饲用抗生素替代品研究进展
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摘要
饲料抗生素的滥用使病原微生物的抗药性越来越强,给人类健康带来潜在的威胁,同时降低了畜禽产品的品质。为了减少抗生素的使用,抗生素替代产品的研究与应用引起了广大研究者和饲料生产厂家的重视。阐述了无抗饲料添加剂的分类、研究进展、存在的问题及未来发展方向,为饲料减抗、替抗技术的应用提供参考。
The abuse of feed antibiotics make pathogenic microbes have an increasing resistance,that bring a potential threat to human health, meanwhile,the quality of livestock and poultry products has been reduced.To reduce the use of antibiotics,the researchers and feed manufacturers think highly of the application of antibiotic substitutes.We described the classification,research progress, existing problems and future development of feed additives without antibiotics,to provide a reference for the application of feed antibiotics reduction and replacement technology.
The abuse of feed antibiotics make pathogenic microbes have an increasing resistance,that bring a potential threat to human health, meanwhile,the quality of livestock and poultry products has been reduced.To reduce the use of antibiotics,the researchers and feed manufacturers think highly of the application of antibiotic substitutes.We described the classification,research progress, existing problems and future development of feed additives without antibiotics,to provide a reference for the application of feed antibiotics reduction and replacement technology.
引文
[1] ZHANG D F,SUN B B,YUE Y Y.Anticoccidial activity of traditional Chinese herbal Dichroa febrifuga Lour. extract against Eimeria tenella infection in chickens[J].Parasitology Research,2006,40(3):1-5.
[2] 彭娟,邓夏青,敖钰舒,等.岩藻黄素抗肥胖和抗糖尿病活性研究进展[J].现代食品科技,2015,31(9):314-325.
[3] LIEN T F,LIN K J,YANG L L,et al.Effects of supplemental levels of bazhen on growth performances,serum traits,immunity,meat quality and antioxidant activity of taiwan country chickens[J].Asian-Australasian Journal of Animal Sciences,2013,26(5):675-682.
[4] WU Y R,GONG Q F,FANG H,et al.Effect of sophoraflavescens on non-specific immune response of tilapia (GIFT Oreochromisniloticus) and disease resistance against streptococcus agalactiae[J].Fish & Shellfish Immunology,2013,34(1):220-227.
[5] LI X T,WANG B,LI J L,et al.Effects of Dangguibuxue Tang,a Chinese herbal medicine,on growth performance and immune responses in broiler chicks[J].Biological Research,2013,46(2):183-188.
[6] 6. YEH H S,WENG B C,LIEN T F.Effects of Chinese traditional herbal medicine complex supplementation on the growth performance,immunity and serum traitsofpigs[J].Animal Science Journal,2011,82(6):747-752.
[7] LIANG X,YAMAZAKI K,KAMRUZZAMAN M,et al.Effects of Chinese herbal medicine on plasma glucose,protein and energy metabolism in sheep[J].Journal of Animal Science and Biotechnology,2013,4:12.
[8] WANG EL,CHEN X,WANG KY,et al.Plant polysaccharides used as immunostimulants enhance innate immune response and diseaseresistance against Aeromonas hydrophila infection in fish [J].Fish & Shellfish Immunology,2016,59:196-202.
[9] JUTURU V,WU J C.Insight into microbial hemicellulases other than xylanases: a review[J].J Chem Technol Biot,2013,88(3):353-363.
[10] 许梓荣,卢建军,杨英.饲粮中添加半纤维素酶对生长猪的促生长作用及其内分泌机制[J].中国兽医学报,2002,22(2):201-202.
[11] BAREKATAIN M R,ANTIPATIS C,RODGERS N,et al.Evaluation of high dietary inclusion of distillers dried grains with solubles and supplementation of protease and xylanase in the diets of broiler chickens under necrotic enteritis challenge[J].Poultry Science.2013,92(6):1 579-1 594.
[12] 武明欣,王雅平,李培玉,等.饲料中添加木聚糖酶对刺参幼参生长、消化和体腔液酶活力的影响[J].大连海洋大学学报,2018,33(3):329-335.
