浅谈射频消融在肝癌治疗中的临床选择
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摘要
<正>肝细胞性肝癌(HCC)仍是全球常见的恶性肿瘤之一,其发病率及病死率持续增长,在世界肝癌发病率中占第6位,其导致的死亡率占第3位~([1])。而我国作为肝癌高发地区,肝癌治疗任重道远。早期肝癌可以通过肝脏移植术、肝脏切除术和射频消融术(RFA)达到治愈~([2])。我国供体肝脏的缺乏,限制了肝脏移植技术的应用,所以肝脏切除术仍被看作是肝癌治疗的首选方式。不过只有20%左右的患
引文
1 Ferlay J,Shin HR,Bray F,et al.Estimates of worldwide burden of cancer in 2008:Globocan 2008.Int J Cancer,2010,127(12):2893-2917.
2 Bruix J,Sherman M;American Association for the Study of Liver Diseases.Management of hepatocellular carcinoma:an update.Hepatology,2011,53(3):1020-1022
3 Ikai I,Arii S,Okazaki M,et al.Report of the 18th follow-up survey of primary liver cancer in Japan.Hepatol Res,2010,40(9):1043-1059.
4 Duffy JP,Hiatt JR,Busuttil RW.Surgical resection of hepatocellular carcinoma.Cancer J,2008,14(2):100-110.
5 Nishikawa H,Kimura T,Kita R,et al.Radiofrequency ablation for hepatocellular carcinoma.Int J Hyperthermia,2013,29(6):558-568.
6 Curley SA.Radiofrequency ablation leads to excellent local tumor control and durable longterm survival in speci?c subsets of early stage HCC patients confirming to the Milan criteria.Ann Surg,2010,252(6):913-914.
7 Lau WY,Lai EC.The current role of radiofrequency ablation in the management of hepatocellular carcinoma:a systematic review.Ann Surg,2009,249(1):20-25.
8 Casaccia M,Santori G,Bottino G,et al.Laparoscopic resection vslaparoscopic radiofrequency ablation for the treatment of smallhepatocellular carcinomas:a single-center analysis.World JGastroenterol,2017,23(4):653-660.
9 Kang TW,Kim JM,Rhim H,et al.Small hepatocellular carcinoma:radiofrequency ablation versus nonanatomic resection-propensityscore analyses of long-term outcomes.Radiology,2015,275(3):908-919.
10 Song J,Wang Y,Ma K,et al.Laparoscopic hepatectomy versusradiofrequency ablation for minimally invasive treatment of single,small hepatocellular carcinomas.Surg Endosc,2016,30(10):4249-4257.20
11 Imai K,Beppu T,Chikamoto A,et al.Comparison between he-patic resection and radiofrequency ablation as?rst-line treatment for solitary small-sized hepatocellular carcinoma of 3 cm or less.Hepatol Res,2013,43(8):853-864.
12 Feng K,Kuansheng Ma,et al.A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma.J Hepatol,2012,57(4):794-802.
13 Hocquelet A,Papadopoulos P,Trillaud H.No-Touch multibipolar radiofrequency ablation:the new standard ablative technique for hepatocellular carcinoma 5 cm or smaller.Radiology,2016,281(3):975-976
14 Liu ZH,Zhou YK,Zhang P,et al.Meta-analysis of the therapeutic effect of hepatectomy versus radiofrequency ablation for the treatment of hepatocellular carcinoma.Surg Laparosc Endosc Percutan Tech,2010,20:130-140
15樊嘉,史颖弘,高强.小肝癌的规范化治疗路径.中国实用外科杂志,2011,31(1):36-38.
16 Zhou Y,Zhao Y,Li B,et al.Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma.BMC Gastroenterol,2010,10:78
17 Hocquelet A,AubéC,Rode A,et al.Comparison of no-touch multi-bipolar vs.monopolar radiofrequency ablation for small HCC.JHepatol,2017,66(1):67-74.DOI:10.1016/j.jhep.2016.07.010.
18 Liang HH,Chen MS,Peng ZW,et al.Percutaneous radiofre-quency ablation versus repeat hepatectomy for recurrent hepa-tocellular carcinoma:a retrospective study.Ann Surg Oncol,2008,15(12):3484-3493.
