芪明颗粒联合阴阳九针治疗围绝经期干眼
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摘要
目的探讨芪明颗粒联合阴阳九针治疗围绝经期女性干眼的疗效。方法选取2016年2月-2017年12月于沈阳市中医院门诊眼科就诊的围绝经期干眼患者58例(112眼),予芪明颗粒口服联合阴阳九针针刺,不予局部用药,5周为1个疗程。分别记录治疗前后患者的自觉症状积分、泪液分泌试验(SIT)、泪膜破裂时间(BUT)、角膜荧光素染色(FL)评分值的变化情况。结果 58例(112眼)患者中治愈40例(78眼),治愈率为69.64%,有效14例(26眼),有效率为23.22%,总有效率达92.86%。患者自觉症状积分、SIT、BUT、FL评分均较治疗前有明显改善,差异有统计学意义(P <0.05),围绝经期全身症状亦有改善。结论芪明颗粒联合阴阳九针可改善围绝经期干眼患者的临床症状,提高生活质量,可以作为有效疗法之一临床推广。
Objective To explore the clinical effect of Qiming granule combined with Yinyang Jiuzhen for the treatment of perimenopausal dry eye. Methods 58 women patients(112 eyes) with perimenopausal dry eye in Shenyang hospital of traditional Chinese medicine over a period from February 2016 to December 2017. They were given Qiming granule combined with Yinyang Jiuzhen for five weeks. The scores of subjective symptom, SIT, BUT,FL score were recorded before and after treatment. Results 40 cases(78 eyes) were cured, the cure rate was 69.64%,14 cases(26 eyes) were effective, the effective rate was 23.22%. The total effective rate was 92.86%. The subjective symptom, SIT, BUT and FL were improved. The statistical analysis showed significant dif ference(P < 0.05). Perimenopausal systemic symptoms also improved. Conclusions Qiming granule combined with Yinyang Jiuzhen can improve the clinical symptoms and quality of life of peri-menopausal dry eye patients and can be used as an effective therapy for clinical promotion.
Objective To explore the clinical effect of Qiming granule combined with Yinyang Jiuzhen for the treatment of perimenopausal dry eye. Methods 58 women patients(112 eyes) with perimenopausal dry eye in Shenyang hospital of traditional Chinese medicine over a period from February 2016 to December 2017. They were given Qiming granule combined with Yinyang Jiuzhen for five weeks. The scores of subjective symptom, SIT, BUT,FL score were recorded before and after treatment. Results 40 cases(78 eyes) were cured, the cure rate was 69.64%,14 cases(26 eyes) were effective, the effective rate was 23.22%. The total effective rate was 92.86%. The subjective symptom, SIT, BUT and FL were improved. The statistical analysis showed significant dif ference(P < 0.05). Perimenopausal systemic symptoms also improved. Conclusions Qiming granule combined with Yinyang Jiuzhen can improve the clinical symptoms and quality of life of peri-menopausal dry eye patients and can be used as an effective therapy for clinical promotion.
引文
[1]潘兰兰,贾卉.中老年干眼患者临床特征分析[J].国际眼科杂志,2006,6(5):1203-1207.
[2]ERDEM U,OZDEGIRMENCI O,SOBACI E,et al.Dry eye in postmenopausal women using hormone replacement therapy[J].Maturitas,2007,56(3):257-262.
[3]中华医学会眼科学分会角膜病学组.干眼临床诊疗专家共识[J].中华眼科杂志,2013,49(1):73-75.
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[5]杨雪艳,周瑞芳.杞菊地黄汤内服联合超声雾化治疗围绝经期干眼的临床观察[J].中国中医眼科杂志,2015,25(3):187-189.
[6]于静,王辉,邱礼新.“葆青汤”治疗围绝经期干眼的疗效观察[J].中国中医眼科杂志,2015,25(4):273-275.
[7]赵素琴.六味地黄丸加味治疗围绝经期干眼症的疗效及机制[J].光明中医,2014,29(2):274-276.
[8]陈亚娟,廖良,宫晓红.围绝经期女性干眼发病相关影响因素分析[J].国际眼科杂志,2017,17(2):263-265.
[9]SULLIVAN D A.Androgen defi cienoy&dry eyesyndromes[J].Arch Soc Esp Oftalmol,2004,79(2):49-50.
[10]SUZUKI T,SUIIIVAN D A.Estrogen stimulation of proinflammatory cytokine and matrix metalloproteinase gene expression in human corneal epiIhelial cells[J].Cornea,2005,24(8):1004-1009.
[11]SUZUKI T,SCHIRRA F,RICHARDS S M,et al.Estrogen and progesterone control of gene expression in the mouse meibomian glang[J].Invest Ophthalmol Vis Sci,2008,49(5):1797-1808.
