当归饮子方治疗血虚风燥型湿疹临床疗效及对外周血T淋巴细胞亚群、血清IL-31、SP的影响
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摘要
目的:观察当归饮子方治疗血虚风燥型湿疹临床疗效及对外周血T淋巴细胞亚群、血清白介素-31 (IL-31)、P物质(SP)的影响。方法:选取我院收治的134例血虚风燥型湿疹患者作为研究对象,按照随机数字表法分为观察组和对照组各67例,2组均给予健康教育、饮食指导等基础干预,在此基础对照组给予常规治疗,观察组在对照组基础上联合当归饮子方治疗。观察2组湿疹面积及严重程度、瘙痒程度、皮肤病生活质量,统计临床治疗总有效率,检测外周血T淋巴细胞亚群和血清IL-31、SP水平。结果:治疗后2组EASI、VAS、DLQI评分显著低于治疗前(P <0. 05),且观察组显著低于对照组(P <0. 05);观察组总有效率92. 54%显著高于对照组79. 10%(P <0. 05);治疗后2组CD3+、CD4+、CD4+/CD8+水平显著高于治疗前(P <0. 05),且观察组显著高于对照组(P <0. 05),2组CD8+水平显著低于治疗前(P <0. 05),且观察组显著低于对照组(P <0. 05);治疗后2组IL-31、SP水平显著低于治疗前(P <0. 05),且观察组显著低于对照组(P <0. 05)。结论:当归饮子方能够有效改善血虚风燥型湿疹患者外周血T淋巴细胞亚群和血清IL-31、SP水平,提高临床疗效。
Objective: To analyze clinical effect of using Danggu Yinzi Recipe in treatment of blood-deficiency and winddryness eczema and its influence on peripheral blood T lymphocyte subsets,serum interleukin-31( IL-31) and substance P( SP). Methods: 134 cases of patients with blood deficiency and wind dryness eczema treated in our hospital were selected as the study objects,and were divided into observation group and controlled group according to random number table method,67 cases in each group. All the two groups were given basic intervention,such as health education and diet guidance,on the basis of that,the controlled group were given routine treatment,and the observation group were combined with Danggu Yinzi Recipe on the basis of the controlled group. Eczema area and severity,degree of pruritus,skin diseases and quality of life were observed in the two groups,the total effective rate of clinical treatment was figured,and peripheral blood T lymphocyte subsets and serum levels of IL-31 and SP were detected. Results: After treatment,EASI,VAS and DLQI scores were significantly lower than those before treatment in the two groups( P < 0. 05),and those in the observation group were significantly lower than those in the controlled group( P < 0. 05). The total efficiency in the observation group was 92. 54%,significantly higher than that of 79. 10%in the controlled group( P < 0. 05). After treatment,CD3+,CD4+ and CD4+/CD8+ levels were significantly higher than those before treatment( P < 0. 05),and those in the observation group were significantly higher than those in the controlled group( P< 0. 05). CD8+ level was significantly lower than that before treatment in the two groups( P < 0. 05),and that in the observation group was significantly lower than that in the controlled group( P < 0. 05). After treatment,IL-31 and SP levels were significantly lower than those before treatment in the two groups( P < 0. 05),and those in the observation group were significantly lower than those in the controlled group( P < 0. 05). Conclusion: Danggu Yinzi Recipe can effectively improve peripheral blood T lymphocyte subsets and serum IL-31 and SP levels of patients with blood deficiency and wind dryness eczema,and improve clinical efficacy.
Objective: To analyze clinical effect of using Danggu Yinzi Recipe in treatment of blood-deficiency and winddryness eczema and its influence on peripheral blood T lymphocyte subsets,serum interleukin-31( IL-31) and substance P( SP). Methods: 134 cases of patients with blood deficiency and wind dryness eczema treated in our hospital were selected as the study objects,and were divided into observation group and controlled group according to random number table method,67 cases in each group. All the two groups were given basic intervention,such as health education and diet guidance,on the basis of that,the controlled group were given routine treatment,and the observation group were combined with Danggu Yinzi Recipe on the basis of the controlled group. Eczema area and severity,degree of pruritus,skin diseases and quality of life were observed in the two groups,the total effective rate of clinical treatment was figured,and peripheral blood T lymphocyte subsets and serum levels of IL-31 and SP were detected. Results: After treatment,EASI,VAS and DLQI scores were significantly lower than those before treatment in the two groups( P < 0. 05),and those in the observation group were significantly lower than those in the controlled group( P < 0. 05). The total efficiency in the observation group was 92. 54%,significantly higher than that of 79. 10%in the controlled group( P < 0. 05). After treatment,CD3+,CD4+ and CD4+/CD8+ levels were significantly higher than those before treatment( P < 0. 05),and those in the observation group were significantly higher than those in the controlled group( P< 0. 05). CD8+ level was significantly lower than that before treatment in the two groups( P < 0. 05),and that in the observation group was significantly lower than that in the controlled group( P < 0. 05). After treatment,IL-31 and SP levels were significantly lower than those before treatment in the two groups( P < 0. 05),and those in the observation group were significantly lower than those in the controlled group( P < 0. 05). Conclusion: Danggu Yinzi Recipe can effectively improve peripheral blood T lymphocyte subsets and serum IL-31 and SP levels of patients with blood deficiency and wind dryness eczema,and improve clinical efficacy.
