健康人群血脂指标随年龄变化趋势的研究
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摘要
目的基于健康体检人群的血脂指标,探讨血脂随年龄变化的趋势,为建立慢性病预警模型提供科学依据。方法收集某医院2010-2013年连续4年健康体检者的血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)数据。将指标取十倍对数(LTC、LTG、LHDL-C)转换,应用曲线拟合的方法纵向建立随年龄的变化率曲线,积分后得到血脂指标随年龄的变化趋势方程,并通过横断面拟合误差筛选最优方程。结果 LTC随年龄变化方程为fLTC(x)=0.184lnx-0.0013x+1.047,TC随年龄增长呈升高趋势;LTG随年龄变化方程为fLTG(x)=1.226lnx-0.0331x-2.233,TG随年龄增长呈先上升后下降趋势;HDL-C随年龄增长无明显变化,但女性高于男性。结论健康体检中应关注个体血脂指标特别是TC、TG的变化趋势,尽早发现异常变化,以防制相关慢性病。
Objective To investigate the variation tendency of blood lipid indices along with age. Methods Data of TC,TG and HDL-C are collected from 1054 peoplewho attended the physical examination from 2010 to 2013.Mathematical methodswere used to establish models about the average change of TC,TG and HDL-C for four consecutive years and the age.After integral,w e obtained the variation tendency of TC,TG and HDL-C in normal people by filtering horizontal error and then draw the graphics changewith age. Results The equation of the lg( TC × 10) and age is fLTC( x) = 0. 184lnx- 0. 0013 x +1. 047; the established equation of lg( TG × 10) and age is fLTC( x) = 1. 226lnx- 0. 0331x- 2. 233. From the graphics we found that the TC present a rising tendencywith age; the TG is a trend of rise first then fallwith age; and the HDL-C has no changing obviouswith age,but discovered gender differences. Conclusion Finding abnormal trendency of blood lipid indices by comparedwith the variation tendency of blood lipid indices alongwith age among health people. To prevent the develping of the chronic disease.
Objective To investigate the variation tendency of blood lipid indices along with age. Methods Data of TC,TG and HDL-C are collected from 1054 peoplewho attended the physical examination from 2010 to 2013.Mathematical methodswere used to establish models about the average change of TC,TG and HDL-C for four consecutive years and the age.After integral,w e obtained the variation tendency of TC,TG and HDL-C in normal people by filtering horizontal error and then draw the graphics changewith age. Results The equation of the lg( TC × 10) and age is fLTC( x) = 0. 184lnx- 0. 0013 x +1. 047; the established equation of lg( TG × 10) and age is fLTC( x) = 1. 226lnx- 0. 0331x- 2. 233. From the graphics we found that the TC present a rising tendencywith age; the TG is a trend of rise first then fallwith age; and the HDL-C has no changing obviouswith age,but discovered gender differences. Conclusion Finding abnormal trendency of blood lipid indices by comparedwith the variation tendency of blood lipid indices alongwith age among health people. To prevent the develping of the chronic disease.
引文
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[16]Liu X,Tao L,Cao K,et al.Association of high-density lipopro-tein with development of metabolic syndrome compon-ents:a five-year follow-up in adult-s.BMC Public Health,2015,15(1):1-9.
[17]张蕊,郑黎强,潘国伟.疾病发病风险预测模型的应用与建立.中国卫生统计,2015,32(4):724-726.
[2]林旻洁综述,赵水平.甘油三酯与冠心病发病关系及机制的研究进展.中国动脉硬化杂志,2011,19(12):1043-1046.
[3]Azevedo A,Bettencourt P,Almeida PB,et a1.Increasing number of compo-nents of the metabolic syndrome and cardiac structural and functional abnormalities-CROSS-sectional study of the general population.BM C Cardiovasc Disor-d,2007,7(1):17-26.
[4]中华人民共和国国家卫生和计划生育委员会.2013中国卫生统计年鉴.http://www.nhfpc.gov.cn/zwgkzt/tjnj/list.shtml,2015-04-08:255.
[5]Wilson PW,Meigs JB,Sullivan L,et al.Prediction of Incident Diabetes M e-llitus in M iddle-aged Adults.Archives of Internal M edicine,2007,167(10):1068-1074.
[6]孙凤,陶庆梅,詹思延,等.中国台湾地区35-74岁健检人群2型糖尿病患病率以及5年发病风险预测模型.中华疾病控制,2013,17(5):369-373.
[7]许海燕,项志敏,陆宗良.中国成人血脂异常防治指南(2007)概要与解读.中华老年心脑血管病杂志,2008,10(3):238-240.
[8]吴正林,黄英,李涛,等.深圳地区人群2001~2008年血清胆固醇水平变化趋势.现代检验医学杂志,2010,25(5):88-89.
[9]刘丽君,贺佩祥,任志强,等.健康成年男性血脂随年龄的变化规律及血脂异常的分布特征.中国当代医药,2010,17(2):9-11.
[10]闻剑,李世聪,张永慧,等.广东省城市居民血脂水平现状及变化趋势.中国公共卫生,2014,30(11):1460-1463.
[11]朱晓敏,赵海亮,冯彦成,等.铁路工人生活方式对中心性肥胖影响的探讨.中国卫生统计,2016,33(3):426-429.
[12]赵宝昌主编.生物化学.第2版.北京:高等教育出版社,2009,163-164
[13]王虎林,孙兰英,杨运旗.老年人血脂变化分析.西南军医,2005,7(4):13-14.
[14]Carroll MD,Lacher DA,Sorlie PD,et al.Trends in serum lipids and lipoproteins of adults,1960-2002.JAMA,2005,294(14):1773-1781.
[15]Venkitachalam L,Wang K,Porath A,et al.Global variation in the prevalenc-e of elevated cholesterol in outpatients with establishedvascular disease or 3 c-ardiovascular risk factors according to nation-al indices of economic developme-nt and health system performance.Circulation,2012,125(15):1858-1869.
[16]Liu X,Tao L,Cao K,et al.Association of high-density lipopro-tein with development of metabolic syndrome compon-ents:a five-year follow-up in adult-s.BMC Public Health,2015,15(1):1-9.
[17]张蕊,郑黎强,潘国伟.疾病发病风险预测模型的应用与建立.中国卫生统计,2015,32(4):724-726.