香砂六君子汤加味治疗化疗后迟发性恶心呕吐的临床研究
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摘要
目的研讨化疗患者接受香砂六君子汤加味治疗对迟发性恶心呕吐症状的改善效果。方法选择2016年1月至2017年12月在我院接受化疗治疗且符合标准的30例迟发性恶心呕吐患者作随机非盲实验,同时划分患者为两组,Ⅰ组按常规西医标准给予格拉司琼使用,Ⅱ组接受香砂六君子汤加味温服,观察评估两组的恶心呕吐症状改善情况。结果Ⅱ组相对Ⅰ组在迟发性恶心呕吐的疗效上明显提高,总有效率达到100.0%(15/15),比较有统计学意义(P<0.05)。施治前,两组在KPS评分、证候积分方面相比,无统计学意义(P>0.05);施治后,两组在KPS评分、证候积分上相对施治前均有明显改善,比较有统计学意义(P<0.05);且Ⅱ组相对Ⅰ组在上述2项评分上改善更显著,比较有统计学意义(P<0.05)。结论对化疗后迟发性恶心呕吐患者使用香砂六君子汤加味温服是一种可行的治疗方案,能够有效提升疗效,促进恶心呕吐症状的缓解,同时对患者的生活质量也有明显的改善效果,值得推荐。
Objective To study the effect of modified Xiangsha Liujunzi Decoction in chemotherapy patients on the improvement of symptoms of delayed nausea and vomiting. Methods Thirty patients with delayed nausea and vomiting treated with chemotherapy in our hospital from January 2016 to December 2017 were randomized and unblinded. At the same time, patients were divided into two groups. Group I was given conventional western medicine standards. Granisetron was used. Group Ⅱ received warm dressing with Xiangsha Liujunzi Decoction. The symptoms of nausea and vomiting improved in both groups. Results The efficacy of group Ⅱ relative to group Ⅰ was significantly improved in delayed nausea and vomiting. The total effective rate was 100.0%(15/15), which was statistically significant(P<0.05). Before treatment, there was no statistically significant difference in KPS scores and syndrome scores between the two groups(P > 0.05). After treatment, the two groups showed significant improvements in KPS scores and syndrome scores before treatment. There was a statistically significant difference(P< 0.05), and the improvement in the above two scores was more significant in group Ⅱ relative to group Ⅰ, with statistical significance(P< 0.05). Conclusion The use of Xiangsha Liujunzi Decoction Warming Dressing for patients with delayed nausea and vomiting after chemotherapy is a feasible treatment plan, and at the same time significantly improve the quality of life of patients.
Objective To study the effect of modified Xiangsha Liujunzi Decoction in chemotherapy patients on the improvement of symptoms of delayed nausea and vomiting. Methods Thirty patients with delayed nausea and vomiting treated with chemotherapy in our hospital from January 2016 to December 2017 were randomized and unblinded. At the same time, patients were divided into two groups. Group I was given conventional western medicine standards. Granisetron was used. Group Ⅱ received warm dressing with Xiangsha Liujunzi Decoction. The symptoms of nausea and vomiting improved in both groups. Results The efficacy of group Ⅱ relative to group Ⅰ was significantly improved in delayed nausea and vomiting. The total effective rate was 100.0%(15/15), which was statistically significant(P<0.05). Before treatment, there was no statistically significant difference in KPS scores and syndrome scores between the two groups(P > 0.05). After treatment, the two groups showed significant improvements in KPS scores and syndrome scores before treatment. There was a statistically significant difference(P< 0.05), and the improvement in the above two scores was more significant in group Ⅱ relative to group Ⅰ, with statistical significance(P< 0.05). Conclusion The use of Xiangsha Liujunzi Decoction Warming Dressing for patients with delayed nausea and vomiting after chemotherapy is a feasible treatment plan, and at the same time significantly improve the quality of life of patients.
引文
[1]李陆振,方灿途,张华堂,等.香砂六君子汤加减治疗晚期非小细胞肺癌34例化疗呕吐的临床研究[J].实用中西医结合临床,2016,16(9):34-35.
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[7]景鑫艳,李仁廷.加味香砂六君子汤联合胃复安治疗晚期直肠癌化疗后消化道不良反应的临床观察[J].现代中医药,2017,16(1):27-29.
[8]周凤华.香砂六君子汤加味治疗肿瘤患者化疗所致食欲不振的临床效果分析[J].深圳中西医结合杂志,2014,24(7):47-48.