引文
[1]戴前梅,胡春艳,陈朋,等.玉屏风胶囊联合枸地氯雷他定治疗慢性湿疹45例[J].河南中医,2015,35(12):3082~3084
[2]刘斌,李静,胡惠清,等.白芍总苷对Nc/Nga小鼠特应性皮炎的保护作用[J].中国麻风皮肤病杂志,2017,33(01):31~33
[3]马丽,李作孝.白芍总苷的免疫调节功能及其临床应用[J].中国实验方剂学杂志,2010,16(17):244~246
[4]姜艳.复方甘草酸苷片联合氯雷他定片治疗慢性湿疹的疗效观察[J].中国医院用药评价与分析,2015,15(11):1457~1459
[5]卢志坚.当归饮子外洗治疗血虚风燥湿疹随机平行对照研究[J].实用中医内科杂志,2017,31(01):14~15
[6]赵辨.中国临床皮肤病学[M].江苏科学技术出版社,2010
[7]中华人民共和国卫生部.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:228~229
[8]赵辨.湿疹面积及严重度指数评分法[J].中华皮肤科杂志,2004,37(1):3~4
[9]严广斌.视觉模拟评分法[J].中华关节外科杂志(电子版),2014,8(02):125~128
[10]王晓玲,袁玲玲,赵天恩.皮肤病生活质量指数的研究进展[J].国际皮肤性病学杂志,2004,30(2):85~87
[11]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994
[12]徐佳,谢倩.针刺加穴位放血对湿疹患者T淋巴细胞亚群的影响[J].南京中医药大学学报,2013,29(04):390~392
[13]焦春秀,赵鋆,刘桂芬.白介素-31与特应性皮炎的相关性研究进展[J].中国医学创新,2016,13(36):133~136
[14]朱莲花,南美兰,金哲虎.慢性荨麻疹患者血清IL-25及IL-31水平的检测[J].中国皮肤性病学杂志,2017,31(01):43~44
[15]林武全.荆肤止痒颗粒对儿童重症湿疹中血清组胺与P物质的影响[J].中国现代药物应用,2016,10(21):187~188
[16]王帅,包永睿,杨欣欣.白芍总苷对小鼠单核巨噬细胞作用时-效曲线研究[J].时珍国医国药,2017,28(03):541~544
[17]袁丽.血虚风燥汤联合西药治疗血虚风燥型湿疹随机平行对照研究[J].实用中医内科杂志,2015,29(12):93~94
[18]程靖.当归饮子联合西药治疗慢性荨麻疹血虚风燥证临床研究[J].新中医,2016,48(04):184~186
[19]王中元,王赛.健脾除湿方治疗慢性湿疹临床研究[J].中医学报,2017,32(07):1319~1321
[20]熊家青,刘丽芳,范洪桥.止痒润肤乳联合当归饮子治疗血虚风燥型老年性皮肤瘙痒症临床观察[J].中医药临床杂志,2015,27(08):1129~1131
[2]刘斌,李静,胡惠清,等.白芍总苷对Nc/Nga小鼠特应性皮炎的保护作用[J].中国麻风皮肤病杂志,2017,33(01):31~33
[3]马丽,李作孝.白芍总苷的免疫调节功能及其临床应用[J].中国实验方剂学杂志,2010,16(17):244~246
[4]姜艳.复方甘草酸苷片联合氯雷他定片治疗慢性湿疹的疗效观察[J].中国医院用药评价与分析,2015,15(11):1457~1459
[5]卢志坚.当归饮子外洗治疗血虚风燥湿疹随机平行对照研究[J].实用中医内科杂志,2017,31(01):14~15
[6]赵辨.中国临床皮肤病学[M].江苏科学技术出版社,2010
[7]中华人民共和国卫生部.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:228~229
[8]赵辨.湿疹面积及严重度指数评分法[J].中华皮肤科杂志,2004,37(1):3~4
[9]严广斌.视觉模拟评分法[J].中华关节外科杂志(电子版),2014,8(02):125~128
[10]王晓玲,袁玲玲,赵天恩.皮肤病生活质量指数的研究进展[J].国际皮肤性病学杂志,2004,30(2):85~87
[11]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994
[12]徐佳,谢倩.针刺加穴位放血对湿疹患者T淋巴细胞亚群的影响[J].南京中医药大学学报,2013,29(04):390~392
[13]焦春秀,赵鋆,刘桂芬.白介素-31与特应性皮炎的相关性研究进展[J].中国医学创新,2016,13(36):133~136
[14]朱莲花,南美兰,金哲虎.慢性荨麻疹患者血清IL-25及IL-31水平的检测[J].中国皮肤性病学杂志,2017,31(01):43~44
[15]林武全.荆肤止痒颗粒对儿童重症湿疹中血清组胺与P物质的影响[J].中国现代药物应用,2016,10(21):187~188
[16]王帅,包永睿,杨欣欣.白芍总苷对小鼠单核巨噬细胞作用时-效曲线研究[J].时珍国医国药,2017,28(03):541~544
[17]袁丽.血虚风燥汤联合西药治疗血虚风燥型湿疹随机平行对照研究[J].实用中医内科杂志,2015,29(12):93~94
[18]程靖.当归饮子联合西药治疗慢性荨麻疹血虚风燥证临床研究[J].新中医,2016,48(04):184~186
[19]王中元,王赛.健脾除湿方治疗慢性湿疹临床研究[J].中医学报,2017,32(07):1319~1321
[20]熊家青,刘丽芳,范洪桥.止痒润肤乳联合当归饮子治疗血虚风燥型老年性皮肤瘙痒症临床观察[J].中医药临床杂志,2015,27(08):1129~1131