畜牧养殖业废弃物中抗生素及抗性基因研究进展
摘要
抗生素抗性基因(antibiotic resistance genes,ARGs)可以持久性存在于环境中,通过基因水平转移功能广泛传播于菌群之间,携带有抗性基因的细菌最终可能通过食物链进入人体,引发难以治愈的细菌性疾病,给人类健康带来严重威胁。该文主要针对畜禽养殖废弃物中抗生素及抗性基因污染这一问题,结合国内外最新研究对畜禽养殖中抗生素及抗性基因的污染现状、产生和传播机制以及消除技术等进行了综述,为我国畜牧业可持续发展提供理论参考。
引文
[1]周启星,罗义,王美娥.抗生素的环境残留、生态毒性及抗性基因污染[J].生态毒理学报,2007,2(3):243-251.
[2]张俊亚,魏源送,陈梅雪,等.畜禽粪便生物处理与土地利用全过程中抗生素和重金属抗性基因的迁移转化研究进展[J].环境科学学报,2015,35(4):935-946.
[3]Zhang Q Q,Ying G G,Pan C G,et a1.Comprehensive evaluation of antibiotics emission and fate in the river basins of China:Source analysis,multimedia modeling,and linkage to bacterial resistance[J].EnvironSciTechnol,2015,49(11):6 772-6 782.
[4]闵继胜,孔祥智.我国农业面源污染问题的研究进展[J].华中农业大学学报(社会科学版),2016(2):59-66.
[5]李振,王云建.畜禽养殖中抗生素使用的现状、问题及对策[J].今日畜牧兽医,2009(8):1-3.
[6]Van Boeckel T P,Brower C,Gilbert M,et a1.Global trends in antimicrobial use in food animus[J].Proceedingsof the National Academy of Sciences,2015,112(18):5 649-5 654.
[7]Hu X G,Zhou Q X,Luo Y.Occurrence and source analysis of typical veterinary antibiotics in manure,soil,vegetables and groundwater from organic vegetable bases,Northern China[J].Environmental Pollution,2010,158(9):2 992-2 998.
[8]Wei R C,Ge F,Huang S Y,et a1.Occurrence of veterinary antibiotics in animal wastewater and surface water around farms in Jiangsu Province,China[J].Chemosphere,2011,82(10):1 408-1 414.
[9]Pan X,Qiang Z M,Ben W,et a1.Residual veterinary antibiotics in swine manure from concentrated animal feeding operations in Shandong Province[J].Chemosphere,2011,84(5):695-700.
[10]Danzeisen J L,Kim H B,Isaacson R E,et a1.Modulations of the chicken cecalmicrobiome and meta-genome in response to anticoccidial and growth promoter treatment[J].PLoS One,2011,6(11):27 949-27 956.
[11]Loof T,Johnson T A,Allen H K,et a1.From the cover:In-feed antibiotic effects on the swine intestinal microbiome[J].Proceedings of the National Academy of Sciences,2012,109(5):1 691-1 696.
[12]Bibbal D,Dupouy V,Ferr J P,et a1.Impact of three ampicillin dosage regimens on selection of ampicillin resistance in Enterobactenaceae and excretion of blaTEM genes in swine feces[J].Applied and Environmental Microbiology,2007,73(15):4 785-4 790.
[13]Yang Q,Ren S,Niu T,et a1.Distribution of antibioticresistant bacteria in chicken manure and manurefertilizedvegetables[J].Environmental Science and Pollution Research,2014,21(2):1 231-1 241.
[14]隋倩雯,张俊亚,魏源送,等.畜禽养殖过程中抗生素使用与耐药病原菌及其抗性基因赋存的研究进展[J].生态毒理学报,2015(5):20-34.
[15]Jaglic Z,Vlkova H,Bardon J,et a1.Distribution,characterization and genetic bases of erythromycin resistance in Staphylococci and Enterococci originating from livestock[J].Zoonoses Public Health,2012,59(3):202-211.
[16]Walczak J J,Xu S.Manure as a source of antibiotic-resistant Eschedchia coli and Enterococci:A case study of a Wisconsin,USA family dairy farm[J].Water Air SoilPollution,2011,219(1-4):579-589.
[17]Kotzamanidis C,Zdragas A,Kourelis A,et a1.Characterizafionof van-type EnteTococcusfaecium isolates from urban and hospital wastewater and pigs[J].Journal ofApplied Microbiology,2009,107(3):997-1 005.
[18]Cheenier M R,Juteau P.Fate of chlortetracycline-and-tylosinresistant bacteria in all aerobic thermophilic sequencing batch reactor treating swine waste[J].Microbial Ecology,2009,58(1):86-97.