[13] NORAG M A A,EL-SHENAWY A M,FADL S E,et al.Effect of phytase enzyme on growth performance, serum biochemical alteration,immune response and gene expression in Nile tilapia[J].Fish & Shellfish Immunology,2018,80,97-108.
[14] 王坛,赵金鑫,刘东来,等.饲用溶菌酶对吉富罗非鱼消化道组织结构和营养物质消化吸收的影响[J/OL].渔业科学进展,2018-11-12.DOI:10.19663/j.issn2095-9869.20180918001.
[15] ZOU LJ,XIONG X,LIU HN,et al.Effects of dietary lysozyme levels on growth performance,intestinal morphology,immunity response and microbiota community of growing pigs[J].Journal of the Science of Food and Agriculture,2019,99(4):1 643-1 650.
[16] 张哲,殷海成,贾峰,等.发酵饲料对黄河鲤生长、非特异性免疫功能的影响[J].粮食与饲料工业,2015(3):56-59.
[17] 姜旭东.枯草芽孢杆菌对白羽肉鸡生产性能的影响[J].中国畜牧兽医文摘,2017,33(3),224-225.
[18] GALAGARZA O A,SMITH S A, DRAHOS D J,et al.Modulation of innate immunity in Nile tilapia (Oreochromis niloticus) by dietary supplementation of Bacillus subtilis endospores [J].Fish & Shellfish Immunology,2018,83:171-179.
[19] NGUYEN N V,ONODA S,KHANH T V,et al.Evaluation of dietary Heat-killed Lactobacillus plantarum strain L-137 supplementation on growth performance,immunity and stress resistance of Nile tilapia (Oreochromis niloticus) [J].Aquaculture,2019,498:371-379.
[20] MA Y X,LI L Y,LI M,et al.Effects of dietary probiotic yeast on growth parameters in juvenile sea cucumber,Apostichopus japonicas [J].Aquaculture,2019,499:203-211.
[21] GRANDIOSA R,MERIEN F,YOUNG T,et al.Multi-strain probiotics enhance immune responsiveness and alters metabolic profiles in the New Zealand black-footed abalone (Haliotis iris) [J].Fish & Shellfish Immunology,2018,82:330-338.
[22] 仝慧芳,吴明芳,凌晓东,等.枯草芽孢杆菌在水产养殖中的应用及研究现状[J].江西水产科技,2016(3):37-38.
[23] 张旭,王京树,杨元金,等.微生物制剂在水产养殖中的应用[J].畜牧与饲料科学,2011,32(2):101-102.
[24] LI C L,ZHU J H,WANG Y Q,et al.Antibacterial activity of aI-hemocidin 2,a novel N-terminal peptide of hemoglobin purified from Arcainflata[J].Marine Drugs,2017,15:7.
[25] ENNAAS N,HAMMAMI R,GOMAA A,et al.Collagencin,an antibacterial peptide from fish collagen:Activity,structure and interaction dynamicswithmembrane[J].Biochemical and Biophysical Research Communications,2016,473(2):642-647.
[26] XIN HY ,JI S Y,PENG J Y,et al.Isolation and characterisation of a novel antibacterial peptide from a native swine intestinal tract-derived bacterium[J].International Journal of Antimicrobial Agents,2017,49(4):427-436.
[27] XIN H Y,JI S Y,PENG J Y,et al.K1K8:an Hp1404-derived antibacterial peptide[J].Applied Microbiology and Iotechnology,2016,100(11):5 069-5 077.
[28] 柴仙琦,冷向军.抗菌肽在凡纳滨对虾饲料中的应用研究[J].养殖与饲料,2012(9):99-100.
[29] SHI J K,ZHANG P,XU M M,et al.Effects of composite antimicrobial peptide on growth performance and health in weaned piglets [J].Animal Science Journal,2018,89(2):397-403.
[30] YUAN W,JIN H T,REN Z H,et al.Effects of antibacterial peptide on humoral immunity in weaned piglets [J].Food and Agricultural Immunology,2015,26(5):682-689.
