骨髓细胞和血小板参数联合检测对血液疾病的诊断价值分析
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摘要
目的 探讨与分析骨髓细胞和血小板参数联合检测应用到血液疾病临床诊断中的价值。方法 随机抽取98例患者,根据疾病类型将其分为再生障碍性贫血组(AA)29例,急性白血病组(AL)37例,特发性血小板减少性紫癜组(ITP)32例,另外选取同期来本院进行健康检查的35例正常人员作为对照组。对四组患者均行骨髓细胞检测与血小板检测。观察四组患者骨髓细胞检查结果以及血液各项指标检测结果。结果 AA组、AL组、ITP组患者PLT、PCT水平均低于对照组,ITP组患者MPV水平高于对照组,AA组、ITP组患者PDW水平高于对照组,差异均有统计学意义(P<0.05)。AA组骨髓增生程度显著下降,AL组、ITP组骨髓增生程度明显活跃;AA组、AL组、ITP组巨核细胞数均以幼稚型为主,血小板呈现出单个偶见分布;对照组巨核细胞数以成熟产板型为主,血小板呈现出成堆式分布。结论 骨髓细胞和血小板参数联合检测能够通过对人体内的血液各项水平及骨髓细胞情况进行分析,可以作为诊断血液疾病的主要方式。
Objective To explore and analyze the value of combined detection of bone marrow cells and platelet parameters in clinical diagnosis of hematological diseases. Methods 98 patients were randomized and divided into 29 patients with aplastic anemia(AA), 37 patients with acute leukemia(AL), and 32 patients with idiopathic thrombocytopenic purpura(ITP) according to disease type. In the same period, 35 normal persons who came to our hospital for health examination were selected as the control group. Bone marrow cell and platelet tests were performed on the four groups of patients. Observed four groups of patients with bone marrow cell test results and blood test results. Results The levels of PLT and PCT in AA group, AL group and ITP group were lower than those in control group. The MPV levels in ITP group were higher than those in control group. The PDW levels in AA group and ITP group were higher than those in control group. The differences were statistically significant(P<0.05). The degree of myeloproliferation in AA group was significantly decreased. The degree of myeloproliferation in AL group and ITP group was significantly active. The number of megakaryocytes in AA group, AL group and ITP group was mainly infant-type, and the platelets showed a single occasional distribution; the number of megakaryocytes in control group was significantly increased. With mature plate production as the main form, platelets have a stacking distribution. Conclusion The combined detection of bone marrow cells and platelet parameters can be used to analyze blood levels and bone marrow cells in the human body, which can be used as the main method for diagnosis of blood diseases.
Objective To explore and analyze the value of combined detection of bone marrow cells and platelet parameters in clinical diagnosis of hematological diseases. Methods 98 patients were randomized and divided into 29 patients with aplastic anemia(AA), 37 patients with acute leukemia(AL), and 32 patients with idiopathic thrombocytopenic purpura(ITP) according to disease type. In the same period, 35 normal persons who came to our hospital for health examination were selected as the control group. Bone marrow cell and platelet tests were performed on the four groups of patients. Observed four groups of patients with bone marrow cell test results and blood test results. Results The levels of PLT and PCT in AA group, AL group and ITP group were lower than those in control group. The MPV levels in ITP group were higher than those in control group. The PDW levels in AA group and ITP group were higher than those in control group. The differences were statistically significant(P<0.05). The degree of myeloproliferation in AA group was significantly decreased. The degree of myeloproliferation in AL group and ITP group was significantly active. The number of megakaryocytes in AA group, AL group and ITP group was mainly infant-type, and the platelets showed a single occasional distribution; the number of megakaryocytes in control group was significantly increased. With mature plate production as the main form, platelets have a stacking distribution. Conclusion The combined detection of bone marrow cells and platelet parameters can be used to analyze blood levels and bone marrow cells in the human body, which can be used as the main method for diagnosis of blood diseases.