19 Peng ZW,Zhang YJ,Chen MS,et al.Radiofrequency ablation withor without transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma:a prospective randomizedtrial.JClin Oncol,2013,31(4):426-432.
20 Morimoto M,Numata K,Kondou M,et al.Midterm outcomes inpatients with intermediate-sized hepatocellular carcinoma:arandomized controlled trial for determining the efficacy ofradiofrequency ablation combined with transcatheter arterialchemoembolization.Cancer,2010,116(23):5452-5460.26
21 Shibata T,Isoda H,Hirokawa Y,et al.Small hepatocellularcarcinoma:is radiofrequency ablation combined with transcatheterarterial chemoembolization more effective than radiofrequencyablation alone for treatment?Radiology,2009,252(3):905-913.28
22王瑜,马宽生,陈健.RFA联合TACE治疗合并肝硬化的早期肝细胞肝癌的疗效研究.局解手术学杂志,2015,24(3):273-276
23 Mazzaferro V,Regalia E,Doci R,et al.Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis.N Engl J Med,1996,334(11):693-699.
24 Llovet JM,Mas X,Aponte JJ,et al.Cost effectiveness of adju-vant therapy for hepatocellular carcinoma during the waiting list for liver transplantation.Gut,2002,50(1):123-128.
25 Pulvirenti A,Garbagnati F,Regalia E,et al.Experience with radiofrequency ablation of small hepatocellular carcinomas before liver transplantation.Transplant Proc,2001,33(1/2):1516-1517.
26 Fontana RJ,Hamidullah H,Nghiem H,et al.Percutaneous radiofrequency thermal ablation of hepatocellular carcinoma:a safe and effective bridge to liver transplantation.Liver Transpl,2002,8(12):1165-1174.
27 N’Kontchou G,Aout M,Laurent A,et al.Survival after radi-ofrequency ablation and salvage transplantation in patients with hepatocellular carcinoma and Child-Pugh A cirrhosis.J Hepatol,2012,56(1):160-166.
28 Yao FY,Kerlan RK,Hirose R,et al.Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation:an intention-to-treat analysis.Hepatology,2008,48(3):819-827.
29 Yoshinaga Y,Enomoto Y,Fujimitsu R,et al.Image and path-ological changes after radiofrequency ablation of invasivebreast cancer:a pilot study of nonsurgical therapy of earlybreast cancer.World J Surg,2013,37(2):356-363.
30 Choi D,Lim HK,Joh JW,et al.Combined hepatectomy and radiofrequency ablation for multifocal hepatocellular carcinomas:long-term follow-up results and prognostic factors.Ann Surg Oncol,2007,14(12):3510-3518.
31 Ishiko T,Beppu T,Sugiyama S,et al.Radiofrequency ablationwith hand-assisted laparoscopic surgery for the treatmentofhepatocellular carcinoma in the caudate lobe.SurgLaparosc Endosc Percutan Tech,2008,18(3):272-276.
32 Minami Y,Kudo M.Radiofrequency ablation of hepatocellularcarcinoma:a literature review.Int J Hepatol,2011,2011:104 685.
33唐寒秋,杨瑞.腹腔镜下射频消融术对原发性肝癌的远期生存及安全性评价.医学综述,2016,22(11):2 188-2191.
34 Elias D,Debaere T,Muttillo I,et al.Intraoperative use of radi-ofrequency treatment allows an increase in the rate of curative liver resection.J Surg Oncol,1998,67(3):190-191.
35 Elias D,Goharin A,El Otmany A,et al.Usefulness of intraop-erative radiofrequency thermoablation of liver tumours associated or not with hepatectomy.Eur J Surg Oncol,2000,26(8):763-769.
36 Cheung TT,Ng KK,Chok KS,et al.Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma:prognosis and outcomes.World J Gastroenterol,2010,16(24):3056-3062.
37 Choi D,Lim HK,Rhim H.Concurrent and subsequent radio-frequency ablation combined with hepatectomy for hepatocellular carcinomas.World J Gastrointest Surg,2010,2(4):137-142.
