针刺支沟穴对健康人脑内以额下回为种子点功能连接网络时变效应的差异影响
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摘要
目的:运用静息态f MRI技术研究针刺支沟穴对健康人脑内以额下回为种子点功能连接网络响应脑区在针刺前后不同时间序列内的差异。方法:对18名健康受试者分别进行针刺前静息态扫描(R1)、留针期间静息态扫描(R2-R5)和拔针后静息态扫描(R6-R7),以额下回为种子点进行功能连接分析。结果:与R1比较,一是R2序列内左侧颞中回、颞下回等脑区,R3序列内左侧颞中回、颞下回、中央后回、右侧中央前回与额下回功能连接减弱,右侧额中回功能连接增强,R4序列内右侧中央前回功能连接减弱,R5序列内右侧顶上回功能连接减弱、双侧额中、上回功能连接增强;二是R6序列内右侧额中、上回及右侧顶上回与额下回功能连接减弱,R7序列内左侧小脑前、后叶及右侧颞中回、颞下回功能连接减弱。结论:结合支沟穴临床功效和额下回功能,推测左侧颞中、下回、中央后回、中央旁小叶、小脑前、后叶,右侧中央前回、顶上回、双侧额中、上回为与额下回随时间序列功能连接网络变化重要响应脑区。
Objective: To observed the difference changes of functional connectivity network of time-varying effect with inferior frontal gyrus as interest of region. Methods: Eighteen healthy participants were recruited in this trial. The scanning involved pure resting state( R1),acupuncting states( R2-R5) and withdrawing needle states( R6-R7). All scan imagery was analyzed with functional connectivity method with inferior frontal gyrus as interest of region. Results: Compared with R1,different altered regions of functional connectivity with inferior frontal gyrus as interest of region followed by time-varying showed: left middle temporal gyrus,inferior temporal gurus,postcentral gyrus and right precentral gyrus significantly weakened with inferior frontal gurus only within R2 state. Left middle temporal gyrus,inferior temporal gurus significantly weakened and right middle frontal gyrus significantly strengthened only within R3 state. Right precentral gyrus significantly weakened only within R4 state. Right superior parietal lobule significantly weakened and bilateral superior frontal gyrus and middle frontal gurus significantly strengthened only within R5 state. Right superior frontal gyrus,middle frontal gurus and superior parietal lobule significantly weakened only within R6 state. Left posterior cerbellar lobe,anterior cerebellar lobe and right middle temporal gyrus, inferior temporal gurus significantly weakened only within R7 state. Conclusion:Associated with the clinical application of TE6 and the function of inferior frontal gyrus,we speculated regions including left middle temporal gyrus,inferior temporal gyrus,postcentral gyrus,paracentral gyrus,posterior cerbellar lobe,anterior cerebellar lobe and right precentral gyrus,superior parietal lobule and bilateral superior frontal gyrus,middle frontal gurus were different activated/deactivated regions which altered with time-varying after needle TE6 on left forearm in healthy participants.
Objective: To observed the difference changes of functional connectivity network of time-varying effect with inferior frontal gyrus as interest of region. Methods: Eighteen healthy participants were recruited in this trial. The scanning involved pure resting state( R1),acupuncting states( R2-R5) and withdrawing needle states( R6-R7). All scan imagery was analyzed with functional connectivity method with inferior frontal gyrus as interest of region. Results: Compared with R1,different altered regions of functional connectivity with inferior frontal gyrus as interest of region followed by time-varying showed: left middle temporal gyrus,inferior temporal gurus,postcentral gyrus and right precentral gyrus significantly weakened with inferior frontal gurus only within R2 state. Left middle temporal gyrus,inferior temporal gurus significantly weakened and right middle frontal gyrus significantly strengthened only within R3 state. Right precentral gyrus significantly weakened only within R4 state. Right superior parietal lobule significantly weakened and bilateral superior frontal gyrus and middle frontal gurus significantly strengthened only within R5 state. Right superior frontal gyrus,middle frontal gurus and superior parietal lobule significantly weakened only within R6 state. Left posterior cerbellar lobe,anterior cerebellar lobe and right middle temporal gyrus, inferior temporal gurus significantly weakened only within R7 state. Conclusion:Associated with the clinical application of TE6 and the function of inferior frontal gyrus,we speculated regions including left middle temporal gyrus,inferior temporal gyrus,postcentral gyrus,paracentral gyrus,posterior cerbellar lobe,anterior cerebellar lobe and right precentral gyrus,superior parietal lobule and bilateral superior frontal gyrus,middle frontal gurus were different activated/deactivated regions which altered with time-varying after needle TE6 on left forearm in healthy participants.
引文
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[3]赵吉平,李瑛.针灸学[M].北京:人民卫生出版社,2012:105.
[4]方小萍,刘友谊.语言理解中句法加工的脑机制[J].心理科学进展,2012,20(12):1940-1951.
[5]王国瑞.扁鹊神应针灸玉龙经[M].北京:中医古籍出版社,2008:131-132.
[6]皇甫谧.针灸甲乙经[M].北京:中国医药科技出版社,2011:267.
[7]李莹,莫雷,史大鹏.不同性质汉语隐喻句认知加工的f MRI研究[J].浙江大学学报:人文社会科学版,2016,46(6):34-45.
[8]SHIBATA M, TOYOMURA A, MOTOYAMA H. Dose Silile Comprehension Differ from Metaphor Comprehension? A Functional MRI Study[J]. Brain Lang,2012,121(3):254-260.
[9]JUNG-BEEMAN M. Bilateral Brain Processes for Comprehending Natural Language[J]. Trends Cogn Sci,2005,9(11):512-518.
[10]R CAPLAN,M DAPRETTO. Making Sense during Conversation:an f MRI Study[J]. Neuro Report,2001,12(16):3625-3632.
[11]J M RODD,M H DAVIS,I S JOHNSRUDE. The Neural Mechanisms of Speech Comprehension:f MRI Studies of Semantic Ambiguity[J]. Cerebral Cortex,2005,15(8):1261-1269.
[12]翟洪昌,任静,肖胜勇.读写分离的脑神经机制:来自f MRI的证据[J].心理学报,2011,43(2):132-142.
[13]WT SIOK,CA PEFETTI,Z JIN. Biological abnormality of impaired reading is constrained by culture[J]. Nature,2004,431(7004):71-76.
[14]BOOTH JR,LU D,BURMAN DD.Specialization of phonological and semantic processing in Chinese word reading[J]. Brain Research,2006,1071(1):197-207.
[15]苏得权,钟元,曾红.汉语动作成语语义理解激活脑区及其具身效应:来自f MRI的证据[J].心理学报,2013,45(11):1187-1199.
[16]ESOPENKO C,GOULD L,CUMMINE J. A neuroanatomical examination of embodied cognition:semantic generation to actionrelated stimuli[J]. Frontiers in Human Neuroscience,2012,20(6):84.
[17]MATHIAS BENEDEK,EMANUEL JAUK,ANDREAS FINK.Neubauer To create or to recall? Neural mechanisms underlying the generation of creative new ideas[J]. Neuroimage,2014,88(100):125-133.
[18]杜杨杨,郝磊,王勇超.双稳态知觉的脑机制[J].中国科学:生命科学,2015,45(8):789-798.
[19]PENG HW,CHEN LD. Advance in cerebellum's involvement in cognition(review)[J]. Chinese Journal of Rehabilitation Theory and Practice,2015,21(12):1370-1374.