[12]林静,王传富,杨珊珊.去势雌干眼症模型鼠角膜上皮损伤的研究[J].眼科研究,2007,25(11):814-817.
[13]王海彬,王军舰,黄辉.黄芪注射液对雌激素受体的激活作用研究[J].时珍国医国药,2006,17(11):2113.
[14]王爱梅,李戈,陈亚奇.葛根异黄酮对衰老大鼠卵巢形态和功能的影响[J].中国妇幼保健,2011,26(36):5786.
[15]仵春云,张杜平,赵昌涛,等.地黄多糖干预对多次低剂量X线照射小鼠血清性激素水平的影响[J].中国生殖医学杂志,2016,25(3):264.
[16]潘思源,常英,魏路香.茺蔚子总碱和水苏碱收缩离体小鼠子宫的比较[J].中草药,1998,29(1):678-688.
[17]黄晓兰,杨明亮,吴晓旻,等.枸杞多糖对雄性大鼠睾丸组织损伤的保护作用[J].中国公共卫生,2003,19(9):1052-1054.
[18]韩昌志.决明子的明目作用[J].中国医院药学杂志,1993,13(5):200-201.
[19]周丽,邓伟民,李晓昊.张辛补肾健脾化瘀法对围绝经期妇女性激素及血管舒缩症状的影响[J].新中医,2009,41(1):49-50.
[20]林洁,王璇,刘超萍.蒲黄黄酮对成年雌性大鼠雌孕激素及其受体的影响[J].中国现代医学杂志,2012,22(21):18-20.
[2]ERDEM U,OZDEGIRMENCI O,SOBACI E,et al.Dry eye in postmenopausal women using hormone replacement therapy[J].Maturitas,2007,56(3):257-262.
[3]中华医学会眼科学分会角膜病学组.干眼临床诊疗专家共识[J].中华眼科杂志,2013,49(1):73-75.
[4]国家中医药管理局.中医病症诊断疗效标准[S].南京:南京大学出版社,1994:101.
[5]杨雪艳,周瑞芳.杞菊地黄汤内服联合超声雾化治疗围绝经期干眼的临床观察[J].中国中医眼科杂志,2015,25(3):187-189.
[6]于静,王辉,邱礼新.“葆青汤”治疗围绝经期干眼的疗效观察[J].中国中医眼科杂志,2015,25(4):273-275.
[7]赵素琴.六味地黄丸加味治疗围绝经期干眼症的疗效及机制[J].光明中医,2014,29(2):274-276.
[8]陈亚娟,廖良,宫晓红.围绝经期女性干眼发病相关影响因素分析[J].国际眼科杂志,2017,17(2):263-265.
[9]SULLIVAN D A.Androgen defi cienoy&dry eyesyndromes[J].Arch Soc Esp Oftalmol,2004,79(2):49-50.
[10]SUZUKI T,SUIIIVAN D A.Estrogen stimulation of proinflammatory cytokine and matrix metalloproteinase gene expression in human corneal epiIhelial cells[J].Cornea,2005,24(8):1004-1009.
[11]SUZUKI T,SCHIRRA F,RICHARDS S M,et al.Estrogen and progesterone control of gene expression in the mouse meibomian glang[J].Invest Ophthalmol Vis Sci,2008,49(5):1797-1808.
[12]林静,王传富,杨珊珊.去势雌干眼症模型鼠角膜上皮损伤的研究[J].眼科研究,2007,25(11):814-817.
[13]王海彬,王军舰,黄辉.黄芪注射液对雌激素受体的激活作用研究[J].时珍国医国药,2006,17(11):2113.
[14]王爱梅,李戈,陈亚奇.葛根异黄酮对衰老大鼠卵巢形态和功能的影响[J].中国妇幼保健,2011,26(36):5786.
[15]仵春云,张杜平,赵昌涛,等.地黄多糖干预对多次低剂量X线照射小鼠血清性激素水平的影响[J].中国生殖医学杂志,2016,25(3):264.
[16]潘思源,常英,魏路香.茺蔚子总碱和水苏碱收缩离体小鼠子宫的比较[J].中草药,1998,29(1):678-688.
[17]黄晓兰,杨明亮,吴晓旻,等.枸杞多糖对雄性大鼠睾丸组织损伤的保护作用[J].中国公共卫生,2003,19(9):1052-1054.
[18]韩昌志.决明子的明目作用[J].中国医院药学杂志,1993,13(5):200-201.
[19]周丽,邓伟民,李晓昊.张辛补肾健脾化瘀法对围绝经期妇女性激素及血管舒缩症状的影响[J].新中医,2009,41(1):49-50.
[20]林洁,王璇,刘超萍.蒲黄黄酮对成年雌性大鼠雌孕激素及其受体的影响[J].中国现代医学杂志,2012,22(21):18-20.