冠脉再通膏治疗冠脉临界病变痰瘀互阻型患者61例临床观察
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摘要
目的:观察冠脉再通膏治疗冠脉临界病变痰瘀互阻型患者的临床疗效。方法:选择冠状动脉临界病变患者61例,按随机数字表法分为观察组31例,对照组30例,2组患者均给予基础治疗,观察组同时再给予冠脉再通膏,对照组再给予丹蒌片,2组疗程均为6个月。于治疗前及治疗后进行随访,对2组患者心绞痛疗效、心电图疗效、血管内超声(IVUS)疗效、中医证候疗效、血生化等项目进行观察和检测。结果:治疗6个月后,观察组心绞痛疗效、心电图疗效、血管内超声疗效、中医证候疗效总有效率分别为90. 32%、87. 10%、70. 97%、90. 32%,对照组分别为50. 0%、40. 0%、43. 33%、56. 67%,观察组均优于对照组,2组患者治疗后与治疗前比较,TC、TG、LDL-C、HLD-C差异有统计学意义。结论:冠脉再通膏可改善冠脉临界病变患者中医症状体征及心绞痛,对改善患者的生活质量、防治冠脉狭窄程度的加重具有潜在疗效。
引文
[1]中华医学会心血管病学分会介入心脏病学组.中国经皮冠状动脉介入治疗指南(2016)[J].中华心血管病杂志,2016,44(5):382-400.
[2]高立建,延荣强,亩朝伟,等.冠状动脉临界病变和急性心肌梗死的关系[J].岭南心血管病杂志,2014,20(1):18-21.
[3] BURKE AP,KOLODGIE FD,FARB A,et al. Plaque erosion is a major substrate for coronary thrombosis in acute myocardial infarction[J]. Heart,1999,82(9):269-272.
[4] MANOHARAN G,NTALIANIS A,MULLER O,et al. Healed plaque ruptures and sudden coronary death:evidence that subclinical rupture has a role in plaque progression[J].Circulation,2001,103(1):934-940.
[5]杨晓正,郑轶,郭三强,等.从痰论治冠脉临界病变不稳定心绞痛疗效观察[J].中医临床研究,2014,6(17):12-14.
[6]李占全,金元哲.冠状动脉造影与临床[M]. 3版.沈阳:辽宁科学技术出版社,2012:178-179.
[7]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:68-73.
[8]中华中医药学会.中医内科常见病诊疗指南·中医病证部分[M].北京:中国中医药出版社,2008:39-42.
[9]刘亚忠,曹雪滨.特殊人群冠心病的抗栓治疗策略[J].中国循证心血管病杂志,2013,5(6):555-558.
[10]全国中西医结合治疗冠心病心绞痛及心律失常座谈会.冠心病心绞痛及心电图疗效评定标准[J].中国药事,1987,1(2):71.
[11] MR FERNANDES,GVSILVA,A CAIXETA,et al. Assessing intermediate cornary lesions:angiographic prediction of lesion severity on intravascular ultrasound[J]. Journal of Invasive Cardiology,2007,19(10):412-416.
[2]高立建,延荣强,亩朝伟,等.冠状动脉临界病变和急性心肌梗死的关系[J].岭南心血管病杂志,2014,20(1):18-21.
[3] BURKE AP,KOLODGIE FD,FARB A,et al. Plaque erosion is a major substrate for coronary thrombosis in acute myocardial infarction[J]. Heart,1999,82(9):269-272.
[4] MANOHARAN G,NTALIANIS A,MULLER O,et al. Healed plaque ruptures and sudden coronary death:evidence that subclinical rupture has a role in plaque progression[J].Circulation,2001,103(1):934-940.
[5]杨晓正,郑轶,郭三强,等.从痰论治冠脉临界病变不稳定心绞痛疗效观察[J].中医临床研究,2014,6(17):12-14.
[6]李占全,金元哲.冠状动脉造影与临床[M]. 3版.沈阳:辽宁科学技术出版社,2012:178-179.
[7]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:68-73.
[8]中华中医药学会.中医内科常见病诊疗指南·中医病证部分[M].北京:中国中医药出版社,2008:39-42.
[9]刘亚忠,曹雪滨.特殊人群冠心病的抗栓治疗策略[J].中国循证心血管病杂志,2013,5(6):555-558.
[10]全国中西医结合治疗冠心病心绞痛及心律失常座谈会.冠心病心绞痛及心电图疗效评定标准[J].中国药事,1987,1(2):71.
[11] MR FERNANDES,GVSILVA,A CAIXETA,et al. Assessing intermediate cornary lesions:angiographic prediction of lesion severity on intravascular ultrasound[J]. Journal of Invasive Cardiology,2007,19(10):412-416.