38 MULLER S,NI Y,JAMART J,et a1.Local recurrence after hepatic radiofrequency coagulation:multivariate meta-analysis and review of contributing factors.Ann Surg,2005,242(2):158-171
39 Weber JC,Navarra G,Jiao LR,et al.New technique for liver resection using heat coagulative necrosis.Ann Surg,2002,236(5):560-563.
40 Pai M,Spalding D,Jiao L,et al.Use of bipolar radiofrequency in parenchymal transection of the liver,pancreas and kidney.Dig Surg,2012,29(1):43-47.
41高苗苗,徐芳野,木合布力·阿布力孜.肝癌治疗靶点及肝靶向抗癌药物研究进展.新疆医科大学学报,2012,35(2):146-152.
42 Chaorro M,Trapero-Marugán M,et al.Review article:pharmacological therapy for hepatocellular carcinoma with sorafenib and other oral agents.Aliment Phar-macol Ther,2008,28(11-12):1269-1277.
43 Xu M,Xie XH,Xie XY,et al.Sorafenib suppresses the rapid progress of hepatocellular carcinoma after insufficient radiofrequency ablation therapy:an experiment in vivo.Acta Radiol.2013;54:199-204.
44 Er9s de Bethlenfalva-Hora C,Mertens JC,Piguet AC,Kettenbach J,Schmitt J,Terracciano L,Weimann R,Dufour JF,Geier A.Clin Sci(Lond).2014 Feb;126(3):243-52
45 Xiaobin Feng,Ruocai Xu,Xilin Du,Kefeng Dou,Xiao Qin,Jun Xu,Weidong Jia,Zhiming Wang,Hongzhi Zhao,Shufa Yang,Chenyang Guo,Tianqi Liu,Kuansheng Ma*.Combination Therapy With Sorafenib and Radiofrequency Ablation for BCLC Stage 0-B1Hepatocellular Carcinoma:A Multicenter Retrospective Cohort Study.Am J Gastroenterol 2014;109:1891-1899.
46王凌霄,肖典,周辛波.口服多靶点酪氨酸激酶抑制剂-乐伐替尼.临床药物治疗杂志,2015,13(5):11-14.
47 Ma HQ,Zhang YJ,Wang QJ,et al.Therapeutic safety and effects of adjuvant autologous Retro Nectin activated killer cell immunothera-py for patients with primary hepatocellular carcinoma after radiofrequency ablation.Cancer Biol Ther,2010,9(4):1-5.
48常小峰,郭金滕,皋军.介入治疗联合免疫检查点抑制剂在肿瘤治疗中的研究进展.中华放射学杂志,2018,52(11):883-888.
2 Bruix J,Sherman M;American Association for the Study of Liver Diseases.Management of hepatocellular carcinoma:an update.Hepatology,2011,53(3):1020-1022
3 Ikai I,Arii S,Okazaki M,et al.Report of the 18th follow-up survey of primary liver cancer in Japan.Hepatol Res,2010,40(9):1043-1059.
4 Duffy JP,Hiatt JR,Busuttil RW.Surgical resection of hepatocellular carcinoma.Cancer J,2008,14(2):100-110.
5 Nishikawa H,Kimura T,Kita R,et al.Radiofrequency ablation for hepatocellular carcinoma.Int J Hyperthermia,2013,29(6):558-568.
6 Curley SA.Radiofrequency ablation leads to excellent local tumor control and durable longterm survival in speci?c subsets of early stage HCC patients confirming to the Milan criteria.Ann Surg,2010,252(6):913-914.
7 Lau WY,Lai EC.The current role of radiofrequency ablation in the management of hepatocellular carcinoma:a systematic review.Ann Surg,2009,249(1):20-25.
8 Casaccia M,Santori G,Bottino G,et al.Laparoscopic resection vslaparoscopic radiofrequency ablation for the treatment of smallhepatocellular carcinomas:a single-center analysis.World JGastroenterol,2017,23(4):653-660.
9 Kang TW,Kim JM,Rhim H,et al.Small hepatocellular carcinoma:radiofrequency ablation versus nonanatomic resection-propensityscore analyses of long-term outcomes.Radiology,2015,275(3):908-919.