[19]Graves A K,Liwimbi L,Israel D W.Distribution of ten antibiotic resistance genes in E.coli isolates from swine manure,lagoon effluent and soil collected from a lagoon waste application field[J].Folia Microbiologica,2011,56(2):131-137.
[20]Lutz E,McCarty M J,Mollenkopf D F,et a1.Ceftiofiaruse in finishing swine barns and the recovery of fecalEscheHclfacoil or Salmonella spp.resistant to ceftriaxone[J].Foodborne Pathogens and Disease,2011,8(11):1 229-1 234.
[21]Horton R A,Randall L P,Snary E L,et a1.Fecal carriage and shedding density of CTX-M extended-spectrumβ-lactamase·producing Eschetichia coli in cattle,chickens,and pigs:Implications for environmental contamination and food production[J].Applied and Environmental Microbiology,2011,77(11):3 715-3 719.
[22]Miller R.Environmental bacteriophage-host interactions:Factors contribution to natural transduction[J].Antonie Van Leeuwenhoek,2001,79(2):141-147.
[23]Binh C T T,Heuer H,Kaupeohaun M,et a1.Piggery manure used for soil fertilization is a reservoir for transferable antibiotic resistance plasmids[J].FEMS Microbiology Ecology,2008,66(1):25-37.
[24]Zhang X Y,Ding L J,Yue J.Occurrence and characteristics of class 1 and class 2 integrons in resistant Eschedchia coli isolates from animals and farm workers in Northeastern China[J].Microbial Drug Resistance,2009,15(4):323-328.
[25]Thomas C M,Nielsen K M.Mechanisms of barriers tohorizontal gene transfer between bacteria[J].Nature Reviews Microbiology,2005,3(9):711-721.
[26]Frost L S,Leplae R,Summers A O,et a1.Mobile genetic elements:The agents of open source evolution[J].Nature Reviews Microbiology,2005,3(9):722-732.
[27]王惠惠,王淑平.畜禽排泄物中抗生素残留与控制技术研究进展[J].土壤通报,2011,42(1):250-256.
[28]卢信,罗佳,高岩,等.畜禽养殖废水中抗生素和重金属的污染效应及其修复研究进展[J].江苏农业学报,20l4,30(3):671-681.
[29]ZHANG Yingying,ZHUANG Yao,GENG Jiniu,et al.Inactivation of antibiotic resistance genes inmunicipal wastewater effluent by chlorination and sequential UV/chlorination disinfection[J].Science 0f The Total Environment,2015(512):125-132.
[30]贾晗,吴若菁,黄婧,等.生物法处理畜禽养殖污水的研究现状与展望[J].水处理技术,2008,34(7):7-11.
[31]王贤瑞,何雅萍.人工湿地在处理养殖污水中的应用研究[J].安徽农业科学,2012,40(32):15 839-15 841.
[2]张俊亚,魏源送,陈梅雪,等.畜禽粪便生物处理与土地利用全过程中抗生素和重金属抗性基因的迁移转化研究进展[J].环境科学学报,2015,35(4):935-946.
[3]Zhang Q Q,Ying G G,Pan C G,et a1.Comprehensive evaluation of antibiotics emission and fate in the river basins of China:Source analysis,multimedia modeling,and linkage to bacterial resistance[J].EnvironSciTechnol,2015,49(11):6 772-6 782.
[4]闵继胜,孔祥智.我国农业面源污染问题的研究进展[J].华中农业大学学报(社会科学版),2016(2):59-66.
[5]李振,王云建.畜禽养殖中抗生素使用的现状、问题及对策[J].今日畜牧兽医,2009(8):1-3.
[6]Van Boeckel T P,Brower C,Gilbert M,et a1.Global trends in antimicrobial use in food animus[J].Proceedingsof the National Academy of Sciences,2015,112(18):5 649-5 654.
[7]Hu X G,Zhou Q X,Luo Y.Occurrence and source analysis of typical veterinary antibiotics in manure,soil,vegetables and groundwater from organic vegetable bases,Northern China[J].Environmental Pollution,2010,158(9):2 992-2 998.
[8]Wei R C,Ge F,Huang S Y,et a1.Occurrence of veterinary antibiotics in animal wastewater and surface water around farms in Jiangsu Province,China[J].Chemosphere,2011,82(10):1 408-1 414.
[9]Pan X,Qiang Z M,Ben W,et a1.Residual veterinary antibiotics in swine manure from concentrated animal feeding operations in Shandong Province[J].Chemosphere,2011,84(5):695-700.
[10]Danzeisen J L,Kim H B,Isaacson R E,et a1.Modulations of the chicken cecalmicrobiome and meta-genome in response to anticoccidial and growth promoter treatment[J].PLoS One,2011,6(11):27 949-27 956.
