血清学标志物对胰腺癌早期诊断的研究进展
摘要
<正>胰腺癌是常见的消化系统恶性肿瘤之一,据统计,胰腺癌在美国位居肿瘤相关死因的第3位,5年生存率约为8.0%[1],在我国其发病率和死亡率也居高不下。手术治疗是惟一的根治方案,但大部分患者在诊断时已失去手术机会,同时胰腺癌细胞对化疗的敏感性较低,因此早期诊断将是提高患者生存率的关键。本文拟就胰腺癌早期血清学诊断标志物的研究进展作一综述。1 传统血清肿瘤标志物单独及联合应用的研究临床上最常用的胰腺癌诊断血清学标志物是糖类抗原CA199
引文
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[2] CHAKRABORTY S,BAINE M,SASSON A,et al.Current status of molecular markers for early detection of sporadic pancreatic cancer[J].Biochim Biophys Acta,2011,1815:44-64.
[3] CHEN Y,KANG M,LU W,et al.A novel biomarker and a selected target gene for overcoming chemoresistance in pancreatic cancer[J].Cancer Res Clin Oncol,2012,138:1463-1474.
[4] M?RTEN A,BUCHLER M,WERFT W,et al.Soluble iC3 b as an early marker for pancreatic adenocarcinoma is superior to CA199 and radiology[J].Immunother,2010,33:219-224.
[5] WU S,WILLIAMS P,GROVER A,et al.Early detection of pancreatic cancer in mouse models using a novel antibody TAB004[J].PLoS One,2018,13:e0193260.
[6] TAKAYAMA R,NAKAGAWA H,SAWAKI A,et al.Serum tumor antigen REG4 as a diagnostic biomarker in pancreatic ductal adenocarcinoma[J].J Gastroenterol,2010,45:52-59.
[7] WANG F,CHEN L,DING W,et al.Serum APRIL,a potential tumor marker in pancreatic cancer[J].Clin Chem Lab Med,2011,49:1715-1719.
[8] CONRAD C,FERNáNDEZ-DEL CASTILLO C.Preoperative evaluation and management of the pancreatic head mass[J].J Surg Oncol,2013,107:23-32.
[9] WAN C,SHEN Y,YANG T,et al.Diagnostic value of microRNA for pancreatic cancer:a meta-analysis[J].Arch Med Sci,2012,8:749-755.
[10] LIU J,GAO Y,DU Z,et al.Combination of plasma microRNAs with serum CA199 for early detection of pancreatic cancer[J].Int J Cancer,2012,131:683-691.
[11] YU J,LI A,HONG S,et al.MicroRNA alterations of pancreatic intraepithelial neoplasias[J].Clin Cancer Res,2012,18:981-992.
[12] LIU R,CHEN X,DU Y,et al.Serum microRNA expression profile as a biomarker in the diagnosis and prognosis of pancreatic cancer[J].Clin Chem,2012,58:610-618
[13] SAN LUCAS F A,ALLENSON K,BERNARD V,et al.Minimal16 xt-generation sequencing of circulating exosomes[J].Ann Oncol,2016,27:635-641.
[14] MELO S,LUECKE B,KAHLERT C,et al.Glypican-1 identifies cancer exosomes and detects early pancreatic cancer[J].Nature,2015,523:177-182.
[15] MADHAVEN B,YUE S,GALLI U,et al.Combined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity[J].Int J Cancer,2015,136:2616-2627.
[16] LIU S,LI N,YU X,et al.Expression of intercellular adhesion molecule 1 by hepatocellular carcinoma stem cells and circulating tumor cells[J].Gastroenterology,2013.144:1031-1041.
[17] IWANICKI-CARON I,BASILE P,TOURE E,et al.Usefulness of circulating tumor cell detection in pancreatic adenocarcinoma diagnosis[J].Am J Gastroenterol,2013,108:152-155.
[18] SEFRIOUI D,BLANCHARD F,TOURE E,et al.Diagnostic value of CA199,circulating tumour DNA and circulating tumour cells in patients with solid pancreatic tumours[J].Br J Cancer,2017,117:1017-1025.
[19] KOBAYASHI T,NISHIUMI S,IKEDA A,et al.A novel serum metabolomics-based diagnostic approach to pancreatic cancer[J].Cancer Epidemiol Biomarkers Prev,2013,22:571-579.
[20] DI GANGI IM,MAZZA T,FONTANA A,et al.Metabolomic profile in pancreatic cancer patients:a consensus-based approach to identify highly discriminating metabolites[J].Oncotarget,2016,7:5815-5829.
[21] AGGARWAL G,KAMADA P,CHARI S T.Prevalence of diabetes mellitus in pancreatic cancer compared to common cancers[J].Pancreas,2013,42:198-201.
[22] DAI X,PANG W,ZHOU Y,et al.Altered profile of serum microRNAs in pancreatic cancer-associated new-onset diabetes mellitus[J].J Diabetes,2016,8:422-433.
[23] AGGARWAL G,RAMACHANDRAN V,JAVEED N,et al.Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in beta cells and mice[J].Gastroenterology,2012,143:1510-1517.
[24] GROTE V A,ROHRMANN S,DOSSUS L,et al.The association of circulating adiponectin levels with pancreatic cancer risk:a study within the prospective EPIC cohort[J].Int J Cancer,2012,130:2428-2437.
[25] 庞文璟,贲其稳,袁耀宗,等.脂肪因子对合并糖尿病的胰腺癌诊断和预后分析的价值[J].中华消化杂志,2018,38(1):32-37.