[31] DONG X Q,ZHANG D M,CHEN Y K,et al.Effects of antimicrobial peptides (AMPs) on blood biochemical parameters,antioxidase activity,and immune function in the common carp (Cyprinus carpio) [J].Fish & Shellfish Immunology,2015,47(1):429-434.
[32] 吴醒强.天然植物精油和有机酸复合物添加剂在肉鸡生产中替代抗生素的应用[J].广东饲料,2017,26(2):25-27.
[33] 张文静,雷连成,魏静元,等.植物精油对肉仔鸡生长、屠宰性能和免疫功能的影响[J].饲料工业,2016,37(8):35-40.
[34] SU G Q,ZHOU X W,WANG Y,et al.Effects of plant essential oil supplementation on growth performance, immune function and antioxidant activities in weaned pigs [J].Lipids in Health and Disease,2018,17.
[35] ZHU B,ZHANG Q L,HUA J W,et al.The traditional uses, phytochemistry,and pharmacology of Atractylodes macrocephala Koidz.:A review [J].Journal of Ethnopharmacology,2018,226:143-167.
[36] LEE H W,KIM S R,JUN J H,et al.Effects of herbal medicine (gan mai da zao decoction) on several types of neuropsychiatric disorders in an animal model:A systematic review [J].Journal of Pharmacopuncture,2017,20(1):5-9.
[37] HUANG Y,WANG Y,YAN R J,et al.The role of traditional Chinese herbal medicines and bioactive ingredients on ion channels:a brief review and prospect [J].CNS & Neurological Disorders Drug Targets,2018.
[38] 冯定远.饲料酶制剂应用技术与产业开发现状和展望[J].饲料工业,2018,39(17):1-6.
[39] 王志强,张爱忠,姜宁,等.抗菌肽在畜牧业上的应用研究及问题分析[J].黑龙江八一农垦大学学报,2013,25(5):21-26.
[40] PERRON G G,ZASLOF M,BELL G.Experimental evolution of resisitance to an antimicrobial peptide[J].Proc Biol Sci,2006,273:251-256.
[41] KANG C H,JEON H,SHIN Y,et al.Heat adaptation improves viability of Lactococcus lactis subsp. lactis HE-1 after heat stress[J].Food Science and Biotechnology,2015,24(5):1 823-1 827.
[42] DUAR R M,FRESE S A,LIN X X B E,et al.Xperimental evaluation of host adaptation of lactobacillus reuteri to different vertebrate species[J].Applied and Environmental Microbiology,2017,83(12).
[43] GRANATA G,STRACQUADANIO S,LEONARDI M,et al.Essential oils encapsulated in polymer-based nanocapsules as potential candidates for application in food preservation[J].Food Chemistry,2018,269:286-292.
[2] 彭娟,邓夏青,敖钰舒,等.岩藻黄素抗肥胖和抗糖尿病活性研究进展[J].现代食品科技,2015,31(9):314-325.
[3] LIEN T F,LIN K J,YANG L L,et al.Effects of supplemental levels of bazhen on growth performances,serum traits,immunity,meat quality and antioxidant activity of taiwan country chickens[J].Asian-Australasian Journal of Animal Sciences,2013,26(5):675-682.
[4] WU Y R,GONG Q F,FANG H,et al.Effect of sophoraflavescens on non-specific immune response of tilapia (GIFT Oreochromisniloticus) and disease resistance against streptococcus agalactiae[J].Fish & Shellfish Immunology,2013,34(1):220-227.
[5] LI X T,WANG B,LI J L,et al.Effects of Dangguibuxue Tang,a Chinese herbal medicine,on growth performance and immune responses in broiler chicks[J].Biological Research,2013,46(2):183-188.
[6] 6. YEH H S,WENG B C,LIEN T F.Effects of Chinese traditional herbal medicine complex supplementation on the growth performance,immunity and serum traitsofpigs[J].Animal Science Journal,2011,82(6):747-752.