[11]Loof T,Johnson T A,Allen H K,et a1.From the cover:In-feed antibiotic effects on the swine intestinal microbiome[J].Proceedings of the National Academy of Sciences,2012,109(5):1 691-1 696.
[12]Bibbal D,Dupouy V,Ferr J P,et a1.Impact of three ampicillin dosage regimens on selection of ampicillin resistance in Enterobactenaceae and excretion of blaTEM genes in swine feces[J].Applied and Environmental Microbiology,2007,73(15):4 785-4 790.
[13]Yang Q,Ren S,Niu T,et a1.Distribution of antibioticresistant bacteria in chicken manure and manurefertilizedvegetables[J].Environmental Science and Pollution Research,2014,21(2):1 231-1 241.
[14]隋倩雯,张俊亚,魏源送,等.畜禽养殖过程中抗生素使用与耐药病原菌及其抗性基因赋存的研究进展[J].生态毒理学报,2015(5):20-34.
[15]Jaglic Z,Vlkova H,Bardon J,et a1.Distribution,characterization and genetic bases of erythromycin resistance in Staphylococci and Enterococci originating from livestock[J].Zoonoses Public Health,2012,59(3):202-211.
[16]Walczak J J,Xu S.Manure as a source of antibiotic-resistant Eschedchia coli and Enterococci:A case study of a Wisconsin,USA family dairy farm[J].Water Air SoilPollution,2011,219(1-4):579-589.
[17]Kotzamanidis C,Zdragas A,Kourelis A,et a1.Characterizafionof van-type EnteTococcusfaecium isolates from urban and hospital wastewater and pigs[J].Journal ofApplied Microbiology,2009,107(3):997-1 005.
[18]Cheenier M R,Juteau P.Fate of chlortetracycline-and-tylosinresistant bacteria in all aerobic thermophilic sequencing batch reactor treating swine waste[J].Microbial Ecology,2009,58(1):86-97.
[19]Graves A K,Liwimbi L,Israel D W.Distribution of ten antibiotic resistance genes in E.coli isolates from swine manure,lagoon effluent and soil collected from a lagoon waste application field[J].Folia Microbiologica,2011,56(2):131-137.
[20]Lutz E,McCarty M J,Mollenkopf D F,et a1.Ceftiofiaruse in finishing swine barns and the recovery of fecalEscheHclfacoil or Salmonella spp.resistant to ceftriaxone[J].Foodborne Pathogens and Disease,2011,8(11):1 229-1 234.
[21]Horton R A,Randall L P,Snary E L,et a1.Fecal carriage and shedding density of CTX-M extended-spectrumβ-lactamase·producing Eschetichia coli in cattle,chickens,and pigs:Implications for environmental contamination and food production[J].Applied and Environmental Microbiology,2011,77(11):3 715-3 719.
[22]Miller R.Environmental bacteriophage-host interactions:Factors contribution to natural transduction[J].Antonie Van Leeuwenhoek,2001,79(2):141-147.
[23]Binh C T T,Heuer H,Kaupeohaun M,et a1.Piggery manure used for soil fertilization is a reservoir for transferable antibiotic resistance plasmids[J].FEMS Microbiology Ecology,2008,66(1):25-37.
[24]Zhang X Y,Ding L J,Yue J.Occurrence and characteristics of class 1 and class 2 integrons in resistant Eschedchia coli isolates from animals and farm workers in Northeastern China[J].Microbial Drug Resistance,2009,15(4):323-328.
[25]Thomas C M,Nielsen K M.Mechanisms of barriers tohorizontal gene transfer between bacteria[J].Nature Reviews Microbiology,2005,3(9):711-721.
[26]Frost L S,Leplae R,Summers A O,et a1.Mobile genetic elements:The agents of open source evolution[J].Nature Reviews Microbiology,2005,3(9):722-732.
[27]王惠惠,王淑平.畜禽排泄物中抗生素残留与控制技术研究进展[J].土壤通报,2011,42(1):250-256.
[28]卢信,罗佳,高岩,等.畜禽养殖废水中抗生素和重金属的污染效应及其修复研究进展[J].江苏农业学报,20l4,30(3):671-681.
[29]ZHANG Yingying,ZHUANG Yao,GENG Jiniu,et al.Inactivation of antibiotic resistance genes inmunicipal wastewater effluent by chlorination and sequential UV/chlorination disinfection[J].Science 0f The Total Environment,2015(512):125-132.
[30]贾晗,吴若菁,黄婧,等.生物法处理畜禽养殖污水的研究现状与展望[J].水处理技术,2008,34(7):7-11.
[31]王贤瑞,何雅萍.人工湿地在处理养殖污水中的应用研究[J].安徽农业科学,2012,40(32):15 839-15 841.