10 Song J,Wang Y,Ma K,et al.Laparoscopic hepatectomy versusradiofrequency ablation for minimally invasive treatment of single,small hepatocellular carcinomas.Surg Endosc,2016,30(10):4249-4257.20
11 Imai K,Beppu T,Chikamoto A,et al.Comparison between he-patic resection and radiofrequency ablation as?rst-line treatment for solitary small-sized hepatocellular carcinoma of 3 cm or less.Hepatol Res,2013,43(8):853-864.
12 Feng K,Kuansheng Ma,et al.A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma.J Hepatol,2012,57(4):794-802.
13 Hocquelet A,Papadopoulos P,Trillaud H.No-Touch multibipolar radiofrequency ablation:the new standard ablative technique for hepatocellular carcinoma 5 cm or smaller.Radiology,2016,281(3):975-976
14 Liu ZH,Zhou YK,Zhang P,et al.Meta-analysis of the therapeutic effect of hepatectomy versus radiofrequency ablation for the treatment of hepatocellular carcinoma.Surg Laparosc Endosc Percutan Tech,2010,20:130-140
15樊嘉,史颖弘,高强.小肝癌的规范化治疗路径.中国实用外科杂志,2011,31(1):36-38.
16 Zhou Y,Zhao Y,Li B,et al.Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma.BMC Gastroenterol,2010,10:78
17 Hocquelet A,AubéC,Rode A,et al.Comparison of no-touch multi-bipolar vs.monopolar radiofrequency ablation for small HCC.JHepatol,2017,66(1):67-74.DOI:10.1016/j.jhep.2016.07.010.
18 Liang HH,Chen MS,Peng ZW,et al.Percutaneous radiofre-quency ablation versus repeat hepatectomy for recurrent hepa-tocellular carcinoma:a retrospective study.Ann Surg Oncol,2008,15(12):3484-3493.
19 Peng ZW,Zhang YJ,Chen MS,et al.Radiofrequency ablation withor without transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma:a prospective randomizedtrial.JClin Oncol,2013,31(4):426-432.
20 Morimoto M,Numata K,Kondou M,et al.Midterm outcomes inpatients with intermediate-sized hepatocellular carcinoma:arandomized controlled trial for determining the efficacy ofradiofrequency ablation combined with transcatheter arterialchemoembolization.Cancer,2010,116(23):5452-5460.26
21 Shibata T,Isoda H,Hirokawa Y,et al.Small hepatocellularcarcinoma:is radiofrequency ablation combined with transcatheterarterial chemoembolization more effective than radiofrequencyablation alone for treatment?Radiology,2009,252(3):905-913.28
22王瑜,马宽生,陈健.RFA联合TACE治疗合并肝硬化的早期肝细胞肝癌的疗效研究.局解手术学杂志,2015,24(3):273-276
23 Mazzaferro V,Regalia E,Doci R,et al.Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis.N Engl J Med,1996,334(11):693-699.
24 Llovet JM,Mas X,Aponte JJ,et al.Cost effectiveness of adju-vant therapy for hepatocellular carcinoma during the waiting list for liver transplantation.Gut,2002,50(1):123-128.
25 Pulvirenti A,Garbagnati F,Regalia E,et al.Experience with radiofrequency ablation of small hepatocellular carcinomas before liver transplantation.Transplant Proc,2001,33(1/2):1516-1517.
26 Fontana RJ,Hamidullah H,Nghiem H,et al.Percutaneous radiofrequency thermal ablation of hepatocellular carcinoma:a safe and effective bridge to liver transplantation.Liver Transpl,2002,8(12):1165-1174.
27 N’Kontchou G,Aout M,Laurent A,et al.Survival after radi-ofrequency ablation and salvage transplantation in patients with hepatocellular carcinoma and Child-Pugh A cirrhosis.J Hepatol,2012,56(1):160-166.
28 Yao FY,Kerlan RK,Hirose R,et al.Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation:an intention-to-treat analysis.Hepatology,2008,48(3):819-827.
29 Yoshinaga Y,Enomoto Y,Fujimitsu R,et al.Image and path-ological changes after radiofrequency ablation of invasivebreast cancer:a pilot study of nonsurgical therapy of earlybreast cancer.World J Surg,2013,37(2):356-363.