[7] LIANG X,YAMAZAKI K,KAMRUZZAMAN M,et al.Effects of Chinese herbal medicine on plasma glucose,protein and energy metabolism in sheep[J].Journal of Animal Science and Biotechnology,2013,4:12.
[8] WANG EL,CHEN X,WANG KY,et al.Plant polysaccharides used as immunostimulants enhance innate immune response and diseaseresistance against Aeromonas hydrophila infection in fish [J].Fish & Shellfish Immunology,2016,59:196-202.
[9] JUTURU V,WU J C.Insight into microbial hemicellulases other than xylanases: a review[J].J Chem Technol Biot,2013,88(3):353-363.
[10] 许梓荣,卢建军,杨英.饲粮中添加半纤维素酶对生长猪的促生长作用及其内分泌机制[J].中国兽医学报,2002,22(2):201-202.
[11] BAREKATAIN M R,ANTIPATIS C,RODGERS N,et al.Evaluation of high dietary inclusion of distillers dried grains with solubles and supplementation of protease and xylanase in the diets of broiler chickens under necrotic enteritis challenge[J].Poultry Science.2013,92(6):1 579-1 594.
[12] 武明欣,王雅平,李培玉,等.饲料中添加木聚糖酶对刺参幼参生长、消化和体腔液酶活力的影响[J].大连海洋大学学报,2018,33(3):329-335.
[13] NORAG M A A,EL-SHENAWY A M,FADL S E,et al.Effect of phytase enzyme on growth performance, serum biochemical alteration,immune response and gene expression in Nile tilapia[J].Fish & Shellfish Immunology,2018,80,97-108.
[14] 王坛,赵金鑫,刘东来,等.饲用溶菌酶对吉富罗非鱼消化道组织结构和营养物质消化吸收的影响[J/OL].渔业科学进展,2018-11-12.DOI:10.19663/j.issn2095-9869.20180918001.
[15] ZOU LJ,XIONG X,LIU HN,et al.Effects of dietary lysozyme levels on growth performance,intestinal morphology,immunity response and microbiota community of growing pigs[J].Journal of the Science of Food and Agriculture,2019,99(4):1 643-1 650.
[16] 张哲,殷海成,贾峰,等.发酵饲料对黄河鲤生长、非特异性免疫功能的影响[J].粮食与饲料工业,2015(3):56-59.
[17] 姜旭东.枯草芽孢杆菌对白羽肉鸡生产性能的影响[J].中国畜牧兽医文摘,2017,33(3),224-225.
[18] GALAGARZA O A,SMITH S A, DRAHOS D J,et al.Modulation of innate immunity in Nile tilapia (Oreochromis niloticus) by dietary supplementation of Bacillus subtilis endospores [J].Fish & Shellfish Immunology,2018,83:171-179.
[19] NGUYEN N V,ONODA S,KHANH T V,et al.Evaluation of dietary Heat-killed Lactobacillus plantarum strain L-137 supplementation on growth performance,immunity and stress resistance of Nile tilapia (Oreochromis niloticus) [J].Aquaculture,2019,498:371-379.
[20] MA Y X,LI L Y,LI M,et al.Effects of dietary probiotic yeast on growth parameters in juvenile sea cucumber,Apostichopus japonicas [J].Aquaculture,2019,499:203-211.
[21] GRANDIOSA R,MERIEN F,YOUNG T,et al.Multi-strain probiotics enhance immune responsiveness and alters metabolic profiles in the New Zealand black-footed abalone (Haliotis iris) [J].Fish & Shellfish Immunology,2018,82:330-338.
[22] 仝慧芳,吴明芳,凌晓东,等.枯草芽孢杆菌在水产养殖中的应用及研究现状[J].江西水产科技,2016(3):37-38.
[23] 张旭,王京树,杨元金,等.微生物制剂在水产养殖中的应用[J].畜牧与饲料科学,2011,32(2):101-102.
[24] LI C L,ZHU J H,WANG Y Q,et al.Antibacterial activity of aI-hemocidin 2,a novel N-terminal peptide of hemoglobin purified from Arcainflata[J].Marine Drugs,2017,15:7.
