[J].实用医学杂志,2018,34(18):3036-3040.
[4]NAVINéS-FERRER A,SERRANO-CANDELAS E,MOLINA-MOLINA G J,et al.Ig E-related chronic diseases and anti-igebased treatments[J].J Immunol Res,2016,8163803.
[5]IWEALA O I,BURKS A W.Food allergy:Our evolving understanding of its pathogenesis,prevention,and treatment[J].Curr Allergy Asthma Rep,2016,16(5):37.
[6]LIMA J O,ZHANG L,ATKINSON T P,et al.Early expression of iepsilon,CD23(Fcepsilon RII),IL-4Ralpha,and Ig Ein the human fetus[J].J Allergy Clin Immunol,2000,106(5):911-917.
[7]LIMA J O,ZHANG L,ATKINSON T P,et al.Asthma heredity,cord blood Ig E and asthma-related symptoms and medication in adulthood:A long-term follow-up in a swedish birth cohort[J].PLOS ONE,2013,8(6):e66777.
[8]SHAH P S,WEGIENKA G,HAVSTAD S,et al.The relationship between cord blood immunoglobulin E levels and allergy-related outcomes in young adults[J].Ann Allergy Asthma Immunol,2011,106(3):245-251.
[9]SCHOEMAKER A A,SPRIKKELMAN A B,GRIMSHAW KE,et al.Incidence and natural history of challenge-proven cow′s milk allergy in European children-Euro Prevall birth cohort[J].Allergy,2015,70(8):963-972.
[10]LUYT D,BALL H,MAKWANA N,et al.BSACI guideline for the diagnosis and management of cow′s milkallergy[J].Clin Exp Allergy,2014,44(5):642-672.
[11]TAKAOKA Y,FUTAMURA M,SAKAMOTO T,et al.,Analysis of the risk factors to persistent milk allergy[J].Arerugi,2010,59(11):1562-1571.
[12]NABAVI M,GHORBANI R,ASADI A M,et al.Factors associated with cord blood Ig E levels[J].Asian Pac J Allergy Immunol,2013,31(2):157-162.
[13]SIMON-NOBBE B,DENK U,P?LL V,et al.The spectrum of fungal allergy[J].Int Arch Allergy Immunol,2008,145(1):58-86.
[14]SULLIVAN DILLIE K T,TISLER C J,DASILVA D F,et al.The influence of processing factors and non-atopyrelated maternal and neonate characteristics on yield and cytokine responses of cord blood mononuclear cells[J].Clin Exp Allergy,2008,38(2):298-304.
[15]PICHLER J,GERSTMAYR M,SZéPFALUSI Z,et al.1 alpha,25(OH)2D3 inhibits not only Th1 But also Th2 differentiation in human cord blood T cells[J].Pediatr Res,2002,52(1):12-18.
[16]SHAH S,BAPAT M M.Parental history of allergy,maternal serum Ig E and cord serum Ig E[J].Indian J Med Sci,2006,60(1):13-18.
[17]SYBILSKI A J,DOBOSZYNSKA A,SAMOLINSKI B.Total and antigen-specific IGE levels in umbilical cord blood[J].Eur J Med Res,2009,14(Suppl 4):233-236.
[2]OWNBY D R.Pediatric asthma and development of atopy[J].Curr Opin Allergy Clin Immunol,2006,6(2):136-138.
[3]蔡传旭,刘晓清,胡海圣,等.过敏性疾病患者外周血可溶性PD-L1的表达及意义[J].实用医学杂志,2018,34(18):3036-3040.
[4]NAVINéS-FERRER A,SERRANO-CANDELAS E,MOLINA-MOLINA G J,et al.Ig E-related chronic diseases and anti-igebased treatments[J].J Immunol Res,2016,8163803.
[5]IWEALA O I,BURKS A W.Food allergy:Our evolving understanding of its pathogenesis,prevention,and treatment[J].Curr Allergy Asthma Rep,2016,16(5):37.
[6]LIMA J O,ZHANG L,ATKINSON T P,et al.Early expression of iepsilon,CD23(Fcepsilon RII),IL-4Ralpha,and Ig Ein the human fetus[J].J Allergy Clin Immunol,2000,106(5):911-917.
[7]LIMA J O,ZHANG L,ATKINSON T P,et al.Asthma heredity,cord blood Ig E and asthma-related symptoms and medication in adulthood:A long-term follow-up in a swedish birth cohort[J].PLOS ONE,2013,8(6):e66777.
[8]SHAH P S,WEGIENKA G,HAVSTAD S,et al.The relationship between cord blood immunoglobulin E levels and allergy-related outcomes in young adults[J].Ann Allergy Asthma Immunol,2011,106(3):245-251.
[9]SCHOEMAKER A A,SPRIKKELMAN A B,GRIMSHAW KE,et al.Incidence and natural history of challenge-proven cow′s milk allergy in European children-Euro Prevall birth cohort[J].Allergy,2015,70(8):963-972.
[10]LUYT D,BALL H,MAKWANA N,et al.BSACI guideline for the diagnosis and management of cow′s milkallergy[J].Clin Exp Allergy,2014,44(5):642-672.
[11]TAKAOKA Y,FUTAMURA M,SAKAMOTO T,et al.,Analysis of the risk factors to persistent milk allergy[J].Arerugi,2010,59(11):1562-1571.
[12]NABAVI M,GHORBANI R,ASADI A M,et al.Factors associated with cord blood Ig E levels[J].Asian Pac J Allergy Immunol,2013,31(2):157-162.
[13]SIMON-NOBBE B,DENK U,P?LL V,et al.The spectrum of fungal allergy[J].Int Arch Allergy Immunol,2008,145(1):58-86.
[14]SULLIVAN DILLIE K T,TISLER C J,DASILVA D F,et al.The influence of processing factors and non-atopyrelated maternal and neonate characteristics on yield and cytokine responses of cord blood mononuclear cells[J].Clin Exp Allergy,2008,38(2):298-304.
[15]PICHLER J,GERSTMAYR M,SZéPFALUSI Z,et al.1 alpha,25(OH)2D3 inhibits not only Th1 But also Th2 differentiation in human cord blood T cells[J].Pediatr Res,2002,52(1):12-18.
[16]SHAH S,BAPAT M M.Parental history of allergy,maternal serum Ig E and cord serum Ig E[J].Indian J Med Sci,2006,60(1):13-18.
[17]SYBILSKI A J,DOBOSZYNSKA A,SAMOLINSKI B.Total and antigen-specific IGE levels in umbilical cord blood[J].Eur J Med Res,2009,14(Suppl 4):233-236.