氟哌噻吨美利曲辛片联合枸橼酸莫沙必利分散片治疗功能性消化不良的效果
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摘要
目的研究氟哌噻吨美利曲辛片联合枸橼酸莫沙必利分散片治疗功能性消化不良(FD)的效果。方法将106例FD患者随机分为观察组(氟哌噻吨美利曲辛片联合枸橼酸莫沙必利分散片治疗)和对照组(枸橼酸莫沙必利分散片治疗)。比较两组临床疗效、胃动力和EGG变化。结果观察组的治疗总有效率显著高于对照组(P<0.05)。治疗后,两组症状积分、NDLQI均降低,NDSI均升高,且观察组优于对照组(P<0.05)。治疗后,两组餐前、餐后正常慢波百分比、餐后餐前主功率比均升高,GET1/2均缩短,且观察组优于对照组(P<0.05)。结论氟哌噻吨美利曲辛片联合枸橼酸莫沙必利分散片治疗FD可有效改善胃电节律,促进胃动力恢复正常,从而缓解患者症状,提升治疗效果,还能在一定程度上改善患者精神心理状态,提高其生活质量。
Objective To explore the effect of flupentixol and melitracen tablets combined with mosapride citrate dispersible tablets in the treatment of functional dyspepsia(FD). Methods A total of 106 FD patients were randomly divided into observation group(flupentixol and melitracen tablets combined with mosapride citrate dispersible tablets treatment) and control group(mosapride citrate dispersible tablets treatment). Clinical efficacy, gastric motility and EGG changes were compared between the two groups. Results The total effective rate of treatment in the observation group was significantly higher than that of the control group(P<0.05). After treatment, the scores of symptoms and NDLQI in both groups decreased, while NDSI increased, and those in the observation group were better than the control group(P<0.05). After treatment, the percentage of normal slow wave before and after meals and the ratio of main power after meal and before meal in both groups increased,while GET_(1/2) decreased, and those in the observation group were better than the control group(P <0.05). Conclusion Flupenthixol and melitracen tablets combined with mosapride citrate dispersible tablets in the treatment of FD can not only effectively improve gastric electrical rhythm, promote the recovery of gastric motility to normal, thus alleviating symptoms of patients, improve treatment effect, but also to some extent improve the mental state of patients and improve their quality of life.
Objective To explore the effect of flupentixol and melitracen tablets combined with mosapride citrate dispersible tablets in the treatment of functional dyspepsia(FD). Methods A total of 106 FD patients were randomly divided into observation group(flupentixol and melitracen tablets combined with mosapride citrate dispersible tablets treatment) and control group(mosapride citrate dispersible tablets treatment). Clinical efficacy, gastric motility and EGG changes were compared between the two groups. Results The total effective rate of treatment in the observation group was significantly higher than that of the control group(P<0.05). After treatment, the scores of symptoms and NDLQI in both groups decreased, while NDSI increased, and those in the observation group were better than the control group(P<0.05). After treatment, the percentage of normal slow wave before and after meals and the ratio of main power after meal and before meal in both groups increased,while GET_(1/2) decreased, and those in the observation group were better than the control group(P <0.05). Conclusion Flupenthixol and melitracen tablets combined with mosapride citrate dispersible tablets in the treatment of FD can not only effectively improve gastric electrical rhythm, promote the recovery of gastric motility to normal, thus alleviating symptoms of patients, improve treatment effect, but also to some extent improve the mental state of patients and improve their quality of life.
引文
[1]张声生,赵鲁卿.功能性消化不良中医诊疗专家共识意见(2017)[J]中华中医药杂志,2017,32(6):2595-2598.
[2]卢眺眺,朱翔贞,高静芳.功能性消化不良伴焦虑抑郁情绪的研究进展[J].长春中医药大学学报,2016,32(2):437-440.
[3]余姣,郑丹,胡耿诚.功能性消化不良的发病机制及治疗策略[J].临床消化病杂志,2017,29(2):122-125.
[4]孙晓红.功能性消化不良的罗马Ⅳ标准解读[J].中华全科医师杂志,2017,16(9):661-663.
[5]马红晶,缪应雷.联用黛力新治疗功能性消化不良的疗效分析[J]昆明医科大学学报,2016,37(8):72-74.
[6]中华医学会消化病学分会胃肠动力学组.我国消化不良的诊治流程和指南[J].中华内科杂志,2000,39(10):717-718.
[7]李群华,贺国斌,明文,等.改变认知因素对功能性消化不良患者生命质量的影响[J].中华消化杂志,2016,36(11):758-762.
[8]杨昌妮,刘纯伦.精神心理因素与功能性消化不良的相关性研究进展[J].重庆医学,2015,44(15):2129-2131.
[9]高宏.综合干预结合药物治疗功能性消化不良540例[J].陕西医学杂志,2016,45(11):1566.
[10]周鹏,赵志恩,程宏辉,等.健脾消痞膏穴位贴敷联合莫沙必利治疗胃动力障碍40例临床研究[J].江苏中医药,2017,49(9):56-58.
[11]汤净,陈军,谭琰,等.氟哌噻吨美利曲辛片联合常规治疗对功能性消化不良效果观察[J].临床消化病杂志,2016,28(1):16-19.
[12]李晓丽,许言午,吴博威.3种5-HT4受体激动剂对胃肠道动力与心功能影响的实验研究[J].中西医结合心脑血管病杂志,2017,15(22):2827-2829.
[13]李亚宁,彭书涛.疏肝健脾汤联合莫沙比利对功能性消化不良患者胃动力的影响[J].陕西中医,2017,38(4):473-474.
[2]卢眺眺,朱翔贞,高静芳.功能性消化不良伴焦虑抑郁情绪的研究进展[J].长春中医药大学学报,2016,32(2):437-440.
[3]余姣,郑丹,胡耿诚.功能性消化不良的发病机制及治疗策略[J].临床消化病杂志,2017,29(2):122-125.
[4]孙晓红.功能性消化不良的罗马Ⅳ标准解读[J].中华全科医师杂志,2017,16(9):661-663.
[5]马红晶,缪应雷.联用黛力新治疗功能性消化不良的疗效分析[J]昆明医科大学学报,2016,37(8):72-74.
[6]中华医学会消化病学分会胃肠动力学组.我国消化不良的诊治流程和指南[J].中华内科杂志,2000,39(10):717-718.
[7]李群华,贺国斌,明文,等.改变认知因素对功能性消化不良患者生命质量的影响[J].中华消化杂志,2016,36(11):758-762.
[8]杨昌妮,刘纯伦.精神心理因素与功能性消化不良的相关性研究进展[J].重庆医学,2015,44(15):2129-2131.
[9]高宏.综合干预结合药物治疗功能性消化不良540例[J].陕西医学杂志,2016,45(11):1566.
[10]周鹏,赵志恩,程宏辉,等.健脾消痞膏穴位贴敷联合莫沙必利治疗胃动力障碍40例临床研究[J].江苏中医药,2017,49(9):56-58.
[11]汤净,陈军,谭琰,等.氟哌噻吨美利曲辛片联合常规治疗对功能性消化不良效果观察[J].临床消化病杂志,2016,28(1):16-19.
[12]李晓丽,许言午,吴博威.3种5-HT4受体激动剂对胃肠道动力与心功能影响的实验研究[J].中西医结合心脑血管病杂志,2017,15(22):2827-2829.
[13]李亚宁,彭书涛.疏肝健脾汤联合莫沙比利对功能性消化不良患者胃动力的影响[J].陕西中医,2017,38(4):473-474.