引文
[1]肖唐杰,华绪柏.血小板参数对血液疾病的诊断价值[J].血栓与止血学,2017,23(2):300-302.
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[3]杨娣娣,韩秀蕊,张丽洁,等.3374例血液病患者骨髓细胞形态及活检同步检测的比较分析[J].中国实验诊断学,2016,20(6):952-954.
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[6]顾李霖,康慧媛,潘玉玲,等.骨髓细胞形态、细胞化学染色及骨髓活检切片联合检测在低原始细胞骨髓增生异常综合征与溶血性贫血鉴别诊断中的价值[J].中国实验血液学杂志,2016,24(1):138-143.
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[8]高峰,张宏杰,刘瑞芳,等.血小板参数和骨髓巨核细胞计数、分类在May-Hegglin异常疾病中的应用研究[J].检验医学,2017,32(8):668-670.
[9]陈芳,范晓玲.联合检测血清Vit B12及铁蛋白在贫血诊断和鉴别诊断中的价值[J].临床检验杂志(电子版),2017,6(2):229.
[10]何华云,雷翠蓉,陈新红,等.血清炎性因子、血小板相关指标单独及联合检测对新生儿细菌感染性败血症的诊断价值[J].山东医药,2017,57(2):53-55.
[11]崔红美.骨髓细胞检查在贫血病因诊断中的价值探究[J].临床检验杂志(电子版),2017,6(2):184-185.
[12]陈刚,江明,曲建华,等.血细胞分析仪联合血细胞形态学观察筛查血液系统疾病中的价值研究[J].河北医药,2017,39(8):1212-1214.
[13]张林.血细胞参数综合分析在白血病诊断的临床应用分析[J].临床和实验医学杂志,2016,15(24):2485-2486.
[2]石磊,骆志成,王慧,等.血细胞多参数联合分析在大细胞性贫血疾病中的诊断价值[J].标记免疫分析与临床,2017,24(11):1221-1224.
[3]杨娣娣,韩秀蕊,张丽洁,等.3374例血液病患者骨髓细胞形态及活检同步检测的比较分析[J].中国实验诊断学,2016,20(6):952-954.
[4]朱金平,卢兴国.回顾性研究骨髓标本巨核细胞微核检查对血液病诊断价值[J].中华检验医学杂志,2016,39(3):197-200.
[5]乐华文,顾超,张珏.血小板参数在3种疾病诊断中的临床价值[J].检验医学与临床,2016,13(8):1040-1041.
[6]顾李霖,康慧媛,潘玉玲,等.骨髓细胞形态、细胞化学染色及骨髓活检切片联合检测在低原始细胞骨髓增生异常综合征与溶血性贫血鉴别诊断中的价值[J].中国实验血液学杂志,2016,24(1):138-143.
[7]张京,杨柯,白海,等.血液病骨髓涂片与骨髓病理活检诊断对比分析[J].检验医学与临床,2017,14(3):408-410.
[8]高峰,张宏杰,刘瑞芳,等.血小板参数和骨髓巨核细胞计数、分类在May-Hegglin异常疾病中的应用研究[J].检验医学,2017,32(8):668-670.
[9]陈芳,范晓玲.联合检测血清Vit B12及铁蛋白在贫血诊断和鉴别诊断中的价值[J].临床检验杂志(电子版),2017,6(2):229.
[10]何华云,雷翠蓉,陈新红,等.血清炎性因子、血小板相关指标单独及联合检测对新生儿细菌感染性败血症的诊断价值[J].山东医药,2017,57(2):53-55.
[11]崔红美.骨髓细胞检查在贫血病因诊断中的价值探究[J].临床检验杂志(电子版),2017,6(2):184-185.
[12]陈刚,江明,曲建华,等.血细胞分析仪联合血细胞形态学观察筛查血液系统疾病中的价值研究[J].河北医药,2017,39(8):1212-1214.
[13]张林.血细胞参数综合分析在白血病诊断的临床应用分析[J].临床和实验医学杂志,2016,15(24):2485-2486.