脂脱搽剂配合梅花针及补肾养血胶囊治疗雄激素性脱发的临床观察
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摘要
目的:探讨脂脱搽剂配合梅花针及补肾养血胶囊治疗雄激素性脱发的临床疗效。方法:将120例雄激素性脱发患者随机分为治疗组和对照组各60例。治疗组患者采用脂脱搽剂配合梅花针及补肾养血胶囊治疗,对照组患者采用5%米诺地尔酊配合梅花针及补肾养血胶囊治疗。两组均治疗3个月。观察记录患者治疗前后中医证候积分;记录患者治疗后1个月、3个月脱发区头发生长情况。结果:总有效率治疗组为95.00%,对照组为78.33%;治疗组疗效优于对照组(P<0.05);治疗后,两组患者中医证候积分均降低(P<0.05);治疗后治疗组患者中医证候积分低于对照组,差异有统计学意义(P<0.05);治疗后1个月两组患者脱发区头发生长情况比较,差异无统计学意义(P>0.05);治疗3个月后,治疗组患者脱发区头发数量高于对照组,差异有统计学意义(P<0.05);对照组1例患者出现治疗区域轻度泛红,治疗组患者未见明显不良反应。结论:脂脱搽剂配合梅花针及补肾养血胶囊治疗雄激素性脱发有较好临床疗效,安全性良好。
Objective: To investigate the clinical effect of Zhituo liniment, plum-blossom needle and Bushen Yangxue capsule on androgenic alopecia. Methods: A total of 120 patients with androgenic alopecia were randomly divided into treatment and control groups, 60 cases in each group. Patients were treated with Zhituo liniment, plum-blossom needle and Bushen Yangxue capsule in the treatment group. Patients were treated with 5%Minoxidil Tincture, plum-blossom needle and Bushen Yangxue capsule in control group. The two groups were treated for 3 months. The scores of TCM syndromes before and after treatment were recorded and the hair growth in the alopecia area was recorded at 1 st months and 3 rd months after treatment. Results: The total effective was 95.00% in treatment group and 78.33% in control group. The treatment group showed better efficacy than the control group(P <0.05). After the treatment, the scores of TCM syndromes were reduced in the two groups(P<0.05), and the treatment group showed lower TCM syndrome score than the control group(P<0.05). At the 1 st month after treatment, there was no significant difference in hair growth in hair area between the two groups(P >0.05). After 3 months of treatment, the treatment group showed more hair on the alopecia location than the control group, and the difference was statistically significant(P<0.05). In the control group, one case showed mild redness in the treatment area in one case, and there was no obvious adverse reaction in the treatment group. Conclusion: The application of Zhituo liniment, plum-blossom needle and Bushen Yangxue capsule showed good efficacy on androgenic alopecia, and the safety of drugs is good.
Objective: To investigate the clinical effect of Zhituo liniment, plum-blossom needle and Bushen Yangxue capsule on androgenic alopecia. Methods: A total of 120 patients with androgenic alopecia were randomly divided into treatment and control groups, 60 cases in each group. Patients were treated with Zhituo liniment, plum-blossom needle and Bushen Yangxue capsule in the treatment group. Patients were treated with 5%Minoxidil Tincture, plum-blossom needle and Bushen Yangxue capsule in control group. The two groups were treated for 3 months. The scores of TCM syndromes before and after treatment were recorded and the hair growth in the alopecia area was recorded at 1 st months and 3 rd months after treatment. Results: The total effective was 95.00% in treatment group and 78.33% in control group. The treatment group showed better efficacy than the control group(P <0.05). After the treatment, the scores of TCM syndromes were reduced in the two groups(P<0.05), and the treatment group showed lower TCM syndrome score than the control group(P<0.05). At the 1 st month after treatment, there was no significant difference in hair growth in hair area between the two groups(P >0.05). After 3 months of treatment, the treatment group showed more hair on the alopecia location than the control group, and the difference was statistically significant(P<0.05). In the control group, one case showed mild redness in the treatment area in one case, and there was no obvious adverse reaction in the treatment group. Conclusion: The application of Zhituo liniment, plum-blossom needle and Bushen Yangxue capsule showed good efficacy on androgenic alopecia, and the safety of drugs is good.
引文
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[13]周晴,魏跃钢,胡源,等.雄激素源性脱发与血液流变学变化的关系探讨[J].中国中西医结合皮肤性病学杂志,2006,5(3):147-148.
[2]赵辨.中国临床皮肤病学[M].南京:江苏科学技术出版社,2010.
[3]范瑞强,邓丙戌,杨志波.中医皮肤性病学[M].北京:科学技术文献出版社,2010.
[4]国家技术监督局.中医临床诊疗术语证候部分[M].北京:中国标准出版社,1997.
[5]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002.
[6]王光斌,段西凌.雄激素性脱发治疗进展[J].临床合理用药杂志,2014,7(11):180-181.
[7]陈声利,孙建方.米诺地尔治疗脱发的药理与临床研究[J].国外医学:皮肤性病学分册,2004,30(5):276-278.
[8]刘雪花.苦参生物碱的药理研究进展[J].中国实用医药,2009,4(14):232-234.
[9]赵明宇.何首乌化学成分和药理作用[J].北方药学,2018,15(3):192-193.
[10]王焕江,赵金娟,刘金贤,等.菟丝子的药理作用及其开发前景[J].中医药学报,2012,40(6):123-125.
[11]孙乐,张小东,郭迎迎.桑葚的化学成分和药理作用研究进展[J].人参研究,2016,28(2):49-54.
[12]陈平,邓承颖.中药黑芝麻的研究概况及其应用[J].现代医药卫生,2014,30(4):541-543.
[13]周晴,魏跃钢,胡源,等.雄激素源性脱发与血液流变学变化的关系探讨[J].中国中西医结合皮肤性病学杂志,2006,5(3):147-148.