[25] ENNAAS N,HAMMAMI R,GOMAA A,et al.Collagencin,an antibacterial peptide from fish collagen:Activity,structure and interaction dynamicswithmembrane[J].Biochemical and Biophysical Research Communications,2016,473(2):642-647.
[26] XIN HY ,JI S Y,PENG J Y,et al.Isolation and characterisation of a novel antibacterial peptide from a native swine intestinal tract-derived bacterium[J].International Journal of Antimicrobial Agents,2017,49(4):427-436.
[27] XIN H Y,JI S Y,PENG J Y,et al.K1K8:an Hp1404-derived antibacterial peptide[J].Applied Microbiology and Iotechnology,2016,100(11):5 069-5 077.
[28] 柴仙琦,冷向军.抗菌肽在凡纳滨对虾饲料中的应用研究[J].养殖与饲料,2012(9):99-100.
[29] SHI J K,ZHANG P,XU M M,et al.Effects of composite antimicrobial peptide on growth performance and health in weaned piglets [J].Animal Science Journal,2018,89(2):397-403.
[30] YUAN W,JIN H T,REN Z H,et al.Effects of antibacterial peptide on humoral immunity in weaned piglets [J].Food and Agricultural Immunology,2015,26(5):682-689.
[31] DONG X Q,ZHANG D M,CHEN Y K,et al.Effects of antimicrobial peptides (AMPs) on blood biochemical parameters,antioxidase activity,and immune function in the common carp (Cyprinus carpio) [J].Fish & Shellfish Immunology,2015,47(1):429-434.
[32] 吴醒强.天然植物精油和有机酸复合物添加剂在肉鸡生产中替代抗生素的应用[J].广东饲料,2017,26(2):25-27.
[33] 张文静,雷连成,魏静元,等.植物精油对肉仔鸡生长、屠宰性能和免疫功能的影响[J].饲料工业,2016,37(8):35-40.
[34] SU G Q,ZHOU X W,WANG Y,et al.Effects of plant essential oil supplementation on growth performance, immune function and antioxidant activities in weaned pigs [J].Lipids in Health and Disease,2018,17.
[35] ZHU B,ZHANG Q L,HUA J W,et al.The traditional uses, phytochemistry,and pharmacology of Atractylodes macrocephala Koidz.:A review [J].Journal of Ethnopharmacology,2018,226:143-167.
[36] LEE H W,KIM S R,JUN J H,et al.Effects of herbal medicine (gan mai da zao decoction) on several types of neuropsychiatric disorders in an animal model:A systematic review [J].Journal of Pharmacopuncture,2017,20(1):5-9.
[37] HUANG Y,WANG Y,YAN R J,et al.The role of traditional Chinese herbal medicines and bioactive ingredients on ion channels:a brief review and prospect [J].CNS & Neurological Disorders Drug Targets,2018.
[38] 冯定远.饲料酶制剂应用技术与产业开发现状和展望[J].饲料工业,2018,39(17):1-6.
[39] 王志强,张爱忠,姜宁,等.抗菌肽在畜牧业上的应用研究及问题分析[J].黑龙江八一农垦大学学报,2013,25(5):21-26.
[40] PERRON G G,ZASLOF M,BELL G.Experimental evolution of resisitance to an antimicrobial peptide[J].Proc Biol Sci,2006,273:251-256.
[41] KANG C H,JEON H,SHIN Y,et al.Heat adaptation improves viability of Lactococcus lactis subsp. lactis HE-1 after heat stress[J].Food Science and Biotechnology,2015,24(5):1 823-1 827.
[42] DUAR R M,FRESE S A,LIN X X B E,et al.Xperimental evaluation of host adaptation of lactobacillus reuteri to different vertebrate species[J].Applied and Environmental Microbiology,2017,83(12).
[43] GRANATA G,STRACQUADANIO S,LEONARDI M,et al.Essential oils encapsulated in polymer-based nanocapsules as potential candidates for application in food preservation[J].Food Chemistry,2018,269:286-292.