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[10]韩瑞雪,马阳,李仁廷.加味香砂六君子汤缓解胃癌化疗消化道反应临床观察[J].山西中医,2012,28(6):11-12.
[11]黄景彬,林清,陈雁秋,等.香砂六君子汤加味治疗化疗后厌食症[J].中医临床研究,2015,12(8):64-66.
[12]张林英,林才志,陈漫,等.加味香砂六君子汤联合5-HT3受体拮抗剂类止吐药治疗肿瘤化疗呕吐的系统评价[J].湖南中医杂志,2016,32(1):147-149.
[13]赵莉莎,李仁廷.加味香砂六君子汤合旋覆代赭石汤防治化疗消化道反应25例[J].江西中医药,2016,47(10):58-60.
[14]陈鹄.加味香砂六君子汤缓解肿瘤化疗致胃肠道反应的疗效观察[J].海峡药学,2014,12(6):159-160.
[15]欧阳现强,王燕国.香砂六君子汤加味配合胃复安足三里穴封治疗恶性中瘤化疗后胃肠道反应疗效观察[J].内蒙古中医药,2014,33(8):22.
[16]仝欣,徐川,李敏,等.加味香砂六君子汤对大肠癌术后化疗患者生存质量的影响[J].云南中医学院学报,2017,40(1):37-40.
[17]章淼,盛文,郭利华.加味香砂六君子汤治疗化疗所致迟发性呕吐20例疗效观察[J].云南中医中药杂志,2014,35(1):40.
[2]王建平,魏品康.中西药合用防治顺铂联合化疗所致迟发性恶心呕吐50例[J].实用中医药杂志,2012,28(8):672-673.
[3]徐川,于小伟,李敏.加味香砂六君子汤联合FOLFIRI方案治疗晚期结肠癌[J].中国临床医学,2012,19(1):36-37.
[4]龚举君.香砂六君子汤加味治疗功能性消化不良30例[J].实用中医药杂志,2015,11(6):518.
[5]钟旭辉,李娟,陈星.香砂六君子汤联合西药治疗化疗导致的恶心呕吐临床观察[J].中国乡村医药,2014,9(10):48-49.
[6]孟涛.加味香砂六君子汤用于胃癌化疗消化道反应缓解中的疗效观察[J].临床医药文献电子杂志,2017,4(10):148-149.
[7]景鑫艳,李仁廷.加味香砂六君子汤联合胃复安治疗晚期直肠癌化疗后消化道不良反应的临床观察[J].现代中医药,2017,16(1):27-29.
[8]周凤华.香砂六君子汤加味治疗肿瘤患者化疗所致食欲不振的临床效果分析[J].深圳中西医结合杂志,2014,24(7):47-48.
[9]夏青,陈军.香砂六君子汤加味合盐酸昂丹司琼注射液治疗化疗后恶心呕吐[J].吉林中医药,2014,34(2):164-165.
[10]韩瑞雪,马阳,李仁廷.加味香砂六君子汤缓解胃癌化疗消化道反应临床观察[J].山西中医,2012,28(6):11-12.
[11]黄景彬,林清,陈雁秋,等.香砂六君子汤加味治疗化疗后厌食症[J].中医临床研究,2015,12(8):64-66.
[12]张林英,林才志,陈漫,等.加味香砂六君子汤联合5-HT3受体拮抗剂类止吐药治疗肿瘤化疗呕吐的系统评价[J].湖南中医杂志,2016,32(1):147-149.
[13]赵莉莎,李仁廷.加味香砂六君子汤合旋覆代赭石汤防治化疗消化道反应25例[J].江西中医药,2016,47(10):58-60.
[14]陈鹄.加味香砂六君子汤缓解肿瘤化疗致胃肠道反应的疗效观察[J].海峡药学,2014,12(6):159-160.
[15]欧阳现强,王燕国.香砂六君子汤加味配合胃复安足三里穴封治疗恶性中瘤化疗后胃肠道反应疗效观察[J].内蒙古中医药,2014,33(8):22.
[16]仝欣,徐川,李敏,等.加味香砂六君子汤对大肠癌术后化疗患者生存质量的影响[J].云南中医学院学报,2017,40(1):37-40.
[17]章淼,盛文,郭利华.加味香砂六君子汤治疗化疗所致迟发性呕吐20例疗效观察[J].云南中医中药杂志,2014,35(1):40.