30 Choi D,Lim HK,Joh JW,et al.Combined hepatectomy and radiofrequency ablation for multifocal hepatocellular carcinomas:long-term follow-up results and prognostic factors.Ann Surg Oncol,2007,14(12):3510-3518.
31 Ishiko T,Beppu T,Sugiyama S,et al.Radiofrequency ablationwith hand-assisted laparoscopic surgery for the treatmentofhepatocellular carcinoma in the caudate lobe.SurgLaparosc Endosc Percutan Tech,2008,18(3):272-276.
32 Minami Y,Kudo M.Radiofrequency ablation of hepatocellularcarcinoma:a literature review.Int J Hepatol,2011,2011:104 685.
33唐寒秋,杨瑞.腹腔镜下射频消融术对原发性肝癌的远期生存及安全性评价.医学综述,2016,22(11):2 188-2191.
34 Elias D,Debaere T,Muttillo I,et al.Intraoperative use of radi-ofrequency treatment allows an increase in the rate of curative liver resection.J Surg Oncol,1998,67(3):190-191.
35 Elias D,Goharin A,El Otmany A,et al.Usefulness of intraop-erative radiofrequency thermoablation of liver tumours associated or not with hepatectomy.Eur J Surg Oncol,2000,26(8):763-769.
36 Cheung TT,Ng KK,Chok KS,et al.Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma:prognosis and outcomes.World J Gastroenterol,2010,16(24):3056-3062.
37 Choi D,Lim HK,Rhim H.Concurrent and subsequent radio-frequency ablation combined with hepatectomy for hepatocellular carcinomas.World J Gastrointest Surg,2010,2(4):137-142.
38 MULLER S,NI Y,JAMART J,et a1.Local recurrence after hepatic radiofrequency coagulation:multivariate meta-analysis and review of contributing factors.Ann Surg,2005,242(2):158-171
39 Weber JC,Navarra G,Jiao LR,et al.New technique for liver resection using heat coagulative necrosis.Ann Surg,2002,236(5):560-563.
40 Pai M,Spalding D,Jiao L,et al.Use of bipolar radiofrequency in parenchymal transection of the liver,pancreas and kidney.Dig Surg,2012,29(1):43-47.
41高苗苗,徐芳野,木合布力·阿布力孜.肝癌治疗靶点及肝靶向抗癌药物研究进展.新疆医科大学学报,2012,35(2):146-152.
42 Chaorro M,Trapero-Marugán M,et al.Review article:pharmacological therapy for hepatocellular carcinoma with sorafenib and other oral agents.Aliment Phar-macol Ther,2008,28(11-12):1269-1277.
43 Xu M,Xie XH,Xie XY,et al.Sorafenib suppresses the rapid progress of hepatocellular carcinoma after insufficient radiofrequency ablation therapy:an experiment in vivo.Acta Radiol.2013;54:199-204.
44 Er9s de Bethlenfalva-Hora C,Mertens JC,Piguet AC,Kettenbach J,Schmitt J,Terracciano L,Weimann R,Dufour JF,Geier A.Clin Sci(Lond).2014 Feb;126(3):243-52
45 Xiaobin Feng,Ruocai Xu,Xilin Du,Kefeng Dou,Xiao Qin,Jun Xu,Weidong Jia,Zhiming Wang,Hongzhi Zhao,Shufa Yang,Chenyang Guo,Tianqi Liu,Kuansheng Ma*.Combination Therapy With Sorafenib and Radiofrequency Ablation for BCLC Stage 0-B1Hepatocellular Carcinoma:A Multicenter Retrospective Cohort Study.Am J Gastroenterol 2014;109:1891-1899.
46王凌霄,肖典,周辛波.口服多靶点酪氨酸激酶抑制剂-乐伐替尼.临床药物治疗杂志,2015,13(5):11-14.
47 Ma HQ,Zhang YJ,Wang QJ,et al.Therapeutic safety and effects of adjuvant autologous Retro Nectin activated killer cell immunothera-py for patients with primary hepatocellular carcinoma after radiofrequency ablation.Cancer Biol Ther,2010,9(4):1-5.
48常小峰,郭金滕,皋军.介入治疗联合免疫检查点抑制剂在肿瘤治疗中的研究进展.中华放射学杂志,2018,52(11):883-888.