肝硬化并发肝性脑病的预后相关因素分析
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摘要
目的分析肝硬化并发肝性脑病(HE)的预后相关因素。方法选择我院自2014年1月至2017年12月收治的87例单纯肝硬化患者作为对照组,选择同期收治的87例肝硬化并发肝性脑病(HE)患者作为观察组,对两组患者临床指标进行比较,包括谷丙转氨酶(ALT)、血钠、血氨等水平,对比两组患者感染、上消化道出血及腹水发生情况,对肝硬化患者并发的危险因素进行分析。结果经Logistic多元回归分析,血钠、血氨水平、上消化出血、Child-Pugh分级及HE分期是影响HE预后的独立危险因素。结论影响肝硬化并发HE预后的因素较多,要做好预防措施,尽量降低HE的发生。
Objective To analyzed prognostic factors in liver cirrhosis complicated by hepatic encephalopathy.Methods The87 patients with cirrhosis admitted to our hospital from January 2014 to December 2017 were selected as the control group.87 patients with cirrhosis complicated with hepatic encephalopathy treated in the same period were selected as the observation group.The clinical indicators of the two groups were compared.Including alanine aminotransferase(ALT),blood sodium,and blood ammonialevels,and comparing infections,upper gastrointestinal bleeding,and ascites in both groups,and analyzed risk factors for hepatic encephalopathy in patients with cirrhosis.Results Logistic multiple regression analysis revealed that serum sodium,blood ammonia levels,upper digestive hemorrhage,Child-Pugh grade,and HE staging were independent risk factors for prognosis of HE.Conclusion There are many factors that affect the prognosis of hepatic cirrhosis complicated by hepatic encephalopathy.Preventive measures should be taken to minimize the incidence of senile encephalopathy.
Objective To analyzed prognostic factors in liver cirrhosis complicated by hepatic encephalopathy.Methods The87 patients with cirrhosis admitted to our hospital from January 2014 to December 2017 were selected as the control group.87 patients with cirrhosis complicated with hepatic encephalopathy treated in the same period were selected as the observation group.The clinical indicators of the two groups were compared.Including alanine aminotransferase(ALT),blood sodium,and blood ammonialevels,and comparing infections,upper gastrointestinal bleeding,and ascites in both groups,and analyzed risk factors for hepatic encephalopathy in patients with cirrhosis.Results Logistic multiple regression analysis revealed that serum sodium,blood ammonia levels,upper digestive hemorrhage,Child-Pugh grade,and HE staging were independent risk factors for prognosis of HE.Conclusion There are many factors that affect the prognosis of hepatic cirrhosis complicated by hepatic encephalopathy.Preventive measures should be taken to minimize the incidence of senile encephalopathy.
引文
[1]李玉兰,王新绘,杨力.大黄乌梅煎剂灌肠联合培菲康口服对肝硬化并发肝性脑病患者肝肾功能及血氨、血浆内毒素水平的影响[J].内科,2018,13(1):23-26.
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[3]王结实.门-体分流术后并发肝性脑病的危险因素分析[J].中国实用神经疾病杂志,2017,20(19):105-107.
[4]陈晓锋,李秋元.肝硬化并发肝性脑病的危险因素及预后分析[J].临床医学工程,2017,24(5):649-650.
[5]孟唤男,刘永刚,杨璇,等.益木脑液灌肠佐治肝硬化并发肝性脑病32例疗效观察[J].国医论坛,2016,31(5):50-52.
[6]程荷珍,张忠元.精氨酸联合纳洛酮治疗肝硬化并发肝性脑病的效果分析[J].中国当代医药,2016,23(26):121-123.
[7]张小军,郭艳,朱祈锋.肝硬化并发肝性脑病的危险因素与预后相关因素分析[J].中国实用神经疾病杂志,2016,19(9):71-73.
[8]张仲慧,李广鉴.肝硬化肝性脑病分期与血清甲状腺激素水平相关性分析[J].河北联合大学学报(医学版),2015,17(5):97-99.
[2]董亚茹,张琳,由凤秋,等.酒精性肝硬化并发肝性脊髓病的临床分析[J].卒中与神经疾病,2017,24(6):558-560.
[3]王结实.门-体分流术后并发肝性脑病的危险因素分析[J].中国实用神经疾病杂志,2017,20(19):105-107.
[4]陈晓锋,李秋元.肝硬化并发肝性脑病的危险因素及预后分析[J].临床医学工程,2017,24(5):649-650.
[5]孟唤男,刘永刚,杨璇,等.益木脑液灌肠佐治肝硬化并发肝性脑病32例疗效观察[J].国医论坛,2016,31(5):50-52.
[6]程荷珍,张忠元.精氨酸联合纳洛酮治疗肝硬化并发肝性脑病的效果分析[J].中国当代医药,2016,23(26):121-123.
[7]张小军,郭艳,朱祈锋.肝硬化并发肝性脑病的危险因素与预后相关因素分析[J].中国实用神经疾病杂志,2016,19(9):71-73.
[8]张仲慧,李广鉴.肝硬化肝性脑病分期与血清甲状腺激素水平相关性分析[J].河北联合大学学报(医学版),2015,17(5):97-99.